Amendment Flag Current Fiscal Year End Date Document Period End Date Entity Well-known Seasoned Issuer Entity Voluntary Filers Entity Current Reporting Status Entity Filer Category Entity Registrant Name Entity Central Index Key Document Fiscal Year Focus Document Fiscal Period Focus Document Type Award Type [Axis] Summary of Significant Accounting Policies [Abstract] Accounts payable Accounts Payable, Current Accrued Expenses [Abstract] Other accrued compensation and benefits Accrued Bonuses, Current Accrued consulting and professional fees Accrued Professional Fees, Current Accrued expenses Accrued expenses Reduction in value of accumulated depreciation Accumulated Depreciation, Depletion and Amortization, Property, Plant and Equipment, Period Increase (Decrease) Accumulated depreciation, Property and equipment Accumulated depreciation, property and equipment Less accumulated depreciation Deficit accumulated during the development stage [Member] Additional paid-in capital Additional Paid-in Capital [Member] Adjustments to reconcile net loss to net cash used in operating activities: Stock-based compensation expense Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition Stock-based compensation expense Amortization of deferred financing costs Noncash charge to interest expense Amortization of net discount on short-term investments Antidilutive securities excluded from computation of earnings per share (in shares) Potentially dilutive securities have been excluded from computations of diluted weighted-average shares outstanding (in shares) Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive Securities, Name [Domain] Antidilutive Securities [Axis] Total fair value of assets Assets, Fair Value Disclosure Current assets: ASSETS ASSETS Total current assets Assets, Current Total assets Assets Assets: License Agreement Party [Axis] Activity related to lease liability [Abstract] Balance at December 31, 2011 Balance at June 30, 2012 Capital Lease Obligations Capital Leased Assets [Line Items] Current portion of lease liability Less current portion Less current portion Lease liability Cash and cash equivalents, including $1,661 and $1,194 of cash as of December 31, 2010 and 2011, respectively, collateralizing letters of credit (Note 16) Cash and cash equivalents, including $1,194 of cash at December 31, 2011 and June 30, 2012, collateralizing letters of credit (Note 14) Cash and cash equivalents, beginning of period Cash and cash equivalents, end of period Cash and Cash Equivalents Net (decrease) increase in cash and cash equivalents Cash and Cash Equivalents, Period Increase (Decrease) Cash and Cash Equivalents [Abstract] Cash and cash equivalents Noncash investing and financing activities: [Abstract] Supplemental Cash Flow Information Supplemental Cash Flow Information President And Chief Executive Officer [Member] Class of Warrant or Right [Table] Class of Warrant or Right [Line Items] Class of Warrant or Right [Domain] Class of Warrant or Right [Axis] Exercise price (in dollars per share) Class of Stock [Domain] Warrants to purchase common stock (in shares) Number of shares (in shares) Preferred stock warrants converted in warrants to purchase Common Stock (in shares) Commitments and Contingencies Commitments and Contingencies Commitments and Contingencies [Abstract] Commitments and contingencies (Note 14) Common Stock [Member] Common stock, shares outstanding (in shares) Balance (in shares) Common stock, $0.001 par value; 90,000 shares authorized; 1,239 and 2,381 shares issued and outstanding at December 31, 2010 and 2011, respectively Common stock, $0.001 par value; 90,000 shares authorized; 2,381 and 2,450 shares issued and outstanding at December 31, 2011 and June 30, 2012, respectively Common stock, shares issued (in shares) Common stock, par value (in dollars per share) Common stock, shares authorized (in shares) Common stock, voting rights Employee Benefit Plan [Abstract] Deferred tax assets [Abstract] Computer Equipment [Member] Conversion of redeemable convertible preferred stock into shares of common stock (in shares) Conversion of redeemable convertible preferred stock into shares of common stock (in shares) Corporate securities [Member] Long-term debt including unamortized debt discount Long-term Debt, Gross Debt Instrument [Line Items] Schedule of Long-term Debt Instruments [Table] Debt Debt Debt [Abstract] Unamortized debt discount Debt Instrument, Unamortized Discount Debt interest rate (in hundredths) Deferred Compensation [Member] Deferred Compensation, Share-based Payments [Member] Title of Individual [Axis] Deferred equity offering costs Deferred Offering Costs Financing costs Total deferred tax assets Deferred Tax Assets, Net of Valuation Allowance Research and development credits Deferred Tax Assets, in Process Research and Development Gross deferred tax asset Deferred Tax Assets, Gross Net operating loss carryforwards Deferred tax asset related to domestic net operating loss carryforwards Other temporary differences Deferred tax assets valuation allowance Deferred Tax Assets, Valuation Allowance Security and restoration deposits Depreciation Depreciation Effect of dilutive securities: Employee [Member] Stock-based Compensation Disclosure of Compensation Related Costs, Share-based Payments [Text Block] Stock-based Compensation [Abstract] Federal net operating losses [Member] Diluted net income (loss) attributable to common stockholders per share (in dollars per share) Earnings Per Share, Diluted Per common share information [Abstract] Basic net income (loss) attributable to common stockholders per share (in dollars per shares) Basic and diluted net (loss) income per share Basic and diluted net loss attributable to common stockholders per share (in dollars per share) Net Loss Attributable to Common Stockholders Per Share Net Loss Per Share Net Income (Loss) Attributable to Common Stockholders Per Share [Abstract] Percent of pre-tax income: Effective income tax expense rate (in hundredths) U.S. federal statutory income tax rate (in hundredths) Interest expense -revaluation of warrants (in hundredths) State taxes, net of federal benefit (in hundredths) Valuation allowance (in hundredths) Other (in hundredths) Accrued compensation and benefits Accrued compensation and benefits Weighted average period for recognizing compensation expense Weighted average period for recognizing compensation expense Unrecognized compensation expense related to unvested employee stock options Unrecognized compensation expense Unrecognized compensation expense related to restricted stock awards Severance Benefits [Member] Accrued Severance Benefits [Member] Accrued compensation and benefits [Abstract] Equity Component [Domain] Volatility rate (in hundredths) Volatility (in hundredths) Probability of Fundamental Transaction or Delisting (in hundredths) Charge related to fair value of liability Fair Value, Option, Changes