Chief Financial Officer

0001144204-17-027430.txt : 20170515 0001144204-17-027430.hdr.sgml : 20170515 20170515160017 ACCESSION NUMBER: 0001144204-17-027430 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20170331 FILED AS OF DATE: 20170515 DATE AS OF CHANGE: 20170515 EFFECTIVENESS DATE: 20170515 FILER: COMPANY DATA: COMPANY CONFORMED NAME: BAKER BROS. ADVISORS LP CENTRAL INDEX KEY: 0001263508 IRS NUMBER: 134093645 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10519 FILM NUMBER: 17844067 BUSINESS ADDRESS: STREET 1: 667 MADISON AVE STREET 2: 21ST FLOOR CITY: NEW YORK STATE: NY ZIP: 10065 BUSINESS PHONE: 2123395600 MAIL ADDRESS: STREET 1: 667 MADISON AVE STREET 2: 21ST FLOOR CITY: NEW YORK STATE: NY ZIP: 10065 FORMER COMPANY: FORMER CONFORMED NAME: BAKER BROS ADVISORS LLC DATE OF NAME CHANGE: 20030911 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001263508 XXXXXXXX 03-31-2017 03-31-2017 false BAKER BROS. ADVISORS LP

667 Madison Ave 21st Floor New York NY 10065

13F HOLDINGS REPORT 028-10519 N Alexandra Toohey Chief Financial Officer 212-339-5690 /s/ Alexandra Toohey New York NY 05-15-2017 0 119 12220691 INFORMATION TABLE 2 infotable.xml Abeona Therapeutics Inc. COM 00289Y107 8422 1684364 SH SOLE 1684364 0 0 ACADIA Pharmaceuticals Inc. COM 004225108 887684 25819768 SH SOLE 25819768 0 0 Acceleron Pharma Inc. COM 00434H108 761 28765 SH SOLE 28765 0 0 Achaogen, Inc. COM 004449104 115613 4582382 SH SOLE 4582382 0 0 Achillion Pharmaceuticals, Inc. COM 00448Q201 7816 1856637 SH SOLE 1856637 0 0 Acorda Therapeutics, Inc. COM 00484M106 69338 3301791 SH SOLE 3301791 0 0 Adamas Pharmaceuticals, Inc. COM 00548A106 3021 172630 SH SOLE 172630 0 0 Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 551 100000 SH SOLE 600000 0 0 Advanced Accelerator Applications S.A. SPONSORED ADS 00790T100 88557 2221706 SH SOLE 4443412 0 0 Aeglea BioTherapeutics, Inc. COM 00773J103 1415 189987 SH SOLE 189987 0 0 Aerie Pharmaceuticals, Inc. COM 00771V108 13576 299356 SH SOLE 299356 0 0 Aevi Genomic Medicine, Inc. COM 00835P105 3010 1618089 SH SOLE 1618089 0 0 Affimed N.V. COM N01045108 920 400000 SH SOLE 400000 0 0 Agios Pharmaceuticals, Inc. COM 00847X104 7514 128666 SH SOLE 128666 0 0 Aimmune Therapeutics, Inc. COM 00900T107 14644 673908 SH SOLE 673908 0 0 Akari Therapeutics plc SPONSORED ADR 00972G108 5501 496901 SH SOLE 49690100 0 0 Alder BioPharmaceuticals, Inc. COM 014339105 4520 217328 SH SOLE 217328 0 0 Alexion Pharmaceuticals, Inc. COM 015351109 793410 6544130 SH SOLE 6544130 0 0 Alkermes plc SHS G01767105 8790 150251 SH SOLE 150251 0 0 Amarin Corporation plc SPONSORED ADR NEW 023111206 72501 22656469 SH SOLE 22656469 0 0 AnaptysBio, Inc. COM ADDED 032724106 4163 150000 SH SOLE 150000 0 0 Aquinox Pharmaceuticals, Inc. COM 03842B101 182491 10934154 SH SOLE 10934154 0 0 Arbutus Biopharma Corporation COM 03879J100 587 180582 SH SOLE 180582 0 0 Array BioPharma Inc. COM 04269X105 14178 1585913 SH SOLE 1585913 0 0 Ascendis Pharma A/S SPONSORED ADR 04351P101 37841 1351463 SH SOLE 1351463 0 0 Assembly Biosciences, Inc. COM 045396108 6373 250000 SH SOLE 250000 0 0 AveXis, Inc. COM 05366U100 38015 500000 SH SOLE 500000 0 0 BeiGene, Ltd. SPONSORED ADR 07725L102 134475 3673175 SH SOLE 47751275 0 0 Bellicum Pharmaceuticals, Inc. COM 079481107 62099 5032313 SH SOLE 5032313 