Chief Financial Officer

0001144204-16-119409.txt : 20160815 0001144204-16-119409.hdr.sgml : 20160815 20160815160718 ACCESSION NUMBER: 0001144204-16-119409 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20160630 FILED AS OF DATE: 20160815 DATE AS OF CHANGE: 20160815 EFFECTIVENESS DATE: 20160815 FILER: COMPANY DATA: COMPANY CONFORMED NAME: BAKER BROS. ADVISORS LP CENTRAL INDEX KEY: 0001263508 IRS NUMBER: 134093645 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10519 FILM NUMBER: 161832676 BUSINESS ADDRESS: STREET 1: 667 MADISON AVE STREET 2: 21ST FLOOR CITY: NEW YORK STATE: NY ZIP: 10065 BUSINESS PHONE: 2123395600 MAIL ADDRESS: STREET 1: 667 MADISON AVE STREET 2: 21ST FLOOR CITY: NEW YORK STATE: NY ZIP: 10065 FORMER COMPANY: FORMER CONFORMED NAME: BAKER BROS ADVISORS LLC DATE OF NAME CHANGE: 20030911 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001263508 XXXXXXXX 06-30-2016 06-30-2016 false BAKER BROS. ADVISORS LP

667 Madison Ave 21st Floor New York NY 10065

13F HOLDINGS REPORT 028-10519 N Alexandra Toohey Chief Financial Officer 212-339-5690 /s/ Alexandra Toohey New York NY 08-15-2016 0 135 9537918 INFORMATION TABLE 2 infotable.xml AbbVie Inc. COM 00287Y109 889866 14373538 SH SOLE 14373538 0 0 ACADIA Pharmaceuticals Inc. COM 004225108 795813 24516738 SH SOLE 24516738 0 0 Acceleron Pharma Inc. COM 00434H108 977 28765 SH SOLE 28765 0 0 Achaogen, Inc. COM 004449104 379 100000 SH SOLE 100000 0 0 Achillion Pharmaceuticals, Inc. COM 00448Q201 19309 2475515 SH SOLE 2475515 0 0 Acorda Therapeutics, Inc. COM 00484M106 93376 3661082 SH SOLE 3661082 0 0 Adamas Pharmaceuticals, Inc. COM 00548A106 2614 172630 SH SOLE 172630 0 0 Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 815 100000 SH SOLE 600000 0 0 Advanced Accelerator Applications S.A. SPONSORED ADR 00790T100 25188 833089 SH SOLE 1666178 0 0 Aeglea BioTherapeutics, Inc. COM 00773J103 1965 404230 SH SOLE 404230 0 0 Aerie Pharmaceuticals, Inc. COM 00771V108 5269 299356 SH SOLE 299356 0 0 Affimed N.V. COM N01045108 992 400000 SH SOLE 400000 0 0 Agios Pharmaceuticals, Inc. COM 00847X104 8711 207915 SH SOLE 207915 0 0 Aimmune Therapeutics, Inc. COM 00900T107 7292 673908 SH SOLE 673908 0 0 Akari Therapeutics plc SPONSORED ADR 00972G108 6703 496901 SH SOLE 49690100 0 0 Alcobra Ltd. SHS M2239P109 10490 2336359 SH SOLE 2336359 0 0 Alder BioPharmaceuticals, Inc. COM 014339105 5427 217328 SH SOLE 217328 0 0 Aldeyra Therapeutics, Inc. COM 01438T106 808 142000 SH SOLE 142000 0 0 Alexion Pharmaceuticals, Inc. COM 015351109 763995 6543295 SH SOLE 6543295 0 0 Alkermes plc SHS G01767105 10816 250251 SH SOLE 250251 0 0 Alnylam Pharmaceuticals, Inc. COM 02043Q107 629 11340 SH SOLE 11340 0 0 Amarin Corporation plc SPONSORED ADR NEW 023111206 1732 801860 SH SOLE 801860 0 0 Aquinox Pharmaceuticals, Inc. COM 03842B101 