in Fair Value, Gain (Loss) Fair Value, Hierarchy [Axis] Reconciliation of warrant liability measured at fair value on a recurring basis using unobservable inputs (Level 3) Balance Balance Fair Value, Measurement with Unobservable Inputs Reconciliations, Recurring Basis, Liability Value Risk free interest rate (in hundredths) Fair Value Measurements, Recurring and Nonrecurring [Table] Expected term Expected term Noncash property and equipment additions Fair Value, Measurements, Fair Value Hierarchy [Domain] Exercise price per share of warrant (in dollars per share) Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Dividend yield (in hundredths) Short-term Investments and Financial Instruments [Abstract] Fair value [Abstract] Short-term Investments and Fair Value of Financial Instruments Short-term Investments and Financial Instruments Financial assets and liabilities measured at fair value on a recurring basis [Abstract] Fair Value of Financial Instruments Significant unobservable inputs (Level 3) [Member] Quoted prices in active markets for identical assets (Level 1) [Member] Significant other observable inputs (Level 2) [Member] Reconciliation of warrant liability measured at fair value on a recurring basis using unobservable inputs (Level 3) [Abstract] Change in fair value of warrant liability Change in fair value of warrant liability Financial Instrument [Axis] Furniture and Fixtures [Member] Loss on disposition of property and equipment Gain (Loss) on Disposition of Property Patent costs recorded as general and administrative expense General and administrative General and Administrative Expense General and administrative expense [Member] Short-term investments Held-to-maturity Securities, Current Short-term investments Held-to-maturity Securities, Fair Value Disclosure Impairment of Long-Lived Assets Impairment of property and equipment Impairment of property and equipment Impairment of property and equipment Statements of Operations [Abstract] Income Statement Location [Axis] Income Taxes Income Tax Disclosure [Text Block] Income Taxes [Abstract] Income Tax Authority [Axis] Income Tax Authority [Domain] Loss from operations Income (Loss) from Continuing Operations before Equity Method Investments, Income Taxes, Extraordinary Items, Noncontrolling Interest Income Statement Location [Domain] Income Taxes Accounts payable Accrued expenses and other Changes in operating assets and liabilities: Increase (Decrease) in Operating Capital [Abstract] Prepaid expenses and other assets Increase (Decrease) in Prepaid Expense and Other Assets Changes in operating assets and liabilities: Increase (Decrease) in Stockholders' Equity [Roll Forward] Increase (Decrease) in Stockholders' Equity [Roll Forward] Effect of dilutive securities (in shares) Incremental Common Shares Attributable to Share-based Payment Arrangements Interest expense Interest expense Cash paid for interest, net of amounts capitalized Interest expense Interest Expense, Debt Interest income Investment Income, Interest Investment Type Categorization [Domain] Investment Type [Axis] Initial Public Offering [Member] Long-term Debt, Type [Domain] Long-term Debt, Type [Axis] Rent expenses under operating lease Extended lease term Lease Expiration Date Leasehold Improvements [Member] Lease Liability [Abstract] Lease Liability Lease Liability Total current liabilities Liabilities, Current Warrant liability Liabilities, Fair Value Disclosure Current liabilities: Liabilities, Current [Abstract] Total liabilities Liabilities LIABILITIES AND STOCKHOLDERS' EQUITY LIABILITIES AND STOCKHOLDERS' EQUITY Charges utilized Liabilities, Fair Value Adjustment Liabilities: Total liabilities and stockholders' equity Liabilities and Equity Initial license fee License Costs Total debt Total debt outstanding [Abstract] Principal payments maturity [Abstract] 2014 Long-term Debt, Maturities, Repayments of Principal in Year Three 2013 Long-term Debt, Maturities, Repayments of Principal in Year Two 2012 Long-term Debt, Maturities, Repayments of Principal in Next Twelve Months Current portion of long-term debt Less current portion Less current portion Long-term debt Total debt excluding current portion Cash settlement value for warrants if delisted Maximum [Member] Minimum [Member] Cash flows from financing activities: Net loss attributable to common stockholders Net Income (Loss) Available to Common Stockholders, Basic Net cash provided by (used in) investing activities Net Cash Provided by (Used in) Investing Activities Net cash (used in) provided by financing activities Net Cash Provided by (Used in) Financing Activities Cash flows from investing activities: Cash flows from operating activities: Net income (loss) Numerator for basic and diluted et income (loss) per share - net (loss) income attributable to common stockholders Net loss Net loss Net cash used in operating activities Net Cash Provided by (Used in) Operating Activities Non-operating income (expense) Non-operating income Summarizes future minimum lease payments [Abstract] Operating expenses: Carryforwards of net operating losses, expiration dates Total operating expenses Total operating expenses Operating Expenses Operating Loss Carryforwards [Table] Carryforwards of net operating losses 2014 2013 2012 2015 Operating Loss Carryforwards [Line Items] 2016 Total minimum lease payments Operating Leases, Future Minimum Payments Due Organization and Nature of Operations [Abstract] Organization and Nature of Operations Organization and Nature of Operations Basis of Presentation and Reverse Stock Split - 10-Q Other assets Commitment to deposit cash related obligation Other expense Other Expenses Other current liabilities Other Liabilities, Current Other liabilities Other Other Accrued Liabilities, Current Other accrued compensation and benefits Payments for rent Repurchases of common stock Payments for Repurchase of Common Stock Cash paid for property and equipment Payments to Acquire Property, Plant, and Equipment Purchases of short-term investments Payments to Acquire Short-term Investments Employee Benefit Plan Pension and Other Postretirement Benefits Disclosure [Text Block] Plan Name [Domain] Plan Name [Axis] Preferred stock, $0.001 par value; 10,000 shares authorized; zero shares issued or outstanding at December 31, 2010 and 2011, respectively Preferred stock, $0.001 par value; 10,000 shares authorized; zero shares issued or outstanding at December 31, 2011 and June 30, 2012, respectively Preferred stock, shares authorized (in shares) Preferred stock, dividend rate (in hundredths) Cumulative accretion on redeemable convertible preferred stock Accretion of redeemable convertible preferred stock to redemption value Preferred stock, shares issued (in shares) Accretion of redeemable convertible preferred stock to redemption value Preferred Stock Dividends and Other Adjustments Preferred stock, par value ( in dollars per