Chief Compliance Officer

0001104659-18-067879.txt : 20181113 0001104659-18-067879.hdr.sgml : 20181113 20181113144610 ACCESSION NUMBER: 0001104659-18-067879 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20180930 FILED AS OF DATE: 20181113 DATE AS OF CHANGE: 20181113 EFFECTIVENESS DATE: 20181113 FILER: COMPANY DATA: COMPANY CONFORMED NAME: Tekla Capital Management LLC CENTRAL INDEX KEY: 0001300336 IRS NUMBER: 010628853 STATE OF INCORPORATION: DE FISCAL YEAR END: 0930 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10950 FILM NUMBER: 181177355 BUSINESS ADDRESS: STREET 1: 100 FEDERAL STREET STREET 2: 19TH FLOOR CITY: BOSTON STATE: MA ZIP: 02110 BUSINESS PHONE: 617 772-8500 MAIL ADDRESS: STREET 1: 100 FEDERAL STREET STREET 2: 19TH FLOOR CITY: BOSTON STATE: MA ZIP: 02110 FORMER COMPANY: FORMER CONFORMED NAME: Hambrecht & Quist Capital Management LLC DATE OF NAME CHANGE: 20040811 13F-HR 1 primary_doc.xml 13F-HR LIVE 0001300336 XXXXXXXX 09-30-2018 09-30-2018 false Tekla Capital Management LLC

100 FEDERAL STREET 19TH FLOOR BOSTON MA 02110

13F HOLDINGS REPORT 028-10950 N Laura Woodward Chief Compliance Officer 617-772-8500 /s/ Laura Woodward Boston MA 11-13-2018 0 212 2757323 false INFORMATION TABLE 2 a18-36498_1informationtable.xml INFORMATION TABLE Abbott Laboratories Common 002824100 28737 391719 SH SOLE 391719 0 0 AbbVie Inc. Common 00287Y109 46541 492078 SH SOLE 492078 0 0 ABIOMED, Inc. Common 003654100 1687 3750 SH SOLE 3750 0 0 AC Immune SA Shares H00263105 1375 171813 SH SOLE 171813 0 0 Acadia Healthcare Company, Inc. Common 00404A109 9588 272400 SH SOLE 272400 0 0 ACADIA Pharmaceuticals Inc. Common 004225108 1945 93689 SH SOLE 93689 0 0 Acceleron Pharma Inc. Common 00434H108 9773 170766 SH SOLE 170766 0 0 Achillion Pharmaceuticals, Inc. Common 00448Q201 1710 464761 SH SOLE 464761 0 0 Adaptimmune Therapeutics plc Sponsored ADR 00653A107 4768 351618 SH SOLE 351618 0 0 Aegerion Pharmaceuticals, Inc. Note 2.00% 8/15/19 00767EAB8 9740 13000000 PRN SOLE 13000000 0 0 Aerie Pharmaceuticals, Inc. Common 00771V108 2386 38770 SH SOLE 38770 0 0 Aerpio Pharmaceuticals, Inc. Common 00810B105 2364 765000 SH SOLE 765000 0 0 Aetna Inc. Common 00817Y108 16966 83637 SH SOLE 83637 0 0 Affimed NV Common N01045108 1105 254000 SH SOLE 254000 0 0 Agilent Technologies, Inc. Common 00846U101 4007 56800 SH SOLE 56800 0 0 Agios Pharmaceuticals, Inc. Common 00847X104 2612 33870 SH SOLE 33870 0 0 Akebia Therapeutics, Inc. Common 00972D105 2354 266612 SH SOLE 266612 0 0 Albireo Pharma, Inc. Common 01345P106 4120 125000 SH SOLE 125000 0 0 Alexion Pharmaceuticals, Inc. Common 015351109 60944 438416 SH SOLE 438416 0 0 Align Technology, Inc. Common 016255101 4399 11244 SH SOLE 11244 0 0 Alkermes