Chief Compliance Officer

0001104659-21-066586.txt : 20210514 0001104659-21-066586.hdr.sgml : 20210514 20210514110241 ACCESSION NUMBER: 0001104659-21-066586 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20210331 FILED AS OF DATE: 20210514 DATE AS OF CHANGE: 20210514 EFFECTIVENESS DATE: 20210514 FILER: COMPANY DATA: COMPANY CONFORMED NAME: Tekla Capital Management LLC CENTRAL INDEX KEY: 0001300336 IRS NUMBER: 010628853 STATE OF INCORPORATION: DE FISCAL YEAR END: 0930 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10950 FILM NUMBER: 21922673 BUSINESS ADDRESS: STREET 1: 100 FEDERAL STREET STREET 2: 19TH FLOOR CITY: BOSTON STATE: MA ZIP: 02110 BUSINESS PHONE: 617 772-8500 MAIL ADDRESS: STREET 1: 100 FEDERAL STREET STREET 2: 19TH FLOOR CITY: BOSTON STATE: MA ZIP: 02110 FORMER COMPANY: FORMER CONFORMED NAME: Hambrecht & Quist Capital Management LLC DATE OF NAME CHANGE: 20040811 13F-HR 1 primary_doc.xml 13F-HR LIVE 0001300336 XXXXXXXX 03-31-2021 03-31-2021 false Tekla Capital Management LLC

100 FEDERAL STREET 19TH FLOOR BOSTON MA 02110

13F HOLDINGS REPORT 028-10950 N Laura Woodward Chief Compliance Officer 617-772-8500 /s/ Laura Woodward Boston MA 05-14-2021 0 196 2907088 false INFORMATION TABLE 2 a21-12116_1informationtable.xml INFORMATION TABLE 1Life Healthcare, Inc. Common 68269G107 1222 31266 SH SOLE 31266 0 0 Abbott Laboratories Common 002824100 89120 743657 SH SOLE 743657 0 0 AbbVie Inc. Common 00287Y109 67070 619759 SH SOLE 619759 0 0 ACADIA Pharmaceuticals Inc. Common 004225108 8560 331789 SH SOLE 331789 0 0 Adaptive Biotechnologies Corp. Common 00650F109 13597 337722 SH SOLE 337722 0 0 Addus HomeCare Corp. Common 006739106 3937 37640 SH SOLE 37640 0 0 Affimed N.V. Common N01045108 2278 288019 SH SOLE 288019 0 0 Agilent Technologies, Inc. Common 00846U101 6678 52525 SH SOLE 52525 0 0 Alexion Pharmaceuticals, Inc. Common 015351109 16926 110693 SH SOLE 110693 0 0 Align Technology, Inc. Common 016255101 5375 9925 SH SOLE 9925 0 0 Alkermes plc Shares G01767105 3174 169930 SH SOLE 169930 0 0 Allakos Inc. Common 01671P100 18783 163645 SH SOLE 163645 0 0 Alnylam Pharmaceuticals, Inc. Common 02043Q107 21871 154902 SH SOLE 154902 0 0 Amedisys, Inc. Common 023436108 5136 19395 SH SOLE 19395 0 0 Amgen Inc. Common 031162100 103644 416560 SH SOLE 416560 0 0 Amicus Therapeutics, Inc. Common 03152W109 6142 621659 SH SOLE 621659 0 0 Anthem, Inc. Common 036752103 59147 164777 SH SOLE 164777 0 0 Apellis Pharmaceuticals, Inc. Common 03753U106 6545 152538 SH SOLE 152538 0 0 ARCA biopharma, Inc. Common 00211Y506 118 32461 SH SOLE 32461 0 0 Arcutis Biotherapeutics, Inc. Common 03969K108 3808 131633 SH SOLE 131633 0 0 Ardelyx, Inc. Common 039697107 4023 607698 SH SOLE 607698 0 0 Arena Pharmaceuticals, Inc. Common 040047607 13627 196385 SH SOLE 196385 0 0 Argenx SE Sponsored ADR 04016X101 17720 64344 SH SOLE 64344 0 0 Arrowhead Pharmaceuticals, Inc. Common 04280A100 8812 132886 SH SOLE 132886 0 0 Arvinas, Inc. Common 04335A105 5684 85997 SH SOLE 85997 0 0 Ascendis Pharma A/S Sponsored