share) Preferred stock, shares outstanding (in shares) Prepaid expenses and other Reclassification Equity Financing [Member] Proceeds from issuance through private placement Proceeds from long-term debt, net of issuance costs Gross proceeds from initial public offering Proceeds from Issuance of Common Stock Cash proceeds from issuance of preferred stock Proceeds from sale of redeemable convertible preferred stock, net Net proceeds received after underwriting fees and offering expenses Proceeds from Issuance Initial Public Offering Proceeds from the sale of property and equipment Sales and redemptions of short-term investments Property and equipment estimated useful life Property, Plant and Equipment, Type [Domain] Property and Equipment [Abstract] Property and Equipment Property and equipment, net of accumulated depreciation of $19,830 and $12,622 as of December 31, 2010 and 2011, respectively Property and equipment, net of accumulated depreciation of $12,622 and $12,866 as of December 31, 2011 and June 30, 2012, respectively Property and equipment, net Property, Plant and Equipment [Line Items] Property and equipment, gross Schedule of property and equipment Property, Plant and Equipment, Type [Axis] Property and Equipment Property, Plant and Equipment Disclosure [Text Block] Quarterly Financial Data (Unaudited) [Abstract] Quarterly Financial Data (Unaudited) Quarterly Financial Information [Text Block] Range [Axis] Range [Domain] Redeemable Convertible Preferred Stock [Member] Repayment of debt Payments on long-term debt License Agreement Party [Domain] Research and development Research and development expense Research and Development Expense Research and development expense [Member] Research and Development Cash held at bank Restricted Stock [Member] Unvested restricted stock [Member] Restricted Stock [Member] Collateralizing letters of credit Estimated charge for personnel related termination costs Restructuring and Related Cost, Expected Cost Restructuring Expenses Restructuring Expenses Number of employees by which headcount is reduced Restructuring and Related Cost, Number of Positions Eliminated Restructuring Plan [Domain] Restructuring Type [Axis] Net Charges paid Charges to operations Charges paid Restructuring Expenses [Abstract] Restructuring Plan [Axis] Summarizes activity related to accrued severance benefits [Abstract] Restructuring Cost and Reserve [Line Items] Accrued severance benefits Balance at December 31, 2011 Balance at June 30, 2012 Deficit accumulated during the development stage Deficit accumulated during the development stage Retained Earnings (Accumulated Deficit) Revenue Vested and expected to vest at June 30, 2012 Vested and expected to vest at December 31, 2011 Expected term Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term Exercisable at June 30, 2012 Exercisable at December 31, 2011 Outstanding at December 31, 2011 Outstanding at June 30, 2012 Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term Sale of Stock, Name of Transaction [Domain] Financial assets and liabilities measured at fair value on a recurring basis Restricted stock activity Additional cash flow information Debt outstanding Weighted-average assumptions Computations of net (loss) income per share Principle payments due Potentially dilutive shares have been excluded from the calculation of diluted net loss per share Potentially Dilutive Securities Activity related to lease liability Reconciliation of statutory U.S. federal rate to entity's effective tax rate Schedule of accrued expenses Stock option activity Schedule of Capital Leased Assets [Table] Future minimum lease payments Quarterly Financial Data (Unaudited) Deferred tax assets Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Outstanding warrants Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Activity related to accrued severance benefits Schedule of Restructuring and Related Costs [Table] Schedule of Property, Plant and Equipment [Table] Security and restoration deposits Security deposit Security Deposit Series A Preferred Stock [Member] Series C Preferred Stock [Member] Series B Preferred Stock [Member] Personnel-related termination costs Charge related to termination benefits Number of shares Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward] Stock-based compensation expense Share-based Compensation Forfeited (in dollars per share) Granted (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value Cancellation of non-vested restricted stock (in shares) Forfeited (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period Nonvested (in dollars per share) Nonvested (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value Weighted-average exercise price [Abstract] Equity awards granted under plan vesting period Equity awards granted under plan vesting period Weighted-average grant date fair value Granted (in shares) Stock options issued for purchase of common stock (in shares) Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Nonvested (in shares) Nonvested (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number Vested (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period Forfeited (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value Sale price per share of stock (in dollars per share) Closing price per share of common stock (in dollars per share) Granted (in dollars per share) Issuance of restricted stock to employees (in shares) Granted (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period Exercised (in dollars per share) Risk free interest rate (in hundredths) Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate Volatility (in hundredths) Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate Dividend yield (in hundredths) Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate Vested (in dollars per share) Fair value of options (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value Exercisable at June 30, 2012 (in shares) Exercisable at December 31, 2011 (in shares) Number of shares available for future grants (in shares) Number of shares [Abstract] Weighted-average assumptions [Abstract] Forfeited (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period Vested and expected to vest at June 30, 2012 (in shares) Vested and expected to vest at December 31, 2011 (in shares) Exercisable at June 30, 2012 Exercisable at December 31, 2011 Outstanding (in dollars per share) Outstanding (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price Outstanding at December 31, 2011 Outstanding at June 30, 2012 Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value Vested and expected to vest at June 30, 2012 Vested and expected to vest at December 31, 2011 Exercisable at June 30, 2012 (in dollars per share) Outstanding (in shares) Outstanding (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number Award Type [Domain] Stock-Based Compensation Vested and expected to vest at June 30, 2012 (in dollars