Chief Compliance Officer

0001104659-19-029242.txt : 20190514 0001104659-19-029242.hdr.sgml : 20190514 20190514142549 ACCESSION NUMBER: 0001104659-19-029242 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20190331 FILED AS OF DATE: 20190514 DATE AS OF CHANGE: 20190514 EFFECTIVENESS DATE: 20190514 FILER: COMPANY DATA: COMPANY CONFORMED NAME: Tekla Capital Management LLC CENTRAL INDEX KEY: 0001300336 IRS NUMBER: 010628853 STATE OF INCORPORATION: DE FISCAL YEAR END: 0930 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10950 FILM NUMBER: 19822111 BUSINESS ADDRESS: STREET 1: 100 FEDERAL STREET STREET 2: 19TH FLOOR CITY: BOSTON STATE: MA ZIP: 02110 BUSINESS PHONE: 617 772-8500 MAIL ADDRESS: STREET 1: 100 FEDERAL STREET STREET 2: 19TH FLOOR CITY: BOSTON STATE: MA ZIP: 02110 FORMER COMPANY: FORMER CONFORMED NAME: Hambrecht & Quist Capital Management LLC DATE OF NAME CHANGE: 20040811 13F-HR 1 primary_doc.xml 13F-HR LIVE 0001300336 XXXXXXXX 03-31-2019 03-31-2019 false Tekla Capital Management LLC

100 FEDERAL STREET 19TH FLOOR BOSTON MA 02110

13F HOLDINGS REPORT 028-10950 N Laura Woodward Chief Compliance Officer 617-772-8500 /s/ Laura Woodward Boston MA 05-14-2019 0 194 2462331 false INFORMATION TABLE 2 a19-6941_1informationtable.xml INFORMATION TABLE Abbott Laboratories Common 002824100 36536 457048 SH SOLE 457048 0 0 AbbVie Inc. Common 00287Y109 25806 320213 SH SOLE 320213 0 0 ABIOMED, Inc. Common 003654100 6850 23986 SH SOLE 23986 0 0 AC Immune SA Shares H00263105 868 171813 SH SOLE 171813 0 0 Acadia Healthcare Company, Inc. Common 00404A109 5075 173155 SH SOLE 173155 0 0 ACADIA Pharmaceuticals Inc. Common 004225108 2812 104714 SH SOLE 104714 0 0 Acceleron Pharma Inc. Common 00434H108 8773 188388 SH SOLE 188388 0 0 Adaptimmune Therapeutics plc Sponsored ADR 00653A107 983 228496 SH SOLE 228496 0 0 Aerie Pharmaceuticals, Inc. Common 00771V108 3254 68496 SH SOLE 68496 0 0 Aerpio Pharmaceuticals, Inc. Common 00810B105 667 740000 SH SOLE 740000 0 0 Affimed N.V. Common N01045108 1067 254000 SH SOLE 254000 0 0 Agios Pharmaceuticals, Inc. Common 00847X104 6189 91776 SH SOLE 91776 0 0 Akebia Therapeutics, Inc. Common 00972D105 1752 213942 SH SOLE 213942 0 0 Albireo Pharma, Inc. Common 01345P106 4026 125000 SH SOLE 125000 0 0 Alexion Pharmaceuticals, Inc. Common 015351109 50788 375705 SH SOLE 375705 0 0 Align Technology, Inc. Common 016255101 8040 28278 SH SOLE 28278 0 0 Alkermes plc Shares G01767105 7227 198048 SH SOLE 198048 0 0 Allakos Inc. Common 01671P100 989 24414 SH SOLE 24414 0 0 Allergan plc Shares G0177J108 28296 193263 SH SOLE 193263 0 0 Alliqua BioMedical, Inc. Common 019621309 437 148500 SH SOLE 148500 0 0 Alnylam Pharmaceuticals, Inc. Common 02043Q107 12472 133458 SH SOLE 133458 0 0 Amarin Corporation plc Sponsored ADR 023111206 12692 611352 SH SOLE 611352 0 0 AmerisourceBergen Corporation Common 03073E105 6300 79226 SH SOLE 79226 0 0 Amgen Inc. Common 031162100 133819 704383 SH SOLE 704383 0 0 Amicus Therapeutics, Inc. Common 03152W109 4279 314597 SH SOLE 