0001144204-19-007156.txt : 20190213 0001144204-19-007156.hdr.sgml : 20190213 20190213161418 ACCESSION NUMBER: 0001144204-19-007156 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20181231 FILED AS OF DATE: 20190213 DATE AS OF CHANGE: 20190213 EFFECTIVENESS DATE: 20190213 FILER: COMPANY DATA: COMPANY CONFORMED NAME: BAKER BROS. ADVISORS LP CENTRAL INDEX KEY: 0001263508 IRS NUMBER: 134093645 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10519 FILM NUMBER: 19597284 BUSINESS ADDRESS: STREET 1: 860 WASHINGTON STREET STREET 2: 3RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 BUSINESS PHONE: 2123395600 MAIL ADDRESS: STREET 1: 860 WASHINGTON STREET STREET 2: 3RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 FORMER COMPANY: FORMER CONFORMED NAME: BAKER BROS ADVISORS LLC DATE OF NAME CHANGE: 20030911 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001263508 XXXXXXXX 12-31-2018 12-31-2018 false BAKER BROS. ADVISORS LP

860 WASHINGTON STREET 3RD FLOOR NEW YORK NY 10014

13F HOLDINGS REPORT 028-10519 N Alexandra Toohey 212-339-5690 /s/ Alexandra Toohey New York NY 02-13-2019 0 93 12212527 INFORMATION TABLE 2 infotable.xml Abeona Therapeutics Inc. COM 00289Y107 15017 2103164 SH SOLE 2103164 0 0 ACADIA Pharmaceuticals Inc. COM 004225108 642173 39713842 SH SOLE 39713842 0 0 Acceleron Pharma Inc. COM 00434H108 3654 83900 SH SOLE 83900 0 0 Achillion Pharmaceuticals, Inc. COM 00448Q201 1742 1095359 SH SOLE 1095359 0 0 Adamas Pharmaceuticals, Inc. COM 00548A106 1474 172630 SH SOLE 172630 0 0 Aeglea BioTherapeutics, Inc. COM 00773J103 12835 1713604 SH SOLE 1713604 0 0 Aevi Genomic Medicine, Inc. COM 00835P105 2765 3950419 SH SOLE 3950419 0 0 Affimed N.V. COM N01045108 622 200000 SH SOLE 200000 0 0 Aimmune Therapeutics, Inc. COM 00900T107 16120 673908 SH SOLE 673908 0 0 Albireo Pharma, Inc. COM 01345P106 6133 250000 SH SOLE 250000 0 0 Alexion Pharmaceuticals, Inc. COM 015351109 833002 8555894 SH SOLE 8555894 0 0 Alkermes plc SHS G01767105 1977 67000 SH SOLE 67000 0 0 Amarin Corporation plc SPONSORED ADR 023111206 579688 42592824 SH SOLE 42592824 0 0 AnaptysBio, Inc. COM 032724106 7214 113086 SH SOLE 113086 0 0 Apellis Pharmaceuticals, Inc. COM 03753U106 2586 196078 SH SOLE 196078 0 0 Aquestive Therapeutics, Inc. COM 03843E104 627 99600 SH SOLE 99600 0 0 Aquinox Pharmaceuticals, Inc. COM 03842B101 23618 10934154 SH SOLE 10934154 0 0 Aravive, Inc. COM 03890D108 1423 404384 SH SOLE 404384 0 0 Arcus Biosciences, Inc. COM 03969F109 1309 121534 SH SOLE 121534 0 0 argenx SE SPONSORED ADR 04016X101 97949 1019557 SH SOLE 1019557 0 0 Array BioPharma Inc. COM 04269X105 71844 5041696 