Chief Financial Officer

0001144204-17-058963.txt : 20171114 0001144204-17-058963.hdr.sgml : 20171114 20171114154552 ACCESSION NUMBER: 0001144204-17-058963 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20170930 FILED AS OF DATE: 20171114 DATE AS OF CHANGE: 20171114 EFFECTIVENESS DATE: 20171114 FILER: COMPANY DATA: COMPANY CONFORMED NAME: BAKER BROS. ADVISORS LP CENTRAL INDEX KEY: 0001263508 IRS NUMBER: 134093645 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10519 FILM NUMBER: 171201170 BUSINESS ADDRESS: STREET 1: 860 WASHINGTON STREET STREET 2: 3RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 BUSINESS PHONE: 2123395600 MAIL ADDRESS: STREET 1: 860 WASHINGTON STREET STREET 2: 3RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 FORMER COMPANY: FORMER CONFORMED NAME: BAKER BROS ADVISORS LLC DATE OF NAME CHANGE: 20030911 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001263508 XXXXXXXX 09-30-2017 09-30-2017 false BAKER BROS. ADVISORS LP

860 WASHINGTON STREET 3RD FLOOR NEW YORK NY 10014

13F HOLDINGS REPORT 028-10519 N Alexandra Toohey Chief Financial Officer 212-339-5690 /s/ Alexandra Toohey New York NY 11-14-2017 0 121 12330918 INFORMATION TABLE 2 infotable.xml Abeona Therapeutics Inc. COM 00289Y107 28718 1684364 SH SOLE 1684364 0 0 ACADIA Pharmaceuticals Inc. COM 004225108 972631 25819768 SH SOLE 25819768 0 0 Acceleron Pharma Inc. COM 00434H108 6117 163900 SH SOLE 163900 0 0 Achaogen, Inc. COM 004449104 61996 3886878 SH SOLE 3886878 0 0 Achillion Pharmaceuticals, Inc. COM 00448Q201 8336 1856637 SH SOLE 1856637 0 0 Acorda Therapeutics, Inc. COM 00484M106 12286 519500 SH SOLE 519500 0 0 Adamas Pharmaceuticals, Inc. COM 00548A106 3655 172630 SH SOLE 172630 0 0 Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 819 100000 SH SOLE 600000 0 0 Advanced Accelerator Applications S.A. SPONSORED ADS 00790T100 151689 2243262 SH SOLE 4486524 0 0 Aeglea BioTherapeutics, Inc. COM 00773J103 5609 1137872 SH SOLE 1137872 0 0 Aerie Pharmaceuticals, Inc. COM 00771V108 14549 299356 SH SOLE 299356 0 0 Aevi Genomic Medicine, Inc. COM 00835P105 5728 4546426 SH SOLE 4546426 0 0 Affimed N.V. COM N01045108 900 400000 SH SOLE 400000 0 0 Agios Pharmaceuticals, Inc. COM 00847X104 8588 128666 SH SOLE 128666 0 0 Aimmune Therapeutics, Inc. COM 00900T107 16706 673908 SH SOLE 673908 0 0 Akari Therapeutics plc SPONSORED ADR 00972G108 3051 496901 SH SOLE 49690100 0 0 Albireo Pharma, Inc. COM 01345P106 4190 200000 SH SOLE 200000 0 0 Alexion Pharmaceuticals, Inc. COM 015351109 1200022 8553864 SH SOLE 8553864 0 0 Alkermes plc SHS G01767105 7639 150251 SH SOLE 150251 0 0 Amarin Corporation plc SPONSORED ADR NEW 023111206 79343 22669509 SH SOLE 22669509 0 0 AnaptysBio, Inc. COM 032724106 3893 111386 SH SOLE 111386 0 0 Aquinox Pharmaceuticals, Inc. COM 03842B101 155156 10934154 SH SOLE 10934154 0 0 Arbutus Biopharma Corporation COM 03879J100 1120 180582 SH SOLE 180582 0 0 argenx SE SPONSORED ADR 04016X101 2261 100000 SH SOLE 100000 0 0 Array BioPharma Inc. COM 04269X105 64126 5213528 SH SOLE 5213528 0 0 Ascendis Pharma A/S SPONSORED ADR 04351P101 85145 2348840 SH SOLE 2348840 0 0 Assembly Biosciences, Inc. COM 045396108 8730 250000 SH SOLE 250000 0 0 AveXis, Inc. COM 05366U100 74966 775000 SH SOLE 775000 0 0 BeiGene, Ltd. SPONSORED ADR 07725L102 403332 3898431 SH SOLE 50679603 0 0 Bellicum Pharmaceuticals, Inc. COM 