plc Shares G01767105 7259 171042 SH SOLE 171042 0 0 Allergan plc Shares G0177J108 47398 248836 SH SOLE 248836 0 0 Alliqua BioMedical, Inc. Common 019621309 375 165000 SH SOLE 165000 0 0 Alnylam Pharmaceuticals, Inc. Common 02043Q107 11043 126176 SH SOLE 126176 0 0 Amarin Corporation plc Sponsored ADR 023111206 12268 754049 SH SOLE 754049 0 0 AmerisourceBergen Corporation Common 03073E105 10311 111807 SH SOLE 111807 0 0 Amgen Inc. Common 031162100 140513 677855 SH SOLE 677855 0 0 Amicus Therapeutics, Inc. Common 03152W109 10582 875304 SH SOLE 875304 0 0 AnaptysBio, Inc. Common 032724106 4580 45910 SH SOLE 45910 0 0 Anthem, Inc. Common 036752103 38681 141147 SH SOLE 141147 0 0 ARCA biopharma, Inc. Common 00211Y407 454 811227 SH SOLE 811227 0 0 Ardelyx, Inc. Common 039697107 2781 639370 SH SOLE 639370 0 0 Arena Pharmaceuticals, Inc. Common 040047607 4315 93767 SH SOLE 93767 0 0 argenx SE Sponsored ADR 04016X101 1152 15188 SH SOLE 15188 0 0 ArQule, Inc. Common 04269E107 1415 250000 SH SOLE 250000 0 0 Array BioPharma Inc. Common 04269X105 5535 364166 SH SOLE 364166 0 0 Ascendis Pharma A/S Sponsored ADR 04351P101 4656 65714 SH SOLE 65714 0 0 Assertio Therapeutics, Inc. Common 04545L107 6 1000 SH SOLE 1000 0 0 AstraZeneca PLC Sponsored ADR 046353108 28436 718624 SH SOLE 718624 0 0 Athenex, Inc. Common 04685N103 708 45530 SH SOLE 45530 0 0 Audentes Therapeutics, Inc. Common 05070R104 1534 38740 SH SOLE 38740 0 0 Avadel Pharmaceuticals plc Sponsored ADR 05337M104 3576 814588 SH SOLE 814588 0 0 Bausch Health Companies Inc. Common 071734107 4929 192000 SH SOLE 192000 0 0 Baxter International Inc. Sponsored ADR 071813109 11258 146040 SH SOLE 146040 0 0 Becton, Dickinson and Company Common 075887109 16750 64178 SH SOLE 64178 0 0 BeiGene, Ltd. Sponsored ADR 07725L102 14769 85755 SH SOLE 85755 0 0 Bellicum Pharmaceuticals, Inc. Common 079481107 370 60000 SH SOLE 60000 0 0 Biogen Inc. Common 09062X103 138286 391402 SH SOLE 391402 0 0 BioMarin Pharmaceutical Inc. Common 09061G101 13628 140538 SH SOLE 140538 0 0 bluebird bio, Inc. Common 09609G100 12817 87788 SH SOLE 87788 0 0 Blueprint Medicines Corporation Common 09627Y109 11397 146001 SH SOLE 146001 0 0 Boston Scientific Corporation Common 101137107 17132 444991 SH SOLE 444991 0 0 Bristol-Myers Squibb Company Common 110122108 22725 366064 SH SOLE 366064 0 0 Cardinal Health, Inc. Common 14149Y108 340 6300 SH SOLE 6300 0 0 Celgene Corporation Common 151020104 117442 1312350 SH SOLE 1312350 0 0 Celldex Therapeutics, Inc. Common 15117B103 48 105800 SH SOLE 105800 0 0 Cellectis SA Sponsored ADR 15117K103 7873 278988 SH SOLE 278988 0 0 Centene Corporation Common 15135B101 24159 166869 SH SOLE 166869 0 0 Charles River Laboratories International, Inc. Common 