Chief Financial Officer

0001144204-16-102596.txt : 20160516 0001144204-16-102596.hdr.sgml : 20160516 20160516161219 ACCESSION NUMBER: 0001144204-16-102596 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20160331 FILED AS OF DATE: 20160516 DATE AS OF CHANGE: 20160516 EFFECTIVENESS DATE: 20160516 FILER: COMPANY DATA: COMPANY CONFORMED NAME: BAKER BROS. ADVISORS LP CENTRAL INDEX KEY: 0001263508 IRS NUMBER: 134093645 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10519 FILM NUMBER: 161653891 BUSINESS ADDRESS: STREET 1: 667 MADISON AVE STREET 2: 21ST FLOOR CITY: NEW YORK STATE: NY ZIP: 10065 BUSINESS PHONE: 2123395600 MAIL ADDRESS: STREET 1: 667 MADISON AVE STREET 2: 21ST FLOOR CITY: NEW YORK STATE: NY ZIP: 10065 FORMER COMPANY: FORMER CONFORMED NAME: BAKER BROS ADVISORS LLC DATE OF NAME CHANGE: 20030911 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001263508 XXXXXXXX 03-31-2016 03-31-2016 false BAKER BROS. ADVISORS LP

667 Madison Ave 21st Floor New York NY 10065

13F HOLDINGS REPORT 028-10519 N Alexandra Toohey Chief Financial Officer 212-339-5690 /s/ Alexandra Toohey New York NY 05-16-2016 0 134 9482104 INFORMATION TABLE 2 infotable.xml AbbVie Inc. COM 00287Y109 821016 14373538 SH SOLE 14373538 0 0 ACADIA Pharmaceuticals Inc. COM 004225108 677019 24213838 SH SOLE 24213838 0 0 Acceleron Pharma, Inc. COM 00434H108 759 28765 SH SOLE 28765 0 0 Achaogen, Inc. COM 004449104 276 100000 SH SOLE 100000 0 0 Achillion Pharmaceuticals, Inc. COM 00448Q201 19111 2475515 SH SOLE 2475515 0 0 Acorda Therapeutics, Inc. COM 00484M106 96836 3661082 SH SOLE 3661082 0 0 Adamas Pharmaceuticals, Inc. COM 00548A106 2496 172630 SH SOLE 172630 0 0 Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 813 100000 SH SOLE 100000 0 0 Advanced Accelerator Applications S.A. SPONSORED ADR 00790T100 21538 615033 SH SOLE 1230066 0 0 Aerie Pharmaceuticals, Inc. COM 00771V108 3640 299356 SH SOLE 299356 0 0 Affimed N.V. COM N01045108 1496 400000 SH SOLE 400000 0 0 Agios Pharmaceuticals, Inc. COM 00847X104 12501 307915 SH SOLE 307915 0 0 Aimmune Therapeutics, Inc. COM 00900T107 3390 250000 SH SOLE 250000 0 0 Akari Therapeutics plc SPONSORED ADR 00972G108 5542 395882 SH SOLE 395882 0 0 Alcobra Ltd. SHS M2239P109 8855 2336359 SH SOLE 2336359 0 0 Aldeyra Therapeutics, Inc. COM 01438T106 595 142000 SH SOLE 142000 0 0 Alexion Pharmaceuticals, Inc. COM 015351109 910861 6542599 SH SOLE 6542599 0 0 Alkermes plc SHS G01767105 8556 250251 SH SOLE 250251 0 0 Alnylam Pharmaceuticals, Inc. COM 02043Q107 712 11340 SH SOLE 11340 0 0 Amarin Corporation plc SPONSORED ADR NEW 023111206 1227 801860 SH SOLE 801860 0 0 Anacor Pharmaceuticals, Inc. COM 032420101 273791 5122375 SH SOLE 5122375 0 0 Aptose Biosciences Inc. COM NEW 03835T200 100 33397 SH SOLE 33397 0 0 Aquinox Pharmaceuticals, Inc. COM 03842B101 68377 7752487 