314597 0 0 AnaptysBio, Inc. Common 032724106 4810 65845 SH SOLE 65845 0 0 Anthem, Inc. Common 036752103 40567 141358 SH SOLE 141358 0 0 ARCA biopharma, Inc. Common 00211Y407 303 811227 SH SOLE 811227 0 0 Ardelyx, Inc. Common 039697107 1790 639370 SH SOLE 639370 0 0 Arena Pharmaceuticals, Inc. Common 040047607 2343 52262 SH SOLE 52262 0 0 argenx SE Sponsored ADR 04016X101 3543 28381 SH SOLE 28381 0 0 ArQule, Inc. Common 04269E107 1198 250000 SH SOLE 250000 0 0 Array BioPharma Inc. Common 04269X105 8878 364166 SH SOLE 364166 0 0 Arrowhead Pharmaceuticals, Inc. Common 04280A100 563 30700 SH SOLE 30700 0 0 Ascendis Pharma A/S Sponsored ADR 04351P101 7222 61360 SH SOLE 61360 0 0 AstraZeneca PLC Sponsored ADR 046353108 14595 360998 SH SOLE 360998 0 0 Athenex, Inc. Common 04685N103 558 45530 SH SOLE 45530 0 0 Audentes Therapeutics, Inc. Common 05070R104 2051 52574 SH SOLE 52574 0 0 Avadel Pharmaceuticals plc Sponsored ADR 05337M104 1173 814588 SH SOLE 814588 0 0 Bausch Health Companies Inc. Common 071734107 4170 168812 SH SOLE 168812 0 0 Baxter International Inc. Common 071813109 11194 137668 SH SOLE 137668 0 0 Becton, Dickinson and Company Common 075887109 15414 61721 SH SOLE 61721 0 0 BeiGene, Ltd. Sponsored ADR 07725L102 12525 94889 SH SOLE 94889 0 0 Bellicum Pharmaceuticals, Inc. Common 079481107 202 60000 SH SOLE 60000 0 0 Bio-Techne Corporation Common 09073M104 4309 21701 SH SOLE 21701 0 0 Biogen Inc. Common 09062X103 74289 314278 SH SOLE 314278 0 0 BioMarin Pharmaceutical Inc. Common 09061G101 19728 222086 SH SOLE 222086 0 0 bluebird bio, Inc. Common 09609G100 14322 91029 SH SOLE 91029 0 0 Blueprint Medicines Corporation Common 09627Y109 9263 115720 SH SOLE 115720 0 0 Boston Scientific Corporation Common 101137107 18177 473619 SH SOLE 473619 0 0 Bristol-Myers Squibb Company Common 110122108 35212 738044 SH SOLE 738044 0 0 Cardinal Health, Inc. Common 14149Y108 303 6300 SH SOLE 6300 0 0 Celgene Corporation Common 151020104 139030 1473710 SH SOLE 1473710 0 0 Celldex Therapeutics, Inc. Common 15117B202 35 7053 SH SOLE 7053 0 0 Cellectis SA Sponsored ADR 15117K103 3173 173035 SH SOLE 173035 0 0 Centene Corporation Common 15135B101 6812 128295 SH SOLE 128295 0 0 Charles River Laboratories International, Inc. Common 159864107 1545 10640 SH SOLE 10640 0 0 Cidara Therapeutics, Inc. Common 171757107 421 158784 SH SOLE 158784 0 0 Cigna Corporation Common 125523100 18777 116756 SH SOLE 116756 0 0 Clearside Biomedical, Inc. Common 185063104 228 165330 SH SOLE 165330 0 0 Clovis Oncology, Inc. Common 189464100 1871 75400 SH SOLE 75400 0 0 Coherus Biosciences, Inc. Common 19249H103 4299 315162 SH SOLE 315162 0 0 Community Health Systems, Inc. Common 203668108 761 203935 SH SOLE 203935 0 0 Concert Pharmaceuticals, Inc. Common 206022105 548 45362 SH SOLE 45362 0 0 CRISPR Therapeutics AG Namen AKT H17182108 6371 178348 SH SOLE 178348 0 0 CVS Health Corporation Common 126650100 27308 506364 SH SOLE 506364 0 0 Danaher Corporation Common 235851102 20982 158931 SH SOLE 158931 0 0 Denali