Chief Financial Officer

0001144204-16-082790.txt : 20160216 0001144204-16-082790.hdr.sgml : 20160215 20160216165218 ACCESSION NUMBER: 0001144204-16-082790 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20151231 FILED AS OF DATE: 20160216 DATE AS OF CHANGE: 20160216 EFFECTIVENESS DATE: 20160216 FILER: COMPANY DATA: COMPANY CONFORMED NAME: BAKER BROS. ADVISORS LP CENTRAL INDEX KEY: 0001263508 IRS NUMBER: 134093645 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10519 FILM NUMBER: 161429748 BUSINESS ADDRESS: STREET 1: 667 MADISON AVE STREET 2: 21ST FLOOR CITY: NEW YORK STATE: NY ZIP: 10065 BUSINESS PHONE: 2123395600 MAIL ADDRESS: STREET 1: 667 MADISON AVE STREET 2: 21ST FLOOR CITY: NEW YORK STATE: NY ZIP: 10065 FORMER COMPANY: FORMER CONFORMED NAME: BAKER BROS ADVISORS LLC DATE OF NAME CHANGE: 20030911 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001263508 XXXXXXXX 12-31-2015 12-31-2015 false BAKER BROS. ADVISORS LP

667 Madison Ave 21st Floor New York NY 10065

13F HOLDINGS REPORT 028-10519 N Alexandra Toohey Chief Financial Officer 212-339-5690 /s/ Alexandra Toohey New York NY 02-16-2016 0 133 12071272 INFORMATION TABLE 2 infotable.xml AbbVie Inc. COM 00287Y109 851488 14373538 SH SOLE 14373538 0 0 ACADIA Pharmaceuticals Inc. COM 004225108 730163 20481442 SH SOLE 20481442 0 0 Acceleron Pharma, Inc. COM 00434H108 1403 28765 SH SOLE 28765 0 0 Achaogen, Inc. COM 004449104 574 100000 SH SOLE 100000 0 0 Achillion Pharmaceuticals, Inc. COM 00448Q201 21580 2000000 SH SOLE 2000000 0 0 Acorda Therapeutics, Inc. COM 00484M106 153157 3580112 SH SOLE 3580112 0 0 Adaptimmune Therapeutics plc SPONDS ADR 00653A107 1206 100000 SH SOLE 100000 0 0 Advanced Accelerator Applications SA SPONSORED ADS 00790T100 17744 567454 SH SOLE 1134908 0 0 Aerie Pharmaceuticals, Inc. COM 00771V108 7289 299356 SH SOLE 299356 0 0 Affimed N.V. COM N01045108 2848 400000 SH SOLE 400000 0 0 Agios Pharmaceuticals, Inc. COM 00847X104 6492 100000 SH SOLE 100000 0 0 Aimmune Therapeutics, Inc. COM 00900T107 4613 250000 SH SOLE 250000 0 0 Akari Therapeutics PLC SPONSORED ADR 00972G108 5740 395882 SH SOLE 395882 0 0 Alcobra Ltd. SHS M2239P109 14672 2336359 SH SOLE 2336359 0 0 Aldeyra Therapeutics, Inc. COM 01438T106 963 142000 SH SOLE 142000 0 0 Alexion Pharmaceuticals, Inc. COM 015351109 1248001 6542599 SH SOLE 6542599 0 0 Alkermes PLC SHS G01767105 19865 250251 SH SOLE 250251 0 0 Alnylam Pharmaceuticals, Inc. COM 02043Q107 1068 11340 SH SOLE 11340 0 0 Amarin Corporation plc SPONS ADR NEW 023111206 4169 2205710 SH SOLE 2205710 0 0 Anacor Pharmaceuticals, Inc. COM 032420101 474307 4198520 SH SOLE 4198520 0 0 Aptose Biosciences, Inc. COM NEW 03835T200 84 33397 SH SOLE 33397 0 0 Aquinox Pharmaceuticals, Inc. COM 