Chief Compliance Officer

0001104659-21-021559.txt : 20210212 0001104659-21-021559.hdr.sgml : 20210212 20210212121255 ACCESSION NUMBER: 0001104659-21-021559 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20201231 FILED AS OF DATE: 20210212 DATE AS OF CHANGE: 20210212 EFFECTIVENESS DATE: 20210212 FILER: COMPANY DATA: COMPANY CONFORMED NAME: Tekla Capital Management LLC CENTRAL INDEX KEY: 0001300336 IRS NUMBER: 010628853 STATE OF INCORPORATION: DE FISCAL YEAR END: 0930 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10950 FILM NUMBER: 21624703 BUSINESS ADDRESS: STREET 1: 100 FEDERAL STREET STREET 2: 19TH FLOOR CITY: BOSTON STATE: MA ZIP: 02110 BUSINESS PHONE: 617 772-8500 MAIL ADDRESS: STREET 1: 100 FEDERAL STREET STREET 2: 19TH FLOOR CITY: BOSTON STATE: MA ZIP: 02110 FORMER COMPANY: FORMER CONFORMED NAME: Hambrecht & Quist Capital Management LLC DATE OF NAME CHANGE: 20040811 13F-HR 1 primary_doc.xml 13F-HR LIVE 0001300336 XXXXXXXX 12-31-2020 12-31-2020 false Tekla Capital Management LLC

100 FEDERAL STREET 19TH FLOOR BOSTON MA 02110

13F HOLDINGS REPORT 028-10950 N Laura Woodward Chief Compliance Officer 617-772-8500 /s/ Laura Woodward Boston MA 02-12-2021 0 200 2845923 false INFORMATION TABLE 2 a20-38664_1informationtable.xml INFORMATION TABLE Abbott Laboratories Common 002824100 47206 431145 SH SOLE 431145 0 0 AbbVie Inc. Common 00287Y109 66407 619759 SH SOLE 619759 0 0 ABIOMED, Inc. Common 003654100 3505 10812 SH SOLE 10812 0 0 AC Immune SA Shares H00263105 888 171813 SH SOLE 171813 0 0 ACADIA Pharmaceuticals Inc. Common 004225108 17737 331789 SH SOLE 331789 0 0 Adaptive Biotechnologies Corporation Common 00650F109 16912 286013 SH SOLE 286013 0 0 Addus HomeCare Corporation Common 006739106 4407 37640 SH SOLE 37640 0 0 Aerie Pharmaceuticals, Inc. Common 00771V108 901 66688 SH SOLE 66688 0 0 Affimed N.V. Common N01045108 1560 268019 SH SOLE 268019 0 0 Agilent Technologies, Inc. Common 00846U101 6224 52525 SH SOLE 52525 0 0 Alcon Inc. Ordinary Shares H01301128 2064 31286 SH SOLE 31286 0 0 Alexion Pharmaceuticals, Inc. Common 015351109 78423 501942 SH SOLE 501942 0 0 Align Technology, Inc. Common 016255101 5366 10041 SH SOLE 10041 0 0 Alkermes plc Shares G01767105 3390 169930 SH SOLE 169930 0 0 Allakos Inc. Common 01671P100 18331 130937 SH SOLE 130937 0 0 Allogene Therapeutics, Inc. Common 019770106 1214 48089 SH SOLE 48089 0 0 Alnylam Pharmaceuticals, Inc. Common 02043Q107 22731 174894 SH SOLE 174894 0 0 Amarin Corporation PLC Sponsored ADR 023111206 4154 849588 SH SOLE 849588 0 0 Amedisys, Inc. Common 023436108 5689 19395 SH SOLE 19395 0 0 Amgen Inc. Common 031162100 95775 416560 SH SOLE 416560 0 0 Amicus Therapeutics, Inc. Common 03152W109 9366 405626 SH SOLE 405626 0 0 Anthem, Inc. Common 036752103 11923 37133 SH SOLE 37133 0 0 Apellis Pharmaceuticals, Inc. Common 03753U106 12356 216017 SH SOLE 216017 0 0 ARCA biopharma, Inc. Common 00211Y506 130 32461 SH SOLE 32461 0 0 Ardelyx, Inc. Common 039697107 3932 607698 SH SOLE 607698 0 0 Arena Pharmaceuticals, Inc. Common 040047607 19436 252971 SH SOLE 252971 0 0 Argenx SE Sponsored ADR 04016X101 18142 61687 SH SOLE 61687 