0 0 BioCryst Pharmaceuticals, Inc. COM 09058V103 98421 11716784 SH SOLE 11716784 0 0 BioDelivery Sciences International, Inc. COM 09060J106 399 210021 SH SOLE 210021 0 0 Biogen Inc. COM 09062X103 4511 16500 SH SOLE 16500 0 0 BioMarin Pharmaceutical Inc. COM 09061G101 421913 4806483 SH SOLE 4806483 0 0 BioPharmX Corporation COM 09072X101 191 377295 SH SOLE 377295 0 0 BioTime, Inc. *W EXP 10/1/201 09066L162 12 20084 SH SOLE 20084 0 0 Bioverativ Inc. COM ADDED 09075E100 449 8249 SH SOLE 8249 0 0 bluebird bio, Inc. COM 09609G100 31946 351441 SH SOLE 351441 0 0 Catalyst Pharmaceuticals, Inc. COM 14888U101 9949 5102153 SH SOLE 5102153 0 0 Cellectis S.A. SPONSORED ADS 15117K103 1200 50000 SH SOLE 50000 0 0 Cerus Corporation COM 157085101 58087 13053275 SH SOLE 13053275 0 0 ChemoCentryx, Inc. COM 16383L106 357 49064 SH SOLE 49064 0 0 Chimerix, Inc. COM 16934W106 735 115216 SH SOLE 115216 0 0 ContraFect Corporation COM 212326102 7283 4045876 SH SOLE 4045876 0 0 Corbus Pharmaceuticals Holdings, Inc. COM 21833P103 1074 130129 SH SOLE 130129 0 0 Cyclacel Pharmaceuticals, Inc. PFD CONV EX 6% 23254L207 83 13253 SH SOLE 13253 0 0 CymaBay Therapeutics, Inc. COM 23257D103 6078 1413499 SH SOLE 1413499 0 0 DBV Technologies S.A. SPONSORED ADR 23306J101 194047 5509560 SH SOLE 2754780 0 0 Dermira, Inc. COM 24983L104 14171 415448 SH SOLE 415448 0 0 Dimension Therapeutics, Inc. COM 25433V105 2191 1251881 SH SOLE 1251881 0 0 Dynavax Technologies Corporation COM NEW 268158201 446 75000 SH SOLE 75000 0 0 Epizyme, Inc. COM 29428V104 3987 232481 SH SOLE 232481 0 0 Exelixis, Inc. COM 30161Q104 56419 2603569 SH SOLE 2603569 0 0 Five Prime Therapeutics, Inc. COM 33830X104 696 19247 SH SOLE 19247 0 0 Foamix Pharmaceuticals Ltd. SHS M46135105 12210 2466702 SH SOLE 2466702 0 0 Fulgent Genetics, Inc. COM 359664109 1365 125000 SH SOLE 125000 0 0 Galapagos NV SPONSORED ADR 36315X101 22400 259894 SH SOLE 259894 0 0 Genomic Health, Inc. COM 37244C101 433648 13770982 SH SOLE 13770982 0 0 GlycoMimetics, Inc. COM 38000Q102 2070 381235 SH SOLE 381235 0 0 Halozyme Therapeutics, Inc. COM 40637H109 18034 1391507 SH SOLE 1391507 0 0 Heron Therapeutics, Inc. COM 427746102 41754 2783569 SH SOLE 2783569 0 0 Idera Pharmaceuticals, Inc. COM NEW 45168K306 25408 10286483 SH SOLE 10286483 0 0 Ignyta, Inc. COM 451731103 4911 571000 SH SOLE 571000 0 0 Immune Design Corp. COM 45252L103 1013 148937 SH SOLE 148937 0 0 ImmunoGen, Inc. COM 45253H101 11669 3015353 SH SOLE 3015353 0 0 Incyte Corporation COM 45337C102 4559485 34110011 SH SOLE 34110011 0 0 Infinity Pharmaceuticals, Inc. COM 45665G303 1875 580400 SH SOLE 580400 0 0 Insmed Incorporated COM PAR $.01 457669307 7004 400000 SH SOLE 400000 0 0 Intellia Therapeutics, Inc. COM 45826J105 14965 1062120 SH SOLE 1062120 0 0 Intra-Cellular Therapies, Inc. COM 46116X101 9899 609166 SH SOLE 609166 0 0 Invitae Corporation COM 46185L103 80609 7288300 SH SOLE 7288300 0 0 InVivo Therapeutics Holdings Corp. COM NEW 46186M209 1620 400000 SH SOLE 400000 0 0 Jounce Therapeutics, Inc. COM ADDED 481116101 2199 100000 SH SOLE 100000 0 0 Juno Therapeutics, Inc. COM 48205A109 1110 50000 SH SOLE 50000 0 0 Karyopharm Therapeutics Inc. COM 48576U106 2786 216990 SH SOLE 216990 0 0 La Jolla Pharmaceutical Company COM PAR $.0001 2 503459604 11317 379134 SH SOLE 379134 0 0 Ligand