Chief Financial Officer

0001144204-17-043086.txt : 20170814 0001144204-17-043086.hdr.sgml : 20170814 20170814154813 ACCESSION NUMBER: 0001144204-17-043086 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20170630 FILED AS OF DATE: 20170814 DATE AS OF CHANGE: 20170814 EFFECTIVENESS DATE: 20170814 FILER: COMPANY DATA: COMPANY CONFORMED NAME: BAKER BROS. ADVISORS LP CENTRAL INDEX KEY: 0001263508 IRS NUMBER: 134093645 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10519 FILM NUMBER: 171029873 BUSINESS ADDRESS: STREET 1: 667 MADISON AVE STREET 2: 21ST FLOOR CITY: NEW YORK STATE: NY ZIP: 10065 BUSINESS PHONE: 2123395600 MAIL ADDRESS: STREET 1: 667 MADISON AVE STREET 2: 21ST FLOOR CITY: NEW YORK STATE: NY ZIP: 10065 FORMER COMPANY: FORMER CONFORMED NAME: BAKER BROS ADVISORS LLC DATE OF NAME CHANGE: 20030911 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001263508 XXXXXXXX 06-30-2017 06-30-2017 false BAKER BROS. ADVISORS LP

667 Madison Ave 21st Floor New York NY 10065

13F HOLDINGS REPORT 028-10519 N Alexandra Toohey Chief Financial Officer 212-339-5690 /s/ Alexandra Toohey New York NY 08-14-2017 0 120 11438426 INFORMATION TABLE 2 infotable.xml Abeona Therapeutics Inc. COM 00289Y107 10780 1684364 SH SOLE 1684364 0 0 ACADIA Pharmaceuticals Inc. COM 004225108 720113 25819768 SH SOLE 25819768 0 0 Acceleron Pharma Inc. COM 00434H108 874 28765 SH SOLE 28765 0 0 Achaogen, Inc. COM 004449104 104404 4804604 SH SOLE 4804604 0 0 Achillion Pharmaceuticals, Inc. COM 00448Q201 8522 1856637 SH SOLE 1856637 0 0 Adamas Pharmaceuticals, Inc. COM 00548A106 3019 172630 SH SOLE 172630 0 0 Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 449 100000 SH SOLE 600000 0 0 Advanced Accelerator Applications S.A. SPONSORED ADS 00790T100 86735 2221706 SH SOLE 4443412 0 0 Aeglea BioTherapeutics, Inc. COM 00773J103 4381 1137872 SH SOLE 1137872 0 0 Aerie Pharmaceuticals, Inc. COM 00771V108 15731 299356 SH SOLE 299356 0 0 Aevi Genomic Medicine, Inc. COM 00835P105 2152 1618089 SH SOLE 1618089 0 0 Affimed N.V. COM N01045108 820 400000 SH SOLE 400000 0 0 Agios Pharmaceuticals, Inc. COM 00847X104 6620 128666 SH SOLE 128666 0 0 Aimmune Therapeutics, Inc. COM 00900T107 13856 673908 SH SOLE 673908 0 0 Akari Therapeutics plc SPONSORED ADR 00972G108 2291 496901 SH SOLE 49690100 0 0 Albireo Pharma, Inc. COM 01345P106 4120 200000 SH SOLE 200000 0 0 Alder BioPharmaceuticals, Inc. COM 014339105 2488 217328 SH SOLE 217328 0 0 Alexion Pharmaceuticals, Inc. COM 015351109 1040749 8553864 SH SOLE 8553864 0 0 Alkermes plc SHS G01767105 8710 150251 SH SOLE 150251 0 0 Amarin Corporation plc SPONSORED ADR NEW 023111206 91358 22669509 SH SOLE 22669509 0 0 AnaptysBio, Inc. COM 032724106 2805 117211 SH SOLE 117211 0 0 Aquinox Pharmaceuticals, Inc. COM 03842B101 153844 10934154 SH SOLE 10934154 0 0 Arbutus Biopharma Corporation COM 03879J100 650 180582 SH SOLE 180582 0 0 argenx SE SPONSORED ADR ADDED 04016X101 2121 100000 SH SOLE 100000 0 0 Array BioPharma Inc. COM 04269X105 13274 1585913 SH SOLE 1585913 0 0 Ascendis Pharma A/S SPONSORED ADR 04351P101 48621 1751463 SH SOLE 1751463 0 0 Assembly Biosciences, Inc. COM 045396108 5163 250000 SH SOLE 250000 0 0 AveXis, Inc. COM 05366U100 51350 625000 SH SOLE 625000 0 0 BeiGene, Ltd. SPONSORED ADR 07725L102 165293 3673175 SH SOLE 47751275 0 0 Bellicum