SH SOLE 7752487 0 0 Array BioPharma Inc. COM 04269X105 12716 4310666 SH SOLE 4310666 0 0 Arrowhead Pharmaceuticals, Inc. COM NEW 04280A100 4866 1009509 SH SOLE 1009509 0 0 Ascendis Pharma A/S SPONSORED ADR 04351P101 9377 505521 SH SOLE 505521 0 0 Assembly Biosciences, Inc. COM 045396108 1255 250000 SH SOLE 250000 0 0 aTyr Pharma, Inc. COM 002120103 8422 2137606 SH SOLE 2137606 0 0 Aurinia Pharmaceuticals Inc. COM 05156V102 2082 711499 SH SOLE 711499 0 0 BeiGene, Ltd. SPONSORED ADR 07725L102 56061 1912680 SH SOLE 24864840 0 0 Bellicum Pharmaceuticals, Inc. COM 079481107 45494 4865647 SH SOLE 4865647 0 0 BioCryst Pharmaceuticals, Inc. COM 09058V103 42480 15010534 SH SOLE 15010534 0 0 BioDelivery Sciences International, Inc. COM 09060J106 678 210021 SH SOLE 210021 0 0 BioMarin Pharmaceutical Inc. COM 09061G101 396439 4806483 SH SOLE 4806483 0 0 BioTime, Inc. *W EXP 10/1/201 09066L162 12 20084 SH SOLE 20084 0 0 bluebird bio, Inc. COM 09609G100 15000 352943 SH SOLE 352943 0 0 Catalyst Pharmaceuticals, Inc. COM 14888U101 6433 5498459 SH SOLE 5498459 0 0 Cellectis S.A. SPONSORED ADS 15117K103 1375 50000 SH SOLE 50000 0 0 Cerus Corporation COM 157085101 80371 13553275 SH SOLE 13553275 0 0 ChemoCentryx, Inc. COM 16383L106 122 49064 SH SOLE 49064 0 0 Chimerix, Inc. COM 16934W106 589 115216 SH SOLE 115216 0 0 Concert Pharmaceuticals, Inc. COM 206022105 6774 495908 SH SOLE 495908 0 0 Curis, Inc. COM 231269101 3219 1999303 SH SOLE 1999303 0 0 Cyclacel Pharmaceuticals, Inc. PFD CONV EX 6% 23254L207 76 13253 SH SOLE 13253 0 0 CytRx Corporation COM PAR $.001 232828509 1769 659995 SH SOLE 659995 0 0 DBV Technologies S.A. SPONSORED ADR 23306J101 179336 5509560 SH SOLE 2754780 0 0 Derma Sciences, Inc. COM PAR $.01 249827502 11632 3752390 SH SOLE 3752390 0 0 Dermira, Inc. COM 24983L104 5687 275000 SH SOLE 275000 0 0 Dimension Therapeutics, Inc. COM 25433V105 9802 1251881 SH SOLE 1251881 0 0 Discovery Laboratories, Inc. COM PAR 254668502 426 254973 SH SOLE 254973 0 0 Dynavax Technologies Corporation COM NEW 268158201 1443 75000 SH SOLE 75000 0 0 Enanta Pharmaceuticals, Inc. COM 29251M106 2213 75357 SH SOLE 75357 0 0 Endocyte, Inc. COM 29269A102 5257 1695865 SH SOLE 1695865 0 0 Epizyme, Inc. COM 29428V104 2818 232481 SH SOLE 232481 0 0 Exelixis, Inc. COM 30161Q104 10320 2580000 SH SOLE 2580000 0 0 Five Prime Therapeutics, Inc. COM 33830X104 782 19247 SH SOLE 19247 0 0 Foamix Pharmaceuticals Ltd. SHS M46135105 14616 2241702 SH SOLE 2241702 0 0 Foundation Medicine, Inc. COM 350465100 380 20892 SH SOLE 20892 0 0 Galapagos NV SPONSORED ADR 36315X101 12688 303394 SH SOLE 303394 0 0 Genomic Health, Inc. COM 37244C101 338354 13659832 SH SOLE 13659832 0 0 Global Blood Therapeutics, Inc. COM 37890U108 9516 600000 SH SOLE 600000 0 0 GW Pharmaceuticals plc ADS 36197T103 1082 15000 SH SOLE 15000 0 0 Halozyme