Chief Compliance Officer

0001104659-18-009590.txt : 20180214 0001104659-18-009590.hdr.sgml : 20180214 20180214125540 ACCESSION NUMBER: 0001104659-18-009590 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20171231 FILED AS OF DATE: 20180214 DATE AS OF CHANGE: 20180214 EFFECTIVENESS DATE: 20180214 FILER: COMPANY DATA: COMPANY CONFORMED NAME: Tekla Capital Management LLC CENTRAL INDEX KEY: 0001300336 IRS NUMBER: 010628853 STATE OF INCORPORATION: DE FISCAL YEAR END: 0930 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10950 FILM NUMBER: 18610084 BUSINESS ADDRESS: STREET 1: 100 FEDERAL STREET STREET 2: 19TH FLOOR CITY: BOSTON STATE: MA ZIP: 02110 BUSINESS PHONE: 617 772-8500 MAIL ADDRESS: STREET 1: 100 FEDERAL STREET STREET 2: 19TH FLOOR CITY: BOSTON STATE: MA ZIP: 02110 FORMER COMPANY: FORMER CONFORMED NAME: Hambrecht & Quist Capital Management LLC DATE OF NAME CHANGE: 20040811 13F-HR 1 primary_doc.xml 13F-HR LIVE 0001300336 XXXXXXXX 12-31-2017 12-31-2017 false Tekla Capital Management LLC

100 FEDERAL STREET 19TH FLOOR BOSTON MA 02110

13F HOLDINGS REPORT 028-10950 N Laura Woodward Chief Compliance Officer 617-772-8500 /s/ Laura Woodward Boston MA 02-14-2018 0 161 2592759 false INFORMATION TABLE 2 a18-2150_1informationtable.xml INFORMATION TABLE Abbott Laboratories Common 002824100 45577 798619 SH SOLE 798619 0 0 AbbVie Inc. Common 00287Y109 33492 346313 SH SOLE 346313 0 0 AC Immune SA Shares H00263105 2199 171813 SH SOLE 171813 0 0 Acadia Healthcare Company, Inc. Common 00404A109 8888 272400 SH SOLE 272400 0 0 ACADIA Pharmaceuticals Inc. Common 004225108 7404 245885 SH SOLE 245885 0 0 Acceleron Pharma Inc. Common 00434H108 12027 283383 SH SOLE 283383 0 0 Achillion Pharmaceuticals, Inc. Common 00448Q201 1774 616000 SH SOLE 616000 0 0 Adaptimmune Therapeutics plc Sponsored ADR 00653A107 6248 935368 SH SOLE 935368 0 0 Adverum Biotechnologies, Inc. Common 00773U108 2604 743974 SH SOLE 743974 0 0 Aegerion Pharmaceuticals, Inc. Note 2.00% 8/15/19 00767EAB8 10335 13000000 PRN SOLE 13000000 0 0 Aetna Inc. Common 00817Y108 8580 47566 SH SOLE 47566 0 0 Affimed N.V. Common N01045108 1827 1405324 SH SOLE 1405324 0 0 Alexion Pharmaceuticals, Inc. Common 015351109 78884 659618 SH SOLE 659618 0 0 Alkermes plc Shares G01767105 7885 144072 SH SOLE 144072 0 0 Allergan plc Shares G0177J108 34054 208180 SH SOLE 208180 0 0 Allergan plc 5.50% Convertible Preferred Series A G0177J116 2931 5000 SH SOLE 5000 0 0 Alliqua BioMedical, Inc. Common 019621309 302 165000 SH SOLE 165000 0 0 Alnylam Pharmaceuticals, Inc. Common 02043Q107 14606 114966 SH SOLE 114966 0 0 Amarin Corporation plc Sponsored ADR 023111206 3835 956300 SH SOLE 956300 0 0 AmerisourceBergen Corporation Common 03073E105 15362 167307 SH SOLE 167307 0 0 Amgen Inc. Common 031162100 149932 862174 SH SOLE 862174 0 0 Amicus Therapeutics, Inc. Common 03152W109 8705 604920 SH SOLE 604920 0 0 Anthem, Inc. Common 036752103 10107 44918 SH SOLE 44918 0 0 ARCA biopharma, Inc. Common 00211Y407 1115 811227 SH SOLE 811227 0 0 Ardelyx, Inc. Common 039697107 4220 639370 SH SOLE 639370 0 0 argenx SE Sponsored ADR 04016X101 2934 46466 SH SOLE 46466 0 0 AstraZeneca PLC Sponsored ADR 046353108 15358 442600 SH SOLE 