03842B101 84207 6747332 SH SOLE 6747332 0 0 Array BioPharma Inc. COM 04269X105 18191 4310666 SH SOLE 4310666 0 0 Arrowhead Research Corp. COM NEW 042797209 6208 1009509 SH SOLE 1009509 0 0 Ascendis Pharma A/S SPONSORED ADR 04351P101 9261 505521 SH SOLE 505521 0 0 Assembly Biosciences, Inc. COM 045396108 1878 250000 SH SOLE 250000 0 0 aTyr Pharma Inc. COM 002120103 22954 2335125 SH SOLE 2335125 0 0 Aurinia Pharmaceuticals Inc. COM 05156V102 1789 711499 SH SOLE 711499 0 0 Bellicum Pharmaceuticals, Inc. COM 079481107 98627 4865647 SH SOLE 4865647 0 0 BioCryst Pharmaceuticals, Inc. COM 09058V103 146727 14217779 SH SOLE 14217779 0 0 BioDelivery Sciences International, Inc. COM 09060J106 1006 210021 SH SOLE 210021 0 0 BioMarin Pharmaceutical Inc. COM 09061G101 431096 4115083 SH SOLE 4115083 0 0 BioTime, Inc. *W EXP 10/01/201 09066L162 24 20084 SH SOLE 20084 0 0 bluebird bio, Inc. COM 09609G100 9062 141105 SH SOLE 141105 0 0 Catalyst Pharmaceuticals, Inc. COM 14888U101 20275 8275630 SH SOLE 8275630 0 0 Cellectis S.A. SPONSORED ADS 15117K103 1552 50000 SH SOLE 50000 0 0 Cerus Corporation COM 157085101 85657 13553275 SH SOLE 13553275 0 0 ChemoCentryx, Inc. COM 16383L106 397 49064 SH SOLE 49064 0 0 Chimerix, Inc. COM 16934W106 1031 115216 SH SOLE 115216 0 0 Concert Pharmaceuticals, Inc. COM 206022105 9407 495908 SH SOLE 495908 0 0 Curis, Inc. COM 231269101 5818 1999303 SH SOLE 1999303 0 0 Cyclacel Pharmaceuticals, Inc. PFD CONV EX 6% 23254L207 52 13253 SH SOLE 13253 0 0 CytRx Corporation COM PAR $.001 232828509 1749 659995 SH SOLE 659995 0 0 DBV Technologies S.A. SPONSORED ADR 23306J101 198326 5462019 SH SOLE 2731009 0 0 Derma Sciences, Inc. COM PAR $.01 249827502 17148 3752390 SH SOLE 3752390 0 0 Dermira, Inc. COM 24983L104 9518 275000 SH SOLE 275000 0 0 Dimension Therapeutics, Inc. COM 25433V105 13925 1234481 SH SOLE 1234481 0 0 Discovery Laboratories, Inc. COM NEW 254668403 764 3569643 SH SOLE 3569643 0 0 Dyax Corp. COM 26746E103 312623 8310017 SH SOLE 8310017 0 0 Dynavax Technologies Corporation COM NEW 268158201 1812 75000 SH SOLE 75000 0 0 Enanta Pharmaceuticals, Inc. COM 29251M106 2488 75357 SH SOLE 75357 0 0 Endocyte, Inc. COM 29269A102 6800 1695865 SH SOLE 1695865 0 0 Epizyme, Inc. COM 29428V104 3724 232481 SH SOLE 232481 0 0 Five Prime Therapeutics, Inc. COM 33830X104 799 19247 SH SOLE 19247 0 0 Flexion Therapeutics, Inc. COM 33938J106 2826 146642 SH SOLE 146642 0 0 Foamix Pharmaceuticals Ltd. SHS M46135105 16601 2046967 SH SOLE 2046967 0 0 Foundation Medicine, Inc. COM 350465100 440 20892 SH SOLE 20892 0 0 Galapagos NV SPON ADR 36315X101 23220 369276 SH SOLE 369276 0 0 Genomic Health, Inc. COM 37244C101 480806 13659264 SH SOLE 13659264 0 0 Gilead Sciences, Inc. COM 375558103 25297 249995 