Chief Financial Officer

0001144204-18-044607.txt : 20180814 0001144204-18-044607.hdr.sgml : 20180814 20180814154826 ACCESSION NUMBER: 0001144204-18-044607 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20180630 FILED AS OF DATE: 20180814 DATE AS OF CHANGE: 20180814 EFFECTIVENESS DATE: 20180814 FILER: COMPANY DATA: COMPANY CONFORMED NAME: BAKER BROS. ADVISORS LP CENTRAL INDEX KEY: 0001263508 IRS NUMBER: 134093645 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10519 FILM NUMBER: 181017040 BUSINESS ADDRESS: STREET 1: 860 WASHINGTON STREET STREET 2: 3RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 BUSINESS PHONE: 2123395600 MAIL ADDRESS: STREET 1: 860 WASHINGTON STREET STREET 2: 3RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 FORMER COMPANY: FORMER CONFORMED NAME: BAKER BROS ADVISORS LLC DATE OF NAME CHANGE: 20030911 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001263508 XXXXXXXX 06-30-2018 06-30-2018 false BAKER BROS. ADVISORS LP

860 WASHINGTON STREET 3RD FLOOR NEW YORK NY 10014

13F HOLDINGS REPORT 028-10519 N Alexandra Toohey Chief Financial Officer 212-339-5690 /s/ Alexandra Toohey New York NY 08-14-2018 0 119 13308803 INFORMATION TABLE 2 infotable.xml Abeona Therapeutics Inc. COM 00289Y107 34950 2184364 SH SOLE 2184364 0 0 ACADIA Pharmaceuticals Inc. COM 004225108 415777 27228338 SH SOLE 27228338 0 0 Acceleron Pharma Inc. COM 00434H108 7952 163900 SH SOLE 163900 0 0 Achillion Pharmaceuticals, Inc. COM 00448Q201 5500 1943620 SH SOLE 1943620 0 0 Acorda Therapeutics, Inc. COM 00484M106 4968 173100 SH SOLE 173100 0 0 Adamas Pharmaceuticals, Inc. COM 00548A106 4459 172630 SH SOLE 172630 0 0 Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 1187 100000 SH SOLE 100000 0 0 Aeglea BioTherapeutics, Inc. COM 00773J103 14684 1387872 SH SOLE 1387872 0 0 Aerie Pharmaceuticals, Inc. COM 00771V108 4063 60155 SH SOLE 60155 0 0 Aevi Genomic Medicine, Inc. COM 00835P105 4501 4055142 SH SOLE 4055142 0 0 Affimed N.V. COM N01045108 660 400000 SH SOLE 400000 0 0 Aimmune Therapeutics, Inc. COM 00900T107 18121 673908 SH SOLE 673908 0 0 Akari Therapeutics, Plc SPONSORED ADR 00972G108 115 58770 SH SOLE 58770 0 0 Albireo Pharma, Inc. COM 01345P106 8875 250000 SH SOLE 250000 0 0 Alexion Pharmaceuticals, Inc. COM 015351109 1062214 8555894 SH SOLE 8555894 0 0 Alkermes plc SHS G01767105 4126 100251 SH SOLE 100251 0 0 Amarin Corporation plc SPONSORED ADR NEW 023111206 70049 22669509 SH SOLE 22669509 0 0 AnaptysBio, Inc. COM 032724106 5192 73086 SH SOLE 73086 0 0 Apellis Pharmaceuticals, Inc. COM 03753U106 4314 196078 SH SOLE 196078 0 0 Aquinox Pharmaceuticals, Inc. COM 03842B101 28976 10934154 SH SOLE 10934154 0 0 Arbutus Biopharma Corporation COM 03879J100 1318 180582 SH SOLE 180582 0 0 Arcus Biosciences, Inc. COM 03969F109 1488 121534 SH SOLE 121534 0 0 argenx SE SPONSORED ADR 04016X101 79691 961754 SH SOLE 961754 0 0 Array BioPharma Inc. COM 04269X105 94911 5656196 SH SOLE 5656196 0 0 Ascendis Pharma A/S SPONSORED ADR 04351P101 188741 2837352 SH SOLE 2837352 0 0 Assembly Biosciences, Inc. COM 045396108 5826 148587 SH SOLE 148587 0 0 Audentes Therapeutics, Inc. COM 05070R104 15025 393222 SH SOLE 393222 0 0 Autolus Therapeutics plc SPON ADS 05280R100 6304 235294 SH SOLE 235294 0 0 BeiGene, Ltd. SPONSORED ADR 07725L102 1838584 11959824 