442600 0 0 Auris Medical Holding AG Common H03579101 457 774504 SH SOLE 774504 0 0 Avadel Pharmaceuticals plc Sponsored ADR 05337M104 5119 624288 SH SOLE 624288 0 0 AveXis, Inc. Common 05366U100 7785 70347 SH SOLE 70347 0 0 BeiGene, Ltd. Sponsored ADR 07725L102 2557 26170 SH SOLE 26170 0 0 Bellicum Pharmaceuticals, Inc. Common 079481107 505 60000 SH SOLE 60000 0 0 BioCryst Pharmaceuticals, Inc. Common 09058V103 2206 449255 SH SOLE 449255 0 0 Biogen Inc. Common 09062X103 141957 445607 SH SOLE 445607 0 0 BioMarin Pharmaceutical Inc. Common 09061G101 43671 489745 SH SOLE 489745 0 0 bluebird bio, Inc. Common 09609G100 8387 47093 SH SOLE 47093 0 0 Boston Scientific Corporation Common 101137107 6559 264600 SH SOLE 264600 0 0 Bristol-Myers Squibb Company Common 110122108 21394 349121 SH SOLE 349121 0 0 Cardinal Health, Inc. Common 14149Y108 386 6300 SH SOLE 6300 0 0 Cascadian Therapeutics, Inc. Common 14740B606 2741 740769 SH SOLE 740769 0 0 Celgene Corporation Common 151020104 157991 1513904 SH SOLE 1513904 0 0 Celldex Therapeutics, Inc. Common 15117B103 300 105800 SH SOLE 105800 0 0 Cellectis S.A. Sponsored ADR 15117K103 9044 310250 SH SOLE 310250 0 0 Centene Corporation Common 15135B101 23218 230158 SH SOLE 230158 0 0 Charles River Laboratories International, Inc. Common 159864107 9391 85804 SH SOLE 85804 0 0 Cidara Therapeutics, Inc. Common 171757107 1948 286472 SH SOLE 286472 0 0 Cigna Corporation Common 125509109 20309 100002 SH SOLE 100002 0 0 Clovis Oncology, Inc. Common 189464100 5127 75400 SH SOLE 75400 0 0 Coherus BioSciences, Inc. Common 19249H103 792 90000 SH SOLE 90000 0 0 Community Health Systems, Inc. Common 203668108 869 203935 SH SOLE 203935 0 0 CVS Health Corporation Common 126650100 26573 366521 SH SOLE 366521 0 0 CymaBay Therapeutics, Inc. Common 23257D103 1932 209962 SH SOLE 209962 0 0 Cytokinetics, Inc. Common 23282W605 2855 350300 SH SOLE 350300 0 0 CytomX Therapeutics, Inc. Common 23284F105 5595 265045 SH SOLE 265045 0 0 Danaher Corporation Common 235851102 1411 15203 SH SOLE 15203 0 0 Dermira, Inc. Common 24983L104 7467 268500 SH SOLE 268500 0 0 DexCom, Inc. Common 252131107 3096 53950 SH SOLE 53950 0 0 Diplomat Pharmacy, Inc. Common 25456K101 12855 640492 SH SOLE 640492 0 0 Edwards Lifesciences Corporation Common 28176E108 7337 65100 SH SOLE 65100 0 0 Egalet Corporation Note 5.50% 4/1/20 28226BAB0 3334 7000000 PRN SOLE 7000000 0 0 Eli Lilly & Company Common 532457108 32357 383099 SH SOLE 383099 0 0 Endo International plc Shares G30401106 7088 914548 SH SOLE 914548 0 0 Epizyme, Inc. Common 29428V104 5723 456000 SH SOLE 456000 0 0 Evolent Health, Inc. Class A 30050B101 1507 122500 SH SOLE 122500 0 0 Exelixis, Inc. Common 30161Q104 11820 388822 SH SOLE 388822 0 0 Express Scripts Holding Company Common 30219G108 6307 84500 SH SOLE 84500 0 0 Foamix Pharmaceuticals Ltd. Shares M46135105 5592 930398 SH SOLE 930398 0 0 Galapagos NV Sponsored ADR 36315X101 4988 53200 SH SOLE 53200 0 0 Gilead Sciences, Inc. Common 375558103 180553 2520281 SH SOLE 2520281 0 0 Glaukos Corporation Common 377322102 1413 55079 SH SOLE 55079 0 0 GlaxoSmithKline plc Shares 37733W105 12734 359000 SH SOLE 359000 0 0 Global Blood Therapeutics, Inc. Common 37890U108 