51321 7752487 SH SOLE 7752487 0 0 Arbutus Biopharma Corporation COM 03879J100 628 180582 SH SOLE 180582 0 0 Array BioPharma Inc. COM 04269X105 15346 4310666 SH SOLE 4310666 0 0 Arrowhead Pharmaceuticals, Inc. COM 04280A100 5371 1009509 SH SOLE 1009509 0 0 Ascendis Pharma A/S SPONSORED ADR 04351P101 9893 745521 SH SOLE 745521 0 0 Assembly Biosciences, Inc. COM 045396108 1388 250000 SH SOLE 250000 0 0 Aurinia Pharmaceuticals Inc. COM 05156V102 2120 711499 SH SOLE 711499 0 0 BeiGene, Ltd. SPONSORED ADR 07725L102 56998 1912680 SH SOLE 24864840 0 0 Bellicum Pharmaceuticals, Inc. COM 079481107 63059 4865647 SH SOLE 4865647 0 0 BioCryst Pharmaceuticals, Inc. COM 09058V103 42630 15010534 SH SOLE 15010534 0 0 BioDelivery Sciences International, Inc. COM 09060J106 496 210021 SH SOLE 210021 0 0 BioMarin Pharmaceutical Inc. COM 09061G101 373944 4806483 SH SOLE 4806483 0 0 BioTime, Inc. *W EXP 10/1/201 09066L162 9 20084 SH SOLE 20084 0 0 bluebird bio, Inc. COM 09609G100 12725 293943 SH SOLE 293943 0 0 Catalyst Pharmaceuticals, Inc. COM 14888U101 3637 5122153 SH SOLE 5122153 0 0 Cellectis S.A. SPONSORED ADS 15117K103 1330 50000 SH SOLE 50000 0 0 Cerus Corporation COM 157085101 84572 13553275 SH SOLE 13553275 0 0 ChemoCentryx, Inc. COM 16383L106 220 49064 SH SOLE 49064 0 0 Chimerix, Inc. COM 16934W106 453 115216 SH SOLE 115216 0 0 Concert Pharmaceuticals, Inc. COM 206022105 5279 470058 SH SOLE 470058 0 0 Curis, Inc. COM 231269101 3119 1999303 SH SOLE 1999303 0 0 Cyclacel Pharmaceuticals, Inc. PFD CONV EX 6% 23254L207 83 13253 SH SOLE 13253 0 0 CytRx Corporation COM PAR $.001 232828509 1472 659995 SH SOLE 659995 0 0 DBV Technologies S.A. SPONSORED ADR 23306J101 179722 5509560 SH SOLE 2754780 0 0 Derma Sciences, Inc. COM PAR $.01 249827502 14784 3752390 SH SOLE 3752390 0 0 Dermira, Inc. COM 24983L104 9548 326428 SH SOLE 326428 0 0 Dimension Therapeutics, Inc. COM 25433V105 7511 1251881 SH SOLE 1251881 0 0 Dynavax Technologies Corporation COM NEW 268158201 1094 75000 SH SOLE 75000 0 0 Enanta Pharmaceuticals, Inc. COM 29251M106 1662 75357 SH SOLE 75357 0 0 Endocyte, Inc. COM 29269A102 3629 1130577 SH SOLE 1130577 0 0 Epizyme, Inc. COM 29428V104 2381 232481 SH SOLE 232481 0 0 Exelixis, Inc. COM 30161Q104 20150 2580000 SH SOLE 2580000 0 0 Five Prime Therapeutics, Inc. COM 33830X104 796 19247 SH SOLE 19247 0 0 Foamix Pharmaceuticals Ltd. SHS M46135105 14235 2241702 SH SOLE 2241702 0 0 Foundation Medicine, Inc. COM 350465100 390 20892 SH SOLE 20892 0 0 Galapagos NV SPONSORED ADR 36315X101 14416 259894 SH SOLE 259894 0 0 Genomic Health, Inc. COM 37244C101 353955 13668866 SH SOLE 13668866 0 0 GlycoMimetics, Inc. COM 38000Q102 2772 381235 SH SOLE 381235 0 0 GW Pharmaceuticals plc ADS 36197T103 1374 15000 SH SOLE 180000 0 0 Halozyme Therapeutics, Inc. COM 40637H109 15862 1838057 SH SOLE 1838057 0 0 