SH SOLE 249995 0 0 Global Blood Therapeutics, Inc. COM 37890U108 12932 400000 SH SOLE 400000 0 0 Halozyme Therapeutics, Inc. COM 40637H109 33465 1931057 SH SOLE 1931057 0 0 Heron Therapeutics, Inc. COM 427746102 77638 2907784 SH SOLE 2907784 0 0 Idera Pharmaceuticals, Inc. COM NEW 45168K306 21578 6983107 SH SOLE 6983107 0 0 Ignyta, Inc. COM 451731103 7651 571000 SH SOLE 571000 0 0 Immune Design Corp. COM 45252L103 2991 148937 SH SOLE 148937 0 0 ImmunoGen, Inc. COM 45253H101 60420 4452445 SH SOLE 4452445 0 0 Incyte Corporation COM 45337C102 2112098 19475316 SH SOLE 19475316 0 0 Insmed, Inc. COM PAR $.01 457669307 18150 1000000 SH SOLE 1000000 0 0 Intra-Cellular Therapies, Inc. COM 46116X101 32767 609166 SH SOLE 609166 0 0 Invitae Corporation COM 46185L103 53816 6554967 SH SOLE 6554967 0 0 Ironwood Pharmaceuticals, Inc. COM CL A 46333X108 1961 169163 SH SOLE 169163 0 0 Ionis Pharmaceuticals, Inc. COM 462222100 3539 57140 SH SOLE 57140 0 0 Juno Therapeutics, Inc. COM 48205A109 3518 80000 SH SOLE 80000 0 0 Karyopharm Therapeutics Inc. COM 48576U106 2875 216990 SH SOLE 216990 0 0 La Jolla Pharmaceutical Company COM PAR $.0001 2 503459604 371 13746 SH SOLE 13746 0 0 Ligand Pharmaceuticals Incorporated COM NEW 53220K504 7957 73386 SH SOLE 73386 0 0 Lion Biotechnologies, Inc. COM 53619R102 14031 1817429 SH SOLE 1817429 0 0 Loxo Oncology, Inc. COM 548862101 3919 137735 SH SOLE 137735 0 0 MacroGenics, Inc. COM 556099109 11263 363676 SH SOLE 363676 0 0 Marinus Pharmaceuticals, Inc. COM 56854Q101 1528 200000 SH SOLE 200000 0 0 Mast Therapeutics, Inc. COM 576314108 2016 4797442 SH SOLE 4797442 0 0 Medivation, Inc. COM 58501N101 31892 659752 SH SOLE 659752 0 0 Medgenics Inc. COM NEW 58436Q203 4605 765000 SH SOLE 765000 0 0 MediWound Ltd. ORD SHS M68830104 1922 225000 SH SOLE 225000 0 0 Mirati Therapeutics, Inc. COM 60468T105 93380 2955074 SH SOLE 2955074 0 0 Nabriva Therapeutics AG SPONSORED ADR 62957M104 3367 350000 SH SOLE 350000 0 0 Natera, Inc. COM 632307104 2700 250000 SH SOLE 250000 0 0 Neurocrine Biosciences, Inc. COM 64125C109 48126 850739 SH SOLE 850739 0 0 NeuroDerm Ltd. ORD SHS M74231107 5200 305000 SH SOLE 305000 0 0 Novavax, Inc. COM 670002104 18422 2195687 SH SOLE 2195687 0 0 Ohr Pharmaceuticals, Inc. COM NEW 67778H200 2274 370370 SH SOLE 370370 0 0 Omeros Corporation COM 682143102 5289 336226 SH SOLE 336226 0 0 Ophthotech Corporation COM 683745103 2800 35649 SH SOLE 35649 0 0 Osiris Therapeutics, Inc. COM 68827R108 5182 499193 SH SOLE 499193 0 0 Palatin Technologies, Inc. COM PAR $ .01 696077403 1361 2050000 SH SOLE 2050000 0 0 Progenics Pharmaceuticals, Inc. COM 743187106 26670 4350808 SH SOLE 4350808 0 0 Pronai Therapeutics, Inc. COM 74346L101 3008 200000 SH SOLE 200000 0 0 ProQR