ADR 04351P101 15251 118336 SH SOLE 118336 0 0 Assertio Holdings, Inc. Common 04546C106 1121 1642302 SH SOLE 1642302 0 0 AstraZeneca PLC Sponsored ADR 046353108 17120 344333 SH SOLE 344333 0 0 Atreca, Inc. Class A Common 04965G109 5403 352424 SH SOLE 352424 0 0 Aurinia Pharmaceuticals Inc. Common 05156V102 5167 397920 SH SOLE 397920 0 0 Becton, Dickinson and Co. Common 075887109 10530 43307 SH SOLE 43307 0 0 BeiGene, Ltd. Sponsored ADR 07725L102 14059 40389 SH SOLE 40389 0 0 Bellicum Pharmaceuticals, Inc. Common 079481404 23 6000 SH SOLE 6000 0 0 Bio-Techne Corp. Common 09073M104 2903 7600 SH SOLE 7600 0 0 Biogen Inc. Common 09062X103 69055 246844 SH SOLE 246844 0 0 BioMarin Pharmaceutical Inc. Common 09061G101 9666 128004 SH SOLE 128004 0 0 BioNTech SE Sponsored ADS 09075V102 7514 68814 SH SOLE 68814 0 0 Black Diamond Therapeutics, Inc. Common 09203E105 3202 131990 SH SOLE 131990 0 0 Blueprint Medicines Corp. Common 09627Y109 11930 122699 SH SOLE 122699 0 0 Boston Scientific Corp. Common 101137107 7186 185931 SH SOLE 185931 0 0 BridgeBio Pharma, Inc. Common 10806X102 4602 74714 SH SOLE 74714 0 0 Bristol-Myers Squibb Co. Common 110122108 56341 892453 SH SOLE 892453 0 0 Catalent, Inc. Common 148806102 8427 80025 SH SOLE 80025 0 0 Celldex Therapeutics, Inc. Common 15117B202 145 7053 SH SOLE 7053 0 0 Cellectis Sponsored ADR 15117K103 242 11955 SH SOLE 11955 0 0 Centene Corp. Common 15135B101 4301 67290 SH SOLE 67290 0 0 Charles River Laboratories International, Inc. Common 159864107 12484 43074 SH SOLE 43074 0 0 ChemoCentryx, Inc. Common 16383L106 7401 144447 SH SOLE 144447 0 0 Cigna Corp. Common 125523100 45912 189921 SH SOLE 189921 0 0 Clearside Biomedical, Inc. Common 185063104 408 165330 SH SOLE 165330 0 0 Cogent Biosciences, Inc. Common 19240Q201 4721 537742 SH SOLE 537742 0 0 Community Health Systems, Inc. Common 203668108 1589 117535 SH SOLE 117535 0 0 Community Healthcare Trust Inc. Common 20369C106 687 14900 SH SOLE 14900 0 0 Corbus Pharmaceuticals Holdings, Inc. Common 21833P103 815 413481 SH SOLE 413481 0 0 CRISPR Therapeutics AG Namen AKT H17182108 18394 150958 SH SOLE 150958 0 0 CVS Health Corp. Common 126650100 16550 219995 SH SOLE 219995 0 0 CymaBay Therapeutics, Inc. Common 23257D103 400 88102 SH SOLE 88102 0 0 Danaher Corp. Common 235851102 43044 191240 SH SOLE 191240 0 0 Deciphera Pharmaceuticals, Inc. Common 24344T101 13797 307703 SH SOLE 307703 0 0 Denali Therapeutics Inc. Common 24823R105 8570 150086 SH SOLE 150086 0 0 DENTSPLY SIRONA Inc. Common 24906P109 22425 351427 SH SOLE 351427 0 0 Dexcom, Inc. Common 252131107 26826 74643 SH SOLE 74643 0 0 Dicerna Pharmaceuticals, Inc. Common 253031108 1743 68150 SH SOLE 68150 0 0 Diversified Healthcare Trust Common 25525P107 1710 357720 SH SOLE 357720 0 0 Editas Medicine, Inc. Common 28106W103 638 15190 SH SOLE 15190 0 0 Edwards Lifesciences Corp. Common 28176E108 19969 238755 SH SOLE 238755 0 0 Eli Lilly and Co. Common 532457108 54573 292114 SH SOLE 292114 0 0 Endo International plc Shares G30401106 3939 531570 SH SOLE 