0 0 Arrowhead Pharmaceuticals, Inc. Common 04280A100 10196 132886 SH SOLE 132886 0 0 Arvinas, Inc. Common 04335A105 6239 73459 SH SOLE 73459 0 0 Ascendis Pharma A/S Sponsored ADR 04351P101 16052 96246 SH SOLE 96246 0 0 Assertio Holdings, Inc. Common 04546C106 587 1642302 SH SOLE 1642302 0 0 AstraZeneca PLC Sponsored ADR 046353108 17213 344333 SH SOLE 344333 0 0 Atreca, Inc. Class A Common 04965G109 5692 352424 SH SOLE 352424 0 0 Aurinia Pharmaceuticals Inc. Common 05156V102 4157 300611 SH SOLE 300611 0 0 Avadel Pharmaceuticals plc Sponsored ADR 05337M104 1561 233612 SH SOLE 233612 0 0 Axonics Modulation Technologies, Inc. Common 05465P101 4032 80760 SH SOLE 80760 0 0 Axsome Therapeutics, Inc. Common 05464T104 2574 31591 SH SOLE 31591 0 0 Bausch Health Companies Inc. Common 071734107 2109 101412 SH SOLE 101412 0 0 Becton, Dickinson and Company Common 075887109 32960 131723 SH SOLE 131723 0 0 BeiGene, Ltd. Sponsored ADR 07725L102 7307 28280 SH SOLE 28280 0 0 Bellicum Pharmaceuticals, Inc. Common 079481404 21 6000 SH SOLE 6000 0 0 Bio-Techne Corporation Common 09073M104 16421 51710 SH SOLE 51710 0 0 Biogen Inc. Common 09062X103 60442 246844 SH SOLE 246844 0 0 BioMarin Pharmaceutical Inc. Common 09061G101 24407 278330 SH SOLE 278330 0 0 Blueprint Medicines Corporation Common 09627Y109 13761 122699 SH SOLE 122699 0 0 Boston Scientific Corporation Common 101137107 8847 246089 SH SOLE 246089 0 0 Bristol Myers Squibb Company Common 110122108 61404 989908 SH SOLE 989908 0 0 Bristol Myers Squibb Company Right 110122157 1017 1473710 SH SOLE 1473710 0 0 Celldex Therapeutics, Inc. Common 15117B202 124 7053 SH SOLE 7053 0 0 Cellectis Sponsored ADR 15117K103 324 11955 SH SOLE 11955 0 0 Centene Corporation Common 15135B101 5051 84145 SH SOLE 84145 0 0 Charles River Laboratories International, Inc. Common 159864107 7035 28154 SH SOLE 28154 0 0 ChemoCentryx, Inc. Common 16383L106 8944 144447 SH SOLE 144447 0 0 Cigna Corporation Common 125523100 28253 135712 SH SOLE 135712 0 0 Clearside Biomedical, Inc. Common 185063104 453 165330 SH SOLE 165330 0 0 Cogent Biosciences, Inc. Common 19240Q201 6039 537742 SH SOLE 537742 0 0 Community Health Systems, Inc. Common 203668108 875 117735 SH SOLE 117735 0 0 Community Healthcare Trust Incorporated Common 20369C106 702 14900 SH SOLE 14900 0 0 Corbus Pharmaceuticals Holdings, Inc. Common 21833P103 517 413481 SH SOLE 413481 0 0 CRISPR Therapeutics AG Namen AKT H17182108 11670 76222 SH SOLE 76222 0 0 CVS Health Corporation Common 126650100 15026 219995 SH SOLE 219995 0 0 CymaBay Therapeutics, Inc. Common 23257D103 506 88102 SH SOLE 88102 0 0 Danaher Corporation Common 235851102 48835 219840 SH SOLE 219840 0 0 Deciphera Pharmaceuticals, Inc. Common 24344T101 3502 61370 SH SOLE 61370 0 0 Denali Therapeutics Inc. Common 24823R105 6059 72333 SH SOLE 72333 0 0 DENTSPLY SIRONA Inc. Common 24906P109 19160 365927 SH SOLE 365927 0 0 DexCom, Inc. Common 252131107 27597 74643 SH SOLE 74643 0 0 Dicerna Pharmaceuticals, Inc. Common 253031108 1501 68150 SH SOLE 68150 0 0 Diversified Healthcare Trust Common 25525P107 1474 357720 SH SOLE 357720 0 0 Edwards Lifesciences