per share) Balance (in shares) Balance (in shares) Shares, Outstanding Short-term investments Short-term investments Summary of Significant Accounting Policies Significant Accounting Policies [Text Block] State net operating losses [Member] Statement [Table] Statement [Line Items] Statements of Cash Flows [Abstract] Statement, Equity Components [Axis] Balance Sheets [Abstract] Class of Stock [Axis] Stock Options [Member] Shares underlying options outstanding [Member] Stock Options [Member] Cancellation of restricted stock to employees (in shares) Stock Issued During Period, Shares, Restricted Stock Award, Forfeited Issuance of common stock upon exercise of options Stock Issued During Period, Value, Stock Options Exercised Effect of reverse stock split (see Note 3) (in shares) Stock Issued During Period, Shares, Reverse Stock Splits Issuance of common stock to initial stockholder Stock Issued During Period, Value, New Issues Value of shares issued for conversion of principal and interest on the convertible notes Conversion of preferred stock to common stock Conversion of redeemable convertible preferred stock into 5,652 shares of common stock Cancellation of restricted stock to employees Stock Issued During Period, Value, Share-based Compensation, Forfeited Issuance of common stock (in shares) Issuance of common stock to initial stockholder (in shares) Issuance of common stock upon exercise of options (in shares) Exercised (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period Conversion of preferred stock to common stock (in shares) Stock Issued During Period, Shares, Conversion of Convertible Securities Issuance of restricted common stock to employees Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures Stockholders' equity (deficit): Stockholders equity: Total stockholders' equity Balance Balance Stockholders' Equity Attributable to Parent Capital Structure [Abstract] Reverse stock split ratio Capital Structure Capital Structure Subsidiary or Equity Method Investee, Sale of Stock by Subsidiary or Equity Investee [Table] Subsidiary, Sale of Stock [Line Items] Subsidiary, Sale of Stock [Axis] Summary of carryforwards of net operating losses and tax credits Supplemental Cash Flow Information [Abstract] Research and development credits Title of Individual with Relationship to Entity [Domain] Types of Financial Instruments [Domain] Type of Restructuring [Domain] Use of Estimates U.S. government agency funds [Member] Increase in valuation allowance Shares underlying warrants outstanding [Member] Warrant liability [Member] Warrants [Abstract] Warrant liability Shares used in computing basic and diluted net income (loss) attributable to common stockholders: Computations of net income (loss) per share [Abstract] Basic (in shares) Denominator for basic net income (loss) attributable to common stockholders per share - weighted-average common shares outstanding (in shares) Diluted (in shares) Denominator for diluted net income (loss) attributable to common stockholders per share - weighted-average number of common shares outstanding and dilutive potential common shares (in shares) Weighted-average common stock outstanding - basic and diluted (in shares) Dilutive potential common shares (in shares) Laboratory equipment [Member] Represents the stock based compensation plan 2010 details of stock awards were granted to employees, director, and consultant of the entity. Two Thousand Ten Stock Incentive And Option Plan [Member] 2010 Stock Incentive and Option Plan [Member] Represents the stock based compensation plan 2004 details of stock awards were granted to employees, director, and consultant of the entity. Two thousand Four stock Option Plan [Member] 2004 Stock Option Plan [Member] Element represents the number of days to determine the average volatility of warrants. Number of days to determine average volatility three Number of days used to determine volatility by taking arithmetic average, condition three Element represents the number of days to determine the average volatility of warrants. Number of days to determine average volatility two Number of days used to determine volatility by taking arithmetic average, condition two Element represents the charges utilized related to the lease liability. Charges utilized Charges utilized Basis of Presentation and Reverse Stock Split [Abstract] Number of levels use to prioritize the inputs to valuations techniques. Number of levels Number of levels Disclosure of the use of estimates and assumptions that may affect the financial statements. Use of Estimates [Text Block] Use of Estimates Use of Estimates [Abstract] Equity impact of the value of non-vested restricted common stock repurchased during the period. Repurchased Nonvested Restricted Stock Repurchased nonvested restricted stock Represents the number of exercisable warrants. Warrants exercisable Warrants exercisable (in shares) This line item represents the maximum period for which royalty is payable after expiration of the last-to-expire patent covering such product. Maximum period for payment of royalty after expiration of product This line item represents the period for which royalty is to be paid after first sale or on a product-by-product basis. Period for which royalty is to be paid after first sale Accrued compensation and benefit [Abstract] Accrued compensation and benefits [Abstract] Statements of Redeemable Convertible Preferred Stock and Stockholders' Equity (Deficit) (unaudited) [Abstract] License and Research Agreements [Abstract] Leases and Letters of Credit [Abstract] Leases and Letters of Credit and License and Research Agreements [Abstract] Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. Commitment [Line Items] Schedule setting forth key provisions of an arrangement under which the entity has agreed to fulfill certain commitments over a period of time greater than one year or the normal operating cycle, if longer, including the item for which expenditures will be made, minimum quantities, milestones, time period and committed amount. Commitment [Table] Represents the organization with which entity entered into a license agreement. Wake Forest University Health Sciences [Member] Wake Forest University Health Sciences (WFUHS) [Member] Represents the organization with which entity entered into a license agreement. Children Medical Center Corporation [Member] Children's Medical Center Corporation (CMCC) [Member] The remaining security deposit obligation, typically cash, provided to a counterparty to provide certain assurance of performance by the entity pursuant to the terms of a written or oral agreement, such as a lease. Remaining security deposit obligation Remaining security deposit obligation This line item represents the period after which license maintenance fees required to be paid with respect to each product covered by new development patents. Period after which license maintenance fees