Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We have issued our report dated March 23, 2022, with respect to the consolidated financial statementsincluded in the Annual Report of Alimera Sciences, Inc. on Form 10-K for the year ended December 31, 2021. We consent to the incorporation by reference of said reports in the Registration Statements of Alimera Sciences, Inc. on Forms S-8 (File No. 333-166822, File No. 333-173095, File No. 333-180567, File No. 333-187600, File No. 333-194381, File No. 333-201606, File No. 333-209035, File No. 333-215451, File No. 333-222508, File No. 333-229280, File No. 333-232206, File No. 333-249811 and File No. 333-260617) and on Form S-3 (File No. 333-249804).

/s/ GRANT THORNTON LLP

Atlanta, Georgia

March 23, 2022