Corporation Common 28176E108 24172 264955 SH SOLE 264955 0 0 Eidos Therapeutics, Inc. Common 28249H104 2632 20000 SH SOLE 20000 0 0 Eli Lilly and Company Common 532457108 40106 237537 SH SOLE 237537 0 0 Endo International plc Shares G30401106 3817 531570 SH SOLE 531570 0 0 Esperion Therapeutics, Inc. Common 29664W105 1081 41577 SH SOLE 41577 0 0 Exact Sciences Corporation Common 30063P105 8413 63502 SH SOLE 63502 0 0 Exelixis, Inc. Common 30161Q104 25218 1256520 SH SOLE 1256520 0 0 Fate Therapeutics, Inc. Common 31189P102 15123 166317 SH SOLE 166317 0 0 FibroGen, Inc. Common 31572Q808 7205 194270 SH SOLE 194270 0 0 Five Star Senior Living Inc. Common 33832D205 167 24237 SH SOLE 24237 0 0 Forma Therapeutics Holdings, Inc. Shares 34633R104 5229 149825 SH SOLE 149825 0 0 Galera Therapeutics, Inc. Common 36338D108 10658 1041845 SH SOLE 1041845 0 0 Genmab A/S Sponsored ADS 372303206 10518 258672 SH SOLE 258672 0 0 Gilead Sciences, Inc. Common 375558103 81877 1405371 SH SOLE 1405371 0 0 Global Medical REIT Inc. Common 37954A204 2284 174897 SH SOLE 174897 0 0 Grifols, S.A. Sponsored ADR 398438408 874 47373 SH SOLE 47373 0 0 Gritstone Oncology, Inc. Common 39868T105 1651 419005 SH SOLE 419005 0 0 Guardant Health, Inc. Common 40131M109 15189 117852 SH SOLE 117852 0 0 Harpoon Therapeutics, Inc. Common 41358P106 1768 106419 SH SOLE 106419 0 0 HCA Healthcare, Inc. Common 40412C101 28796 175097 SH SOLE 175097 0 0 Health Care Select Sector SPDR Fund SBI Healthcare 81369Y209 1141 10055 SH SOLE 10055 0 0 Healthcare Realty Trust Incorporated Common 421946104 3079 104024 SH SOLE 104024 0 0 Healthcare Trust of America, Inc. Common 42225P501 1946 70662 SH SOLE 70662 0 0 Healthpeak Properties, Inc. Common 42250P103 4546 150392 SH SOLE 150392 0 0 Helix Acquisition Corp. Class A Common G4444C102 2708 250000 SH SOLE 250000 0 0 Heron Therapeutics, Inc. Common 427746102 2776 131183 SH SOLE 131183 0 0 Hologic, Inc. Common 436440101 2372 32564 SH SOLE 32564 0 0 Horizon Therapeutics plc Shares G46188101 34016 465016 SH SOLE 465016 0 0 Humana Inc. Common 444859102 33973 82807 SH SOLE 82807 0 0 IDEXX Laboratories, Inc. Common 45168D104 17402 34814 SH SOLE 34814 0 0 Illumina, Inc. Common 452327109 95272 257493 SH SOLE 257493 0 0 ImmunoGen, Inc. Common 45253H101 1085 168190 SH SOLE 168190 0 0 Incyte Corporation Common 45337C102 8111 93257 SH SOLE 93257 0 0 Inogen, Inc. Common 45780L104 2297 51406 SH SOLE 51406 0 0 Insmed Incorporated Common 457669307 3275 98387 SH SOLE 98387 0 0 Intercept Pharmaceuticals, Inc. Common 45845P108 1904 77067 SH SOLE 77067 0 0 Intra-Cellular Therapies, Inc. Common 46116X101 11644 366176 SH SOLE 366176 0 0 Intuitive Surgical, Inc. Common 46120E602 17422 21296 SH SOLE 21296 0 0 Ionis Pharmaceuticals, Inc. Common 462222100 10924 193201 SH SOLE 193201 0 0 Iovance Biotherapeutics, Inc. Common 462260100 12578 271073 SH SOLE 271073 0 0 IQVIA Holdings Inc. Common 46266C105 13629 76066 SH SOLE 76066 0 0 Jazz Pharmaceuticals plc Shares G50871105 11134 67456 SH SOLE 67456 0 0 Johnson & Johnson Common 478160104 86056 546805 SH SOLE 546805 0 0 Kadmon Holdings, Inc. Common 48283N106 2963 714008 SH