5113 129948 SH SOLE 129948 0 0 Global Medical REIT Inc. Common 37954A204 602 73400 SH SOLE 73400 0 0 GW Pharmaceuticals plc ADS 36197T103 3300 25000 SH SOLE 25000 0 0 HCA Healthcare, Inc. Common 40412C101 5572 63432 SH SOLE 63432 0 0 HCP, Inc. Common 40414L109 1187 45500 SH SOLE 45500 0 0 Healthcare Realty Trust Incorporated Common 421946104 2184 68000 SH SOLE 68000 0 0 Healthcare Trust of America, Inc. Class A 42225P501 1382 46000 SH SOLE 46000 0 0 Henry Schein, Inc. Common 806407102 2194 31400 SH SOLE 31400 0 0 Horizon Pharma plc Shares G4617B105 2378 162900 SH SOLE 162900 0 0 Humana Inc. Common 444859102 34372 138556 SH SOLE 138556 0 0 IDEXX Laboratories, Inc. Common 45168D104 20697 132352 SH SOLE 132352 0 0 Illumina, Inc. Common 452327109 62442 285791 SH SOLE 285791 0 0 Impax Laboratories, Inc. Common 45256B101 2070 124335 SH SOLE 124335 0 0 Incyte Corporation Common 45337C102 65660 693275 SH SOLE 693275 0 0 Innoviva, Inc. Common 45781M101 3531 248803 SH SOLE 248803 0 0 Intercept Pharmaceuticals, Inc. Note 3.250% 7/1/23 45845PAA6 5486 6900000 PRN SOLE 6900000 0 0 Intuitive Surgical, Inc. Common 46120E602 1405 3850 SH SOLE 3850 0 0 Ionis Pharmaceuticals, Inc. Common 462222100 6485 128930 SH SOLE 128930 0 0 Jazz Pharmaceuticals plc Shares G50871105 13252 98421 SH SOLE 98421 0 0 Johnson & Johnson Common 478160104 102852 736132 SH SOLE 736132 0 0 Karyopharm Therapeutics Inc. Common 48576U106 0 20 SH SOLE 20 0 0 Koninklijke Philips N.V. NY Registry Shares 500472303 2646 70000 SH SOLE 70000 0 0 Lexicon Pharmaceuticals, Inc. Common 528872302 2754 278700 SH SOLE 278700 0 0 LTC Properties, Inc. Common 502175102 9131 209673 SH SOLE 209673 0 0 Mallinckrodt plc Shares G5785G107 1396 61900 SH SOLE 61900 0 0 McKesson Corporation Common 58155Q103 19330 123950 SH SOLE 123950 0 0 Medical Properties Trust, Inc. Common 58463J304 11831 858586 SH SOLE 858586 0 0 Medtronic plc Shares G5960L103 40862 506026 SH SOLE 506026 0 0 Merck & Co., Inc. Common 58933Y105 74400 1322195 SH SOLE 1322195 0 0 Merus B.V. Common N5749R100 9276 479150 SH SOLE 479150 0 0 Mylan N.V. Shares N59465109 67828 1603112 SH SOLE 1603112 0 0 Myovant Sciences Ltd. Common G637AM102 5056 400000 SH SOLE 400000 0 0 NanoString Technologies, Inc. Common 63009R109 555 74250 SH SOLE 74250 0 0 Natera, Inc. Common 632307104 4367 485758 SH SOLE 485758 0 0 Neurocrine Biosciences, Inc. Common 64125C109 25222 325067 SH SOLE 325067 0 0 Nevro Corp. Common 64157F103 13437 194621 SH SOLE 194621 0 0 New Senior Investment Group Inc. Common 648691103 6682 883919 SH SOLE 883919 0 0 Novartis AG Sponsored ADR 66987V109 32063 381882 SH SOLE 381882 0 0 Novavax, Inc. Common 670002104 708 571000 SH SOLE 571000 0 0 Novo Nordisk A/S Sponsored ADR 670100205 14588 271800 SH SOLE 271800 0 0 NuVasive, Inc. Common 670704105 6869 117437 SH SOLE 117437 0 0 Omega Healthcare Investors, Inc. Common 681936100 15967 579785 SH SOLE 579785 0 0 Ovid Therapeutics Inc. Common 690469101 5289 535824 SH SOLE 535824 0 0 Perrigo Company plc Shares G97822103 3251 37300 SH SOLE 37300 0 0 Pfizer Inc. Common 717081103 35318 975087 SH SOLE 975087 0 0 Physicians Realty Trust Common 71943U104 4773 265336 SH SOLE 265336 0 0 Pieris Pharmaceuticals, Inc. Common 