0001144204-18-008839.txt : 20180214 0001144204-18-008839.hdr.sgml : 20180214 20180214154900 ACCESSION NUMBER: 0001144204-18-008839 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20171231 FILED AS OF DATE: 20180214 DATE AS OF CHANGE: 20180214 EFFECTIVENESS DATE: 20180214 FILER: COMPANY DATA: COMPANY CONFORMED NAME: BAKER BROS. ADVISORS LP CENTRAL INDEX KEY: 0001263508 IRS NUMBER: 134093645 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10519 FILM NUMBER: 18611977 BUSINESS ADDRESS: STREET 1: 860 WASHINGTON STREET STREET 2: 3RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 BUSINESS PHONE: 2123395600 MAIL ADDRESS: STREET 1: 860 WASHINGTON STREET STREET 2: 3RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 FORMER COMPANY: FORMER CONFORMED NAME: BAKER BROS ADVISORS LLC DATE OF NAME CHANGE: 20030911 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001263508 XXXXXXXX 12-31-2017 12-31-2017 false BAKER BROS. ADVISORS LP

860 WASHINGTON STREET 3RD FLOOR NEW YORK NY 10014

13F HOLDINGS REPORT 028-10519 N Alexandra Toohey 212-339-5690 /s/ Alexandra Toohey New York NY 02-14-2018 0 123 11537077 INFORMATION TABLE 2 infotable.xml Abeona Therapeutics Inc. COM 00289Y107 31452 1984364 SH SOLE 1984364 0 0 Ablynx NV SPONSORED ADR 00372Y105 103986 4161118 SH SOLE 4161118 0 0 ACADIA Pharmaceuticals Inc. COM 004225108 819845 27228338 SH SOLE 27228338 0 0 Acceleron Pharma Inc. COM 00434H108 6956 163900 SH SOLE 163900 0 0 Achaogen, Inc. COM 004449104 1315 122482 SH SOLE 122482 0 0 Achillion Pharmaceuticals, Inc. COM 00448Q201 8227 2856637 SH SOLE 2856637 0 0 Acorda Therapeutics, Inc. COM 00484M106 4418 205966 SH SOLE 205966 0 0 Adamas Pharmaceuticals, Inc. COM 00548A106 5850 172630 SH SOLE 172630 0 0 Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 668 100000 SH SOLE 600000 0 0 Advanced Accelerator Applications S.A. SPONSORED ADS 00790T100 4499 55125 SH SOLE 110250 0 0 Aeglea BioTherapeutics, Inc. COM 00773J103 6156 1137872 SH SOLE 1137872 0 0 Aerie Pharmaceuticals, Inc. COM 00771V108 17887 299356 SH SOLE 299356 0 0 Aevi Genomic Medicine, Inc. COM 00835P105 4866 4055142 SH SOLE 4055142 0 0 Affimed N.V. COM N01045108 520 400000 SH SOLE 400000 0 0 Agios Pharmaceuticals, Inc. COM 00847X104 7356 128666 SH SOLE 128666 0 0 Aimmune Therapeutics, Inc. COM 00900T107 25487 673908 SH SOLE 673908 0 0 Akari Therapeutics Plc SPONSORED ADR 00972G108 3018 696901 SH SOLE 69690100 0 0 Albireo Pharma, Inc. COM 01345P106 5120 200000 SH SOLE 200000 0 0 Alexion Pharmaceuticals, Inc. COM 015351109 1022957 8553864 SH SOLE 8553864 0 0 Alkermes plc SHS G01767105 8223 150251 SH SOLE 150251 0 0 Amarin Corporation plc SPONSORED ADR NEW 023111206 90905 22669509 SH SOLE 22669509 0 0 AnaptysBio, Inc. COM 032724106 18269 181386 SH SOLE 181386 0 0 Aquinox Pharmaceuticals, Inc. COM 03842B101 128586 10934154 SH SOLE 10934154 0 0 Arbutus Biopharma Corporation COM 03879J100 912 180582 SH SOLE 180582 0 0 argenx SE SPONSORED ADR 04016X101 60725 961754 SH SOLE 961754 0 0 Array BioPharma Inc. COM 04269X105 72399 5656196 SH SOLE 5656196 0 0 Ascendis Pharma A/S SPONSORED ADR 04351P101 104910 2618818 SH SOLE 2618818 0 0 Assembly Biosciences, Inc. COM 045396108 14603 322727 SH SOLE 322727 0 0 AveXis, Inc. COM 05366U100 85769 775000 SH SOLE 775000 0 0 BeiGene, Ltd. SPONSORED ADR 07725L102 376147 3849231 SH SOLE 50040003 0 0 Bellicum Pharmaceuticals, Inc. COM 079481107 