SOLE 714008 0 0 Karuna Therapeutics, Inc. Common 48576A100 8659 85236 SH SOLE 85236 0 0 Karyopharm Therapeutics Inc. Common 48576U106 1018 65743 SH SOLE 65743 0 0 Koninklijke Philips N.V. NY Reg Sh 500472303 3084 56927 SH SOLE 56927 0 0 Kura Oncology, Inc. Common 50127T109 8931 273463 SH SOLE 273463 0 0 Laboratory Corporation of America Holdings Sponsored ADR 50540R409 13150 64603 SH SOLE 64603 0 0 LTC Properties, Inc. Common 502175102 7093 182293 SH SOLE 182293 0 0 Madrigal Pharmaceuticals, Inc. Common 558868105 1483 13340 SH SOLE 13340 0 0 Magenta Therapeutics, Inc. Common 55910K108 1509 192431 SH SOLE 192431 0 0 McKesson Corp. Common 58155Q103 22688 130448 SH SOLE 130448 0 0 Medical Properties Trust, Inc. Common 58463J304 8972 411743 SH SOLE 411743 0 0 Medpace Holdings, Inc. Common 58506Q109 2627 18871 SH SOLE 18871 0 0 Medtronic plc Shares G5960L103 62660 534914 SH SOLE 534914 0 0 Merck & Co., Inc. Common 58933Y105 45882 560903 SH SOLE 560903 0 0 Mettler-Toledo International Inc. Common 592688105 11169 9800 SH SOLE 9800 0 0 Milestone Pharmaceuticals Inc. Common 59935V107 1699 253610 SH SOLE 253610 0 0 Mirati Therapeutics, Inc. Common 60468T105 18402 83784 SH SOLE 83784 0 0 Moderna, Inc. Common 60770K107 25929 248192 SH SOLE 248192 0 0 Molecular Templates, Inc. Common 608550109 2064 219822 SH SOLE 219822 0 0 Molina Healthcare, Inc. Common 60855R100 8458 39769 SH SOLE 39769 0 0 MorphoSys AG Sponsored ADS 617760202 2320 81867 SH SOLE 81867 0 0 National Health Investors, Inc. Common 63633D104 694 10038 SH SOLE 10038 0 0 Nektar Therapeutics Common 640268108 3067 180438 SH SOLE 180438 0 0 Neurocrine Biosciences, Inc. Common 64125C109 28202 294234 SH SOLE 294234 0 0 New Senior Investment Group Inc. Common 648691103 1328 256398 SH SOLE 256398 0 0 Novartis AG Sponsored ADR 66987V109 13647 144525 SH SOLE 144525 0 0 Novavax, Inc. Common 670002401 8540 76585 SH SOLE 76585 0 0 Novo Nordisk A/S Sponsored ADR 670100205 4534 64906 SH SOLE 64906 0 0 NovoCure Limited Ordinary Shares G6674U108 15213 87918 SH SOLE 87918 0 0 NuCana plc Sponsored ADR 67022C106 2068 460672 SH SOLE 460672 0 0 Omega Healthcare Investors, Inc. Common 681936100 11130 306433 SH SOLE 306433 0 0 Ovid Therapeutics Inc. Sponsored ADR 690469101 861 372733 SH SOLE 372733 0 0 Owens & Minor, Inc. Common 690732102 7196 266023 SH SOLE 266023 0 0 PerkinElmer, Inc. Common 714046109 5323 37094 SH SOLE 37094 0 0 Perrigo Company plc Shares G97822103 2291 51224 SH SOLE 51224 0 0 Pfizer Inc. Common 717081103 25961 705259 SH SOLE 705259 0 0 Physicians Realty Trust Common 71943U104 8824 495733 SH SOLE 495733 0 0 Pieris Pharmaceuticals, Inc. Common 720795103 3623 1449269 SH SOLE 1449269 0 0 PRA Health Sciences, Inc. Common 69354M108 22057 175838 SH SOLE 175838 0 0 Praxis Precision Medicines, Inc. Common 74006W108 4127 75000 SH SOLE 75000 0 0 Quest Diagnostics Incorporated Common 74834L100 13068 109659 SH SOLE 109659 0 0 Reata Pharmaceuticals, Inc. Class A 75615P103 4725 38219 SH SOLE 38219 0 0 Regeneron Pharmaceuticals, Inc. Common 75886F107 86663 179385 SH SOLE 179385 0 0 REGENXBIO Inc. Common 75901B107 984 21700 SH SOLE 21700 0 0 ResMed