531570 0 0 Exact Sciences Corp. Common 30063P105 22047 167302 SH SOLE 167302 0 0 Exelixis, Inc. Common 30161Q104 24870 1100920 SH SOLE 1100920 0 0 Fate Therapeutics, Inc. Common 31189P102 12396 150343 SH SOLE 150343 0 0 Five Star Senior Living Inc. Common 33832D205 148 24237 SH SOLE 24237 0 0 Forma Therapeutics Holdings, Inc. Shares 34633R104 4198 149825 SH SOLE 149825 0 0 G1 Therapeutics, Inc. Common 3621LQ109 9426 391754 SH SOLE 391754 0 0 Galera Therapeutics, Inc. Common 36338D108 9189 1041845 SH SOLE 1041845 0 0 Gamida Cell Ltd. Shares M47364100 956 118142 SH SOLE 118142 0 0 Genmab A/S Sponsored ADS 372303206 2397 73015 SH SOLE 73015 0 0 Gilead Sciences, Inc. Common 375558103 117362 1815906 SH SOLE 1815906 0 0 Global Medical REIT Inc. Common 37954A204 2293 174897 SH SOLE 174897 0 0 Grifols, S.A. Sponsored ADR 398438408 819 47373 SH SOLE 47373 0 0 Guardant Health, Inc. Common 40131M109 24230 158727 SH SOLE 158727 0 0 HCA Healthcare, Inc. Common 40412C101 28797 152897 SH SOLE 152897 0 0 Health Care Select Sector SPDR Fund SBI Healthcare 81369Y209 1174 10055 SH SOLE 10055 0 0 Healthcare Realty Trust Inc. Common 421946104 3154 104024 SH SOLE 104024 0 0 Healthcare Trust of America, Inc. Common 42225P501 1949 70662 SH SOLE 70662 0 0 Healthpeak Properties, Inc. Common 42250P103 4773 150392 SH SOLE 150392 0 0 Helix Acquisition Corp. Class A Common G4444C102 2559 250000 SH SOLE 250000 0 0 Heron Therapeutics, Inc. Common 427746102 2126 131183 SH SOLE 131183 0 0 Hologic, Inc. Common 436440101 2422 32564 SH SOLE 32564 0 0 Horizon Therapeutics plc Shares G46188101 74638 810932 SH SOLE 810932 0 0 Humana Inc. Common 444859102 15655 37341 SH SOLE 37341 0 0 I-Mab Sponsored ADS 44975P103 8089 166896 SH SOLE 166896 0 0 Icon plc Shares G4705A100 4633 23592 SH SOLE 23592 0 0 IDEXX Laboratories, Inc. Common 45168D104 17035 34814 SH SOLE 34814 0 0 Illumina, Inc. Common 452327109 94783 246793 SH SOLE 246793 0 0 Incyte Corp. Common 45337C102 8752 107687 SH SOLE 107687 0 0 Insmed Inc. Common 457669307 3351 98387 SH SOLE 98387 0 0 Intellia Therapeutics, Inc. Common 45826J105 4268 53180 SH SOLE 53180 0 0 Intercept Pharmaceuticals, Inc. Common 45845P108 1779 77067 SH SOLE 77067 0 0 Intra-Cellular Therapies, Inc. Common 46116X101 7888 232476 SH SOLE 232476 0 0 Intuitive Surgical, Inc. Common 46120E602 15736 21296 SH SOLE 21296 0 0 Ionis Pharmaceuticals, Inc. Common 462222100 9728 216371 SH SOLE 216371 0 0 Iovance Biotherapeutics, Inc. Common 462260100 16482 520595 SH SOLE 520595 0 0 IQVIA Holdings Inc. Common 46266C105 13494 69866 SH SOLE 69866 0 0 Jazz Pharmaceuticals plc Shares G50871105 11088 67456 SH SOLE 67456 0 0 Johnson & Johnson Common 478160104 99409 604864 SH SOLE 604864 0 0 Jounce Therapeutics, Inc. Common 481116101 3926 382237 SH SOLE 382237 0 0 KalVista Pharmaceuticals, Inc. Common 483497103 1285 50000 SH SOLE 50000 0 0 Karuna Therapeutics, Inc. Common 48576A100 10248 85236 SH SOLE 85236 0 0 Koninklijke Philips N.V. NY Reg Sh 500472303 3247 56927 SH SOLE 56927 0 0 Kura Oncology, Inc. Common 