159864107 3050 22670 SH SOLE 22670 0 0 Cidara Therapeutics, Inc. Common 171757107 699 158784 SH SOLE 158784 0 0 Cigna Corporation Common 125509109 8426 40461 SH SOLE 40461 0 0 Clearside Biomedical, Inc. Common 185063104 508 82665 SH SOLE 82665 0 0 Clovis Oncology, Inc. Common 189464100 2214 75400 SH SOLE 75400 0 0 Coherus Biosciences, Inc. Common 19249H103 2472 149820 SH SOLE 149820 0 0 Community Health Systems, Inc. Common 203668108 706 203935 SH SOLE 203935 0 0 Concert Pharmaceuticals, Inc. Common 206022105 1346 90724 SH SOLE 90724 0 0 CRISPR Therapeutics AG Common H17182108 7910 178348 SH SOLE 178348 0 0 CVS Health Corporation Common 126650100 31575 401101 SH SOLE 401101 0 0 CymaBay Therapeutics, Inc. Common 23257D103 1883 169962 SH SOLE 169962 0 0 Danaher Corporation Common 235851102 22750 209371 SH SOLE 209371 0 0 DENTSPLY SIRONA Inc. Common 24906P109 2174 57600 SH SOLE 57600 0 0 Dermira, Inc. Common 24983L104 2553 234200 SH SOLE 234200 0 0 Diplomat Pharmacy, Inc. Common 25456K101 8521 439001 SH SOLE 439001 0 0 Editas Medicine, Inc. Common 28106W103 2440 76668 SH SOLE 76668 0 0 Edwards Lifesciences Corporation Common 28176E108 13353 76696 SH SOLE 76696 0 0 Egalet Corporation Note 5.50% 4/1/20 28226BAB0 700 7000000 PRN SOLE 7000000 0 0 Eidos Therapeutics, Inc. Common 28249H104 278 27900 SH SOLE 27900 0 0 Eli Lilly and Company Common 532457108 23226 216442 SH SOLE 216442 0 0 Endo International plc Shares G30401106 17151 1019048 SH SOLE 1019048 0 0 Endocyte, Inc. Common 29269A102 746 41980 SH SOLE 41980 0 0 Epizyme, Inc. Common 29428V104 5144 485325 SH SOLE 485325 0 0 Esperion Therapeutics, Inc. Common 29664W105 8399 189287 SH SOLE 189287 0 0 Evolent Health, Inc. Common 30050B101 2394 84300 SH SOLE 84300 0 0 Exelixis, Inc. Common 30161Q104 9816 553940 SH SOLE 553940 0 0 Express Scripts Holding Company Common 30219G108 5059 53250 SH SOLE 53250 0 0 FibroGen, Inc. Common 31572Q808 10826 178207 SH SOLE 178207 0 0 Foamix Pharmaceuticals Ltd. Shares M46135105 4167 727205 SH SOLE 727205 0 0 Galapagos NV Sponsored ADR 36315X101 11222 99815 SH SOLE 99815 0 0 Genomic Health, Inc. Common 37244C101 2439 34740 SH SOLE 34740 0 0 Gilead Sciences, Inc. Common 375558103 149966 1942317 SH SOLE 1942317 0 0 GlaxoSmithKline plc Shares 37733W105 8785 218700 SH SOLE 218700 0 0 Global Blood Therapeutics, Inc. Common 37890U108 5026 132270 SH SOLE 132270 0 0 Global Medical REIT Inc. Common 37954A204 691 73400 SH SOLE 73400 0 0 GW Pharmaceuticals plc ADS 36197T103 7531 43598 SH SOLE 43598 0 0 HCA Healthcare, Inc. Common 40412C101 10341 74335 SH SOLE 74335 0 0 HCP, Inc. Common 40414L109 1198 45500 SH SOLE 45500 0 0 Healthcare Realty Trust Incorporated Common 421946104 1990 68000 SH SOLE 