720795103 14816 1962380 SH SOLE 1962380 0 0 PRA Health Sciences, Inc. Common 69354M108 5912 64920 SH SOLE 64920 0 0 Protagonist Therapeutics, Inc. Common 74366E102 1723 82822 SH SOLE 82822 0 0 Puma Biotechnology, Inc. Common 74587V107 4784 48392 SH SOLE 48392 0 0 Quorum Health Corporation Shares 74909E106 148 23725 SH SOLE 23725 0 0 Quotient Limited Common G73268107 1037 209519 SH SOLE 209519 0 0 Ra Pharmaceuticals, Inc. Common 74933V108 3028 356237 SH SOLE 356237 0 0 Regeneron Pharmaceuticals, Inc. Common 75886F107 64107 170516 SH SOLE 170516 0 0 Revance Therapeutics, Inc. Common 761330109 1152 32225 SH SOLE 32225 0 0 The RMR Group Inc. Class A 74967R106 441 7441 SH SOLE 7441 0 0 Sabra Health Care REIT, Inc. Common 78573L106 13601 724606 SH SOLE 724606 0 0 Sage Therapeutics, Inc. Common 78667J108 11170 67815 SH SOLE 67815 0 0 Sanofi Sponsored ADR 80105N105 7736 179900 SH SOLE 179900 0 0 Sarepta Therapeutics, Inc. Common 803607100 18606 334400 SH SOLE 334400 0 0 Seattle Genetics, Inc. Common 812578102 11968 223700 SH SOLE 223700 0 0 Senior Housing Properties Trust Shares 81721M109 12382 646554 SH SOLE 646554 0 0 Shire plc Sponsored ADR 82481R106 31294 201739 SH SOLE 201739 0 0 Smith & Nephew plc Sponsored ADR 83175M205 1407 40183 SH SOLE 40183 0 0 Spark Therapeutics, Inc. Common 84652J103 1990 38706 SH SOLE 38706 0 0 SPDR S&P Biotech ETF S&P Biotech ETF 78464A870 19220 226460 SH SOLE 226460 0 0 Stryker Corporation Common 863667101 4877 31500 SH SOLE 31500 0 0 Syndax Pharmaceuticals, Inc. Common 87164F105 1752 200000 SH SOLE 200000 0 0 Tenet Healthcare Corporation Common 88033G407 2494 164500 SH SOLE 164500 0 0 TESARO, Inc. Common 881569107 4773 57595 SH SOLE 57595 0 0 Tetraphase Pharmaceuticals, Inc. Common 88165N105 5414 859322 SH SOLE 859322 0 0 Teva Pharmaceutical Industries Ltd. Sponsored ADR 881624209 30000 1583108 SH SOLE 1583108 0 0 TherapeuticsMD, Inc. Common 88338N107 2537 420000 SH SOLE 420000 0 0 Thermo Fisher Scientific Inc. Common 883556102 26197 137968 SH SOLE 137968 0 0 Trillium Therapeutics Inc. Common 89620X506 3285 450000 SH SOLE 450000 0 0 Ultragenyx Pharmaceutical Inc. Shares 90400D108 6890 148558 SH SOLE 148558 0 0 uniQure N.V. Common N90064101 6521 332850 SH SOLE 332850 0 0 United Therapeutics Corporation Common 91307C102 2400 16220 SH SOLE 16220 0 0 UnitedHealth Group Inc. Class B 91324P102 67436 305886 SH SOLE 305886 0 0 Valeant Pharmaceuticals International, Inc. Common 91911K102 3990 192000 SH SOLE 192000 0 0 Ventas, Inc. Common 92276F100 5281 87996 SH SOLE 87996 0 0 Verona Pharma plc Sponsored ADR 925050106 3278 275000 SH SOLE 275000 0 0 Vertex Pharmaceuticals Incorporated Common 92532F100 96474 643762 SH SOLE 643762 0 0 Welltower Inc. 6.50% Preferred Perpetual 95040Q203 11974 200000 SH SOLE 200000 0 0 Welltower Inc. Common 95040Q104 1365 21400 SH SOLE 21400 0 0 Wright Medical Group N.V. Ordinary Shares N96617118 5923 266781 SH SOLE 266781 0 0 Xencor, Inc. Common 98401F105 438 20000 SH SOLE 20000 0 0 Xenon Pharmaceuticals Inc. Common 98420N105 989 350000 SH SOLE 350000 0 0 Zafgen, Inc. Common 98885E103 61 13307 SH SOLE 13307 0 0 Zimmer Biomet Holdings, Inc. Common 98956P102 9690 80300 SH SOLE 80300 0 0