0001144204-18-028818.txt : 20180515 0001144204-18-028818.hdr.sgml : 20180515 20180515154728 ACCESSION NUMBER: 0001144204-18-028818 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20180331 FILED AS OF DATE: 20180515 DATE AS OF CHANGE: 20180515 EFFECTIVENESS DATE: 20180515 FILER: COMPANY DATA: COMPANY CONFORMED NAME: BAKER BROS. ADVISORS LP CENTRAL INDEX KEY: 0001263508 IRS NUMBER: 134093645 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10519 FILM NUMBER: 18836025 BUSINESS ADDRESS: STREET 1: 860 WASHINGTON STREET STREET 2: 3RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 BUSINESS PHONE: 2123395600 MAIL ADDRESS: STREET 1: 860 WASHINGTON STREET STREET 2: 3RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 FORMER COMPANY: FORMER CONFORMED NAME: BAKER BROS ADVISORS LLC DATE OF NAME CHANGE: 20030911 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001263508 XXXXXXXX 03-31-2018 03-31-2018 false BAKER BROS. ADVISORS LP

860 WASHINGTON STREET 3RD FLOOR NEW YORK NY 10014

13F HOLDINGS REPORT 028-10519 N Alexandra Toohey 212-339-5690 /s/ Alexandra Toohey New York NY 05-15-2018 0 114 11797988 INFORMATION TABLE 2 infotable.xml Abeona Therapeutics Inc. COM 00289Y107 31346 2184364 SH SOLE 2184364 0 0 Ablynx NV SPONSORED ADR 00372Y105 118766 2176802 SH SOLE 2176802 0 0 ACADIA Pharmaceuticals Inc. COM 004225108 611821 27228338 SH SOLE 27228338 0 0 Acceleron Pharma Inc. COM 00434H108 6408 163900 SH SOLE 163900 0 0 Achillion Pharmaceuticals, Inc. COM 00448Q201 10598 2856637 SH SOLE 2856637 0 0 Adamas Pharmaceuticals, Inc. COM 00548A106 4126 172630 SH SOLE 172630 0 0 Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 1123 100000 SH SOLE 600000 0 0 Aeglea BioTherapeutics, Inc. COM 00773J103 11288 1137872 SH SOLE 1137872 0 0 Aerie Pharmaceuticals, Inc. COM 00771V108 11699 215655 SH SOLE 215655 0 0 Aevi Genomic Medicine, Inc. COM 00835P105 8151 4055142 SH SOLE 4055142 0 0 Affimed N.V. COM N01045108 740 400000 SH SOLE 400000 0 0 Aimmune Therapeutics, Inc. COM 00900T107 21450 673908 SH SOLE 673908 0 0 Akari Therapeutics, Plc SPONSORED ADR 00972G108 618 339833 SH SOLE 33983300 0 0 Albireo Pharma, Inc. COM 01345P106 8143 250000 SH SOLE 250000 0 0 Alexion Pharmaceuticals, Inc. COM 015351109 953640 8555894 SH SOLE 8555894 0 0 Alkermes plc SHS G01767105 5811 100251 SH SOLE 100251 0 0 Amarin Corporation plc SPONSORED ADR NEW 023111206 68235 22669509 SH SOLE 22669509 0 0 AnaptysBio, Inc. COM 032724106 9480 91086 SH SOLE 91086 0 0 Aquinox Pharmaceuticals, Inc. COM 03842B101 153953 10934154 SH SOLE 10934154 0 0 Arbutus Biopharma Corporation COM 03879J100 903 180582 SH SOLE 180582 0 0 argenx SE SPONSORED ADR 04016X101 77363 961754 SH SOLE 961754 0 0 Array BioPharma Inc. COM 04269X105 92309 5656196 SH SOLE 5656196 0 0 Ascendis Pharma A/S SPONSORED ADR 04351P101 185563 2837352 SH SOLE 2837352 0 0 Assembly Biosciences, Inc. COM 045396108 9523 193787 SH SOLE 193787 0 0 Audentes Therapeutics, Inc. COM 05070R104 11816 393222 SH SOLE 393222 0 0 AveXis, Inc. COM 05366U100 144237 1167157 SH SOLE 1167157 0 0 BeiGene, Ltd. SPONSORED ADR 07725L102 979344 5829429 SH SOLE 75782577 0 0 Bellicum Pharmaceuticals, Inc. COM 079481107 