Therapeutics N.V. SHS EURO N71542109 8578 988299 SH SOLE 988299 0 0 Proteon Therapeutics, Inc. COM 74371L109 4631 298591 SH SOLE 298591 0 0 Ritter Pharmaceuticals, Inc. COM 767836109 680 400000 SH SOLE 400000 0 0 Sage Therapeutics, Inc. COM 78667J108 6122 105000 SH SOLE 105000 0 0 Sangamo BioSciences, Inc. COM 800677106 37030 4055876 SH SOLE 4055876 0 0 Seattle Genetics, Inc. COM 812578102 1673743 37293728 SH SOLE 37293728 0 0 Seres Therapeutics, Inc. COM 81750R102 4386 125000 SH SOLE 125000 0 0 Spark Therapeutics, Inc. COM 84652J103 57199 1262382 SH SOLE 1262382 0 0 Stemline Therapeutics, Inc. COM 85858C107 2104 333497 SH SOLE 333497 0 0 Sunesis Pharmaceuticals, Inc. COM NEW 867328601 3994 4450000 SH SOLE 4450000 0 0 Arbutus Biopharma Corporation COM 03879J100 804 180582 SH SOLE 180582 0 0 Tenax Therapeutics Inc. COM 88032L100 1378 420000 SH SOLE 420000 0 0 TG Therapeutics, Inc. COM 88322Q108 23908 2003991 SH SOLE 2003991 0 0 Trevena, Inc. COM 89532E109 4725 450000 SH SOLE 450000 0 0 Trillium Therapeutics, Inc. COM NEW 89620X506 2671 211792 SH SOLE 211792 0 0 Ultragenyx Pharmaceutical Inc. COM 90400D108 13898 123894 SH SOLE 123894 0 0 UniQure N.V. SHS N90064101 496 30000 SH SOLE 30000 0 0 Versartis, Inc. COM 92529L102 40166 3241783 SH SOLE 3241783 0 0 Vitae Pharmaceuticals, Inc. COM 92847N103 3396 187597 SH SOLE 187597 0 0 Xencor, Inc. COM 98401F105 12750 872072 SH SOLE 872072 0 0 XenoPort, Inc. COM 98411C100 19081 3475672 SH SOLE 3475672 0 0 Zogenix, Inc. COM NEW 98978L204 14740 1000000 SH SOLE 1000000 0 0 Acorda Therapeutics, Inc. NOTE 1.75% 6/15/2021 00484MAA4 59297 51583000 PRN SOLE 51583000 0 0 Anacor Pharmaceuticals Inc. NOTE 2.0% 10/15/2021 032420AC5 152294 42000000 PRN SOLE 42000000 0 0 Aegerion Pharmaceuticals, Inc. NOTE 2.0% 8/15/2019 00767EAB8 17552 26517000 PRN SOLE 26517000 0 0 Array BioPharma Inc. NOTE 3.0% 6/1/2020 04269XAA3 2816 3000000 PRN SOLE 3000000 0 0 BioMarin Pharmaceutical Inc. NOTE 1.875% 4/23/2017 09061GAD3 115158 22379000 PRN SOLE 22379000 0 0 BioMarin Pharmaceutical Inc. NOTE 0.75% 10/15/2018 09061GAE1 15698 12228000 PRN SOLE 12228000 0 0 Clovis Oncology Inc. NOTE 2.5% 9/15/2021 189464AB6 110982 129300000 PRN SOLE 129300000 0 0 Corsicanto Ltd. NOTE 3.5% 1/15/2032 220480AB3 4480 5000000 PRN SOLE 5000000 0 0 Exelixis, Inc. NOTE 4.25% 8/15/2019 30161QAC8 23260 20000000 PRN SOLE 20000000 0 0 Gilead Sciences Inc. NOTE 1.625% 5/1/2016 375558AP8 93469 20944000 PRN SOLE 20944000 0 0 Incyte Corporation NOTE 0.375% 11/15/2018 144A 45337CAK8 556688 259000000 PRN SOLE 259000000 0 0 Incyte Corporation NOTE 1.25% 11/15/2020 144A 45337CAL6 596530 274500000 PRN SOLE 274500000 0 0 Protalix BioTherapeutics, Inc. NOTE 4.50% 9/15/2018 74365AAB7 2375 3423000 PRN SOLE 3423000 0 0