Chief Compliance Officer

0001104659-19-007994.txt : 20190213 0001104659-19-007994.hdr.sgml : 20190213 20190213172121 ACCESSION NUMBER: 0001104659-19-007994 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20181231 FILED AS OF DATE: 20190213 DATE AS OF CHANGE: 20190213 EFFECTIVENESS DATE: 20190213 FILER: COMPANY DATA: COMPANY CONFORMED NAME: Tekla Capital Management LLC CENTRAL INDEX KEY: 0001300336 IRS NUMBER: 010628853 STATE OF INCORPORATION: DE FISCAL YEAR END: 0930 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10950 FILM NUMBER: 19598747 BUSINESS ADDRESS: STREET 1: 100 FEDERAL STREET STREET 2: 19TH FLOOR CITY: BOSTON STATE: MA ZIP: 02110 BUSINESS PHONE: 617 772-8500 MAIL ADDRESS: STREET 1: 100 FEDERAL STREET STREET 2: 19TH FLOOR CITY: BOSTON STATE: MA ZIP: 02110 FORMER COMPANY: FORMER CONFORMED NAME: Hambrecht & Quist Capital Management LLC DATE OF NAME CHANGE: 20040811 13F-HR 1 primary_doc.xml 13F-HR LIVE 0001300336 XXXXXXXX 12-31-2018 12-31-2018 false Tekla Capital Management LLC

100 FEDERAL STREET 19TH FLOOR BOSTON MA 02110

13F HOLDINGS REPORT 028-10950 N Laura Woodward Chief Compliance Officer 617-772-8500 /s/ Laura Woodward Boston MA 02-13-2019 0 203 2336202 false INFORMATION TABLE 2 a19-2067_1informationtable.xml INFORMATION TABLE Abbott Laboratories Common 002824100 28333 391719 SH SOLE 391719 0 0 AbbVie Inc. Common 00287Y109 45365 492078 SH SOLE 492078 0 0 ABIOMED, Inc. Common 003654100 4014 12350 SH SOLE 12350 0 0 AC Immune SA Shares H00263105 1624 171813 SH SOLE 171813 0 0 ACADIA Pharmaceuticals Inc. Common 00404A109 4452 173155 SH SOLE 173155 0 0 Acceleron Pharma Inc. Common 00434H108 7437 170766 SH SOLE 170766 0 0 Achillion Pharmaceuticals, Inc. Common 00448Q201 507 318833 SH SOLE 318833 0 0 Adaptimmune Therapeutics plc Sponsored ADR 00653A107 1314 228496 SH SOLE 228496 0 0 Aegerion Pharmaceuticals, Inc. Note 2.00% 8/15/19 00767EAB8 9734 13000000 PRN SOLE 13000000 0 0 Aerie Pharmaceuticals, Inc. Common 00771V108 1400 38770 SH SOLE 38770 0 0 Aerpio Pharmaceuticals, Inc. Common 00810B105 1301 765000 SH SOLE 765000 0 0 Affimed N.V. Common N01045108 790 254000 SH SOLE 254000 0 0 Agilent Technologies, Inc. Common 00846U101 553 8200 SH SOLE 8200 0 0 Agios Pharmaceuticals, Inc. Common 00847X104 2261 49025 SH SOLE 49025 0 0 Akebia Therapeutics, Inc. Common 00972D105 1183 213942 SH SOLE 213942 0 0 Albireo Pharma, Inc. Common 01345P106 3066 125000 SH SOLE 125000 0 0 Alexion Pharmaceuticals, Inc. Common 015351109 48319 496288 SH SOLE 496288 0 0 Align Technology, Inc. Common 016255101 6254 29860 SH SOLE 29860 0 0 Alkermes plc Shares G01767105 4464 151283 SH SOLE 151283 0 0 Allergan plc Shares G0177J108 31373 234720 SH SOLE 234720 0 0 Alliqua BioMedical, Inc. Common 019621309 278 148500 SH SOLE 148500 0 0 Alnylam Pharmaceuticals, Inc. Common 02043Q107 9199 126176 SH SOLE 126176 0 0 Amarin Corporation plc Sponsored ADR 023111206 8902 654052 SH SOLE 654052 0 0 AmerisourceBergen Corporation Common 03073E105 8318 111807 SH SOLE 111807 0 0 Amgen Inc. Common 031162100 131958 677855 SH SOLE 677855 0 0 Amicus Therapeutics, Inc. Common 03152W109 8385 875304 SH SOLE 875304 0 0 