SH SOLE 5041696 0 0 Ascendis Pharma A/S SPONSORED ADR 04351P101 177760 2837352 SH SOLE 2837352 0 0 Assembly Biosciences, Inc. COM 045396108 3361 148587 SH SOLE 148587 0 0 Audentes Therapeutics, Inc. COM 05070R104 19411 910463 SH SOLE 910463 0 0 Autolus Therapeutics plc SPON ADS 05280R100 5148 156773 SH SOLE 156773 0 0 BeiGene, Ltd. SPONSORED ADR 07725L102 1677485 11959824 SH SOLE 11959824 0 0 Bellicum Pharmaceuticals, Inc. COM 079481107 7819 2677818 SH SOLE 2677818 0 0 BioCryst Pharmaceuticals, Inc. COM 09058V103 121882 15103081 SH SOLE 15103081 0 0 BioMarin Pharmaceutical Inc. COM 09061G101 646228 7589294 SH SOLE 7589294 0 0 bluebird bio, Inc. COM 09609G100 3968 40000 SH SOLE 40000 0 0 Catalyst Pharmaceuticals, Inc. COM 14888U101 5568 2900000 SH SOLE 2900000 0 0 Cerus Corporation COM 157085101 54502 10749937 SH SOLE 10749937 0 0 ChemoCentryx, Inc. COM 16383L106 2259 207029 SH SOLE 207029 0 0 Clementia Pharmaceuticals Inc. COM 185575107 43799 3724445 SH SOLE 3724445 0 0 ContraFect Corporation COM 212326102 10944 7153076 SH SOLE 7153076 0 0 Constellation Pharmaceuticals, Inc. COM 210373106 535 133333 SH SOLE 133333 0 0 Crinetics Pharmaceuticals, Inc. COM 22663K107 3936 131250 SH SOLE 131250 0 0 CymaBay Therapeutics, Inc. COM 23257D103 38702 4917700 SH SOLE 4917700 0 0 DBV Technologies S.A. SPONSORED ADR 23306J101 35371 5509560 SH SOLE 5509560 0 0 Dynavax Technologies Corporation COM 268158201 686 75000 SH SOLE 75000 0 0 Foamix Pharmaceuticals Ltd. SHS M46135105 1788 498189 SH SOLE 498189 0 0 Forty Seven, Inc. COM 34983P104 3930 250000 SH SOLE 250000 0 0 Fulgent Genetics, Inc. COM 359664109 396 125000 SH SOLE 125000 0 0 G1 Therapeutics, Inc. COM 3621LQ109 2437 127236 SH SOLE 127236 0 0 Galapagos NV SPONSORED ADR 36315X101 2300 25072 SH SOLE 25072 0 0 Galmed Pharmaceuticals Ltd. SHS M47238106 1473 215594 SH SOLE 215594 0 0 Genomic Health, Inc. COM 37244C101 756432 11744010 SH SOLE 11744010 0 0 GW Pharmaceuticals plc ADS 36197T103 41717 428345 SH SOLE 428345 0 0 Halozyme Therapeutics, Inc. COM 40637H109 4389 299969 SH SOLE 299969 0 0 Heron Therapeutics, Inc. COM 427746102 130170 5018104 SH SOLE 5018104 0 0 Idera Pharmaceuticals, Inc. COM PAR 45168K405 13396 4836237 SH SOLE 4836237 0 0 Incyte Corporation COM 45337C102 2178060 34251607 SH SOLE 34251607 0 0 Infinity Pharmaceuticals, Inc. COM 45665G303 685 580400 SH SOLE 580400 0 0 InflaRx N.V. COM N44821101 6510 178987 SH SOLE 178987 0 0 Insmed Incorporated COM PAR $.01 457669307 24298 1851982 SH SOLE 1851982 0 0 Intellia Therapeutics, Inc. COM 45826J105 1755 128538 SH SOLE 128538 0 0 Invitae Corporation COM 46185L103 43161 3902421 SH