Therapeutics Inc. Common 24823R105 450 19372 SH SOLE 19372 0 0 DENTSPLY SIRONA Inc. Common 24906P109 7762 156521 SH SOLE 156521 0 0 Diplomat Pharmacy, Inc. Common 25456K101 1248 214845 SH SOLE 214845 0 0 Dr. Reddy's Laboratories Ltd. Sponsored ADR 256135203 1172 28950 SH SOLE 28950 0 0 Editas Medicine, Inc. Common 28106W103 1875 76668 SH SOLE 76668 0 0 Edwards Lifesciences Corporation Common 28176E108 10867 56798 SH SOLE 56798 0 0 Eli Lilly and Company Common 532457108 38321 295320 SH SOLE 295320 0 0 Endo International plc Shares G30401106 4269 531570 SH SOLE 531570 0 0 Epizyme, Inc. Common 29428V104 3586 289404 SH SOLE 289404 0 0 Esperion Therapeutics, Inc. Common 29664W105 7412 184607 SH SOLE 184607 0 0 Evolent Health, Inc. Common 30050B101 530 42150 SH SOLE 42150 0 0 Exelixis, Inc. Common 30161Q104 16148 678467 SH SOLE 678467 0 0 FibroGen, Inc. Common 31572Q808 9552 175742 SH SOLE 175742 0 0 Foamix Pharmaceuticals Ltd Shares M46135105 1128 300781 SH SOLE 300781 0 0 Galapagos NV Sponsored ADR 36315X101 5715 48525 SH SOLE 48525 0 0 Genomic Health, Inc. Common 37244C101 1858 26531 SH SOLE 26531 0 0 Gilead Sciences, Inc. Common 375558103 113728 1749388 SH SOLE 1749388 0 0 GlaxoSmithKline plc Shares 37733W105 9139 218700 SH SOLE 218700 0 0 Global Blood Therapeutics, Inc. Common 37890U108 4551 85988 SH SOLE 85988 0 0 Global Medical REIT Inc. Common 37954A204 721 73400 SH SOLE 73400 0 0 GW Pharmaceuticals plc ADS 36197T103 5882 34891 SH SOLE 34891 0 0 HCA Healthcare, Inc. Common 40412C101 11678 89569 SH SOLE 89569 0 0 HCP, Inc. Common 40414L109 1424 45500 SH SOLE 45500 0 0 Healthcare Realty Trust Incorporated Common 421946104 2183 68000 SH SOLE 68000 0 0 Healthcare Trust of America, Inc. Common 42225P501 1315 46000 SH SOLE 46000 0 0 Hologic, Inc. Common 436440101 946 19546 SH SOLE 19546 0 0 Horizon Pharma plc Shares G4617B105 511 19350 SH SOLE 19350 0 0 Humana Inc. Common 444859102 9491 35682 SH SOLE 35682 0 0 IDEXX Laboratories, Inc. Common 45168D104 14233 63654 SH SOLE 63654 0 0 Illumina, Inc. Common 452327109 73793 237514 SH SOLE 237514 0 0 ImmunoGen, Inc. Common 45253H101 456 168190 SH SOLE 168190 0 0 Immunomedics, Inc. Common 452907108 5526 287687 SH SOLE 287687 0 0 Incyte Corporation Common 45337C102 45511 529133 SH SOLE 529133 0 0 Inogen, Inc. Common 45780L104 763 8000 SH SOLE 8000 0 0 Intellia Therapeutics, Inc. Common 45826J105 2567 150290 SH SOLE 150290 0 0 Intercept Pharmaceuticals, Inc. Common 45845P108 6631 59275 SH SOLE 59275 0 0 Intra-Cellular Therapies, Inc. Common 46116X101 1342 110193 SH SOLE 110193 0 0 Intuitive Surgical, Inc. Common 46120E602 22984 40281 SH SOLE 40281 0 0 Ionis Pharmaceuticals, Inc. Common 462222100 8906 109720 SH SOLE 109720 0 0 Iovance Biotherapeutics, Inc. Common 462260100 2063 216908 SH SOLE 216908 0 0 IQVIA Holdings Inc. Common 46266C105 2358 16391 SH SOLE 16391 0 0 Jazz Pharmaceuticals plc Shares G50871105 9645 67471 SH SOLE 67471 0 0 Johnson & Johnson Common 478160104 125530 897990 SH SOLE 897990 0 0 Jounce Therapeutics, Inc. Common 