AnaptysBio, Inc. Common 032724106 4200 65845 SH SOLE 65845 0 0 Anthem, Inc. Common 036752103 37069 141147 SH SOLE 141147 0 0 ARCA biopharma, Inc. Common 00211Y407 271 811227 SH SOLE 811227 0 0 Ardelyx, Inc. Common 039697107 1144 639370 SH SOLE 639370 0 0 Arena Pharmaceuticals, Inc. Common 040047607 2036 52262 SH SOLE 52262 0 0 ArQule, Inc. Common 04269E107 693 250000 SH SOLE 250000 0 0 Array BioPharma Inc. Common 04269X105 5189 364166 SH SOLE 364166 0 0 Arrowhead Pharmaceuticals, Inc. Common 04280A100 381 30700 SH SOLE 30700 0 0 Ascendis Pharma A/S Sponsored ADR 04351P101 2656 42399 SH SOLE 42399 0 0 AstraZeneca PLC Sponsored ADR 046353108 16256 428024 SH SOLE 428024 0 0 Athenex, Inc. Common 04685N103 578 45530 SH SOLE 45530 0 0 Audentes Therapeutics, Inc. Common 05070R104 1121 52574 SH SOLE 52574 0 0 Avadel Pharmaceuticals plc Sponsored ADR 05337M104 2102 814588 SH SOLE 814588 0 0 Bausch Health Companies Inc. Common 071734107 3546 192000 SH SOLE 192000 0 0 Baxter International Inc. Common 071813109 10612 161233 SH SOLE 161233 0 0 Becton, Dickinson and Company Common 075887109 15722 69778 SH SOLE 69778 0 0 BeiGene, Ltd. Sponsored ADR 07725L102 12028 85755 SH SOLE 85755 0 0 Bellicum Pharmaceuticals, Inc. Common 079481107 175 60000 SH SOLE 60000 0 0 Biogen Inc. Common 09062X103 118834 394902 SH SOLE 394902 0 0 BioMarin Pharmaceutical Inc. Common 09061G101 17663 207434 SH SOLE 207434 0 0 bluebird bio, Inc. Common 09609G100 9764 98429 SH SOLE 98429 0 0 Blueprint Medicines Corporation Common 09627Y109 6750 125207 SH SOLE 125207 0 0 Boston Scientific Corporation Common 101137107 15726 444991 SH SOLE 444991 0 0 Bristol-Myers Squibb Company Common 110122108 33941 652966 SH SOLE 652966 0 0 Cardinal Health, Inc. Common 14149Y108 281 6300 SH SOLE 6300 0 0 Celgene Corporation Common 151020104 88573 1382006 SH SOLE 1382006 0 0 Celldex Therapeutics, Inc. Common 15117B103 21 105800 SH SOLE 105800 0 0 Cellectis SA Sponsored ADR 15117K103 3938 236530 SH SOLE 236530 0 0 Centene Corporation Common 15135B101 19240 166869 SH SOLE 166869 0 0 Charles River Laboratories International, Inc. Common 159864107 2566 22670 SH SOLE 22670 0 0 Cidara Therapeutics, Inc. Common 171757107 373 158784 SH SOLE 158784 0 0 Cigna Corporation Common 125523100 12172 64089 SH SOLE 64089 0 0 Clearside Biomedical, Inc. Common 185063104 177 165330 SH SOLE 165330 0 0 Clovis Oncology, Inc. Common 189464100 1354 75400 SH SOLE 75400 0 0 Coherus Biosciences, Inc. Common 19249H103 2852 315162 SH SOLE 315162 0 0 Community Health Systems, Inc. Common 203668108 575 203935 SH SOLE 203935 0 0 Concert Pharmaceuticals, Inc. Common 206022105 569 45362 SH SOLE 45362 0 0 CRISPR Therapeutics AG Namen AKT H17182108 5095 178348 SH SOLE 178348 0 0 CVS Health Corporation Common 126650100 30185 460698 SH SOLE 460698 0 0 Danaher Corporation Common 235851102 21590 209371 SH SOLE 209371 0 0 DENTSPLY SIRONA Inc. Common 24906P109 4675 125625 SH SOLE 125625 0 0 Dermira, Inc. Common 24983L104 1162 161579 SH SOLE 161579 0 0 Diplomat Pharmacy, Inc. Common 25456K101 6807 505701 SH SOLE 505701 0 0 Dr. Reddy's Laboratories Limited Common 256135203 1376 36500 SH SOLE 36500 