079481107 58123 5032313 SH SOLE 5032313 0 0 BioCryst Pharmaceuticals, Inc. COM 09058V103 73346 13997172 SH SOLE 13997172 0 0 BioDelivery Sciences International, Inc. COM 09060J106 620 210021 SH SOLE 210021 0 0 BioMarin Pharmaceutical Inc. COM 09061G101 549641 5905673 SH SOLE 5905673 0 0 BioPharmX Corporation COM 09072X101 171 598758 SH SOLE 598758 0 0 BioTime, Inc. *W EXP 10/1/201 09066L162 4 20084 SH SOLE 20084 0 0 bluebird bio, Inc. COM 09609G100 33162 241441 SH SOLE 241441 0 0 Catalyst Pharmaceuticals, Inc. COM 14888U101 12857 5102153 SH SOLE 5102153 0 0 Cellectis S.A. SPONSORED ADS 15117K103 1423 50000 SH SOLE 50000 0 0 Cerus Corporation COM 157085101 26604 9745209 SH SOLE 9745209 0 0 ChemoCentryx, Inc. COM 16383L106 364 49064 SH SOLE 49064 0 0 Clementia Pharmaceuticals Inc. COM ADDED 185575107 4223 250000 SH SOLE 250000 0 0 ContraFect Corporation COM 212326102 7940 7153076 SH SOLE 7153076 0 0 Cyclacel Pharmaceuticals, Inc. PFD CONV EX 6% 23254L207 98 13253 SH SOLE 13253 0 0 CymaBay Therapeutics, Inc. COM 23257D103 24114 2991775 SH SOLE 2991775 0 0 DBV Technologies S.A. SPONSORED ADR 23306J101 233826 5509560 SH SOLE 2754780 0 0 Dimension Therapeutics, Inc. COM 25433V105 7511 1251881 SH SOLE 1251881 0 0 Dynavax Technologies Corporation COM NEW 268158201 1613 75000 SH SOLE 75000 0 0 Epizyme, Inc. COM 29428V104 4429 232481 SH SOLE 232481 0 0 Exelixis, Inc. COM 30161Q104 50447 2082012 SH SOLE 2082012 0 0 Five Prime Therapeutics, Inc. COM 33830X104 787 19247 SH SOLE 19247 0 0 Foamix Pharmaceuticals Ltd. SHS M46135105 13690 2466702 SH SOLE 2466702 0 0 Fulgent Genetics, Inc. COM 359664109 599 125000 SH SOLE 125000 0 0 Galapagos NV SPONSORED ADR 36315X101 26444 259894 SH SOLE 259894 0 0 Genomic Health, Inc. COM 37244C101 442215 13780480 SH SOLE 13780480 0 0 GlycoMimetics, Inc. COM 38000Q102 7881 563312 SH SOLE 563312 0 0 GW Pharmaceuticals plc ADS 36197T103 7612 75000 SH SOLE 900000 0 0 Halozyme Therapeutics, Inc. COM 40637H109 27469 1581424 SH SOLE 1581424 0 0 Heron Therapeutics, Inc. COM 427746102 45026 2787992 SH SOLE 2787992 0 0 Idera Pharmaceuticals, Inc. COM NEW 45168K306 22984 10306757 SH SOLE 10306757 0 0 Ignyta, Inc. COM 451731103 16045 1299199 SH SOLE 1299199 0 0 Immune Design Corp. COM 45252L103 1541 148937 SH SOLE 148937 0 0 ImmunoGen, Inc. COM 45253H101 20567 2688489 SH SOLE 2688489 0 0 Incyte Corporation COM 45337C102 3996048 34230323 SH SOLE 34230323 0 0 Infinity Pharmaceuticals, Inc. COM 45665G303 772 580400 SH SOLE 580400 0 0 Insmed Incorporated COM PAR $.01 457669307 21847 700000 SH SOLE 700000 0 0 Intellia Therapeutics, Inc. COM 45826J105 26394 1062120 SH SOLE 1062120 0 0 Intra-Cellular Therapies, Inc. COM 46116X101 9613 609166 SH SOLE 609166 0 0 Invitae Corporation COM 46185L103 68292 7288300 SH SOLE 7288300 0 0 InVivo Therapeutics Holdings Corp. COM NEW 46186M209 580 400000 SH SOLE 400000 0 0 Jounce Therapeutics, Inc. COM 481116101 1558 100000 SH SOLE 100000 0 0 Karyopharm Therapeutics Inc. COM 48576U106 2383 216990 SH SOLE 216990 0 0 Krystal Biotech, Inc. COM ADDED 501147102 1994 200000 SH SOLE 200000 0 0 La Jolla Pharmaceutical Company COM PAR $.0001 2 503459604 5380 154675 SH SOLE 154675 0 0 Ligand Pharmaceuticals Incorporated COM NEW 53220K504 9992 73386 SH SOLE 73386 0 0 Loxo Oncology, Inc. COM 548862101 8849 96062 SH SOLE 96062 0 0 MacroGenics, Inc. COM 556099109 6721 363676 SH SOLE 363676 