481116101 63 10127 SH SOLE 10127 0 0 Koninklijke Philips N.V. NY Reg Sh 500472303 3489 85400 SH SOLE 85400 0 0 Laboratory Corporation of America Holdings Sponsored ADR 50540R409 6985 45657 SH SOLE 45657 0 0 Ligand Pharmaceuticals, Inc. Common 53220K504 3758 29895 SH SOLE 29895 0 0 LivaNova PLC Shares G5509L101 1109 11400 SH SOLE 11400 0 0 LTC Properties, Inc. Common 502175102 6660 145421 SH SOLE 145421 0 0 Madrigal Pharmaceuticals, Inc. Common 558868105 1671 13340 SH SOLE 13340 0 0 Mallinckrodt public limited company Sponsored ADR G5785G107 717 32980 SH SOLE 32980 0 0 Marinus Pharmaceuticals, Inc. Common 56854Q101 1373 328436 SH SOLE 328436 0 0 Masimo Corporation Common 574795100 1482 10715 SH SOLE 10715 0 0 McKesson Corporation Common 58155Q103 8278 70720 SH SOLE 70720 0 0 Medical Properties Trust, Inc. Common 58463J304 6035 326063 SH SOLE 326063 0 0 The Medicines Company Common 584688105 8200 293392 SH SOLE 293392 0 0 Medtronic plc Shares G5960L103 44812 492002 SH SOLE 492002 0 0 Merck & Co., Inc. Common 58933Y105 82595 993083 SH SOLE 993083 0 0 Merus N.V. Common N5749R100 4692 317671 SH SOLE 317671 0 0 Mirati Therapeutics, Inc. Common 60468T105 996 13590 SH SOLE 13590 0 0 Molecular Templates, Inc. Common 608550109 837 144110 SH SOLE 144110 0 0 Mylan N.V. Shares N59465109 26729 943152 SH SOLE 943152 0 0 MyoKardia, Inc. Common 62857M105 2007 38600 SH SOLE 38600 0 0 Myriad Genetics, Inc. Common 62855J104 682 20549 SH SOLE 20549 0 0 Nektar Therapeutics Common 640268108 9532 283679 SH SOLE 283679 0 0 Neurocrine Biosciences, Inc. Common 64125C109 19530 221678 SH SOLE 221678 0 0 New Senior Investment Group Inc. Common 648691103 1437 263647 SH SOLE 263647 0 0 Novartis AG Sponsored ADR 66987V109 26616 276847 SH SOLE 276847 0 0 Novavax, Inc. Common 670002104 315 571000 SH SOLE 571000 0 0 Novo Nordisk A/S Sponsored ADR 670100205 13161 251600 SH SOLE 251600 0 0 Novocure Limited Ordinary Shares G6674U108 3177 65964 SH SOLE 65964 0 0 NuVasive, Inc. Common 670704105 217 3816 SH SOLE 3816 0 0 Omega Healthcare Investors, Inc. Common 681936100 12981 340266 SH SOLE 340266 0 0 Ovid Therapeutics Inc. Sponsored ADR 690469101 880 496977 SH SOLE 496977 0 0 Perrigo Company plc Shares G97822103 1046 21718 SH SOLE 21718 0 0 Pfizer Inc. Common 717081103 87945 2070765 SH SOLE 2070765 0 0 Physicians Realty Trust Common 71943U104 5717 303908 SH SOLE 303908 0 0 Pieris Pharmaceuticals, Inc. Common 720795103 6993 2087380 SH SOLE 2087380 0 0 Portola Pharmaceuticals, Inc. Sponsored ADR 737010108 4006 115448 SH SOLE 115448 0 0 PRA Health Sciences, Inc. Common 69354M108 15831 143537 SH SOLE 143537 0 0 Protagonist Therapeutics, Inc. Common 74366E102 2230 177425 SH SOLE 177425 0 0 PTC Therapeutics, Inc. Common 69366J200 2584 68652 SH SOLE 68652 0 0 Puma Biotechnology, Inc. Common 74587V107 2767 71340 SH SOLE 71340 0 0 Quest Diagnostics, Inc. Common 74834L100 5980 66500 SH SOLE 66500 0 0 Quorum Health Corporation Common 74909E106 33 23725 SH SOLE 23725 0 0 Regeneron Pharmaceuticals, Inc. Common 