0 0 Editas Medicine, Inc. Common 28106W103 1744 76668 SH SOLE 76668 0 0 Edwards Lifesciences Corporation Common 28176E108 8700 56798 SH SOLE 56798 0 0 Egalet Corporation Note 5.50% 4/1/20 28226BAB0 700 7000000 PRN SOLE 7000000 0 0 Eidos Therapeutics, Inc. Common 28249H104 384 27900 SH SOLE 27900 0 0 Eli Lilly and Company Common 532457108 25047 216442 SH SOLE 216442 0 0 Endo International plc Shares G30401106 5236 717274 SH SOLE 717274 0 0 Epizyme, Inc. Common 29428V104 2377 385872 SH SOLE 385872 0 0 Esperion Therapeutics, Inc. Common 29664W105 6545 142289 SH SOLE 142289 0 0 Evolent Health, Inc. Common 30050B101 841 42150 SH SOLE 42150 0 0 Exelixis, Inc. Common 30161Q104 6677 339435 SH SOLE 339435 0 0 FibroGen, Inc. Common 31572Q808 9847 212763 SH SOLE 212763 0 0 Foamix Pharmaceuticals Ltd Shares M46135105 2158 601205 SH SOLE 601205 0 0 Galapagos NV Common 36315X101 9157 99815 SH SOLE 99815 0 0 Genomic Health, Inc. Common 37244C101 1119 17370 SH SOLE 17370 0 0 Gilead Sciences, Inc. Common 375558103 118210 1889846 SH SOLE 1889846 0 0 GlaxoSmithKline plc Shares 37733W105 8357 218700 SH SOLE 218700 0 0 Global Blood Therapeutics, Inc. Common 37890U108 3856 93924 SH SOLE 93924 0 0 Global Medical REIT Inc. Common 37954A204 653 73400 SH SOLE 73400 0 0 GW Pharmaceuticals plc ADS 36197T103 6169 63345 SH SOLE 63345 0 0 HCA Healthcare, Inc. Common 40412C101 9251 74335 SH SOLE 74335 0 0 HCP, Inc. Common 40414L109 1271 45500 SH SOLE 45500 0 0 Healthcare Realty Trust Incorporated Common 421946104 1934 68000 SH SOLE 68000 0 0 Healthcare Trust of America, Inc. Common 42225P501 1164 46000 SH SOLE 46000 0 0 Hologic, Inc. Common 436440101 803 19546 SH SOLE 19546 0 0 Humana Inc. Common 444859102 19620 68487 SH SOLE 68487 0 0 IDEXX Laboratories, Inc. Common 45168D104 9594 51575 SH SOLE 51575 0 0 Illumina, Inc. Common 452327109 78695 262379 SH SOLE 262379 0 0 ImmunoGen, Inc. Common 45253H101 807 168190 SH SOLE 168190 0 0 Immunomedics, Inc. Common 452907108 6158 431527 SH SOLE 431527 0 0 Incyte Corporation Common 45337C102 41044 645442 SH SOLE 645442 0 0 Innoviva, Inc. Common 45781M101 2820 161603 SH SOLE 161603 0 0 Inogen, Inc. Common 45780L104 1676 13500 SH SOLE 13500 0 0 Inovalon Holdings, Inc. Common 45781D101 2498 176163 SH SOLE 176163 0 0 Intellia Therapeutics, Inc. Common 45826J105 2051 150290 SH SOLE 150290 0 0 Intercept Pharmaceuticals, Inc. Common 45845P108 1345 13348 SH SOLE 13348 0 0 Intra-Cellular Therapies, Inc. Common 46116X101 1255 110193 SH SOLE 110193 0 0 Intuitive Surgical, Inc. Common 46120E602 18788 39229 SH SOLE 39229 0 0 Ionis Pharmaceuticals, Inc. Common 462222100 4478 82838 SH SOLE 82838 0 0 Iovance Biotherapeutics, Inc. Common 462260100 1920 216908 SH SOLE 216908 0 0 IQVIA Holdings Inc. Common 46266C105 4542 39100 SH SOLE 39100 0 0 Jazz Pharmaceuticals plc Shares G50871105 14279 115187 SH SOLE 115187 0 0 Johnson & Johnson Common 478160104 133261 1032628 SH SOLE 1032628 0 0 Jounce Therapeutics, Inc. Common 481116101 34 10127 SH SOLE 10127 0 0 Koninklijke Philips N.V. NY Reg Sh 500472303 2998 85400 SH SOLE 85400 0 0 Laboratory Corporation of America Holdings Sponsored ADR 50540R409 3677 