27234 4151578 SH SOLE 4151578 0 0 BioCryst Pharmaceuticals, Inc. COM 09058V103 66838 14012172 SH SOLE 14012172 0 0 BioDelivery Sciences International, Inc. COM 09060J106 473 210021 SH SOLE 210021 0 0 BioMarin Pharmaceutical Inc. COM 09061G101 614761 7583084 SH SOLE 7583084 0 0 BioTime, Inc. *W EXP 10/1/201 09066L162 2 20084 SH SOLE 20084 0 0 bluebird bio, Inc. COM 09609G100 34150 200000 SH SOLE 200000 0 0 Catalyst Pharmaceuticals, Inc. COM 14888U101 10471 4381072 SH SOLE 4381072 0 0 Cellectis S.A. SPONSORED ADS 15117K103 1576 50000 SH SOLE 50000 0 0 Cerus Corporation COM 157085101 58910 10749937 SH SOLE 10749937 0 0 ChemoCentryx, Inc. COM 16383L106 5631 414029 SH SOLE 414029 0 0 Clementia Pharmaceuticals Inc. COM ADDED 185575107 3788 250000 SH SOLE 250000 0 0 ContraFect Corporation COM 212326102 11625 7153076 SH SOLE 7153076 0 0 Corbus Pharmaceuticals Holdings, Inc. COM 21833P103 4030 660714 SH SOLE 660714 0 0 Cyclacel Pharmaceuticals, Inc. PFD CONV EX 6% 23254L207 77 13253 SH SOLE 13253 0 0 CymaBay Therapeutics, Inc. COM 23257D103 50891 3917700 SH SOLE 3917700 0 0 DBV Technologies S.A. SPONSORED ADR 23306J101 127106 5509560 SH SOLE 2754780 0 0 Dynavax Technologies Corporation COM NEW 268158201 1489 75000 SH SOLE 75000 0 0 Endocyte, Inc. COM 29269A102 20705 2277799 SH SOLE 2277799 0 0 ERYTECH Pharma S.A. SPONSORED ADR 29604W108 64891 3090069 SH SOLE 3090069 0 0 Exelixis, Inc. COM 30161Q104 25753 1162644 SH SOLE 1162644 0 0 Foamix Pharmaceuticals Ltd. SHS M46135105 8203 1598991 SH SOLE 1598991 0 0 Fulgent Genetics, Inc. COM 359664109 500 125000 SH SOLE 125000 0 0 G1 Therapeutics, Inc. COM 3621LQ109 6280 169492 SH SOLE 169492 0 0 Galapagos NV SPONSORED ADR 36315X101 25927 259894 SH SOLE 259894 0 0 Genomic Health, Inc. COM 37244C101 431487 13789936 SH SOLE 13789936 0 0 GlycoMimetics, Inc. COM 38000Q102 9143 563312 SH SOLE 563312 0 0 GW Pharmaceuticals plc ADS 36197T103 24990 221800 SH SOLE 2661600 0 0 Halozyme Therapeutics, Inc. COM 40637H109 30980 1581424 SH SOLE 1581424 0 0 Heron Therapeutics, Inc. COM 427746102 138698 5025298 SH SOLE 5025298 0 0 Idera Pharmaceuticals, Inc. COM NEW 45168K306 71100 38641462 SH SOLE 38641462 0 0 Immune Design Corp. COM 45252L103 491 148937 SH SOLE 148937 0 0 Incyte Corporation COM 45337C102 2852448 34230751 SH SOLE 34230751 0 0 Infinity Pharmaceuticals, Inc. COM 45665G303 1219 580400 SH SOLE 580400 0 0 InflaRx N.V. COM N44821101 5768 200000 SH SOLE 200000 0 0 Insmed Incorporated COM PAR $.01 457669307 15764 700000 SH SOLE 700000 0 0 Intellia Therapeutics, Inc. COM 45826J105 17585 833795 SH SOLE 833795 0 0 Invitae Corporation COM 46185L103 39393 8399411 SH SOLE 8399411 0 0 Jounce Therapeutics, Inc. COM 481116101 2235 100000 SH SOLE 100000 0 0 Krystal Biotech, Inc. COM 501147102 2018 200000 SH SOLE 200000 0 0 La Jolla Pharmaceutical Company COM PAR $.0001 2 503459604 4606 154675 SH SOLE 154675 0 0 MacroGenics, Inc. COM 556099109 9150 363676 SH SOLE 363676 0 0 Madrigal Pharmaceuticals, Inc. COM 558868105 71906 615684 SH SOLE 615684 0 0 MediWound Ltd. ORD SHS M68830104 1175 226000 SH SOLE 226000 0 0 Menlo Therapeutics Inc. COM 586858102 26306 700000 SH SOLE 700000 0 0 Merus N.V. COM