42322 5032313 SH SOLE 5032313 0 0 BioCryst Pharmaceuticals, Inc. COM 09058V103 68726 13997172 SH SOLE 13997172 0 0 BioDelivery Sciences International, Inc. COM 09060J106 620 210021 SH SOLE 210021 0 0 BioMarin Pharmaceutical Inc. COM 09061G101 676184 7583084 SH SOLE 7583084 0 0 BioTime, Inc. *W EXP 10/1/201 09066L162 2 20084 SH SOLE 20084 0 0 bluebird bio, Inc. COM 09609G100 35620 200000 SH SOLE 200000 0 0 Catalyst Pharmaceuticals, Inc. COM 14888U101 22882 5852153 SH SOLE 5852153 0 0 Cellectis S.A. SPONSORED ADS 15117K103 1458 50000 SH SOLE 50000 0 0 Cerus Corporation COM 157085101 32939 9745209 SH SOLE 9745209 0 0 ChemoCentryx, Inc. COM 16383L106 292 49064 SH SOLE 49064 0 0 Clementia Pharmaceuticals Inc. COM 185575107 4745 250000 SH SOLE 250000 0 0 ContraFect Corporation COM 212326102 7225 7153076 SH SOLE 7153076 0 0 Corbus Pharmaceuticals Holdings, Inc. COM 21833P103 4691 660714 SH SOLE 660714 0 0 Cyclacel Pharmaceuticals, Inc. PFD CONV EX 6% 23254L207 92 13253 SH SOLE 13253 0 0 CymaBay Therapeutics, Inc. COM 23257D103 27524 2991775 SH SOLE 2991775 0 0 DBV Technologies S.A. SPONSORED ADR 23306J101 135535 5509560 SH SOLE 2754780 0 0 Dynavax Technologies Corporation COM NEW 268158201 1403 75000 SH SOLE 75000 0 0 Endocyte, Inc. COM 29269A102 4654 1087323 SH SOLE 1087323 0 0 Epizyme, Inc. COM 29428V104 2918 232481 SH SOLE 232481 0 0 Erytech Pharma S.A. SPONSORED ADR 29604W108 68043 3090069 SH SOLE 3090069 0 0 Exelixis, Inc. COM 30161Q104 45798 1506499 SH SOLE 1506499 0 0 Five Prime Therapeutics, Inc. COM 33830X104 422 19247 SH SOLE 19247 0 0 Foamix Pharmaceuticals Ltd. SHS M46135105 14825 2466702 SH SOLE 2466702 0 0 Fulgent Genetics, Inc. COM 359664109 548 125000 SH SOLE 125000 0 0 Galapagos NV SPONSORED ADR 36315X101 24368 259894 SH SOLE 259894 0 0 Genomic Health, Inc. COM 37244C101 471314 13781102 SH SOLE 13781102 0 0 GlycoMimetics, Inc. COM 38000Q102 9458 563312 SH SOLE 563312 0 0 GW Pharmaceuticals plc ADS 36197T103 29280 221800 SH SOLE 2661600 0 0 Halozyme Therapeutics, Inc. COM 40637H109 32040 1581424 SH SOLE 1581424 0 0 Heron Therapeutics, Inc. COM 427746102 55398 3060641 SH SOLE 3060641 0 0 Idera Pharmaceuticals, Inc. COM NEW 45168K306 38646 18315802 SH SOLE 18315802 0 0 Ignyta, Inc. COM 451731103 36960 1384266 SH SOLE 1384266 0 0 Immune Design Corp. COM 45252L103 581 148937 SH SOLE 148937 0 0 ImmunoGen, Inc. COM 45253H101 16432 2563489 SH SOLE 2563489 0 0 Incyte Corporation COM 45337C102 3241973 34230523 SH SOLE 34230523 0 0 Infinity Pharmaceuticals, Inc. COM 45665G303 1178 580400 SH SOLE 580400 0 0 InflaRx N.V. COM N44821101 4190 200000 SH SOLE 200000 0 0 Insmed Incorporated COM PAR $.01 457669307 21826 700000 SH SOLE 700000 0 0 Intellia Therapeutics, Inc. COM 45826J105 22016 1145453 SH SOLE 1145453 0 0 Intra-Cellular Therapies, Inc. COM 46116X101 8821 609166 SH SOLE 609166 0 0 Invitae Corporation COM 46185L103 66178 7288300 SH SOLE 7288300 0 0 InVivo Therapeutics Holdings Corp. COM NEW 46186M209 255 331393 SH SOLE 331393 0 0 Jounce Therapeutics, Inc. COM 481116101 1275 100000 SH SOLE 100000 0 0 Karyopharm Therapeutics Inc. COM 48576U106 2083 216990 SH SOLE 216990 0 0 Krystal Biotech, Inc. COM 501147102 2104 200000 SH SOLE 200000 0 0 La Jolla Pharmaceutical Company COM PAR $.0001 2 503459604 4977 154675 SH SOLE 154675 0 0 Ligand Pharmaceuticals Incorporated COM NEW 53220K504 10049 73386 SH SOLE 73386 0 0 