75886F107 58116 141532 SH SOLE 141532 0 0 ResMed Inc. Common 761152107 7171 68974 SH SOLE 68974 0 0 Rhythm Pharmaceuticals, Inc. Common 76243J105 682 24890 SH SOLE 24890 0 0 Sabra Health Care REIT, Inc. Common 78573L106 9078 466247 SH SOLE 466247 0 0 Sage Therapeutics, Inc. Common 78667J108 12701 79856 SH SOLE 79856 0 0 Sangamo Therapeutics, Inc. Common 800677106 2304 241538 SH SOLE 241538 0 0 Sanofi Sponsored ADR 80105N105 7966 179900 SH SOLE 179900 0 0 Sarepta Therapeutics, Inc. Common 803607100 17622 147847 SH SOLE 147847 0 0 Seattle Genetics, Inc. Common 812578102 21234 289925 SH SOLE 289925 0 0 Senior Housing Properties Trust Common 81721M109 4214 357720 SH SOLE 357720 0 0 Smith & Nephew plc Shares 83175M205 7440 185478 SH SOLE 185478 0 0 SPDR S&P Biotech ETF S&P Biotech ETF 78464A870 8060 89022 SH SOLE 89022 0 0 Spectrum Pharmaceuticals, Inc. Common 84763A108 1226 114670 SH SOLE 114670 0 0 STERIS plc Shares G8473T100 6146 48003 SH SOLE 48003 0 0 Stryker Corporation Common 863667101 24305 123050 SH SOLE 123050 0 0 Sutro Biopharma, Inc. Common 869367102 7304 641268 SH SOLE 641268 0 0 Syndax Pharmaceuticals, Inc. Common 87164F105 753 143438 SH SOLE 143438 0 0 Syneos Health, Inc. Class A 87166B102 1502 29027 SH SOLE 29027 0 0 Takeda Pharmaceutical Company Limited Sponsored ADS 874060205 3628 178128 SH SOLE 178128 0 0 Teleflex Incorporated Common 879369106 1927 6379 SH SOLE 6379 0 0 Tenet Healthcare Corporation Common 88033G407 4070 141136 SH SOLE 141136 0 0 Tetraphase Pharmaceuticals, Inc. Common 88165N105 1151 859322 SH SOLE 859322 0 0 Teva Pharmaceutical Industries Limited Sponsored ADR 881624209 13971 890989 SH SOLE 890989 0 0 Thermo Fisher Scientific Inc. Common 883556102 39072 142743 SH SOLE 142743 0 0 Trillium Therapeutics Inc. Common 89620X506 294 446099 SH SOLE 446099 0 0 Ultragenyx Pharmaceutical Inc. Common 90400D108 5338 76958 SH SOLE 76958 0 0 uniQure N.V. Shares N90064101 1178 19751 SH SOLE 19751 0 0 United Therapeutics Corporation Class B 91307C102 4843 41261 SH SOLE 41261 0 0 Unitedhealth Group Incorporated Common 91324P102 80145 324133 SH SOLE 324133 0 0 Varian Medical Systems, Inc. Common 92220P105 3717 26227 SH SOLE 26227 0 0 Ventas, Inc. Common 92276F100 6285 98496 SH SOLE 98496 0 0 Verona Pharma plc Sponsored ADR 925050106 1719 275000 SH SOLE 275000 0 0 Vertex Pharmaceuticals Incorporated Common 92532F100 81621 443712 SH SOLE 443712 0 0 Viking Therapeutics, Inc. Common 92686J106 1133 114016 SH SOLE 114016 0 0 WaVe Life Sciences Ltd. Shares Y95308105 1179 30336 SH SOLE 30336 0 0 WellCare Health Plans, Inc. Common 94946T106 5202 19286 SH SOLE 19286 0 0 Welltower Inc. Common 95040Q104 18416 237322 SH SOLE 237322 0 0 Wright Medical Group N.V. Ordinary Shares N96617118 3610 114776 SH SOLE 114776 0 0 Xencor, Inc. Common 98401F105 2248 72382 SH SOLE 72382 0 0 Zimmer Biomet Holdings, Inc. Common 98956P102 10172 79654 SH SOLE 79654 0 0 Zoetis Inc. Class A 98978V103 25872 257001 SH SOLE 257001 0 0 Zogenix, Inc. Common 98978L204 4938 89762 SH SOLE 89762 0 0