0001306923-16-000045.txt : 20160216 0001306923-16-000045.hdr.sgml : 20160215 20160216170027 ACCESSION NUMBER: 0001306923-16-000045 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20151231 FILED AS OF DATE: 20160216 DATE AS OF CHANGE: 20160216 EFFECTIVENESS DATE: 20160216 FILER: COMPANY DATA: COMPANY CONFORMED NAME: Palo Alto Investors, LLC CENTRAL INDEX KEY: 0001306923 IRS NUMBER: 770558164 STATE OF INCORPORATION: CA FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-11013 FILM NUMBER: 161429888 BUSINESS ADDRESS: STREET 1: 470 UNIVERSITY AVE CITY: PALO ALTO STATE: CA ZIP: 94301 BUSINESS PHONE: 650-325-0772 MAIL ADDRESS: STREET 1: 470 UNIVERSITY AVE CITY: PALO ALTO STATE: CA ZIP: 94301 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001306923 XXXXXXXX 12-31-2015 12-31-2015 Palo Alto Investors, LLC

470 UNIVERSITY AVE PALO ALTO CA 94301

13F HOLDINGS REPORT 028-11013 N Kai Wu 6504703424 /s/ Kai Wu Palo Alto CA 02-16-2016 0 43 1796692 false INFORMATION TABLE 2 pai4q2015.inftab.xml 13F INFORMATION TABLE ABIOMED INCCOM0036541002608652889505SHSOLE0288950500ACELRX PHARMACEUTICALS INCCOM00444T10054881425439SHSOLE0142543900AIMMUNE THERAPEUTICS INCCOM00900T1076007325599SHSOLE032559900ALCOBRA LTDSHSM2239P1091596254188SHSOLE025418800ALIGN TECHNOLOGY INCCOM016255101182827757SHSOLE02775700ALIMERA SCIENCES INCCOM01625910372933013793SHSOLE0301379300AMAG PHARMACEUTICALS INCCOM00163U106856132835792SHSOLE0283579200AMICUS THERAPEUTICS INCCOM03152W109344463551173SHSOLE0355117300ANACOR PHARMACEUTICALS INCCOM0324201012470932187242SHSOLE0218724200ARIAD PHARMACEUTICALS INCCOM04033A100141082257217SHSOLE0225721700BIOMARIN PHARMACEUTICAL INCCOM09061G1011400481336847SHSOLE0133684700CELGENE CORPCOM15102010432431270800SHSOLE027080000CEMPRA INCCOM15130J109366011175733SHSOLE0117573300CLOVIS ONCOLOGY INCCOM1894641001241703547719SHSOLE0354771900CYTOKINETICS INCCOM NEW23282W6051294123686SHSOLE012368600DICERNA PHARMACEUTICALS INCCOM2530311083180267890SHSOLE026789000ENDO INTL PLCSHSG3040110649051801230SHSOLE080123000EPIZYME INCCOM29428V104426292660979SHSOLE0266097900EXACT SCIENCES CORPCOM30063P1053658396276SHSOLE039627600GILEAD SCIENCES INCCOM37555810330650302900SHSOLE030290000HEARTWARE INTL INCCOM42236810012402246068SHSOLE024606800HISTOGENICS CORPCOM43358V1091591454545SHSOLE045454500IDERA PHARMACEUTICALS INCCOM NEW45168K30638861257748SHSOLE0125774800INSMED INCCOM PAR $.01457669307869534790800SHSOLE0479080000INTREXON CORPCOM46122T102142047100SHSOLE04710000KARYOPHARM THERAPEUTICS INCCOM48576U106412433112645SHSOLE0311264500MARINUS PHARMACEUTICALS INCCOM56854Q10145159017SHSOLE05901700MEDIVATION INCCOM58501N10124647509862SHSOLE050986200MOMENTA PHARMACEUTICALS INCCOM60877T100217971468776SHSOLE0146877600OREXIGEN THERAPEUTICS INCCOM68616410428781673024SHSOLE0167302400PROTHENA CORP PLCSHSG7280010847372695518SHSOLE069551800RIGEL PHARMACEUTICALS INCCOM NEW766559603158755239119SHSOLE0523911900SEQUENOM INCCOM NEW8173374051643910023842SHSOLE01002384200SHIRE PLCSPONSORED ADR82481R10621464104700SHSOLE010470000SOPHIRIS BIO INCCOM NEW83578Q209879494000SHSOLE049400000STAAR SURGICAL COCOM PAR $0.01852312305190402666722SHSOLE0266672200SUNESIS PHARMACEUTICALS INCCOM NEW86732860162606974854SHSOLE0697485400UNIQURE NVSHSN9006410133820453SHSOLE02045300UNITED THERAPEUTICS CORP DELCOM91307C1022378361518654SHSOLE0151865400VANDA PHARMACEUTICALS INCCOM921659108375284030908SHSOLE0403090800WRIGHT MED GROUP N VORD SHS 0.03 PARN96617118515562132157SHSOLE0213215700ZELTIQ AESTHETICS INCCOM98933Q10816366573636SHSOLE057363600ZOGENIX INCCOM NEW98978L20442228600SHSOLE02860000