The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACADIA PHARMACEUTICALS INC COM 004225108   75,443,198 2,409,556 SH   SOLE   2,409,556 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106   791,382 225,465 SH   SOLE   225,465 0 0
ALIGN TECHNOLOGY INC COM 016255101   15,263,170 55,705 SH   SOLE   55,705 0 0
ALKERMES PLC SHS G01767105   16,738,316 603,400 SH   SOLE   603,400 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107   29,560,786 154,437 SH   SOLE   154,437 0 0
AMICUS THERAPEUTICS INC COM 03152W109   147,203,016 10,373,715 SH   SOLE   10,373,715 0 0
ANAPTYSBIO INC COM 032724106   14,713,012 686,882 SH   SOLE   686,882 0 0
BIOGEN INC COM 09062X103   98,440,507 380,417 SH   SOLE   380,417 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101   144,702,219 1,500,749 SH   SOLE   1,500,749 0 0
BLUEBIRD BIO INC COM 09609G100   4,600,000 3,333,333 SH   SOLE   3,333,333 0 0
CYTOKINETICS INC COM NEW 23282W605   9,327,252 111,717 SH   SOLE   111,717 0 0
EHEALTH INC COM 28238P109   23,887,385 2,739,379 SH   SOLE   2,739,379 0 0
GOSSAMER BIO INC COM 38341P102   6,530,288 5,958,888 SH   SOLE   5,958,888 0 0
INSMED INC COM PAR $.01 457669307   170,808,234 5,511,721 SH   SOLE   5,511,721 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100   17,128,219 2,106,792 SH   SOLE   2,106,792 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106   4,413,397 5,102,193 SH   SOLE   5,102,193 0 0
MIRUM PHARMACEUTICALS INC COM 604749101   1,909,944 64,700 SH   SOLE   64,700 0 0
NEVRO CORP COM 64157F103   16,147,984 750,371 SH   SOLE   750,371 0 0
NOVOCURE LTD ORD SHS G6674U108   8,389,286 561,908 SH   SOLE   561,908 0 0
PROTHENA CORP PLC SHS G72800108   60,326,471 1,660,057 SH   SOLE   1,660,057 0 0
RELMADA THERAPEUTICS INC COM 75955J402   3,032,136 732,400 SH   SOLE   732,400 0 0
REVANCE THERAPEUTICS INC COM 761330109   46,035,726 5,237,284 SH   SOLE   5,237,284 0 0
SAGE THERAPEUTICS INC COM 78667J108   21,486,347 991,525 SH   SOLE   991,525 0 0
SAREPTA THERAPEUTICS INC COM 803607100   19,373,269 200,905 SH   SOLE   200,905 0 0
SIGHT SCIENCES INC COM 82657M105   896,756 173,790 SH   SOLE   173,790 0 0
STAAR SURGICAL CO COM PAR $0.01 852312305   42,974,610 1,376,950 SH   SOLE   1,376,950 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105   10,212,886 472,600 SH   SOLE   472,600 0 0
TAYSHA GENE THERAPIES INC COM SHS 877619106   937,854 529,861 SH   SOLE   529,861 0 0
TRAVERE THERAPEUTICS INC COM 89422G107   995,364 110,719 SH   SOLE   110,719 0 0
UNITED THERAPEUTICS CORP COM 91307C102   87,028,944 395,784 SH   SOLE   395,784 0 0
UROGEN PHARMA LTD COM M96088105   367,500 24,500 SH   SOLE   24,500 0 0
VANDA PHARMACEUTICALS INC COM 921659108   1,177,317 278,985 SH   SOLE   278,985 0 0
VERVE THERAPEUTICS INC COM 92539P101   8,026,889 575,817 SH   SOLE   575,817 0 0
VYNE THERAPEUTICS INC PIPE COM 92941V308   1,037,861 445,434 SH   SOLE   445,434 0 0