68000 0 0 Healthcare Trust of America, Inc. Common 42225P501 1227 46000 SH SOLE 46000 0 0 Henry Schein, Inc. Common 806407102 2670 31400 SH SOLE 31400 0 0 Hologic, Inc. Common 436440101 801 19546 SH SOLE 19546 0 0 Horizon Pharma plc Shares G4617B105 3190 162900 SH SOLE 162900 0 0 Humana Inc. Common 444859102 23184 68487 SH SOLE 68487 0 0 IDEXX Laboratories, Inc. Common 45168D104 25566 102403 SH SOLE 102403 0 0 Illumina, Inc. Common 452327109 89092 242717 SH SOLE 242717 0 0 ImmunoGen, Inc. Common 45253H101 1593 168190 SH SOLE 168190 0 0 Immunomedics, Inc. Common 452907108 2028 97370 SH SOLE 97370 0 0 Incyte Corporation Common 45337C102 44587 645442 SH SOLE 645442 0 0 Innoviva, Inc. Common 45781M101 2463 161603 SH SOLE 161603 0 0 Inovalon Holdings, Inc. Common 45781D101 1770 176163 SH SOLE 176163 0 0 Intellia Therapeutics, Inc. Common 45826J105 1965 68671 SH SOLE 68671 0 0 Intersect ENT, Inc. Common 46071F103 240 8356 SH SOLE 8356 0 0 Intra-Cellular Therapies, Inc. Common 46116X101 756 34850 SH SOLE 34850 0 0 Intuitive Surgical, Inc. Common 46120E602 14137 24629 SH SOLE 24629 0 0 Ionis Pharmaceuticals, Inc. Common 462222100 4273 82838 SH SOLE 82838 0 0 Iovance Biotherapeutics, Inc. Common 462260100 2440 216908 SH SOLE 216908 0 0 IQVIA Holdings Inc. Common 46266C105 2180 16800 SH SOLE 16800 0 0 Jazz Pharmaceuticals plc Shares G50871105 18570 110452 SH SOLE 110452 0 0 Johnson & Johnson Common 478160104 137751 996968 SH SOLE 996968 0 0 Jounce Therapeutics, Inc. Common 481116101 66 10127 SH SOLE 10127 0 0 Koninklijke Philips N.V. NY Reg Sh 500472303 1506 33100 SH SOLE 33100 0 0 Laboratory Corporation of America Holdings Sponsored ADR 50540R409 2119 12200 SH SOLE 12200 0 0 LeMaitre Vascular, Inc. Common 525558201 1052 27150 SH SOLE 27150 0 0 Lexicon Pharmaceuticals, Inc. Sponsored ADR 528872302 747 70000 SH SOLE 70000 0 0 Ligand Pharmaceuticals Incorporated Common 53220K504 2454 8940 SH SOLE 8940 0 0 LivaNova plc Shares G5509L101 779 6287 SH SOLE 6287 0 0 Loxo Oncology, Inc. Common 548862101 4202 24595 SH SOLE 24595 0 0 LTC Properties, Inc. Common 502175102 9249 209673 SH SOLE 209673 0 0 Madrigal Pharmaceuticals, Inc. Common 558868105 1428 6670 SH SOLE 6670 0 0 Mallinckrodt plc Shares G5785G107 1571 53600 SH SOLE 53600 0 0 Marinus Pharmaceuticals, Inc. Common 56854Q101 3362 336228 SH SOLE 336228 0 0 Masimo Corporation Common 574795100 4237 34020 SH SOLE 34020 0 0 McKesson Corporation Common 58155Q103 11003 82947 SH SOLE 82947 0 0 Medical Properties Trust, Inc. Common 58463J304 7118 477409 SH SOLE 477409 0 0 The Medicines Company Common 584688105 4960 165841 SH SOLE 165841 0 0 Medtronic plc Shares G5960L103 33391 339439 SH SOLE 339439 0 0 Menlo Therapeutics Inc. Common 586858102 244 