required to be paid Third set of number of days used to determine volatility of the net cash settlement value. Condition 3 [Member] Tangible personal property used to produce goods and services, including, but is not limited to, tools, dies and molds, office equipment but excluding computers. Laboratory Office And Warehouse Equipment [Member] Carryforwards of net operating losses and tax credits [Abstract] Carryforwards of net operating losses and tax credits [Abstract] Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from depreciation and amortization. Deferred tax assets depreciation and amortization Depreciation and amortization Represents the Consultants of the entity's board of Consultants who is not a current employee of the entity or any parent or subsidiary. Non-employee consultants [Member] Non-employee consultants [Member] Schedule of share based compensation restricted stock activity [Abstract] Summarizes restricted stock activity [Abstract] Aggregate intrinsic value [Abstract] Aggregate intrinsic value Weighted average remaining contractual term [Abstract] Weighted-average remaining contractual term [Abstract] Second set of number of days used to determine volatility of the net cash settlement value. Condition 2 [Member] Schedule Of Share Based Compensation Activity [Abstract] Summarizes stock option activity [Abstract] Element represents the number of share based plans maintain by the entity. Number of share based compensation plans Represents the director of the entity's board of directors who is not a current employee of the entity or any parent or subsidiary. Non Employee Director [Member] Non-Employee Director [Member] Represents the stock based compensation plan 2010 details of stock awards were granted to employees, director, and consultant of the entity. Stock Incentive And Option Plan, 2010 [Member] 2010 Stock Incentive and Option Plan [Member] Represents the stock based compensation plan 2004 details of stock awards were granted to employees, director, and consultant of the entity. Stock Option Plan, 2004 [Member] 2004 Stock Option Plan [Member] Refers to fair value of issued nonredeemable common stock Warrants (or common stock redeemable solely at the option of the issuer). Change in fair value of common stock warrants Expected dividends to be paid to holders of the underlying shares or financial instruments (expressed as a percentage of the share or instrument's price). Net cash settlement value assumptions dividend yield Dividend yield (in hundredths) Net cash settlement risk-free interest rate assumption used in valuing an instrument. Net cash settlement value assumptions risk free interest rate Risk free interest rate (in hundredths) Period the instrument, asset or liability is expected to be outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. Net cash settlement value assumptions expected term Expected term (years) Measure of dispersion, in percentage terms (for instance, the standard deviation or variance), for a given stock price. Net cash settlement value assumptions volatility Volatility (in hundredths) Represents cash settlement related to closing price of a single share of a number of saleable stocks of a company. Net cash settlement value assumptions closing share price Closing price per share of common stock (in dollars per share) Represents cash settlement value for the exchange of the underlying asset. Net cash settlement value assumptions exercise price of warrant Exercise price per share of warrant (in dollars per share) Element represents the cash settlement value of the warrants. Net cash settlement value of warrants Calculated aggregate value Net cash settlement value [Abstract] Net cash settlement value [Abstract] Element represents the fair value of the warrants. Fair value of warrants Calculated aggregate value Calculated aggregate fair values and net cash settlement value of warrants [Abstract] Calculated aggregate fair values and net cash settlement value [Abstract] Represents the number of days to determine the average volatility of warrants. Number of days to determine average volatility Number of days used to determine volatility by taking arithmetic average, condition one Number of days used to determine volatility by taking arithmetic average Element represents the number of days to determine the volatility of warrants. Number of days to determine volatility Number of days to determine volatility Represents warrants expiration period from the date of issuance or as per the certain conditions specified in warrants agreement. Warrants expiration period Warrants expiration period Element represents the fair value of warrants as of the date of grants. Fair value of warrants grants Fair value of warrants grants (in dollars per share) Represents expiration period range of warrants held. Warrants expiration period range Expiration Warrants Outstanding [Abstract] Outstanding warrants to purchase common stock [Abstract] Represents the entity classified warrants issued to march 2011 equity financing, which are expired over a period. Warrants Issued pursuant to March 2011 equity financing In March 2016 [Member] Warrants issued pursuant to March 2011 equity financing, expired in March 2016 [Member] Represents the entity classified warrants issued to lenders, which are expired over a period. Warrants Issued to lenders expired from October 2015 through September 2019 [Member] Warrants issued to lenders, expired from October 2015 through September 2019 [Member] Represents the entity classified warrants issued to lenders, which are expired over a period. Warrants Issued to lenders from August 2013 through December 2016 [Member] Warrants issued to lenders, expired from August 2013 through December 2016 [Member] Represents the entity classified warrants issued to march 2011 refinancing of working capital note, which are expired over a period. Warrants Issued pursuant to March 2011 refinancing of Working Capital Note in March 2016 [Member] Warrants issued pursuant to March 2011 refinancing of Working Capital Note, expired in March 2016 [Member] Represents the entity classified warrants issued to vendors, which are expired over a period. Warrants issued to vendors expired from September 2015 through December 2016 [Member] Warrants issued to vendors, expired from September 2015 through December 2016 [Member] Domain contains members of expiration of warrants. Expiration Of Warrants [Domain] Axis contains members of expiration of warrants. Expiration Of Warrants [Axis] Represents the warrants issued by the entity classified as liability. Liability classified warrants [Member] Liability classified warrants [Member] Represents the warrants issued by the entity classified as equity. Equity classified warrants [Member] Equity classified warrants [Member] Tabular disclosure of the significant assumptions used during the year to estimate the aggregate fair value of and net cash