50127T109 7731 273463 SH SOLE 273463 0 0 Laboratory Corp. of America Holdings Sponsored ADR 50540R409 25396 99580 SH SOLE 99580 0 0 LTC Properties, Inc. Common 502175102 7605 182293 SH SOLE 182293 0 0 Madrigal Pharmaceuticals, Inc. Common 558868105 1560 13340 SH SOLE 13340 0 0 McKesson Corp. Common 58155Q103 24565 125948 SH SOLE 125948 0 0 Medical Properties Trust, Inc. Common 58463J304 8762 411743 SH SOLE 411743 0 0 Medpace Holdings, Inc. Common 58506Q109 3096 18871 SH SOLE 18871 0 0 Medtronic plc Shares G5960L103 58145 492214 SH SOLE 492214 0 0 Merck & Co., Inc. Common 58933Y105 41760 541703 SH SOLE 541703 0 0 Mereo BioPharma Group plc ADS 589492107 3361 997290 SH SOLE 997290 0 0 Mettler-Toledo International Inc. Common 592688105 11326 9800 SH SOLE 9800 0 0 Mirati Therapeutics, Inc. Common 60468T105 14352 83784 SH SOLE 83784 0 0 Moderna, Inc. Common 60770K107 61848 472302 SH SOLE 472302 0 0 Molecular Templates, Inc. Common 608550109 2517 199420 SH SOLE 199420 0 0 Molina Healthcare, Inc. Common 60855R100 9296 39769 SH SOLE 39769 0 0 Morphic Holding, Inc. Common 61775R105 5667 89559 SH SOLE 89559 0 0 MorphoSys AG Sponsored ADS 617760202 1785 81867 SH SOLE 81867 0 0 National Health Investors, Inc. Common 63633D104 726 10038 SH SOLE 10038 0 0 Nektar Therapeutics Common 640268108 3609 180438 SH SOLE 180438 0 0 Neurocrine Biosciences, Inc. Common 64125C109 20704 212891 SH SOLE 212891 0 0 New Senior Investment Group Inc. Common 648691103 1597 256398 SH SOLE 256398 0 0 Nkarta, Inc. Common 65487U108 954 28988 SH SOLE 28988 0 0 Novartis AG Sponsored ADR 66987V109 11645 136225 SH SOLE 136225 0 0 Novavax, Inc. Common 670002401 19069 105176 SH SOLE 105176 0 0 Novo Nordisk A/S Sponsored ADR 670100205 3264 48406 SH SOLE 48406 0 0 Omega Healthcare Investors, Inc. Common 681936100 11225 306433 SH SOLE 306433 0 0 Ovid Therapeutics Inc. Sponsored ADR 690469101 1498 372733 SH SOLE 372733 0 0 Owens & Minor, Inc. Common 690732102 10000 266023 SH SOLE 266023 0 0 PerkinElmer, Inc. Common 714046109 4759 37094 SH SOLE 37094 0 0 Perrigo Co. plc Shares G97822103 2073 51224 SH SOLE 51224 0 0 Personalis, Inc. Common 71535D106 4423 179731 SH SOLE 179731 0 0 Pfizer Inc. Common 717081103 25552 705259 SH SOLE 705259 0 0 Physicians Realty Trust Common 71943U104 8760 495733 SH SOLE 495733 0 0 Pieris Pharmaceuticals, Inc. Common 720795103 2630 1023348 SH SOLE 1023348 0 0 PRA Health Sciences, Inc. Common 69354M108 15938 103943 SH SOLE 103943 0 0 Praxis Precision Medicines, Inc. Common 74006W108 2457 75000 SH SOLE 75000 0 0 Precision BioSciences, Inc. Common 74019P108 652 63001 SH SOLE 63001 0 0 R1 RCM Inc. Common 749397105 3047 123461 SH SOLE 123461 0 0 Reata Pharmaceuticals, Inc. Class A 75615P103 3810 38219 SH SOLE 38219 0 0 Regeneron Pharmaceuticals, Inc. Common 75886F107 72629 153505 SH SOLE 153505 0 0 REGENXBIO Inc. Common 75901B107 740 21700 SH SOLE 21700 0 0 Replimune Group, Inc. Common 76029N106 6684 219060 SH SOLE 219060 0 0 ResMed Inc. Common 761152107 25677 132344 SH SOLE 132344 0 0 Sabra Health Care