0001144204-19-026555.txt : 20190515 0001144204-19-026555.hdr.sgml : 20190515 20190515160643 ACCESSION NUMBER: 0001144204-19-026555 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20190331 FILED AS OF DATE: 20190515 DATE AS OF CHANGE: 20190515 EFFECTIVENESS DATE: 20190515 FILER: COMPANY DATA: COMPANY CONFORMED NAME: BAKER BROS. ADVISORS LP CENTRAL INDEX KEY: 0001263508 IRS NUMBER: 134093645 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10519 FILM NUMBER: 19828055 BUSINESS ADDRESS: STREET 1: 860 WASHINGTON STREET STREET 2: 3RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 BUSINESS PHONE: 2123395600 MAIL ADDRESS: STREET 1: 860 WASHINGTON STREET STREET 2: 3RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 FORMER COMPANY: FORMER CONFORMED NAME: BAKER BROS ADVISORS LLC DATE OF NAME CHANGE: 20030911 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001263508 XXXXXXXX 03-31-2019 03-31-2019 false BAKER BROS. ADVISORS LP

860 WASHINGTON STREET 3RD FLOOR NEW YORK NY 10014

13F HOLDINGS REPORT 028-10519 N Alexandra Toohey 212-339-5690 /s/ Alexandra Toohey New York NY 05-15-2019 0 96 15621759 INFORMATION TABLE 2 infotable.xml Abeona Therapeutics Inc. COM 00289Y107 9481 1288235 SH SOLE 1288235 0 0 ACADIA Pharmaceuticals Inc. COM 004225108 1066317 39713842 SH SOLE 39713842 0 0 Acceleron Pharma Inc. COM 00434H108 3907 83900 SH SOLE 83900 0 0 Achillion Pharmaceuticals, Inc. COM 00448Q201 3242 1095359 SH SOLE 1095359 0 0 Acorda Therapeutics, Inc. COM 00484M106 3882 292134 SH SOLE 292134 0 0 Adamas Pharmaceuticals, Inc. COM 00548A106 1227 172630 SH SOLE 172630 0 0 Aeglea BioTherapeutics, Inc. COM 00773J103 13795 1713604 SH SOLE 1713604 0 0 Affimed N.V. COM N01045108 840 200000 SH SOLE 200000 0 0 Aimmune Therapeutics, Inc. COM 00900T107 15062 673908 SH SOLE 673908 0 0 Albireo Pharma, Inc. COM 01345P106 8053 250000 SH SOLE 250000 0 0 Alexion Pharmaceuticals, Inc. COM 015351109 1156880 8558068 SH SOLE 8558068 0 0 Alkermes plc SHS G01767105 2445 67000 SH SOLE 67000 0 0 Amarin Corporation plc SPONSORED ADR 023111206 897049 43210459 SH SOLE 43210459 0 0 AnaptysBio, Inc. COM 032724106 8261 113086 SH SOLE 113086 0 0 Apellis Pharmaceuticals, Inc. COM 03753U106 6118 313725 SH SOLE 313725 0 0 Aquestive Therapeutics, Inc. COM 03843E104 688 99600 SH SOLE 99600 0 0 Aquinox Pharmaceuticals, Inc. COM 03842B101 29468 10934154 SH SOLE 10934154 0 0 Aravive, Inc. COM 03890D108 3033 430885 SH SOLE 430885 0 0 Arcus Biosciences, Inc. COM 03969F109 1518 121534 SH SOLE 121534 0 0 argenx SE SPONSORED ADR 04016X101 127281 1019557 SH SOLE 1019557 0 0 Array BioPharma Inc. COM 04269X105 93675 3842289 SH SOLE 3842289 0 0 Ascendis Pharma A/S SPONSORED ADR 04351P101 399035 