SH SOLE 11959824 0 0 Bellicum Pharmaceuticals, Inc. COM 079481107 30210 4093447 SH SOLE 4093447 0 0 BioCryst Pharmaceuticals, Inc. COM 09058V103 80290 14012172 SH SOLE 14012172 0 0 BioDelivery Sciences International, Inc. COM 09060J106 620 210021 SH SOLE 210021 0 0 BioMarin Pharmaceutical Inc. COM 09061G101 714327 7583084 SH SOLE 7583084 0 0 BioTime, Inc. *W EXP 10/1/201 09066L162 1 20084 SH SOLE 20084 0 0 bluebird bio, Inc. COM 09609G100 31390 200000 SH SOLE 200000 0 0 Catalyst Pharmaceuticals, Inc. COM 14888U101 11301 3621962 SH SOLE 3621962 0 0 Cellectis S.A. SPONSORED ADS 15117K103 1415 50000 SH SOLE 50000 0 0 Cerus Corporation COM 157085101 71702 10749937 SH SOLE 10749937 0 0 ChemoCentryx, Inc. COM 16383L106 5453 414029 SH SOLE 414029 0 0 Clementia Pharmaceuticals Inc. COM 185575107 15695 1192595 SH SOLE 1192595 0 0 ContraFect Corporation COM 212326102 15808 7153076 SH SOLE 7153076 0 0 Corbus Pharmaceuticals Holdings, Inc. COM 21833P103 1250 247450 SH SOLE 247450 0 0 Cyclacel Pharmaceuticals, Inc. PFD CONV EX 6% 23254L207 89 13253 SH SOLE 13253 0 0 CymaBay Therapeutics, Inc. COM 23257D103 65996 4917700 SH SOLE 4917700 0 0 DBV Technologies S.A. SPONSORED ADR 23306J101 106279 5509560 SH SOLE 5509560 0 0 Dynavax Technologies Corporation COM NEW 268158201 1144 75000 SH SOLE 75000 0 0 Endocyte, Inc. COM 29269A102 31434 2277799 SH SOLE 2277799 0 0 ERYTECH Pharma S.A. SPONSORED ADR 29604W108 34470 3085969 SH SOLE 3085969 0 0 Exelixis, Inc. COM 30161Q104 11049 513410 SH SOLE 513410 0 0 Foamix Pharmaceuticals Ltd. SHS M46135105 7466 1490201 SH SOLE 1490201 0 0 Forty Seven, Inc. COM 34983P104 4000 250000 SH SOLE 250000 0 0 Fulgent Genetics, Inc. COM 359664109 518 125000 SH SOLE 125000 0 0 G1 Therapeutics, Inc. COM 3621LQ109 7366 169492 SH SOLE 169492 0 0 Galapagos NV SPONSORED ADR 36315X101 23957 259894 SH SOLE 259894 0 0 Galmed Pharmaceuticals Ltd. SHS M47238106 7570 636140 SH SOLE 636140 0 0 Genomic Health, Inc. COM 37244C101 695045 13790574 SH SOLE 13790574 0 0 GlycoMimetics, Inc. COM 38000Q102 4697 291214 SH SOLE 291214 0 0 GW Pharmaceuticals plc ADS 36197T103 44904 321800 SH SOLE 321800 0 0 Halozyme Therapeutics, Inc. COM 40637H109 21660 1283929 SH SOLE 1283929 0 0 Heron Therapeutics, Inc. COM 427746102 195233 5025298 SH SOLE 5025298 0 0 Idera Pharmaceuticals, Inc. COM NEW 45168K405 51024 38654811 SH SOLE 38654811 0 0 Incyte Corporation COM 45337C102 2294819 34251034 SH SOLE 34251034 0 0 Infinity Pharmaceuticals, Inc. COM 45665G303 1109 580400 SH SOLE 580400 0 0 InflaRx N.V. COM N44821101 8347 258824 SH SOLE 258824 0 0 Insmed Incorporated COM PAR $.01 457669307 16555 700000 SH SOLE 700000 0 0 Intellia Therapeutics, Inc. COM 45826J105 14964 546922 SH SOLE 546922 0 0 Invitae Corporation COM 46185L103 61736 8399411 SH SOLE 8399411 0 0 Jounce Therapeutics, Inc. COM 481116101 766 100000 SH SOLE 100000 0 0 Kiniksa Pharmaceuticals, Ltd. COM CL A G5269C101 52050 3000000 SH SOLE 3000000 0 0 Krystal Biotech, Inc. COM 501147102 2974 200000 SH SOLE 200000 0 0 La Jolla Pharmaceutical Company COM PAR $.0001 2 503459604 4512 154675 SH SOLE 154675 0 0 MacroGenics, Inc. COM 556099109 4495 217695 SH SOLE 217695 0 0 Madrigal Pharmaceuticals, Inc. COM 558868105 327035 1169278 SH SOLE 1169278 0 0 MediWound Ltd. ORD SHS M68830104 1559 226000 SH SOLE 226000 0 0 Menlo