Pharmaceuticals Incorporated COM NEW 53220K504 7767 73386 SH SOLE 73386 0 0 Loxo Oncology, Inc. COM 548862101 5796 137735 SH SOLE 137735 0 0 MacroGenics, Inc. COM 556099109 6764 363676 SH SOLE 363676 0 0 Madrigal Pharmaceuticals, Inc. COM 558868105 890 57762 SH SOLE 57762 0 0 MediWound Ltd. ORD SHS M68830104 1492 226000 SH SOLE 226000 0 0 Merus N.V. COM N5749R100 28293 1160014 SH SOLE 1160014 0 0 Mirati Therapeutics, Inc. COM 60468T105 11800 2269198 SH SOLE 2269198 0 0 MyoKardia, Inc. COM 62857M105 1315 100000 SH SOLE 100000 0 0 Nabriva Therapeutics AG SPONSORED ADR 62957M104 4200 350000 SH SOLE 35000 0 0 Natera, Inc. COM 632307104 2028 228676 SH SOLE 228676 0 0 Neurocrine Biosciences, Inc. COM 64125C109 38772 895422 SH SOLE 895422 0 0 NeuroDerm Ltd. ORD SHS M74231107 15178 571667 SH SOLE 571667 0 0 Palatin Technologies, Inc. COM PAR $.01 696077403 671 2050000 SH SOLE 2050000 0 0 Progenics Pharmaceuticals, Inc. COM 743187106 29744 3150808 SH SOLE 3150808 0 0 Proteon Therapeutics, Inc. COM 74371L109 523 298591 SH SOLE 298591 0 0 Ra Pharmaceuticals, Inc. COM 74933V108 3789 177952 SH SOLE 177952 0 0 Rigel Pharmaceuticals, Inc. COM NEW 766559603 8337 2518882 SH SOLE 2518882 0 0 Ritter Pharmaceuticals, Inc. COM 767836109 568 400000 SH SOLE 400000 0 0 Sage Therapeutics, Inc. COM 78667J108 14806 208328 SH SOLE 208328 0 0 Sangamo Therapeutics, Inc. COM 800677106 23561 4530901 SH SOLE 4530901 0 0 Seattle Genetics, Inc. COM 812578102 2873680 45715556 SH SOLE 45715556 0 0 Selecta Biosciences, Inc. COM 816212104 2516 175712 SH SOLE 175712 0 0 Seres Therapeutics, Inc. COM 81750R102 1409 125000 SH SOLE 125000 0 0 Spark Therapeutics, Inc. COM 84652J103 70320 1318341 SH SOLE 1318341 0 0 Spring Bank Pharmaceuticals, Inc. COM 849431101 1952 219298 SH SOLE 219298 0 0 Stemline Therapeutics, Inc. COM 85858C107 5416 633497 SH SOLE 633497 0 0 Sunesis Pharmaceuticals, Inc. COM PAR 867328700 3041 741665 SH SOLE 741665 0 0 Syros Pharmaceuticals, Inc. COM 87184Q107 3257 204465 SH SOLE 204465 0 0 Tonix Pharmaceuticals Holdings Corp. COM ADDED 890260409 2099 449500 SH SOLE 449500 0 0 Trevena, Inc. COM 89532E109 3146 857206 SH SOLE 857206 0 0 Trillium Therapeutics Inc. COM NEW 89620X506 2544 413697 SH SOLE 413697 0 0 Ultragenyx Pharmaceutical Inc. COM 90400D108 3389 50000 SH SOLE 50000 0 0 Versartis, Inc. COM 92529L102 35454 1660593 SH SOLE 1660593 0 0 Windtree Therapeutics, Inc. COM 97382D105 291 254973 SH SOLE 254973 0 0 Xencor, Inc. COM 98401F105 20860 872072 SH SOLE 872072 0 0 Zogenix, Inc. COM NEW 98978L204 4144 381939 SH SOLE 381939 0 0 Acorda Therapeutics, Inc. NOTE 1.75% 6/15/2021 00484MAA4 29696 35083000 PRN SOLE 35083000 0 0 Aegerion Pharmaceuticals, Inc. NOTE 2.0% 8/15/2019 00767EAB8 13241 16517000 PRN SOLE 16517000 0 0 Array BioPharma Inc. NOTE 3.0% 6/1/2020 04269XAA3 4258 3000000 PRN SOLE 3000000 0 0 BioMarin Pharmaceutical Inc. NOTE 1.875% 4/23/2017 09061GAD3 95967 22379000 PRN SOLE 22379000 0 0 BioMarin Pharmaceutical Inc. NOTE 0.75% 10/15/2018 09061GAE1 13830 12228000 PRN SOLE 12228000 0 0 Inotek Pharmaceuticals Corporation NOTE 5.75% 8/1/2021 45780VAB8 3008 5000000 PRN SOLE 5000000 0 0 Novavax, Inc. Note 3.75% 2/1/2023 ADDED 670002AB0 48554 108500000 PRN SOLE 108500000 0 0 Protalix BioTherapeutics, Inc. NOTE 4.5% 9/15/2018 74365AAB7 2543 3423000 PRN SOLE 3423000 0 0