Heron Therapeutics, Inc. COM 427746102 51573 2857250 SH SOLE 2857250 0 0 Idera Pharmaceuticals, Inc. COM NEW 45168K306 10711 7000977 SH SOLE 7000977 0 0 Ignyta, Inc. COM 451731103 3095 571000 SH SOLE 571000 0 0 Immune Design Corp. COM 45252L103 1215 148937 SH SOLE 148937 0 0 ImmunoGen, Inc. COM 45253H101 9287 3015353 SH SOLE 3015353 0 0 Incyte Corporation COM 45337C102 1879426 23498697 SH SOLE 23498697 0 0 Insmed Incorporated COM PAR $.01 457669307 14790 1500000 SH SOLE 1500000 0 0 Intellia Therapeutics, Inc. COM 45826J105 22676 1062120 SH SOLE 1062120 0 0 Intra-Cellular Therapies, Inc. COM 46116X101 23648 609166 SH SOLE 609166 0 0 Invitae Corporation COM 46185L103 48441 6554967 SH SOLE 6554967 0 0 InVivo Therapeutics Holdings Corp. COM NEW 46186M209 2312 400000 SH SOLE 400000 0 0 Ionis Pharmaceuticals, Inc. COM 462222100 1331 57140 SH SOLE 57140 0 0 Juno Therapeutics, Inc. COM 48205A109 3075 80000 SH SOLE 80000 0 0 Karyopharm Therapeutics Inc. COM 48576U106 1456 216990 SH SOLE 216990 0 0 La Jolla Pharmaceutical Company COM PAR $.0001 2 503459604 220 13746 SH SOLE 13746 0 0 Ligand Pharmaceuticals Incorporated COM NEW 53220K504 8753 73386 SH SOLE 73386 0 0 Loxo Oncology, Inc. COM 548862101 3193 137735 SH SOLE 137735 0 0 MacroGenics, Inc. COM 556099109 9816 363676 SH SOLE 363676 0 0 Mast Therapeutics, Inc. COM 576314108 1818 3868026 SH SOLE 3868026 0 0 Medgenics, Inc. COM NEW 58436Q203 4887 880539 SH SOLE 880539 0 0 Medivation, Inc. COM 58501N101 19892 329876 SH SOLE 329876 0 0 MediWound Ltd. ORD SHS M68830104 1783 226000 SH SOLE 226000 0 0 Merus N.V. COM N5749R100 8972 1122859 SH SOLE 1122859 0 0 Minerva Neurosciences, Inc. COM 603380106 5191 508405 SH SOLE 508405 0 0 Mirati Therapeutics, Inc. COM 60468T105 12390 2269198 SH SOLE 2269198 0 0 Nabriva Therapeutics AG SPONSORED ADR 62957M104 2625 350000 SH SOLE 35000 0 0 Natera, Inc. COM 632307104 5429 450000 SH SOLE 450000 0 0 Neurocrine Biosciences, Inc. COM 64125C109 40697 895422 SH SOLE 895422 0 0 NeuroDerm Ltd. ORD SHS M74231107 4956 305000 SH SOLE 305000 0 0 Novavax, Inc. COM 670002104 17297 2379254 SH SOLE 2379254 0 0 Ophthotech Corporation COM 683745103 1819 35649 SH SOLE 35649 0 0 Osiris Therapeutics, Inc. COM 68827R108 2541 499193 SH SOLE 499193 0 0 Palatin Technologies, Inc. COM PAR $.01 696077403 905 2050000 SH SOLE 2050000 0 0 Progenics Pharmaceuticals, Inc. COM 743187106 16754 3970250 SH SOLE 3970250 0 0 ProNAi Therapeutics, Inc. COM 74346L101 398 200000 SH SOLE 200000 0 0 ProQR Therapeutics N.V. SHS EURO N71542109 5973 1234095 SH SOLE 1234095 0 0 Proteon Therapeutics, Inc. COM 74371L109 2398 298591 SH SOLE 298591 0 0 Ritter Pharmaceuticals, Inc. COM 767836109 612 400000 SH SOLE 400000 0 0 Sage Therapeutics, Inc. COM 78667J108 6751 224048 SH SOLE 224048 0 0 Sangamo BioSciences, Inc. COM 800677106 23484 4055876 SH