29100 SH SOLE 29100 0 0 LeMaitre Vascular, Inc. Common 525558201 642 27150 SH SOLE 27150 0 0 Lexicon Pharmaceuticals, Inc. Sponsored ADR 528872302 465 70000 SH SOLE 70000 0 0 Ligand Pharmaceuticals Incorporated Common 53220K504 3589 26450 SH SOLE 26450 0 0 LivaNova plc Shares G5509L101 1043 11400 SH SOLE 11400 0 0 Loxo Oncology, Inc. Common 548862101 3445 24595 SH SOLE 24595 0 0 LTC Properties, Inc. Common 502175102 7445 178623 SH SOLE 178623 0 0 Madrigal Pharmaceuticals, Inc. Common 558868105 752 6670 SH SOLE 6670 0 0 Mallinckrodt plc Sponsored ADR G5785G107 847 53600 SH SOLE 53600 0 0 Marinus Pharmaceuticals, Inc. Common 56854Q101 2169 755776 SH SOLE 755776 0 0 Masimo Corporation Common 574795100 1826 17011 SH SOLE 17011 0 0 McKesson Corporation Common 58155Q103 8696 78720 SH SOLE 78720 0 0 Medical Properties Trust, Inc. Common 58463J304 6654 413809 SH SOLE 413809 0 0 The Medicines Company Common 584688105 8211 428992 SH SOLE 428992 0 0 Medtronic plc Shares G5960L103 43785 481365 SH SOLE 481365 0 0 Merck & Co., Inc. Common 58933Y105 56399 738108 SH SOLE 738108 0 0 Merus N.V. Common N5749R100 5147 367671 SH SOLE 367671 0 0 Mettler-Toledo International Inc. Common 592688105 1980 3500 SH SOLE 3500 0 0 Mirati Therapeutics, Inc. Common 60468T105 576 13590 SH SOLE 13590 0 0 Molecular Templates, Inc. Common 608550109 582 144110 SH SOLE 144110 0 0 Mylan N.V. Shares N59465109 38462 1403728 SH SOLE 1403728 0 0 MyoKardia, Inc. Common 62857M105 1886 38600 SH SOLE 38600 0 0 Nektar Therapeutics Common 640268108 3102 94384 SH SOLE 94384 0 0 Neurocrine Biosciences, Inc. Common 64125C109 15446 216294 SH SOLE 216294 0 0 Nevro Corp. Common 64157F103 2674 68760 SH SOLE 68760 0 0 New Senior Investment Group Inc. Common 648691103 1297 314747 SH SOLE 314747 0 0 Nightstar Therapeutics plc ADR 65413A101 1140 98929 SH SOLE 98929 0 0 Novartis AG Sponsored ADR 66987V109 25032 291717 SH SOLE 291717 0 0 Novavax, Inc. Common 670002104 1051 571000 SH SOLE 571000 0 0 Novo Nordisk A/S ADR 670100205 13909 301900 SH SOLE 301900 0 0 Novocure Limited Ordinary Shares G6674U108 820 24500 SH SOLE 24500 0 0 NuCana plc Sponsored ADR 67022C106 142 9823 SH SOLE 9823 0 0 NuVasive, Inc. Common 670704105 1428 28816 SH SOLE 28816 0 0 Omega Healthcare Investors, Inc. Common 681936100 13361 380122 SH SOLE 380122 0 0 Ovid Therapeutics Inc. ADR 690469101 1203 496977 SH SOLE 496977 0 0 Perrigo Company plc Shares G97822103 1445 37300 SH SOLE 37300 0 0 Pfizer Inc. Common 717081103 66208 1516793 SH SOLE 1516793 0 0 Physicians Realty Trust Common 71943U104 6268 391016 SH SOLE 391016 0 0 Pieris Pharmaceuticals, Inc. Common 720795103 5552 2087380 SH SOLE 2087380 0 0 Portola Pharmaceuticals, Inc. Sponsored ADR 737010108 2254 115448 SH SOLE 115448 0 0 PRA Health Sciences, Inc. Common 69354M108 6480 70460 SH SOLE 70460 0 0 Protagonist Therapeutics, Inc. Common 74366E102 1327 197138 SH SOLE 197138 0 0 PTC Therapeutics, Inc. Common 69366J200 2356 68652 SH SOLE 68652 0 0 Puma Biotechnology, Inc. Common 74587V107 1696 83340 SH SOLE 83340 0 0 Quest Diagnostics Incorporated Common 74834L100 5537 66500 SH SOLE 66500 0 0 Quorum Health Corporation Common 