Pharmaceuticals, Inc. COM 079481107 58777 5032313 SH SOLE 5032313 0 0 BioCryst Pharmaceuticals, Inc. COM 09058V103 65145 11716784 SH SOLE 11716784 0 0 BioDelivery Sciences International, Inc. COM 09060J106 588 210021 SH SOLE 210021 0 0 BioMarin Pharmaceutical Inc. COM 09061G101 536353 5905673 SH SOLE 5905673 0 0 BioPharmX Corporation COM 09072X101 287 598758 SH SOLE 598758 0 0 BioTime, Inc. *W EXP 10/1/201 09066L162 7 20084 SH SOLE 20084 0 0 Bioverativ Inc. COM 09075E100 496 8249 SH SOLE 8249 0 0 bluebird bio, Inc. COM 09609G100 31666 301441 SH SOLE 301441 0 0 Catalyst Pharmaceuticals, Inc. COM 14888U101 14082 5102153 SH SOLE 5102153 0 0 Cellectis S.A. SPONSORED ADS 15117K103 1291 50000 SH SOLE 50000 0 0 Cerus Corporation COM 157085101 25707 10241943 SH SOLE 10241943 0 0 ChemoCentryx, Inc. COM 16383L106 459 49064 SH SOLE 49064 0 0 Chimerix, Inc. COM 16934W106 628 115216 SH SOLE 115216 0 0 ContraFect Corporation COM 212326102 5867 4045876 SH SOLE 4045876 0 0 Corbus Pharmaceuticals Holdings, Inc. COM 21833P103 820 130129 SH SOLE 130129 0 0 Cyclacel Pharmaceuticals, Inc. PFD CONV EX 6% 23254L207 82 13253 SH SOLE 13253 0 0 CymaBay Therapeutics, Inc. COM 23257D103 7441 1291775 SH SOLE 1291775 0 0 DBV Technologies S.A. SPONSORED ADR 23306J101 196746 5509560 SH SOLE 2754780 0 0 Dimension Therapeutics, Inc. COM 25433V105 1815 1251881 SH SOLE 1251881 0 0 Dynavax Technologies Corporation COM NEW 268158201 724 75000 SH SOLE 75000 0 0 Epizyme, Inc. COM 29428V104 3510 232481 SH SOLE 232481 0 0 Exelixis, Inc. COM 30161Q104 51280 2082012 SH SOLE 2082012 0 0 Five Prime Therapeutics, Inc. COM 33830X104 580 19247 SH SOLE 19247 0 0 Foamix Pharmaceuticals Ltd. SHS M46135105 11445 2466702 SH SOLE 2466702 0 0 Fulgent Genetics, Inc. COM 359664109 799 125000 SH SOLE 125000 0 0 Galapagos NV SPONSORED ADR 36315X101 19887 259894 SH SOLE 259894 0 0 Genomic Health, Inc. COM 37244C101 448535 13779866 SH SOLE 13779866 0 0 GlycoMimetics, Inc. COM 38000Q102 6287 563312 SH SOLE 563312 0 0 Halozyme Therapeutics, Inc. COM 40637H109 20274 1581424 SH SOLE 1581424 0 0 Heron Therapeutics, Inc. COM 427746102 38552 2783569 SH SOLE 2783569 0 0 Idera Pharmaceuticals, Inc. COM NEW 45168K306 17707 10294970 SH SOLE 10294970 0 0 Ignyta, Inc. COM 451731103 9274 896000 SH SOLE 896000 0 0 Immune Design Corp. COM 45252L103 1452 148937 SH SOLE 148937 0 0 ImmunoGen, Inc. COM 45253H101 21439 3015353 SH SOLE 3015353 0 0 Incyte Corporation COM 45337C102 4297329 34130161 SH SOLE 34130161 0 0 Infinity Pharmaceuticals, Inc. COM 45665G303 911 580400 SH SOLE 580400 0 0 Insmed Incorporated COM PAR $.01 457669307 6864 400000 SH SOLE 400000 0 0 Intellia Therapeutics, Inc. COM 45826J105 16994 1062120 SH SOLE 1062120 0 0 Intra-Cellular Therapies, Inc. COM 46116X101 7566 609166 SH SOLE 609166 0 0 Invitae Corporation COM 46185L103 69676 7288300 SH SOLE 7288300 0 0 InVivo Therapeutics Holdings Corp. COM NEW 46186M209 1080 400000 SH SOLE 400000 0 0 Jounce Therapeutics, Inc. COM 481116101 1403 100000 SH SOLE 100000 0 0 Juno Therapeutics, Inc. COM 48205A109 1495 50000 SH SOLE 50000 0 0 Karyopharm Therapeutics Inc. COM 48576U106 1964 216990 SH SOLE 216990 0 0 La Jolla Pharmaceutical Company COM PAR $.0001 2 503459604 15026 504732 SH SOLE 504732 0 0 Ligand Pharmaceuticals Incorporated COM NEW 53220K504 8909 73386 SH SOLE 73386 0 0 Loxo