Therapeutics, Inc. COM 40637H109 18287 1931057 SH SOLE 1931057 0 0 Heron Therapeutics, Inc. COM 427746102 55219 2907784 SH SOLE 2907784 0 0 Idera Pharmaceuticals, Inc. COM NEW 45168K306 13841 6990189 SH SOLE 6990189 0 0 Ignyta, Inc. COM 451731103 3866 571000 SH SOLE 571000 0 0 Immune Design Corp. COM 45252L103 1936 148937 SH SOLE 148937 0 0 ImmunoGen, Inc. COM 45253H101 37935 4452445 SH SOLE 4452445 0 0 Incyte Corporation COM 45337C102 1702933 23498460 SH SOLE 23498460 0 0 Insmed Incorporated COM PAR $.01 457669307 19005 1500000 SH SOLE 1500000 0 0 Intra-Cellular Therapies, Inc. COM 46116X101 16935 609166 SH SOLE 609166 0 0 Invitae Corporation COM 46185L103 67057 6554967 SH SOLE 6554967 0 0 InVivo Therapeutics Holdings Corp. COM NEW 46186M209 2792 400000 SH SOLE 400000 0 0 Ironwood Pharmaceuticals, Inc. COM CL A 46333X108 1851 169163 SH SOLE 169163 0 0 Ionis Pharmaceuticals, Inc. COM 462222100 2314 57140 SH SOLE 57140 0 0 Juno Therapeutics, Inc. COM 48205A109 3047 80000 SH SOLE 80000 0 0 Karyopharm Therapeutics Inc. COM 48576U106 1936 216990 SH SOLE 216990 0 0 La Jolla Pharmaceutical Company COM PAR $.0001 2 503459604 287 13746 SH SOLE 13746 0 0 Ligand Pharmaceuticals Incorporated COM NEW 53220K504 7859 73386 SH SOLE 73386 0 0 Lion Biotechnologies, Inc. COM 53619R102 5417 1066285 SH SOLE 1066285 0 0 Loxo Oncology, Inc. COM 548862101 3766 137735 SH SOLE 137735 0 0 MacroGenics, Inc. COM 556099109 6819 363676 SH SOLE 363676 0 0 Mast Therapeutics, Inc. COM 576314108 1309 4797442 SH SOLE 4797442 0 0 Medivation, Inc. COM 58501N101 15168 329876 SH SOLE 329876 0 0 Medgenics Inc. COM NEW 58436Q203 3366 765000 SH SOLE 765000 0 0 MediWound Ltd. ORD SHS M68830104 1824 226000 SH SOLE 226000 0 0 Mirati Therapeutics, Inc. COM 60468T105 69947 3268556 SH SOLE 3268556 0 0 Nabriva Therapeutics AG SPONSORED ADR 62957M104 3136 350000 SH SOLE 350000 0 0 Natera, Inc. COM 632307104 4284 450000 SH SOLE 450000 0 0 Neurocrine Biosciences, Inc. COM 64125C109 35414 895422 SH SOLE 895422 0 0 NeuroDerm Ltd. ORD SHS M74231107 4307 305000 SH SOLE 305000 0 0 Novavax, Inc. COM 670002104 12277 2379254 SH SOLE 2379254 0 0 Omeros Corporation COM 682143102 11493 749250 SH SOLE 749250 0 0 Ophthotech Corporation COM 683745103 1507 35649 SH SOLE 35649 0 0 Osiris Therapeutics, Inc. COM 68827R108 2850 499193 SH SOLE 499193 0 0 Palatin Technologies, Inc. COM PAR $.01 696077403 1107 2050000 SH SOLE 2050000 0 0 Progenics Pharmaceuticals, Inc. COM 743187106 18970 4350808 SH SOLE 4350808 0 0 ProNai Therapeutics, Inc. COM 74346L101 1348 200000 SH SOLE 200000 0 0 ProQR Therapeutics N.V. SHS EURO N71542109 6587 1349719 SH SOLE 1349719 0 0 Proteon Therapeutics Inc. COM 74371L109 2311 298591 SH SOLE 298591 0 0 Ritter Pharmaceuticals, Inc. COM 767836109 452 400000 SH SOLE 400000 0 0 Sage Therapeutics, Inc. COM 78667J108 7183 224048 SH