24784 SH SOLE 24784 0 0 Merck & Co., Inc. Common 58933Y105 45771 645208 SH SOLE 645208 0 0 Merus N.V. Common N5749R100 8175 414115 SH SOLE 414115 0 0 Mettler-Toledo International Inc. Common 592688105 2131 3500 SH SOLE 3500 0 0 Mirati Therapeutics, Inc. Common 60468T105 640 13590 SH SOLE 13590 0 0 Molecular Templates, Inc. Common 608550109 777 144110 SH SOLE 144110 0 0 Mylan N.V. Shares N59465109 60647 1657017 SH SOLE 1657017 0 0 MyoKardia, Inc. Common 62857M105 2517 38600 SH SOLE 38600 0 0 Nektar Therapeutics Common 640268108 12952 212469 SH SOLE 212469 0 0 Neurocrine Biosciences, Inc. Common 64125C109 26143 212630 SH SOLE 212630 0 0 Nevro Corp. Common 64157F103 3919 68760 SH SOLE 68760 0 0 New Senior Investment Group Inc. Common 648691103 3121 528919 SH SOLE 528919 0 0 NewLink Genetics Corporation Common 651511107 490 205026 SH SOLE 205026 0 0 Nightstar Therapeutics plc ADR 65413A101 3065 150000 SH SOLE 150000 0 0 Novartis AG Sponsored ADR 66987V109 27803 322690 SH SOLE 322690 0 0 Novavax, Inc. Common 670002104 1073 571000 SH SOLE 571000 0 0 Novo Nordisk A/S Sponsored ADR 670100205 14232 301900 SH SOLE 301900 0 0 NuCana plc Sponsored ADR 67022C106 245 9823 SH SOLE 9823 0 0 NuVasive, Inc. Common 670704105 1390 19580 SH SOLE 19580 0 0 Omega Healthcare Investors, Inc. Common 681936100 19000 579785 SH SOLE 579785 0 0 Ovid Therapeutics Inc. Common 690469101 3038 535824 SH SOLE 535824 0 0 Perrigo Company plc Shares G97822103 2641 37300 SH SOLE 37300 0 0 Pfizer Inc. Common 717081103 59675 1354093 SH SOLE 1354093 0 0 Physicians Realty Trust Common 71943U104 6593 391016 SH SOLE 391016 0 0 Pieris Pharmaceuticals, Inc. Common 720795103 11689 2087380 SH SOLE 2087380 0 0 Portola Pharmaceuticals, Inc. Sponsored ADR 737010108 3074 115448 SH SOLE 115448 0 0 PRA Health Sciences, Inc. Common 69354M108 3577 32460 SH SOLE 32460 0 0 Protagonist Therapeutics, Inc. Common 74366E102 2254 219042 SH SOLE 219042 0 0 PTC Therapeutics, Inc. Common 69366J200 2274 48390 SH SOLE 48390 0 0 Puma Biotechnology, Inc. Common 74587V107 3821 83340 SH SOLE 83340 0 0 Quest Diagnostics Incorporated Common 74834L100 4208 39000 SH SOLE 39000 0 0 Quorum Health Corporation Common 74909E106 139 23725 SH SOLE 23725 0 0 Regeneron Pharmaceuticals, Inc. Common 75886F107 59086 146237 SH SOLE 146237 0 0 Repligen Corporation Common 759916109 2146 38700 SH SOLE 38700 0 0 ResMed Inc. Common 761152107 6762 58630 SH SOLE 58630 0 0 Revance Therapeutics, Inc. Common 761330109 1936 77919 SH SOLE 77919 0 0 Rhythm Pharmaceuticals, Inc. Sponsored ADR 76243J105 726 24890 SH SOLE 24890 0 0 The RMR Group Inc. Class A 74967R106 494 5323 SH SOLE 5323 0 0 Sabra Health Care REIT, Inc. Common 78573L106 16753 724606 SH SOLE 724606 0 0 Sage