settlement value of warrants , including, but not limited to: (a) expected term, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s). Schedule of fair value and net cash settlement value valuation assumptions [Table Text Block] Aggregate fair values and net cash settlement value This line item represents the cost incurred in connection with the sale of stock during the period. Stock issuance costs Element represents the percentage of aggregate purchase price paid by inventors which has to be paid by the entity to the investors as a partial liquidated damage in case entity fails to satisfy the current public information requirement. Percentage of purchase price which entity obligate to pay if fails to meet legal requirements regarding current public information Entity obligate to pay investors if fails to satisfy current public information requirement (in hundredths) Percentage of purchase price entity is obligated to pay investors upon failure to satisfy current public information requirements (in hundredths) First set of number of days used to determine volatility of the net cash settlement value. Condition 1 [Member] Element represents the percentage of aggregate purchase price paid by inventors which has to be paid by the entity to the investors as a partial liquidated damage in case entity fails to meet certain legal requirements in regards to the registration statement. Percentage Of Purchase Price Which Entity Obligate To Pay If Fails To Meet Legal Requirements Regarding Registration Statement Entity obligate to pay investors if fails to meet legal requirement to registrant statement (in hundredths) Percentage of purchase price entity is obligated to pay investors if registration becomes ineffective (in hundredths) Represents machinery and equipment Loan note facility, taken by the entity to fund equipment. Machinery and Equipment Loan [Member] Represents supplemental working capital note facility taken by the entity to fund other assets. Supplemental working capital note [Member] Supplemental Working Capital Note [Member] Represents equipment note facility, taken by the entity to fund equipment. Equipment note [Member] Equipment Note [Member] Represents working capital note facility taken by the entity to fund other assets. Working Capital Note [Member] Working Capital Note [Member] Represent two types of notes taken by the entity. Equipment note facility is to fund equipment and supplemental working capital note is to fund other assets. Equipment and Supplemental Working Capital Notes [Member] Equipment and Supplemental Working Capital Notes [Member] Element represents the Initial fair value related to the lease liability. Initial fair value Element represents the additional charges to operation related to the lease liability. Additional charges to operations Additional charges to operations Represents term of lease for using the property. Lease term Lease term Facility held for productive use. Office and manufacturing space [Member] Office and manufacturing space [Member] Facility held for store goods and inventories. Warehouse space [Member] Warehouse space [Member] This line item represents the credit recognized due to the decline in per share fair value of the outstanding options granted to non-employees. Credit recognized due to the decline in per share fair value Refers to the components of Accrued compensation and benefits like Severance benefits accrued Compensation. Schedule of accrued compensation and benefits [Table Text Block] Schedule of accrued compensation and benefits Refers to Tangible personal property used in an office setting. Examples include, but are not limited to, computers, copiers and fax machine and Facility designed for the storage of goods or equipment. Office and warehouse equipment [Member] Office and warehouse equipment [Member] Refers to the amount of the liability for the conversion option reclassified to stockholders equity. Reclassification of warrant liability to stockholders' equity Reclassification of warrant liability to stockholders' equity Refers to the Cash inflows from issuance of additional warrants to purchase common shares at predetermined price. Issuance of additional warrants Information regarding the number of days used to calculate volatility of net cash settlement value. Volatility Days [Domain] Reverse Stock Split [Abstract] Element represents the fair value of warrants issued with issuance of long-term debt. Fair value of warrants issued with issuance of long term debt Fair value of warrants issued with issuance of long term debt Element represents the value of convertible note issued to initial shareholder for consulting expenses. Convertible note issued to initial stockholder for consulting expense Convertible note issued to initial stockholder for consulting expense Supplemental cash flow disclosures [Abstract] Supplemental cash flow disclosures: Disclosure of accounting policy for Reverse Stock Split. The reverse stock split arrangement. Also provide the retroactive effect given by the reverse split that occurs after the balance sheet date but before the release of financial statements. Reverse Stock Split [Policy Text Block] Reverse Stock Split Disclosure of accounting policy for Deferred Equity Offering Costs. Deferred Equity Offering Costs [Policy Text Block] Deferred Equity Offering Costs Disclosure of accounting policy for Short-term Investments which are intended to be sold in the short term (usually less than one year or the normal operating cycle, whichever is longer) including trading securities, available-for-sale securities, held-to-maturity securities, and other short-term investments. Short-term Investments [Policy Text Block] Short-term Investments Element represents the price paid to purchase per security. Purchase price per security Purchase price per security (in dollars per share) This line item represents the sales milestone payment to be paid based on cumulative net sales, i.e. if cumulative net sales of all licensed products reach a certain level, the entity will be required to make a one-time sales milestone payment. Sales milestone payment based on specified condition Sales milestone payment based on specified condition Carrying value as of the balance sheet date of obligations incurred through that date and payable for research and development. