Chief Financial Officer

0001144204-17-008836.txt : 20170214 0001144204-17-008836.hdr.sgml : 20170214 20170214161355 ACCESSION NUMBER: 0001144204-17-008836 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20161231 FILED AS OF DATE: 20170214 DATE AS OF CHANGE: 20170214 EFFECTIVENESS DATE: 20170214 FILER: COMPANY DATA: COMPANY CONFORMED NAME: BAKER BROS. ADVISORS LP CENTRAL INDEX KEY: 0001263508 IRS NUMBER: 134093645 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10519 FILM NUMBER: 17608888 BUSINESS ADDRESS: STREET 1: 667 MADISON AVE STREET 2: 21ST FLOOR CITY: NEW YORK STATE: NY ZIP: 10065 BUSINESS PHONE: 2123395600 MAIL ADDRESS: STREET 1: 667 MADISON AVE STREET 2: 21ST FLOOR CITY: NEW YORK STATE: NY ZIP: 10065 FORMER COMPANY: FORMER CONFORMED NAME: BAKER BROS ADVISORS LLC DATE OF NAME CHANGE: 20030911 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001263508 XXXXXXXX 12-31-2016 12-31-2016 false BAKER BROS. ADVISORS LP

667 Madison Ave 21st Floor New York NY 10065

13F HOLDINGS REPORT 028-10519 N Alexandra Toohey Chief Financial Officer 212-339-5690 /s/ Alexandra Toohey New York NY 02-14-2017 0 133 10200965 INFORMATION TABLE 2 infotable.xml AbbVie Inc. COM 00287Y109 105577 1685994 SH SOLE 1685994 0 0 Abeona Therapeutics Inc. COM 00289Y107 8169 1684364 SH SOLE 1684364 0 0 ACADIA Pharmaceuticals Inc. COM 004225108 744642 25819768 SH SOLE 25819768 0 0 Acceleron Pharma Inc. COM 00434H108 734 28765 SH SOLE 28765 0 0 Achaogen, Inc. COM 004449104 59663 4582382 SH SOLE 4582382 0 0 Achillion Pharmaceuticals, Inc. COM 00448Q201 7668 1856637 SH SOLE 1856637 0 0 Acorda Therapeutics, Inc. COM 00484M106 62074 3301791 SH SOLE 3301791 0 0 Adamas Pharmaceuticals, Inc. COM 00548A106 2917 172630 SH SOLE 172630 0 0 Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 405 100000 SH SOLE 600000 0 0 Advanced Accelerator Applications S.A. SPONSORED ADR 00790T100 57993 2167137 SH SOLE 4334274 0 0 Aeglea BioTherapeutics, Inc. COM 00773J103 1758 404230 SH SOLE 404230 0 0 Aerie Pharmaceuticals, Inc. COM 00771V108 11331 299356 SH SOLE 299356 0 0 Aevi Genomic Medicine, Inc. COM ADDED 00835P105 4561 880539 SH SOLE 880539 0 0 Affimed N.V. COM N01045108 720 400000 SH SOLE 400000 0 0 Agios Pharmaceuticals, Inc. COM 00847X104 5369 128666 SH SOLE 128666 0 0 Aimmune Therapeutics, Inc. COM 00900T107 13781 673908 SH SOLE 673908 0 0 Akari Therapeutics plc SPONSORED ADR 00972G108 3498 496901 SH SOLE 49690100 0 0 Alcobra Ltd. SHS M2239P109 4906 2336359 SH SOLE 2336359 0 0 Alder BioPharmaceuticals, Inc. COM 014339105 4520 217328 SH SOLE 217328 0 0 Aldeyra Therapeutics, Inc. COM 01438T106 760 142000 SH SOLE 142000 0 0 Alexion Pharmaceuticals, Inc. COM 015351109 800572 6543295 SH SOLE 6543295 0 0 Alkermes plc