Inc. Common 761152107 28131 132344 SH SOLE 132344 0 0 Revance Therapeutics, Inc. Common 761330109 6059 213808 SH SOLE 213808 0 0 Sabra Health Care REIT, Inc. Common 78573L106 8870 510660 SH SOLE 510660 0 0 Sage Therapeutics, Inc. Common 78667J108 13153 152040 SH SOLE 152040 0 0 Sanofi Sponsored ADR 80105N105 3963 81554 SH SOLE 81554 0 0 Sarepta Therapeutics, Inc. Common 803607100 35204 206487 SH SOLE 206487 0 0 Scholar Rock Holding Corporation Common 80706P103 5634 116094 SH SOLE 116094 0 0 Seagen Inc. Common 81181C104 51424 293619 SH SOLE 293619 0 0 Smith & Nephew plc Shares 83175M205 4198 99560 SH SOLE 99560 0 0 Spectrum Pharmaceuticals, Inc. Common 84763A108 391 114670 SH SOLE 114670 0 0 STERIS plc Shares G8473T100 24030 126779 SH SOLE 126779 0 0 Stryker Corporation Common 863667101 37572 153330 SH SOLE 153330 0 0 Sutro Biopharma, Inc. Common 869367102 15252 702523 SH SOLE 702523 0 0 Syneos Health, Inc. Class A 87166B102 13295 195136 SH SOLE 195136 0 0 Takeda Pharmaceutical Company Limited Sponsored ADS 874060205 3825 210146 SH SOLE 210146 0 0 Teladoc Health, Inc. Common 87918A105 11302 56520 SH SOLE 56520 0 0 Teleflex Incorporated Common 879369106 6195 15052 SH SOLE 15052 0 0 Tenet Healthcare Corporation Common 88033G407 3304 82736 SH SOLE 82736 0 0 Tetraphase Pharmaceuticals, Inc. Common 881CVR013 9 42965 SH SOLE 42965 0 0 Teva Pharmaceutical Industries Ltd. Sponsored ADR 881624209 7045 730051 SH SOLE 730051 0 0 TG Therapeutics, Inc. Common 88322Q108 6933 133269 SH SOLE 133269 0 0 Theravance Biopharma, Inc. Common G8807B106 8108 456296 SH SOLE 456296 0 0 Thermo Fisher Scientific Inc. Common 883556102 59412 127553 SH SOLE 127553 0 0 Trillium Therapeutics Inc. Common 89620X506 12030 817784 SH SOLE 817784 0 0 Turning Point Therapeutics, Inc. Common 90041T108 14540 119324 SH SOLE 119324 0 0 Ultragenyx Pharmaceutical Inc. Common 90400D108 13494 97480 SH SOLE 97480 0 0 uniQure N.V. Shares N90064101 4516 125003 SH SOLE 125003 0 0 United Therapeutics Corporation Class B 91307C102 9641 63513 SH SOLE 63513 0 0 Unitedhealth Group Incorporated Common 91324P102 76864 219185 SH SOLE 219185 0 0 Universal Health Realty Income Trust Shares 91359E105 724 11258 SH SOLE 11258 0 0 Ventas, Inc. Common 92276F100 10206 208108 SH SOLE 208108 0 0 Verona Pharma plc Sponsored ADR 925050106 5263 751905 SH SOLE 751905 0 0 Vertex Pharmaceuticals Incorporated Common 92532F100 72157 305310 SH SOLE 305310 0 0 Viatris Inc. Common 92556V106 251 13400 SH SOLE 13400 0 0 VYNE Therapeutics Inc. Common 92941V100 856 541584 SH SOLE 541584 0 0 Waters Corporation Common 941848103 27095 109510 SH SOLE 109510 0 0 Welltower Inc. Common 95040Q104 13123 203083 SH SOLE 203083 0 0 Xencor, Inc. Common 98401F105 6467 148231 SH SOLE 148231 0 0 Y-mAbs Therapeutics, Inc. Common 984241109 3790 76548 SH SOLE 76548 0 0 Zai Lab Limited ADR 98887Q104 5078 37523 SH SOLE 37523 0 0 Zimmer Biomet Holdings, Inc. Common 98956P102 32977 214014 SH SOLE 214014 0 0 Zoetis Inc. Class A 98978V103 9354 56521 SH SOLE 56521 0 0 Zogenix, Inc. Common 98978L204 1779 88977 SH SOLE 88977 0 0 Zymeworks Inc. Common 98985W102 2644 55938 SH SOLE 55938 0 0