REIT, Inc. Common 78573L106 8865 510660 SH SOLE 510660 0 0 Sage Therapeutics, Inc. Common 78667J108 8542 114119 SH SOLE 114119 0 0 Sanofi Sponsored ADR 80105N105 4034 81554 SH SOLE 81554 0 0 Sarepta Therapeutics, Inc. Common 803607100 9613 128987 SH SOLE 128987 0 0 Scholar Rock Holding Corp. Common 80706P103 2425 47869 SH SOLE 47869 0 0 Seagen Inc. Common 81181C104 31312 225490 SH SOLE 225490 0 0 Smith & Nephew plc Shares 83175M205 3773 99560 SH SOLE 99560 0 0 Spectrum Pharmaceuticals, Inc. Common 84763A108 374 114670 SH SOLE 114670 0 0 STERIS plc Shares G8473T100 24149 126779 SH SOLE 126779 0 0 Stryker Corp. Common 863667101 36983 151830 SH SOLE 151830 0 0 Sutro Biopharma, Inc. Common 869367102 13060 573823 SH SOLE 573823 0 0 Syneos Health, Inc. Class A 87166B102 20680 272647 SH SOLE 272647 0 0 Takeda Pharmaceutical Co. Ltd. Sponsored ADS 874060205 3837 210146 SH SOLE 210146 0 0 TCR2 Therapeutics Inc. Common 87808K106 5207 235808 SH SOLE 235808 0 0 Teladoc Health, Inc. Common 87918A105 5391 29664 SH SOLE 29664 0 0 Teleflex Inc. Common 879369106 914 2200 SH SOLE 2200 0 0 Tenet Healthcare Corp. Common 88033G407 3137 60336 SH SOLE 60336 0 0 Tetraphase Pharmaceuticals, Inc. Common 881CVR013 9 42965 SH SOLE 42965 0 0 Teva Pharmaceutical Industries Ltd. Sponsored ADR 881624209 7623 660551 SH SOLE 660551 0 0 Theravance Biopharma, Inc. Common G8807B106 9313 456296 SH SOLE 456296 0 0 Thermo Fisher Scientific Inc. Common 883556102 51869 113653 SH SOLE 113653 0 0 Travere Therapeutics, Inc. Common 89422G107 5315 212869 SH SOLE 212869 0 0 Trillium Therapeutics Inc. Common 89620X506 5684 529226 SH SOLE 529226 0 0 Turning Point Therapeutics, Inc. Common 90041T108 11287 119324 SH SOLE 119324 0 0 Ultragenyx Pharmaceutical Inc. Common 90400D108 11099 97480 SH SOLE 97480 0 0 uniQure N.V. Shares N90064101 4211 125003 SH SOLE 125003 0 0 United Therapeutics Corp. Class B 91307C102 10624 63513 SH SOLE 63513 0 0 Unitedhealth Group Inc. Common 91324P102 78985 212285 SH SOLE 212285 0 0 Universal Health Realty Income Trust Shares 91359E105 763 11258 SH SOLE 11258 0 0 Universal Health Services, Inc. Class B 913903100 9514 71323 SH SOLE 71323 0 0 Ventas, Inc. Common 92276F100 11100 208108 SH SOLE 208108 0 0 Verona Pharma plc Sponsored ADR 925050106 6286 751905 SH SOLE 751905 0 0 Vertex Pharmaceuticals Inc. Common 92532F100 84943 395288 SH SOLE 395288 0 0 Vir Biotechnology, Inc. Common 92764N102 4173 81400 SH SOLE 81400 0 0 VYNE Therapeutics Inc. Common 92941V209 927 135395 SH SOLE 135395 0 0 Waters Corp. Common 941848103 29187 102710 SH SOLE 102710 0 0 Welltower Inc. Common 95040Q104 14547 203083 SH SOLE 203083 0 0 Xenon Pharmaceuticals Inc. Common 98420N105 2970 165898 SH SOLE 165898 0 0 Y-mAbs Therapeutics, Inc. Common 984241109 5982 197820 SH SOLE 197820 0 0 Zai Lab Ltd. ADR 98887Q104 5007 37523 SH SOLE 37523 0 0 Zimmer Biomet Holdings, Inc. Common 98956P102 33267 207814 SH SOLE 207814 0 0 Zoetis Inc. Class A 98978V103 8901 56521 SH SOLE 56521 0 0 Zogenix, Inc. Common 98978L204 1737 88977 SH SOLE 88977 0 0