MacroGenics, Inc. COM 556099109 6910 363676 SH SOLE 363676 0 0 Madrigal Pharmaceuticals, Inc. COM 558868105 56514 615684 SH SOLE 615684 0 0 MediWound Ltd. ORD SHS M68830104 1006 226000 SH SOLE 226000 0 0 Merus N.V. COM N5749R100 22504 1160014 SH SOLE 1160014 0 0 Mirati Therapeutics, Inc. COM 60468T105 46528 2549461 SH SOLE 2549461 0 0 Molecular Templates, Inc. COM 608550109 726 72412 SH SOLE 72412 0 0 MyoKardia, Inc. COM 62857M105 14957 355264 SH SOLE 355264 0 0 Nabriva Therapeutics plc SHS G63637105 5611 938235 SH SOLE 938235 0 0 Natera, Inc. COM 632307104 2056 228676 SH SOLE 228676 0 0 Nektar Therapeutics COM 640268108 10268 171934 SH SOLE 171934 0 0 Neurocrine Biosciences, Inc. COM 64125C109 77949 1004624 SH SOLE 1004624 0 0 NewLink Genetics Corporation COM 651511107 8169 1007273 SH SOLE 1007273 0 0 Novavax, Inc. COM 670002104 2480 2000000 SH SOLE 2000000 0 0 Ovid Therapeutics Inc. COM 690469101 3290 333333 SH SOLE 333333 0 0 Progenics Pharmaceuticals, Inc. COM 743187106 18747 3150808 SH SOLE 3150808 0 0 Proteon Therapeutics, Inc. COM 74371L109 567 298591 SH SOLE 298591 0 0 Ra Pharmaceuticals, Inc. COM 74933V108 1513 177952 SH SOLE 177952 0 0 Rhythm Pharmaceuticals, Inc. COM 76243J105 59545 2049020 SH SOLE 2049020 0 0 Rigel Pharmaceuticals, Inc. COM NEW 766559603 9773 2518882 SH SOLE 2518882 0 0 Ritter Pharmaceuticals, Inc. COM 767836109 922 2800000 SH SOLE 2800000 0 0 Sage Therapeutics, Inc. COM 78667J108 101546 616514 SH SOLE 616514 0 0 Sangamo Therapeutics, Inc. COM 800677106 34659 2113376 SH SOLE 2113376 0 0 Seattle Genetics, Inc. COM 812578102 2446317 45725556 SH SOLE 45725556 0 0 Selecta Biosciences, Inc. COM 816212104 2783 283716 SH SOLE 283716 0 0 Spark Therapeutics, Inc. COM 84652J103 71172 1384130 SH SOLE 1384130 0 0 Spring Bank Pharmaceuticals, Inc. COM 849431101 5015 373144 SH SOLE 373144 0 0 Stemline Therapeutics, Inc. COM 85858C107 9883 633497 SH SOLE 633497 0 0 Sunesis Pharmaceuticals, Inc. COM PAR 867328700 2737 741665 SH SOLE 741665 0 0 Syros Pharmaceuticals, Inc. COM 87184Q107 5593 574835 SH SOLE 574835 0 0 T2 Biosystems, Inc. COM 89853L104 412 100000 SH SOLE 100000 0 0 Tenax Therapeutics, Inc. COM 88032L100 171 348374 SH SOLE 348374 0 0 Tetraphase Pharmaceuticals, Inc. COM 88165N105 5891 935000 SH SOLE 935000 0 0 Tonix Pharmaceuticals Holdings Corp. COM 890260409 2413 699500 SH SOLE 699500 0 0 Trevena, Inc. COM 89532E109 1520 950000 SH SOLE 950000 0 0 Trillium Therapeutics Inc. COM NEW 89620X506 2968 409323 SH SOLE 409323 0 0 uniQure N.V. SHS N90064101 9453 482557 SH SOLE 482557 0 0 Vanda Pharmaceuticals Inc. COM 921659108 6443 423884 SH SOLE 423884 0 0 Versartis, Inc. COM 92529L102 3138 1426310 SH SOLE 1426310 0 0 Xencor, Inc. COM 98401F105 19116 872072 SH SOLE 872072 0 0 Acorda Therapeutics, Inc. NOTE 1.75% 6/15/2021 00484MAA4 29751 35083000 PRN SOLE 35083000 0 0 Aegerion Pharmaceuticals, Inc. NOTE 2.0% 8/15/2019 00767EAB8 7566 9517000 PRN SOLE 9517000 0 0 BioMarin Pharmaceutical Inc. NOTE 0.75% 10/15/2018 09061GAE1 13218 12228000 PRN SOLE 12228000 0 0 BioMarin Pharmaceutical Inc. NOTE 0.599% 8/1/2024 09061GAH4 14928 15000000 PRN SOLE 15000000 0 0 INOTEK Technologies Corp. NOTE 5.75% 8/1/2021 45780VAB8 4009 5000000 PRN SOLE 5000000 0 0 Novavax, Inc. Note 3.75% 2/1/2023 670002AB0 40863 88500000 PRN SOLE 88500000 0 0 Protalix BioTherapeutics, Inc. NOTE 4.5% 9/15/2018 74365AAB7 2576 3423000 PRN SOLE 3423000 0 0