SOLE 4055876 0 0 SCYNEXIS, Inc. COM 811292101 1015 467600 SH SOLE 467600 0 0 Seattle Genetics, Inc. COM 812578102 1747287 43238967 SH SOLE 43238967 0 0 Selecta Biosciences, Inc. COM 816212104 2504 178950 SH SOLE 178950 0 0 Seres Therapeutics, Inc. COM 81750R102 3631 125000 SH SOLE 125000 0 0 Spark Therapeutics, Inc. COM 84652J103 67407 1318341 SH SOLE 1318341 0 0 Stemline Therapeutics, Inc. COM 85858C107 2258 333497 SH SOLE 333497 0 0 Sunesis Pharmaceuticals, Inc. COM NEW 867328601 2437 4450000 SH SOLE 4450000 0 0 Synta Pharmaceuticals Corp. COM 87162T206 526 2021728 SH SOLE 2021728 0 0 Syros Pharmaceuticals, Inc. COM 87184Q107 3711 204465 SH SOLE 204465 0 0 Tenax Therapeutics, Inc. COM 88032L100 1075 420000 SH SOLE 420000 0 0 TG Therapeutics, Inc. COM 88322Q108 12144 2003991 SH SOLE 2003991 0 0 Trevena, Inc. COM 89532E109 2835 450000 SH SOLE 450000 0 0 Trillium Therapeutics Inc. COM NEW 89620X506 1902 211792 SH SOLE 211792 0 0 Ultragenyx Pharmaceutical Inc. COM 90400D108 5424 110894 SH SOLE 110894 0 0 uniQure N.V. SHS N90064101 1695 230000 SH SOLE 230000 0 0 Versartis, Inc. COM 92529L102 30121 2723399 SH SOLE 2723399 0 0 Vitae Pharmaceuticals, Inc. COM 92847N103 6880 637597 SH SOLE 637597 0 0 Windtree Therapeutics, Inc. COM PAR 97382D105 492 254973 SH SOLE 254973 0 0 Xencor, Inc. COM 98401F105 16561 872072 SH SOLE 872072 0 0 XenoPort, Inc. COM 98411C100 24469 3475672 SH SOLE 3475672 0 0 Zogenix, Inc. COM NEW 98978L204 8050 1000000 SH SOLE 1000000 0 0 Acorda Therapeutics, Inc. Notes 1.75% 6/15/2021 NOTE 1.75% 6/15/2021 00484MAA4 67351 77083000 PRN SOLE 77083000 0 0 Aegerion Pharmaceuticals, Inc. Notes 2.0% 8/15/2019 NOTE 2.0% 8/15/2019 00767EAB8 14840 26517000 PRN SOLE 26517000 0 0 Array BioPharma Inc. Notes 3.0% 6/1/2020 NOTE 3.0% 6/1/2020 04269XAA3 2544 3000000 PRN SOLE 3000000 0 0 BioMarin Pharmaceutical Inc. Notes 1.875% 4/23/2017 NOTE 1.875% 4/23/2017 09061GAD3 84908 22379000 PRN SOLE 22379000 0 0 BioMarin Pharmaceutical Inc. Notes 0.75% 10/15/2018 NOTE 0.75% 10/15/2018 09061GAE1 13573 12228000 PRN SOLE 12228000 0 0 Clovis Oncology, Inc. 2.5% 9/15/2021 NOTE 2.5% 9/15/2021 189464AB6 51310 72758000 PRN SOLE 72758000 0 0 Corsicanto Ltd. 3.5% 1/15/2032 NOTE 3.5% 1/15/2032 220480AB3 15285 15000000 PRN SOLE 15000000 0 0 Exelixis, Inc. Notes 4.25% 8/15/2019 NOTE 4.25% 8/15/2019 30161QAC8 29654 20000000 PRN SOLE 20000000 0 0 Incyte Corporation Notes 0.375% 11/15/2018 144A NOTE 0.375% 11/15/2018 45337CAK8 431835 259000000 PRN SOLE 259000000 0 0 Incyte Corporation Notes 1.25% 11/15/2020 144A NOTE 1.25% 11/15/2020 45337CAL6 467293 274500000 PRN SOLE 274500000 0 0 Protalix BioTherapeutics, Inc. Notes 4.5% 9/15/18 NOTE 4.5% 9/15/2018 74365AAB7 2300 3423000 PRN SOLE 3423000 0 0 XenoPort, Inc. Notes 2.5% 2/1/2022 NOTE 2.5% 2/1/2022 98411CAB6 98471 100000000 PRN SOLE 100000000 0 0