Therapeutics Inc. COM 586858102 5684 700000 SH SOLE 700000 0 0 Merus N.V. COM N5749R100 26402 1160014 SH SOLE 1160014 0 0 Mirati Therapeutics, Inc. COM 60468T105 123914 2513462 SH SOLE 2513462 0 0 Molecular Templates, Inc. COM 608550109 379 72412 SH SOLE 72412 0 0 Momenta Pharmaceuticals, Inc. COM 60877T100 6309 308500 SH SOLE 308500 0 0 MyoKardia, Inc. COM 62857M105 21504 433121 SH SOLE 433121 0 0 Nabriva Therapeutics plc SHS G63637105 3265 938235 SH SOLE 938235 0 0 Natera, Inc. COM 632307104 4304 228676 SH SOLE 228676 0 0 Neurocrine Biosciences, Inc. COM 64125C109 92800 944624 SH SOLE 944624 0 0 NewLink Genetics Corporation COM 651511107 2415 507273 SH SOLE 507273 0 0 Ovid Therapeutics Inc. COM 690469101 1932 247733 SH SOLE 247733 0 0 Progenics Pharmaceuticals, Inc. COM 743187106 7871 979016 SH SOLE 979016 0 0 Proteon Therapeutics, Inc. COM 74371L109 732 298591 SH SOLE 298591 0 0 Ra Pharmaceuticals, Inc. COM 74933V108 1771 177952 SH SOLE 177952 0 0 Rhythm Pharmaceuticals, Inc. COM 76243J105 84658 2708200 SH SOLE 2708200 0 0 Rigel Pharmaceuticals, Inc. COM NEW 766559603 2948 1041612 SH SOLE 1041612 0 0 Ritter Pharmaceuticals, Inc. COM NEW 767836307 720 279999 SH SOLE 279999 0 0 Sage Therapeutics, Inc. COM 78667J108 96000 613300 SH SOLE 613300 0 0 Sangamo Therapeutics, Inc. COM 800677106 18232 1283923 SH SOLE 1283923 0 0 Seattle Genetics, Inc. COM 812578102 3388948 51046060 SH SOLE 51046060 0 0 Selecta Biosciences, Inc. COM 816212104 1242 93750 SH SOLE 93750 0 0 Sesen Bio, Inc. COM 817763105 5118 2624412 SH SOLE 2624412 0 0 Solid Biosciences Inc. COM 83422E105 20946 587884 SH SOLE 587884 0 0 Spark Therapeutics, Inc. COM 84652J103 114551 1384130 SH SOLE 1384130 0 0 Spring Bank Pharmaceuticals, Inc. COM 849431101 4422 373144 SH SOLE 373144 0 0 Stemline Therapeutics, Inc. COM 85858C107 715 44524 SH SOLE 44524 0 0 Sunesis Pharmaceuticals, Inc. COM PAR 867328700 1180 556665 SH SOLE 556665 0 0 Syros Pharmaceuticals, Inc. COM 87184Q107 5869 574835 SH SOLE 574835 0 0 T2 Biosystems, Inc. COM 89853L104 774 100000 SH SOLE 100000 0 0 Tetraphase Pharmaceuticals, Inc. COM 88165N105 3338 935000 SH SOLE 935000 0 0 Tonix Pharmaceuticals Holdings Corp. COM 890260409 3113 699500 SH SOLE 699500 0 0 Trevena, Inc. COM 89532E109 1368 950000 SH SOLE 950000 0 0 Tricida, Inc. COM 89610F101 47840 1600000 SH SOLE 1600000 0 0 Trillium Therapeutics Inc. COM NEW 89620X506 3071 511763 SH SOLE 511763 0 0 uniQure N.V. SHS N90064101 22869 605000 SH SOLE 605000 0 0 Vanda Pharmaceuticals Inc. COM 921659108 5912 310354 SH SOLE 310354 0 0 Versartis, Inc. COM 92529L102 4913 2426310 SH SOLE 2426310 0 0 Xencor, Inc. COM 98401F105 32275 872072 SH SOLE 872072 0 0 Zymeworks Inc. COM 98985W102 19378 1311085 SH SOLE 1311085 0 0 Aegerion Pharmaceuticals, Inc. NOTE 2% 8/15/2019 00767EAB8 6027 9517000 PRN SOLE 9517000 0 0 BioMarin Pharmaceutical Inc. NOTE 0.75% 10/15/2018 09061GAE1 13000 12228000 PRN SOLE 12228000 0 0 BioMarin Pharmaceutical Inc. NOTE 0.599% 8/1/2024 09061GAH4 15198 15000000 PRN SOLE 15000000 0 0 Corsicanto II Designated Activity Company NOTE 3.5% 1/5/2047 220485AB2 10908 10000000 PRN SOLE 10000000 0 0 Neurocrine Biosciences, Inc. NOTE 2.25% 5/15/2024 64125CAD1 14466 10000000 PRN SOLE 10000000 0 0 Novavax, Inc. NOTE 3.75% 2/1/23 670002AB0 42667 73500000 PRN SOLE 73500000 0 0