SOLE 3902421 0 0 Kiniksa Pharmaceuticals, Ltd. COM CL A G5269C101 84270 3000000 SH SOLE 3000000 0 0 Kodiak Sciences Inc. COM 50015M109 64930 9145115 SH SOLE 9145115 0 0 Krystal Biotech, Inc. COM 501147102 16306 784674 SH SOLE 784674 0 0 La Jolla Pharmaceutical Company COM PAR $.0001 2 503459604 1459 154675 SH SOLE 154675 0 0 Madrigal Pharmaceuticals, Inc. COM 558868105 131801 1169278 SH SOLE 1169278 0 0 Marker Therapeutics, Inc. COM 57055L107 8325 1500000 SH SOLE 1500000 0 0 Menlo Therapeutics Inc. COM 586858102 2884 700000 SH SOLE 700000 0 0 Merus N.V. COM N5749R100 16240 1160014 SH SOLE 1160014 0 0 Mirati Therapeutics, Inc. COM 60468T105 106621 2513462 SH SOLE 2513462 0 0 Molecular Templates, Inc. COM 608550109 1027 254230 SH SOLE 254230 0 0 MyoKardia, Inc. COM 62857M105 15403 315243 SH SOLE 315243 0 0 Neurocrine Biosciences, Inc. COM 64125C109 52155 730355 SH SOLE 730355 0 0 Novavax, Inc. COM 670002104 8682 4718318 SH SOLE 4718318 0 0 Orchard Therapeutics plc ADS 68570P101 1966 125000 SH SOLE 125000 0 0 Principia Biopharma Inc. COM 74257L108 48968 1787807 SH SOLE 1787807 0 0 Proteon Therapeutics, Inc. COM 74371L109 678 298591 SH SOLE 298591 0 0 Ra Pharmaceuticals, Inc. COM 74933V108 14981 823113 SH SOLE 823113 0 0 Rhythm Pharmaceuticals, Inc. COM 76243J105 72796 2708200 SH SOLE 2708200 0 0 Ritter Pharmaceuticals, Inc. COM 767836307 168 279999 SH SOLE 279999 0 0 Sangamo Therapeutics, Inc. COM 800677106 11478 999823 SH SOLE 999823 0 0 Seattle Genetics, Inc. COM 812578102 2892270 51046060 SH SOLE 51046060 0 0 Sierra Oncology, Inc. COM 82640U107 2640 2000000 SH SOLE 2000000 0 0 Solid Biosciences Inc. COM 83422E105 15755 587884 SH SOLE 587884 0 0 Spark Therapeutics, Inc. COM 84652J103 54175 1384130 SH SOLE 1384130 0 0 Spring Bank Pharmaceuticals, Inc. COM 849431101 6371 613144 SH SOLE 613144 0 0 Sunesis Pharmaceuticals, Inc. COM PAR 867328700 231 556665 SH SOLE 556665 0 0 Syros Pharmaceuticals, Inc. COM 87184Q107 3202 574835 SH SOLE 574835 0 0 Tricida, Inc. COM 89610F101 37728 1600000 SH SOLE 1600000 0 0 Trillium Therapeutics Inc. COM 89620X506 864 505262 SH SOLE 505262 0 0 uniQure N.V. SHS N90064101 17436 605000 SH SOLE 605000 0 0 Viking Therapeutics, Inc. COM 92686J106 3251 425000 SH SOLE 425000 0 0 Xencor, Inc. COM 98401F105 15917 440186 SH SOLE 440186 0 0 Y-mAbs Therapeutics, Inc. COM 984241109 2091 102800 SH SOLE 102800 0 0 Zymeworks Inc. COM 98985W102 25080 1708472 SH SOLE 1708472 0 0 BioMarin Pharmaceutical Inc. NOTE 0.599% 8/1/2024 09061GAH4 14911 15000000 PRN SOLE 15000000 0 0 Neurocrine Biosciences, Inc. NOTE 2.25% 5/15/2024 64125CAD1 63434 53270000 PRN SOLE 53270000 0 0