SHS G01767105 8351 150251 SH SOLE 150251 0 0 Alnylam Pharmaceuticals, Inc. COM 02043Q107 425 11340 SH SOLE 11340 0 0 Amarin Corporation plc SPONSORED ADR NEW 023111206 68282 22169509 SH SOLE 22169509 0 0 Aptose Biosciences Inc. COM NEW 03835T200 359 258311 SH SOLE 258311 0 0 Aquinox Pharmaceuticals, Inc. COM 03842B101 173951 10536092 SH SOLE 10536092 0 0 Arbutus Biopharma Corporation COM 03879J100 442 180582 SH SOLE 180582 0 0 Array BioPharma Inc. COM 04269X105 22730 2585913 SH SOLE 2585913 0 0 Ascendis Pharma A/S SPONSORED ADR 04351P101 20711 1023266 SH SOLE 1023266 0 0 Assembly Biosciences, Inc. COM 045396108 3038 250000 SH SOLE 250000 0 0 AveXis, Inc. COM 05366U100 15049 315300 SH SOLE 315300 0 0 BeiGene, Ltd. SPONSORED ADR 07725L102 111518 3673175 SH SOLE 47751275 0 0 Bellicum Pharmaceuticals, Inc. COM 079481107 66270 4865647 SH SOLE 4865647 0 0 BioCryst Pharmaceuticals, Inc. COM 09058V103 69402 10963944 SH SOLE 10963944 0 0 BioDelivery Sciences International, Inc. COM 09060J106 368 210021 SH SOLE 210021 0 0 Biogen Inc. COM 09062X103 4679 16500 SH SOLE 16500 0 0 BioMarin Pharmaceutical Inc. COM 09061G101 398169 4806483 SH SOLE 4806483 0 0 BioTime, Inc. *W EXP 10/1/201 09066L162 14 20084 SH SOLE 20084 0 0 bluebird bio, Inc. COM 09609G100 21684 351441 SH SOLE 351441 0 0 Catalyst Pharmaceuticals, Inc. COM 14888U101 5357 5102153 SH SOLE 5102153 0 0 Cellectis S.A. SPONSORED ADS 15117K103 848 50000 SH SOLE 50000 0 0 Cerus Corporation COM 157085101 56782 13053275 SH SOLE 13053275 0 0 ChemoCentryx, Inc. COM 16383L106 363 49064 SH SOLE 49064 0 0 Chimerix, Inc. COM 16934W106 530 115216 SH SOLE 115216 0 0 Colucid Pharmaceuticals, Inc. COM 19716T101 1103 30310 SH SOLE 30310 0 0 Concert Pharmaceuticals, Inc. COM 206022105 1574 152964 SH SOLE 152964 0 0 ContraFect Corporation COM 212326102 7080 4045876 SH SOLE 4045876 0 0 Corbus Pharmaceuticals Holdings, Inc. COM 21833P103 2198 260129 SH SOLE 260129 0 0 Cyclacel Pharmaceuticals, Inc. PFD CONV EX 6% 23254L207 82 13253 SH SOLE 13253 0 0 CymaBay Therapeutics, Inc. COM 23257D103 535 309268 SH SOLE 309268 0 0 DBV Technologies S.A. SPONSORED ADR 23306J101 193551 5509560 SH SOLE 2754780 0 0 Derma Sciences, Inc. COM PAR $.01 249827502 19512 3752390 SH SOLE 3752390 0 0 Dermira, Inc. COM 24983L104 9901 326428 SH SOLE 326428 0 0 Dimension Therapeutics, Inc. COM 25433V105 5446 1251881 SH SOLE 1251881 0 0 Dynavax Technologies Corporation COM NEW 268158201 296 75000 SH SOLE 75000 0 0 Enanta Pharmaceuticals, Inc. COM 29251M106 2524 75357 SH SOLE 75357 0 0 Epizyme, Inc. COM 29428V104 2813 232481 SH SOLE 232481 0 0 Exelixis, Inc. COM 30161Q104 44783 3003569 SH SOLE 3003569 0 0 Five Prime Therapeutics, Inc. COM 33830X104 964 19247 SH SOLE 19247 0 0 Foamix