SOLE 224048 0 0 Sangamo BioSciences, Inc. COM 800677106 24538 4055876 SH SOLE 4055876 0 0 Seattle Genetics, Inc. COM 812578102 1517126 43235267 SH SOLE 43235267 0 0 Seres Therapeutics, Inc. COM 81750R102 3320 125000 SH SOLE 125000 0 0 Spark Therapeutics, Inc. COM 84652J103 37253 1262382 SH SOLE 1262382 0 0 Stemline Therapeutics, Inc. COM 85858C107 1554 333497 SH SOLE 333497 0 0 Sunesis Pharmaceuticals, Inc. COM NEW 867328601 2403 4450000 SH SOLE 4450000 0 0 Arbutus Biopharma Corporation COM 03879J100 746 180582 SH SOLE 180582 0 0 Tenax Therapeutics, Inc. COM 88032L100 861 420000 SH SOLE 420000 0 0 TG Therapeutics, Inc. COM 88322Q108 17074 2003991 SH SOLE 2003991 0 0 Trevena, Inc. COM 89532E109 3722 450000 SH SOLE 450000 0 0 Trillium Therapeutics Inc. COM NEW 89620X506 1959 211792 SH SOLE 211792 0 0 Ultragenyx Pharmaceutical Inc. COM 90400D108 7844 123894 SH SOLE 123894 0 0 uniQure N.V. SHS N90064101 2732 230000 SH SOLE 230000 0 0 Versartis, Inc. COM 92529L102 25660 3199559 SH SOLE 3199559 0 0 Vitae Pharmaceuticals, Inc. COM 92847N103 4227 637597 SH SOLE 637597 0 0 Xencor, Inc. COM 98401F105 11703 872072 SH SOLE 872072 0 0 XenoPort, Inc. COM 98411C100 15675 3475672 SH SOLE 3475672 0 0 Zogenix, Inc. COM NEW 98978L204 9240 1000000 SH SOLE 1000000 0 0 Acorda Therapeutics, Inc. Notes 1.75% 6/15/2021 NOTE 1.75% 6/15/2021 00484MAA4 68456 77083000 PRN SOLE 77083000 0 0 Anacor Pharmaceuticals Inc. 2.0% 15 OCT 2021 NOTE 2.0% 10/15/2021 032420AC5 75337 42000000 PRN SOLE 42000000 0 0 Aegerion Pharmaceuticals, Inc. Notes 2.0% 8/15/2019 NOTE 2.0% 8/15/2019 00767EAB8 13526 26517000 PRN SOLE 26517000 0 0 Array BioPharma Inc. Notes 3.0% 6/1/2020 NOTE 3.0% 6/1/2020 04269XAA3 2382 3000000 PRN SOLE 3000000 0 0 BioMarin Pharmaceutical Inc. Notes 1.875% 4/23/2017 NOTE 1.875% 4/23/2017 09061GAD3 89825 22379000 PRN SOLE 22379000 0 0 BioMarin Pharmaceutical Inc. Notes 0.75% 10/15/2018 NOTE 0.75% 10/15/2018 09061GAE1 14125 12228000 PRN SOLE 12228000 0 0 Clovis Oncology Inc. 2.5% 9/15/2021 NOTE 2.5% 9/15/2021 189464AB6 87801 129300000 PRN SOLE 129300000 0 0 Corsicanto Ltd. 3.5% 1/15/2032 NOTE 3.5% 1/15/2032 220480AB3 12103 15000000 PRN SOLE 15000000 0 0 Exelixis, Inc. Notes 4.25% 8/15/2019 NOTE 4.25% 8/15/2019 30161QAC8 19775 20000000 PRN SOLE 20000000 0 0 Gilead Sciences, Inc. 1.625% 5/1/16 NOTE 1.625% 5/1/2016 375558AP8 85863 20944000 PRN SOLE 20944000 0 0 Incyte Corporation Notes 0.375% 11/15/2018 144A NOTE 0.375% 11/15/2018 45337CAK8 397943 259000000 PRN SOLE 259000000 0 0 Incyte Corporation Notes 1.25% 11/15/2020 144A NOTE 1.25% 11/15/2020 45337CAL6 432150 274500000 PRN SOLE 274500000 0 0 Protalix BioTherapeutics, Inc. Notes 4.5% 9/15/18 NOTE 4.5% 9/15/2018 74365AAB7 2334 3423000 PRN SOLE 3423000 0 0 Xenoport, Inc. Notes 2.5% 2/1/2022 NOTE 2.5% 2/1/2022 98411CAB6 73436 100000000 PRN SOLE 100000000 0 0