3390270 SH SOLE 3390270 0 0 Assembly Biosciences, Inc. COM 045396108 2926 148587 SH SOLE 148587 0 0 Audentes Therapeutics, Inc. COM 05070R104 66926 1715183 SH SOLE 1715183 0 0 Autolus Therapeutics plc SPON ADS 05280R100 4934 156773 SH SOLE 156773 0 0 Axsome Therapeutics, Inc. COM 05464T104 17076 1200000 SH SOLE 1200000 0 0 BeiGene, Ltd. SPONSORED ADR 07725L102 1578697 11959824 SH SOLE 11959824 0 0 Bellicum Pharmaceuticals, Inc. COM 079481107 9024 2677818 SH SOLE 2677818 0 0 BioCryst Pharmaceuticals, Inc. COM 09058V103 123061 15118081 SH SOLE 15118081 0 0 BioMarin Pharmaceutical Inc. COM 09061G101 674157 7589294 SH SOLE 7589294 0 0 bluebird bio, Inc. COM 09609G100 6293 40000 SH SOLE 40000 0 0 Catalyst Pharmaceuticals, Inc. COM 14888U101 14790 2900000 SH SOLE 2900000 0 0 Cerus Corporation COM 157085101 66972 10749937 SH SOLE 10749937 0 0 ChemoCentryx, Inc. COM 16383L106 2876 207029 SH SOLE 207029 0 0 Clementia Pharmaceuticals Inc. COM 185575107 97208 3724445 SH SOLE 3724445 0 0 ContraFect Corporation COM 212326102 1159 2914536 SH SOLE 2914536 0 0 Constellation Pharmaceuticals, Inc. COM 210373106 1807 133333 SH SOLE 133333 0 0 Crinetics Pharmaceuticals, Inc. COM 22663K107 2987 131250 SH SOLE 131250 0 0 CymaBay Therapeutics, Inc. COM 23257D103 75794 5707411 SH SOLE 5707411 0 0 CytomX Therapeutics, Inc. COM 23284F105 2090 194377 SH SOLE 194377 0 0 DBV Technologies S.A. SPONSORED ADR 23306J101 42479 5509560 SH SOLE 5509560 0 0 Dermira, Inc. COM 24983L104 12289 906943 SH SOLE 906943 0 0 Dynavax Technologies Corporation COM 268158201 548 75000 SH SOLE 75000 0 0 Foamix Pharmaceuticals Ltd. SHS M46135105 1868 498189 SH SOLE 498189 0 0 Forty Seven, Inc. COM 34983P104 4040 250000 SH SOLE 250000 0 0 Fulgent Genetics, Inc. COM 359664109 744 125000 SH SOLE 125000 0 0 G1 Therapeutics, Inc. COM 3621LQ109 2112 127236 SH SOLE 127236 0 0 Galapagos NV SPONSORED ADR 36315X101 2953 25072 SH SOLE 25072 0 0 Galmed Pharmaceuticals Ltd. SHS M47238106 1761 215594 SH SOLE 215594 0 0 Genomic Health, Inc. COM 37244C101 714436 10198943 SH SOLE 10198943 0 0 GW Pharmaceuticals plc ADS 36197T103 72206 428345 SH SOLE 428345 0 0 Halozyme Therapeutics, Inc. COM 40637H109 4830 299969 SH SOLE 299969 0 0 Harpoon Therapeutics, Inc. COM 41358P106 2029 214285 SH SOLE 214285 0 0 Heron Therapeutics, Inc. COM 427746102 122642 5018104 SH SOLE 5018104 0 0 Idera Pharmaceuticals, Inc. COM PAR 45168K405 12342 4839895 SH SOLE 4839895 0 0 Incyte Corporation COM 45337C102 2947720 34271827 SH SOLE 34271827 0 0 Infinity Pharmaceuticals, Inc. COM 45665G303 1091 580400 SH SOLE 580400 0 0 InflaRx N.V. COM N44821101 6764 178987 SH SOLE 178987 0 0 Insmed Incorporated COM PAR $.01 457669307 60396 2077601 SH SOLE 