74909E106 69 23725 SH SOLE 23725 0 0 Regeneron Pharmaceuticals, Inc. Common 75886F107 50954 136422 SH SOLE 136422 0 0 ResMed Inc. Common 761152107 6676 58630 SH SOLE 58630 0 0 Rhythm Pharmaceuticals, Inc. Common 76243J105 669 24890 SH SOLE 24890 0 0 Sabra Health Care REIT, Inc. Common 78573L106 8946 542862 SH SOLE 542862 0 0 Sage Therapeutics, Inc. Common 78667J108 9430 98444 SH SOLE 98444 0 0 Sangamo Therapeutics, Inc. Common 800677106 2773 241538 SH SOLE 241538 0 0 Sanofi Sponsored ADR 80105N105 7809 179900 SH SOLE 179900 0 0 Sarepta Therapeutics, Inc. Common 803607100 20935 191837 SH SOLE 191837 0 0 Seattle Genetics, Inc. Common 812578102 12819 226239 SH SOLE 226239 0 0 Senior Housing Properties Trust Common 81721M109 4421 377220 SH SOLE 377220 0 0 Shire plc Sponsored ADR 82481R106 6303 36216 SH SOLE 36216 0 0 Smith & Nephew plc Shares 83175M205 6933 185478 SH SOLE 185478 0 0 Spark Therapeutics, Inc. Common 84652J103 422 10772 SH SOLE 10772 0 0 SPDR S&P Biotech ETF S&P Biotech ETF 78464A870 10362 144424 SH SOLE 144424 0 0 Spectrum Pharmaceuticals, Inc. Common 84763A108 1003 114670 SH SOLE 114670 0 0 STERIS plc Shares G84720104 5129 48003 SH SOLE 48003 0 0 Stryker Corporation Common 863667101 25148 160432 SH SOLE 160432 0 0 Sutro Biopharma, Inc. Common 869367102 2074 229900 SH SOLE 229900 0 0 Syndax Pharmaceuticals, Inc. Common 87164F105 890 200000 SH SOLE 200000 0 0 Takeda Pharmaceutical Co. Ltd. Sponsored ADS 687044008 649 19200 SH SOLE 19200 0 0 Teleflex Incorporated Common 879369106 1649 6379 SH SOLE 6379 0 0 Tenet Healthcare Corporation Common 88033G407 2419 141136 SH SOLE 141136 0 0 Tetraphase Pharmaceuticals, Inc. Common 88165N105 971 859322 SH SOLE 859322 0 0 Teva Pharmaceutical Industries Limited Sponsored ADR 881624209 18687 1211868 SH SOLE 1211868 0 0 Thermo Fisher Scientific Inc. Common 883556102 42944 191895 SH SOLE 191895 0 0 Trillium Therapeutics Inc. Common 89620X506 763 446099 SH SOLE 446099 0 0 Ultragenyx Pharmaceutical Inc. Common 90400D108 3346 76958 SH SOLE 76958 0 0 uniQure N.V. Shares N90064101 1088 37741 SH SOLE 37741 0 0 United Therapeutics Corporation Class B 91307C102 4493 41261 SH SOLE 41261 0 0 Unitedhealth Group Incorporated Common 91324P102 93513 375374 SH SOLE 375374 0 0 Varian Medical Systems, Inc. Common 92220P105 2972 26227 SH SOLE 26227 0 0 Ventas, Inc. Common 92276F100 5771 98496 SH SOLE 98496 0 0 Verona Pharma plc Sponsored ADR 925050106 2475 275000 SH SOLE 275000 0 0 Vertex Pharmaceuticals Incorporated Common 92532F100 70634 426248 SH SOLE 426248 0 0 Viking Therapeutics, Inc. Common 92686J106 436 57008 SH SOLE 57008 0 0 Waters Corporation Common 941848103 2037 10800 SH SOLE 10800 0 0 WellCare Health Plans, Inc. Common 94946T106 3069 13000 SH SOLE 13000 0 0 Welltower Inc. Common 95040Q104 3162 45560 SH SOLE 45560 0 0 Wright Medical Group N.V. Ordinary Shares N96617118 3631 133391 SH SOLE 133391 0 0 Xencor, Inc. Common 98401F105 2031 56172 SH SOLE 56172 0 0 Zimmer Biomet Holdings, Inc. Common 98956P102 9252 89204 SH SOLE 89204 0 0 Zoetis Inc. Class A 98978V103 21506 251415 SH SOLE 251415 0 0 Zogenix, Inc. Common 98978L204 4048 111025 SH SOLE 111025 0 0