Oncology, Inc. COM 548862101 11091 138312 SH SOLE 138312 0 0 MacroGenics, Inc. COM 556099109 6368 363676 SH SOLE 363676 0 0 Madrigal Pharmaceuticals, Inc. COM 558868105 939 57762 SH SOLE 57762 0 0 MediWound Ltd. ORD SHS M68830104 1537 226000 SH SOLE 226000 0 0 Merus N.V. COM N5749R100 18386 1160014 SH SOLE 1160014 0 0 Mirati Therapeutics, Inc. COM 60468T105 8283 2269198 SH SOLE 2269198 0 0 MyoKardia, Inc. COM 62857M105 1310 100000 SH SOLE 100000 0 0 Nabriva Therapeutics plc SHS ADDED G63637105 3668 350000 SH SOLE 350000 0 0 Natera, Inc. COM 632307104 2483 228676 SH SOLE 228676 0 0 Neurocrine Biosciences, Inc. COM 64125C109 28367 616682 SH SOLE 616682 0 0 NeuroDerm Ltd. ORD SHS M74231107 17093 571667 SH SOLE 571667 0 0 NewLink Genetics Corporation COM 651511107 3675 500000 SH SOLE 500000 0 0 Novavax, Inc. COM 670002104 2300 2000000 SH SOLE 2000000 0 0 Ovid Therapeutics Inc. COM ADDED 690469101 3497 333333 SH SOLE 333333 0 0 Palatin Technologies, Inc. COM PAR $.01 696077403 882 2050000 SH SOLE 2050000 0 0 Progenics Pharmaceuticals, Inc. COM 743187106 21394 3150808 SH SOLE 3150808 0 0 Proteon Therapeutics, Inc. COM 74371L109 455 298591 SH SOLE 298591 0 0 Ra Pharmaceuticals, Inc. COM 74933V108 3335 177952 SH SOLE 177952 0 0 Rigel Pharmaceuticals, Inc. COM NEW 766559603 6877 2518882 SH SOLE 2518882 0 0 Ritter Pharmaceuticals, Inc. COM 767836109 220 400000 SH SOLE 400000 0 0 Sage Therapeutics, Inc. COM 78667J108 16591 208328 SH SOLE 208328 0 0 Sangamo Therapeutics, Inc. COM 800677106 36198 4113376 SH SOLE 4113376 0 0 Seattle Genetics, Inc. COM 812578102 2365840 45725556 SH SOLE 45725556 0 0 Selecta Biosciences, Inc. COM 816212104 5756 289809 SH SOLE 289809 0 0 Seres Therapeutics, Inc. COM 81750R102 1413 125000 SH SOLE 125000 0 0 Spark Therapeutics, Inc. COM 84652J103 78758 1318341 SH SOLE 1318341 0 0 Spring Bank Pharmaceuticals, Inc. COM 849431101 5052 373144 SH SOLE 373144 0 0 Stemline Therapeutics, Inc. COM 85858C107 5828 633497 SH SOLE 633497 0 0 Sunesis Pharmaceuticals, Inc. COM PAR 867328700 2002 741665 SH SOLE 741665 0 0 Syros Pharmaceuticals, Inc. COM 87184Q107 9249 574835 SH SOLE 574835 0 0 Tenax Therapeutics, Inc. COM 88032L100 98 132974 SH SOLE 132974 0 0 Tonix Pharmaceuticals Holding Corp. COM 890260409 2212 510922 SH SOLE 510922 0 0 Trevena, Inc. COM 89532E109 2185 950000 SH SOLE 950000 0 0 Trillium Therapeutics Inc. COM NEW 89620X506 1820 413697 SH SOLE 413697 0 0 Ultragenyx Pharmaceutical Inc. COM 90400D108 1553 25000 SH SOLE 25000 0 0 Versartis, Inc. COM 92529L102 28977 1660593 SH SOLE 1660593 0 0 Xencor, Inc. COM 98401F105 18409 872072 SH SOLE 872072 0 0 Zogenix, Inc. COM NEW 98978L204 2687 185290 SH SOLE 185290 0 0 Acorda Therapeutics, Inc. NOTE 1.75% 6/15/2021 00484MAA4 29985 35083000 PRN SOLE 35083000 0 0 Aegerion Pharmaceuticals, Inc. NOTE 2.0% 8/15/2019 00767EAB8 11549 14517000 PRN SOLE 14517000 0 0 Array BioPharma Inc. NOTE 3.0% 6/1/2020 04269XAA3 4066 3000000 PRN SOLE 3000000 0 0 BioMarin Pharmaceutical Inc. NOTE 0.75% 10/15/2018 09061GAE1 13547 12228000 PRN SOLE 12228000 0 0 Inotek Pharmaceuticals Corporation NOTE 5.75% 8/1/2021 45780VAB8 2978 5000000 PRN SOLE 5000000 0 0 Novavax, Inc. NOTE 3.75% 2/1/2023 670002AB0 46429 108500000 PRN SOLE 108500000 0 0 Protalix BioTherapeutics, Inc. NOTE 4.5% 9/15/2018 74365AAB7 2572 3423000 PRN SOLE 3423000 0 0