Pharmaceuticals Ltd. SHS M46135105 27380 2466702 SH SOLE 2466702 0 0 Foundation Medicine, Inc. COM 350465100 370 20892 SH SOLE 20892 0 0 Fulgent Genetics, Inc. COM 359664109 1446 125000 SH SOLE 125000 0 0 Galapagos NV SPONSORED ADR 36315X101 16683 259894 SH SOLE 259894 0 0 Genomic Health, Inc. COM 37244C101 404709 13770302 SH SOLE 13770302 0 0 GlycoMimetics, Inc. COM 38000Q102 2326 381235 SH SOLE 381235 0 0 Halozyme Therapeutics, Inc. COM 40637H109 13748 1391507 SH SOLE 1391507 0 0 Heron Therapeutics, Inc. COM 427746102 31225 2383569 SH SOLE 2383569 0 0 Idera Pharmaceuticals, Inc. COM NEW 45168K306 15408 10272314 SH SOLE 10272314 0 0 Ignyta, Inc. COM 451731103 3026 571000 SH SOLE 571000 0 0 Immune Design Corp. COM 45252L103 819 148937 SH SOLE 148937 0 0 ImmunoGen, Inc. COM 45253H101 6151 3015353 SH SOLE 3015353 0 0 Incyte Corporation COM 45337C102 2356253 23499087 SH SOLE 23499087 0 0 Infinity Pharmaceuticals, Inc. COM 45665G303 784 580400 SH SOLE 580400 0 0 Insmed Incorporated COM PAR $.01 457669307 5292 400000 SH SOLE 400000 0 0 Intellia Therapeutics, Inc. COM 45826J105 13924 1062120 SH SOLE 1062120 0 0 Intra-Cellular Therapies, Inc. COM 46116X101 9192 609166 SH SOLE 609166 0 0 Invitae Corporation COM 46185L103 57869 7288300 SH SOLE 7288300 0 0 InVivo Therapeutics Holdings Corp. COM NEW 46186M209 1680 400000 SH SOLE 400000 0 0 Ionis Pharmaceuticals, Inc. COM 462222100 2733 57140 SH SOLE 57140 0 0 Juno Therapeutics, Inc. COM 48205A109 1508 80000 SH SOLE 80000 0 0 Karyopharm Therapeutics Inc. COM 48576U106 2040 216990 SH SOLE 216990 0 0 La Jolla Pharmaceutical Company COM PAR $.0001 2 503459604 241 13746 SH SOLE 13746 0 0 Ligand Pharmaceuticals Incorporated COM NEW 53220K504 7457 73386 SH SOLE 73386 0 0 Loxo Oncology, Inc. COM 548862101 4423 137735 SH SOLE 137735 0 0 MacroGenics, Inc. COM 556099109 7434 363676 SH SOLE 363676 0 0 Madrigal Pharmaceuticals, Inc. COM 558868105 861 57762 SH SOLE 57762 0 0 MediWound Ltd. ORD SHS M68830104 1035 226000 SH SOLE 226000 0 0 Merus N.V. COM N5749R100 24488 1160014 SH SOLE 1160014 0 0 Minerva Neurosciences, Inc. COM 603380106 3041 258805 SH SOLE 258805 0 0 Mirati Therapeutics, Inc. COM 60468T105 10779 2269198 SH SOLE 2269198 0 0 MyoKardia, Inc. COM 62857M105 1295 100000 SH SOLE 100000 0 0 Nabriva Therapeutics AG SPONSORED ADR 62957M104 2086 350000 SH SOLE 35000 0 0 Natera, Inc. COM 632307104 2919 249269 SH SOLE 249269 0 0 Neurocrine Biosciences, Inc. COM 64125C109 34653 895422 SH SOLE 895422 0 0 NeuroDerm Ltd. ORD SHS M74231107 12691 571667 SH SOLE 571667 0 0 Osiris Therapeutics, Inc. COM 68827R108 2451 499193 SH SOLE 499193 0 0 Palatin Technologies, Inc. COM PAR $.01 696077403 1035 2050000 SH SOLE 2050000 0 0 Progenics Pharmaceuticals, Inc. COM 