0 0 Madrigal Pharmaceuticals, Inc. COM 558868105 2598 57762 SH SOLE 57762 0 0 MediWound Ltd. ORD SHS M68830104 1209 226000 SH SOLE 226000 0 0 Merus N.V. COM N5749R100 23049 1160014 SH SOLE 1160014 0 0 Mirati Therapeutics, Inc. COM 60468T105 26549 2269198 SH SOLE 2269198 0 0 Molecular Templates, Inc. COM ADDED 608550109 505 72412 SH SOLE 72412 0 0 MyoKardia, Inc. COM 62857M105 15223 355264 SH SOLE 355264 0 0 Nabriva Therapeutics plc SHS G63637105 7684 938235 SH SOLE 938235 0 0 Natera, Inc. COM 632307104 2948 228676 SH SOLE 228676 0 0 Neurocrine Biosciences, Inc. COM 64125C109 37790 616682 SH SOLE 616682 0 0 NeuroDerm Ltd. ORD SHS M74231107 22238 571667 SH SOLE 571667 0 0 Newlink Genetics Corporation COM 651511107 10254 1007273 SH SOLE 1007273 0 0 Novavax, Inc. COM 670002104 2280 2000000 SH SOLE 2000000 0 0 Ovid Therapeutics Inc. COM 690469101 2857 333333 SH SOLE 333333 0 0 Progenics Pharmaceuticals, Inc. COM 743187106 23190 3150808 SH SOLE 3150808 0 0 Proteon Therapeutics, Inc. COM 74371L109 597 298591 SH SOLE 298591 0 0 Ra Pharmaceuticals, Inc. COM 74933V108 2598 177952 SH SOLE 177952 0 0 Rigel Pharmaceuticals, Inc. COM NEW 766559603 6398 2518882 SH SOLE 2518882 0 0 Ritter Pharmaceuticals, Inc. COM 767836109 980 2800000 SH SOLE 2800000 0 0 Sage Therapeutics, Inc. COM 78667J108 25262 405485 SH SOLE 405485 0 0 Sangamo Therapeutics, Inc. COM 800677106 31701 2113376 SH SOLE 2113376 0 0 Seattle Genetics, Inc. COM 812578102 2487928 45725556 SH SOLE 45725556 0 0 Selecta Biosciences, Inc. COM 816212104 5289 289809 SH SOLE 289809 0 0 Spark Therapeutics, Inc. COM 84652J103 123409 1384130 SH SOLE 1384130 0 0 Spring Bank Pharmaceuticals, Inc. COM 849431101 6284 373144 SH SOLE 373144 0 0 Stemline Therapeutics, Inc. COM 85858C107 7032 633497 SH SOLE 633497 0 0 Sunesis Pharmaceuticals, Inc. COM PAR 867328700 1439 741665 SH SOLE 741665 0 0 Syros Pharmaceuticals, Inc. COM 87184Q107 8462 574835 SH SOLE 574835 0 0 T2 Biosystems, Inc. COM 89853L104 420 100000 SH SOLE 100000 0 0 Tenax Therapeutics, Inc. COM 88032L100 126 348374 SH SOLE 348374 0 0 Tetraphase Pharmaceuticals, Inc. COM 88165N105 6395 935000 SH SOLE 935000 0 0 Tonix Pharmaceuticals Holdings Corp. COM 890260409 3190 699500 SH SOLE 699500 0 0 Trevena, Inc. COM 89532E109 2423 950000 SH SOLE 950000 0 0 Trillium Therapeutics Inc. COM NEW 89620X506 2131 413697 SH SOLE 413697 0 0 Vanda Pharmaceuticals Inc. COM 921659108 7588 423884 SH SOLE 423884 0 0 Versartis, Inc. COM 92529L102 3521 1437214 SH SOLE 1437214 0 0 Voyager Therapeutics, Inc. COM 92915B106 4880 237014 SH SOLE 237014 0 0 Xencor, Inc. COM 98401F105 19988 872072 SH SOLE 872072 0 0 Acorda Therapeutics, Inc. NOTE 1.75% 6/15/2021 00484MAA4 31574 35083000 PRN SOLE 35083000 0 0 Aegerion Pharmaceuticals, Inc. NOTE 2.0% 8/15/2019 00767EAB8 7576 9517000 PRN SOLE 9517000 0 0 Array BioPharma Inc. NOTE 3.0% 6/1/2020 04269XAA3 5410 3000000 PRN SOLE 3000000 0 0 BioMarin Pharmaceutical Inc. NOTE 0.75% 10/15/2018 09061GAE1 13634 12228000 PRN SOLE 12228000 0 0 BioMarin Pharmaceutical Inc. NOTE 0.599% 8/1/2024 ADDED 09061GAH4 15193 15000000 PRN SOLE 15000000 0 0 Inotek Pharmaceuticals Corporation NOTE 5.75% 8/1/2021 45780VAB8 3904 5000000 PRN SOLE 5000000 0 0 Novavax, Inc. NOTE 3.75% 2/1/2023 670002AB0 39536 88500000 PRN SOLE 88500000 0 0 Protalix BioTherapeutics, Inc. NOTE 4.5% 9/15/2018 74365AAB7 2576 3423000 PRN SOLE 3423000 0 0