N5749R100 21495 1160014 SH SOLE 1160014 0 0 Mirati Therapeutics, Inc. COM 60468T105 78268 2549461 SH SOLE 2549461 0 0 Molecular Templates, Inc. COM 608550109 579 72412 SH SOLE 72412 0 0 Momenta Pharmaceuticals, Inc. COM 60877T100 5599 308500 SH SOLE 308500 0 0 MyoKardia, Inc. COM 62857M105 14165 290264 SH SOLE 290264 0 0 Nabriva Therapeutics plc SHS G63637105 4719 938235 SH SOLE 938235 0 0 Natera, Inc. COM 632307104 2120 228676 SH SOLE 228676 0 0 Nektar Therapeutics COM 640268108 29264 275396 SH SOLE 275396 0 0 Neurocrine Biosciences, Inc. COM 64125C109 78338 944624 SH SOLE 944624 0 0 NewLink Genetics Corporation COM 651511107 3678 507273 SH SOLE 507273 0 0 Novavax, Inc. COM 670002104 4200 2000000 SH SOLE 2000000 0 0 Ovid Therapeutics Inc. COM 690469101 1751 247733 SH SOLE 247733 0 0 Progenics Pharmaceuticals, Inc. COM 743187106 17204 2306184 SH SOLE 2306184 0 0 Proteon Therapeutics, Inc. COM 74371L109 746 298591 SH SOLE 298591 0 0 Ra Pharmaceuticals, Inc. COM 74933V108 945 177952 SH SOLE 177952 0 0 Rhythm Pharmaceuticals, Inc. COM NEW 76243J105 40775 2049020 SH SOLE 2049020 0 0 Rigel Pharmaceuticals, Inc. COM NEW 766559603 8917 2518882 SH SOLE 2518882 0 0 Ritter Pharmaceuticals, Inc. COM 767836307 762 279999 SH SOLE 279999 0 0 Sage Therapeutics, Inc. COM 78667J108 104185 646828 SH SOLE 646828 0 0 Sangamo Therapeutics, Inc. COM 800677106 30544 1607579 SH SOLE 1607579 0 0 Seattle Genetics, Inc. COM 812578102 2594777 49575409 SH SOLE 49575409 0 0 Selecta Biosciences, Inc. COM 816212104 955 93750 SH SOLE 93750 0 0 Solid Biosciences Inc. COM 83422E105 4409 587884 SH SOLE 587884 0 0 Spark Therapeutics, Inc. COM 84652J103 92169 1384130 SH SOLE 1384130 0 0 Spring Bank Pharmaceuticals, Inc. COM 849431101 5739 373144 SH SOLE 373144 0 0 Stemline Therapeutics, Inc. COM 85858C107 4404 287827 SH SOLE 287827 0 0 Sunesis Pharmaceuticals, Inc. COM PAR 867328700 1514 556665 SH SOLE 556665 0 0 Syros Pharmaceuticals, Inc. COM 87184Q107 7461 574835 SH SOLE 574835 0 0 T2 Biosystems, Inc. COM 89853L104 649 100000 SH SOLE 100000 0 0 Tetraphase Pharmaceuticals, Inc. COM 88165N105 2870 935000 SH SOLE 935000 0 0 Tonix Pharmaceuticals Holdings Corp. COM 890260409 2098 699500 SH SOLE 699500 0 0 Trevena, Inc. COM 89532E109 1558 950000 SH SOLE 950000 0 0 Trillium Therapeutics Inc. COM NEW 89620X506 2947 409323 SH SOLE 409323 0 0 uniQure N.V. SHS N90064101 11750 500000 SH SOLE 500000 0 0 Vanda Pharmaceuticals Inc. COM 921659108 10116 600354 SH SOLE 600354 0 0 Versartis, Inc. COM 92529L102 2353 1426310 SH SOLE 1426310 0 0 Xencor, Inc. COM 98401F105 26145 872072 SH SOLE 872072 0 0 Aegerion Pharmaceuticals, Inc. NOTE 2.0% 8/15/2019 00767EAB8 7273 9517000 PRN SOLE 9517000 0 0 BioMarin Pharmaceutical Inc. NOTE 0.75% 10/15/2018 09061GAE1 12537 12228000 PRN SOLE 12228000 0 0 BioMarin Pharmaceutical Inc. NOTE 0.599% 8/1/2024 09061GAH4 14099 15000000 PRN SOLE 15000000 0 0 Corsicanto II Designated Activity Company Note 3.5% 1/5/2047 220485AB2 11025 10000000 PRN SOLE 10000000 0 0 Inotek Pharmaceuticals Corp. NOTE 5.75% 8/1/2021 45780VAB8 4795 5000000 PRN SOLE 5000000 0 0 Novavax, Inc. Note 3.75% 2/1/2023 670002AB0 61864 88500000 PRN SOLE 88500000 0 0