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). Accrued research and development current Represents the director of the entity's board of directors who is employee or not a current employee of the entity or any parent or subsidiary. Employee And Non Employee Director [Member] Element represents the severance agreement provided for the employee to receive monthly severance payments equal to his current monthly salary. Number of monthly severance payments to be received by employee Number of monthly severance payments employee to receive Document and Entity Information [Abstract] This line item represents the aggregate milestones payments to be paid based on development of and obtaining regulatory approval of a licensed product. Aggregate milestones payments to be paid based on condition Aggregate milestones payments to be paid based on condition This line item represents the number of subfields covered under the license for specified aggregate payments. Number of subfields for specified aggregate payments Number of subfields for specified aggregate payments This line item represents the number of development milestones for the first licensed product launched, as defined in the agreement. Number of development milestones achieved This line item represents the number of years for which lease is to be renewed during the period. Number of years for which lease is to be renewed This line item represents the amortization period for start up costs capitalized during the period. Amortization period for capitalized start up costs This line item represents the start up costs capitalized during the period. Capitalized start up costs Capitalized start-up cost Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from capitalized start-up costs. Deferred tax assets capitalized start up costs Capitalized start-up costs This line item represents the repayment period of the debt. Debt Instrument Repayment Period Repayment period of MELF loan This line item represents the fair value of warrant issued in connection with the refinancing. Fair value of warrant issued Fair value of warrant issued in connection with refinancing This line item represents the number of monthly payments of principal and interest for which entity is obligated after January 2012. Number of monthly payments of principal and interest for which entity is obligated Number of monthly payments Information regarding the number of days used to calculate volatility of net cash settlement value. Volatility Days [Axis] Represents the warrants issued for preferred stock. Preferred Stock Warrants [Member] Represents warrants expiration period from the date of issuance or as per the certain conditions specified in warrants agreement. Expiration period Of Warrants Warrants expiration period This line item represents the estimated severance costs paid during next six months. Estimated severance costs in next six months Element represents the liability recorded in connection with severance agreement for expenses incurred. Liability recorded in connection with severance agreement Table of accrued compensation and benefits. Examples including but not limited to severance benefits, Other accrued compensation and benefits. Accrued compensation and benefits [Table] Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. Accrued compensation and benefits [Line Items] Represents the restructuring plan related to the restructuring in 2011. 2011 Restructuring Plan [Member] 2011 Restructuring Plan [Member] This line item represents the severance costs paid during the period. Payment of severance costs This line item represents the reduction in value of impaired assets acquired. Reduction in value of impaired assets acquired Reduction in value of impaired assets acquired Disclosure of the accounting treatment for stock warrants. Warrants [Text Block] Warrants The entire disclosure for accrued expenses. Accrued Expenses [Text Block] Accrued Expenses The entire disclosure for the accrued compensation and benefits. Accrued Compensation And Benefits [Text Block] Accrued compensation and benefits The entire disclosure for the management's plans to continue as a going concern. Management's Plans To Continue As A Going Concern [Text Block] Management's Plans to Continue as a Going Concern Management's Plans To Continue As A Going Concern Management's Plans To Continue As A Going Concern [Abstract] The cash inflow associated with the amount received from entity's first offering of stock to the public, a private placement transaction, and the exercise of stock options. Proceeds From Sale Of Common Stock And Warrants Net Proceeds from sales of common stock and warrants, net Rent expenses included in net income that result in no cash inflows or outflows in the period. Noncash rent expense Noncash rent expense (income) Interest expenses included in net income that result in no cash inflows or outflows in the period. Noncash interest expense Change in value of lease liability for unused property. Change in value of lease liability Charge related to lease liability Value per share of Series C redeemable convertible preferred stock. Series C Redeemable Convertible Preferred Stock, Value Per Share Series C Redeemable Convertible Preferred stock, value per share (in dollars per share) Value per share of Series B redeemable convertible preferred stock. Series B Redeemable Convertible Preferred Stock, Value Per Share Series B Redeemable Convertible Preferred stock, value per share (in dollars per share) Value of restricted common stock per share issued to employees and nonemployees. Restricted Common Stock Value Per Share Restricted common stock issued to employees and nonemployees, value per share (in dollars per share) Value per share of Series A redeemable convertible preferred stock. Series A Redeemable Convertible Preferred Stock, Value Per Share Series A Redeemable Convertible Preferred stock, value per share (in dollars per share) Number of new shares issued during the period from the entity's first offering of stock to the public. Proceeds from initial public offering, net of expenses (in shares) Proceeds from initial public offering, net of expenses (in shares) Equity impact of the value of new stock issued during the period from the entity's first offering of stock to the public, net of expenses incurred with the issuance of the new shares. Proceeds from initial public offering, net of expenses Proceeds from initial public offering, net of expenses Equity impact of the conversion of preferred stock warrants to common stock warrants. Conversion Of Preferred Stock Warrants To Common Stock Warrants Conversion of preferred stock warrants to common stock warrants Conversion of warrant liability Equity impact resulting from the change in value of nonvested restricted common stock. Change In Value Of Nonvested Restricted Common Stock Change in value of restricted common stock subject to vesting Amortization during the period of deferred compensation previously recognized in equity created by employee and nonemployee agreements whereby earned compensation will be paid in the future. Amortization Of Deferred Compensation Amortization of deferred compensation Equity impact of the value of options to purchase common stock issued during the period to consultants for services to be rendered in the future. Issuance Of Common Stock Options Consultants Issuance of options to purchase common stock to consultants for services rendered Number of new common stock shares issued during the