743187106 27223 3150808 SH SOLE 3150808 0 0 ProNAi Therapeutics, Inc. COM 74346L101 298 200000 SH SOLE 200000 0 0 ProQR Therapeutics N.V. SHS EURO N71542109 1042 212698 SH SOLE 212698 0 0 Proteon Therapeutics, Inc. COM 74371L109 740 389394 SH SOLE 389394 0 0 Ra Pharmaceuticals, Inc. COM ADDED 74933V108 2703 177952 SH SOLE 177952 0 0 Rigel Pharmaceuticals, Inc. COM NEW 766559603 4805 2018882 SH SOLE 2018882 0 0 Ritter Pharmaceuticals, Inc. COM 767836109 1084 400000 SH SOLE 400000 0 0 Sage Therapeutics, Inc. COM 78667J108 10637 208328 SH SOLE 208328 0 0 Sangamo Therapeutics, Inc. COM 800677106 12370 4055876 SH SOLE 4055876 0 0 SCYNEXIS, Inc. COM 811292101 1492 467600 SH SOLE 467600 0 0 Seattle Genetics, Inc. COM 812578102 2412215 45711856 SH SOLE 45711856 0 0 Selecta Biosciences, Inc. COM 816212104 3013 175712 SH SOLE 175712 0 0 Seres Therapeutics, Inc. COM 81750R102 1238 125000 SH SOLE 125000 0 0 Spark Therapeutics, Inc. COM 84652J103 65785 1318341 SH SOLE 1318341 0 0 Spring Bank Pharmaceuticals, Inc. COM 849431101 1752 219298 SH SOLE 219298 0 0 Stemline Therapeutics, Inc. COM 85858C107 3568 333497 SH SOLE 333497 0 0 Sunesis Pharmaceuticals, Inc. COM PAR 867328700 2685 741665 SH SOLE 741665 0 0 Syros Pharmaceuticals, Inc. COM 87184Q107 2486 204465 SH SOLE 204465 0 0 Tenax Therapeutics, Inc. COM 88032L100 819 420000 SH SOLE 420000 0 0 Trevena, Inc. COM 89532E109 2646 450000 SH SOLE 450000 0 0 Trillium Therapeutics Inc. COM NEW 89620X506 2337 413697 SH SOLE 413697 0 0 Ultragenyx Pharmaceutical Inc. COM 90400D108 3516 50000 SH SOLE 50000 0 0 uniQure N.V. SHS N90064101 1288 230000 SH SOLE 230000 0 0 Versartis, Inc. COM 92529L102 28621 1920845 SH SOLE 1920845 0 0 Windtree Therapeutics, Inc. COM 97382D105 319 254973 SH SOLE 254973 0 0 Xencor, Inc. COM 98401F105 22953 872072 SH SOLE 872072 0 0 Zogenix, Inc. COM NEW 98978L204 10192 838809 SH SOLE 838809 0 0 Acorda Therapeutics, Inc. NOTE 1.75% 6/15/2021 00484MAA4 26570 35083000 PRN SOLE 35083000 0 0 Aegerion Pharmaceuticals, Inc. NOTE 2.0% 8/15/2019 00767EAB8 19103 26517000 PRN SOLE 26517000 0 0 Array BioPharma Inc. NOTE 3.0% 6/1/2020 04269XAA3 4195 3000000 PRN SOLE 3000000 0 0 BioMarin Pharmaceutical Inc. NOTE 1.875% 4/23/2017 09061GAD3 90531 22379000 PRN SOLE 22379000 0 0 BioMarin Pharmaceutical Inc. NOTE 0.75% 10/15/2018 09061GAE1 13733 12228000 PRN SOLE 12228000 0 0 Incyte Corporation NOTE 0.375% 11/15/2018 45337CAK8 518139 259000000 PRN SOLE 259000000 0 0 Incyte Corporation NOTE 1.25% 11/15/2020 45337CAL6 558650 274500000 PRN SOLE 274500000 0 0 Inotek Pharmaceuticals Corporation NOTE 5.75% 8/1/2021 45780VAB8 5167 5000000 PRN SOLE 5000000 0 0 Protalix BioTherapeutics, Inc. NOTE 4.5% 9/15/2018 74365AAB7 2293 3423000 PRN SOLE 3423000 0 0