Therapeutics, Inc. Common 78667J108 20285 143614 SH SOLE 143614 0 0 Sangamo Therapeutics, Inc. Common 800677106 2914 171889 SH SOLE 171889 0 0 Sanofi Sponsored ADR 80105N105 8036 179900 SH SOLE 179900 0 0 Sarepta Therapeutics, Inc. Common 803607100 36046 223182 SH SOLE 223182 0 0 Seattle Genetics, Inc. Common 812578102 21549 279417 SH SOLE 279417 0 0 Senior Housing Properties Trust Common 81721M109 11353 646554 SH SOLE 646554 0 0 Shire plc Shares 82481R106 6565 36216 SH SOLE 36216 0 0 Smith & Nephew plc Sponsored ADR 83175M205 6879 185478 SH SOLE 185478 0 0 Spark Therapeutics, Inc. Common 84652J103 1203 22046 SH SOLE 22046 0 0 SPDR S&P Biotech ETF S&P Biotech ETF 78464A870 12367 129000 SH SOLE 129000 0 0 Spectrum Pharmaceuticals, Inc. Common 84763A108 1926 114670 SH SOLE 114670 0 0 STERIS plc Shares G84720104 4027 35203 SH SOLE 35203 0 0 Stryker Corporation Common 863667101 28506 160432 SH SOLE 160432 0 0 Sutro Biopharma, Inc. Common 869367102 3750 250000 SH SOLE 250000 0 0 Syndax Pharmaceuticals, Inc. Common 87164F105 1616 200000 SH SOLE 200000 0 0 Teleflex Incorporated Common 879369106 1697 6379 SH SOLE 6379 0 0 Teligent, Inc. Common 87960W104 401 101458 SH SOLE 101458 0 0 Tenet Healthcare Corporation Common 88033G407 4682 164500 SH SOLE 164500 0 0 TESARO, Inc. Common 881569107 3705 94970 SH SOLE 94970 0 0 Tetraphase Pharmaceuticals, Inc. Common 88165N105 2372 859322 SH SOLE 859322 0 0 Teva Pharmaceutical Industries Limited Sponsored ADR 881624209 20096 932948 SH SOLE 932948 0 0 Theravance Biopharma, Inc. Common G8807B106 264 8083 SH SOLE 8083 0 0 Thermo Fisher Scientific Inc. Common 883556102 44031 180395 SH SOLE 180395 0 0 Trillium Therapeutics Inc. Common 89620X506 2717 468399 SH SOLE 468399 0 0 Ultragenyx Pharmaceutical Inc. Common 90400D108 5875 76958 SH SOLE 76958 0 0 uniQure N.V. Shares N90064101 1373 37741 SH SOLE 37741 0 0 United Therapeutics Corporation Class B 91307C102 5276 41261 SH SOLE 41261 0 0 Unitedhealth Group Incorporated Common 91324P102 91647 344486 SH SOLE 344486 0 0 Varian Medical Systems, Inc. Common 92220P105 2936 26227 SH SOLE 26227 0 0 Ventas, Inc. Common 92276F100 5356 98496 SH SOLE 98496 0 0 Verona Pharma plc Sponsored ADR 925050106 3440 275000 SH SOLE 275000 0 0 Vertex Pharmaceuticals Incorporated Common 92532F100 78683 408235 SH SOLE 408235 0 0 Waters Corporation Common 941848103 2103 10800 SH SOLE 10800 0 0 Welltower Inc. Common 95040Q104 2930 45560 SH SOLE 45560 0 0 Wright Medical Group N.V. Ordinary Shares N96617118 7742 266781 SH SOLE 266781 0 0 Zimmer Biomet Holdings, Inc. Common 98956P102 15625 118846 SH SOLE 118846 0 0 Zoetis Inc. Class A 98978V103 20822 227415 SH SOLE 227415 0 0 Zogenix, Inc. Common 98978L204 3283 66182 SH SOLE 66182 0 0