period to holders of convertible notes payable. Issuance of common stock to convertible noteholders (in shares) Issuance of common stock to convertible noteholders (in shares) Equity impact of the value of new common stock issued during the period to holders of convertible notes payable. Stock Issued During Period Value New Issues Convertible Noteholders Issuance of common stock to convertible noteholders Number of new common stock shares issued during the period to consultants for services rendered. Stock Issued During Period Shares New Issues Consultants Issuance of common stock to consultants (in shares) Equity impact of the value of new common stock issued during the period to consultants for services rendered. Stock Issued During Period Value New Issues Consultants Issuance of common stock to consultants Equity impact of the value of warrants to purchase preferred stock issued during the period to holders of notes payable. Issuance Of Preferred Stock Options Noteholders Issuance of warrants to purchase preferred stock to noteholders Number of shares issued during the period to employees and nonemployees related to Restricted Stock Awards. Stock Issued During Period Shares Restricted Stock Award Nonemployees Shares Issuance of restricted common stock to employees and nonemployees (in shares) Value of stock related to Restricted Stock Awards issued during the period to employees and nonemployees. Stock Issued During Period Shares Restricted Stock Award Nonemployees Value Issuance of restricted common stock to employees and nonemployees This line item represents the period of research agreement, for which the agreement is extended. Extended period of research agreement The number of shares of Redeemable Convertible Preferred stock issued during the period for notes payable. Redeemable Convertible Preferred Stock Shares Issued For Notes Payable Conversion of notes payable, including interest (in shares) The fair value of Redeemable Convertible Preferred stock issued during the period for notes payable. Redeemable Convertible Preferred Stock Value Issued For Notes Payable Conversion of notes payable, including interest Conversion of note principal to redeemable convertible preferred stock The number of Series A Redeemable Convertible Preferred stock issued during the period at $1.61683 per share, net of issuance costs. Issuance Of Series Redeemable Convertible Preferred Shares Issuance of Series A Redeemable Convertible Preferred stock, net of expenses (in shares) Equity impact of the value of Series A Redeemable Convertible Preferred stock issued during the period at $1.61683 per share, net of issuance costs. IssuanceOfSeriesRedeemableConvertiblePreferredSharesValue Issuance of Series A Redeemable Convertible Preferred stock, net of expenses Equity impact resulting from the reclassification of warrants to purchase preferred stock. Reclassification Of Preferred Stock Warrants Reclassification of warrants to purchase preferred stock Equity impact resulting from the reclassification of deferred compensation to additional paid-in capital. Reclassification Of Deferred Compensation Reclassification of deferred compensation The number of non-vested restricted stock repurchased during the period. Repurchased Nonvested Restricted Stock Shares Repurchased nonvested restricted stock (in shares) The number of vested restricted stock repurchased during the period. Repurchased Vested Restricted Stock Shares Repurchased vested restricted stock (in shares) Equity impact of the value of vested restricted common stock repurchased during the period. Repurchased Vested Restricted Stock Repurchased vested restricted stock Equity impact of the value of warrants to purchase common stock issued during the period related to debt financing. Issuance Of Common Stock Warrants Debt Financing Issuance of warrants to purchase common stock in connection with debt financing The number of Series B Redeemable Convertible Preferred stock issued during the period at $1.82 per share, net of issuance costs. Issuance Of Series B Redeemable Convertible Preferred Shares Issuance of Series B Redeemable Convertible Preferred stock, net of expenses (in shares) Equity impact of the value of Series B Redeemable Convertible Preferred stock issued during the period at $1.82 per share, net of issuance costs. Issuance Of Series B Redeemable Convertible Preferred Shares Value Issuance of Series B Redeemable Convertible Preferred stock, net of expenses The number of Series C Redeemable Convertible Preferred stock issued during the period at $1.82 per share, net of issuance costs. Issuance Of Series C Redeemable Convertible Preferred Shares Issuance of Series C Redeemable Convertible Preferred stock, net of expenses (in shares) Equity impact of the value of Series C Redeemable Convertible Preferred stock issued during the period at $1.82 per share, net of issuance costs. Issuance Of Series C Redeemable Convertible Preferred Shares Value Issuance of Series C Redeemable Convertible Preferred stock, net of expenses Equity impact of the value of warrants to purchase common stock issued during the period related to equity financing. Issuance Of Common Stock Warrants Equity Financing Issuance of warrants to purchase common stock issued in connection with equity financing Fair value of warrants issued with sale of common stock Issuance of warrants to purchase common stock issued in connection with equity financing Number of shares issued during the period for an equity financing. Stock Issued During Period Shares New Issues Equity Financing Proceeds from equity financing, net of expenses (in shares) Proceeds from equity financing, net of expenses (in shares) Equity impact of the value of new stock issued during the period for an equity financing. Stock Issued During Period Value New Issues Equity Financing Proceeds from equity financing, net of expenses Proceeds from equity financing, net of expenses The reduction in the value of stock outstanding during the period as a result of a reverse stock split. Stock Issued During Period Value Reverse Stock Splits Effect of reverse stock split (see Note 3) Deficits accumulated during the development stage [Member] Accumulated deficits during the development stage [Member] Accumulated deficit during the development stage [Member] Condensed Statements of Redeemable Convertible Preferred Stock and Stockholders' Equity (Deficit) [Abstract] Increase or decrease in fair value of equity warrants to purchase shares of common stock. Increase Decrease In Warrant Liability Change in fair value of warrant liability Change in fair value of warrant liability Change in fair value of warrant liability Additional cash flow information [Abstract] Antidilutive securities excluded from computation of earning per share [Abstract] Potentially dilutive securities have been excluded from computations of diluted weighted-average shares outstanding [Abstract]