2077601 0 0 Intellia Therapeutics, Inc. COM 45826J105 2195 128538 SH SOLE 128538 0 0 Invitae Corporation COM 46185L103 91395 3902421 SH SOLE 3902421 0 0 Kiniksa Pharmaceuticals, Ltd. COM CL A G5269C101 54180 3000000 SH SOLE 3000000 0 0 Kodiak Sciences Inc. COM 50015M109 59718 9145115 SH SOLE 9145115 0 0 Krystal Biotech, Inc. COM 501147102 25816 784674 SH SOLE 784674 0 0 La Jolla Pharmaceutical Company COM PAR $.0001 2 503459604 3249 505240 SH SOLE 505240 0 0 MacroGenics, Inc. COM 556099109 5441 302600 SH SOLE 302600 0 0 Madrigal Pharmaceuticals, Inc. COM 558868105 146464 1169278 SH SOLE 1169278 0 0 Marker Therapeutics, Inc. COM 57055L107 9900 1500000 SH SOLE 1500000 0 0 Menlo Therapeutics Inc. COM 586858102 5495 700000 SH SOLE 700000 0 0 Merus N.V. COM N5749R100 17133 1160014 SH SOLE 1160014 0 0 Mirati Therapeutics, Inc. COM 60468T105 184237 2513462 SH SOLE 2513462 0 0 Molecular Templates, Inc. COM 608550109 1477 254230 SH SOLE 254230 0 0 MyoKardia, Inc. COM 62857M105 52838 1016306 SH SOLE 1016306 0 0 Neurocrine Biosciences, Inc. COM 64125C109 96793 1098670 SH SOLE 1098670 0 0 Orchard Therapeutics plc ADS 68570P101 2235 125000 SH SOLE 125000 0 0 Principia Biopharma Inc. COM 74257L108 60785 1787807 SH SOLE 1787807 0 0 Protagonist Therapeutics, Inc. COM 74366E102 5077 403893 SH SOLE 403893 0 0 Ra Pharmaceuticals, Inc. COM 74933V108 18438 823113 SH SOLE 823113 0 0 Rhythm Pharmaceuticals, Inc. COM 76243J105 74232 2708200 SH SOLE 2708200 0 0 Ritter Pharmaceuticals, Inc. COM 767836307 244 279999 SH SOLE 279999 0 0 Sangamo Therapeutics, Inc. COM 800677106 9538 999823 SH SOLE 999823 0 0 Seattle Genetics, Inc. COM 812578102 3738884 51049760 SH SOLE 51049760 0 0 Sierra Oncology, Inc. COM 82640U107 3420 2000000 SH SOLE 2000000 0 0 Spark Therapeutics, Inc. COM 84652J103 85629 751927 SH SOLE 751927 0 0 Spring Bank Pharmaceuticals, Inc. COM 849431101 6432 613144 SH SOLE 613144 0 0 Sunesis Pharmaceuticals, Inc. COM PAR 867328700 676 556665 SH SOLE 556665 0 0 Syros Pharmaceuticals, Inc. COM 87184Q107 5254 574835 SH SOLE 574835 0 0 Tricida, Inc. COM 89610F101 69641 1803238 SH SOLE 1803238 0 0 Trillium Therapeutics Inc. COM 89620X506 333 505262 SH SOLE 505262 0 0 uniQure N.V. SHS N90064101 36088 605000 SH SOLE 605000 0 0 Viking Therapeutics, Inc. COM 92686J106 4225 425000 SH SOLE 425000 0 0 Xencor, Inc. COM 98401F105 13297 428120 SH SOLE 428120 0 0 Y-mAbs Therapeutics, Inc. COM 984241109 2694 102800 SH SOLE 102800 0 0 Zymeworks Inc. COM 98985W102 27643 1708472 SH SOLE 1708472 0 0 BioMarin Pharmaceutical Inc. NOTE 0.599% 8/1/2024 09061GAH4 15385 15000000 PRN SOLE 15000000 0 0 Neurocrine Biosciences, Inc. NOTE 2.25% 5/15/2024 64125CAD1 71994 53270000 PRN SOLE 53270000 0 0