Chief Financial Officer

0001144204-15-065993.txt : 20151116 0001144204-15-065993.hdr.sgml : 20151116 20151116160748 ACCESSION NUMBER: 0001144204-15-065993 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20150930 FILED AS OF DATE: 20151116 DATE AS OF CHANGE: 20151116 EFFECTIVENESS DATE: 20151116 FILER: COMPANY DATA: COMPANY CONFORMED NAME: BAKER BROS. ADVISORS LP CENTRAL INDEX KEY: 0001263508 IRS NUMBER: 134093645 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10519 FILM NUMBER: 151234425 BUSINESS ADDRESS: STREET 1: 667 MADISON AVE STREET 2: 21ST FLOOR CITY: NEW YORK STATE: NY ZIP: 10065 BUSINESS PHONE: 2123395600 MAIL ADDRESS: STREET 1: 667 MADISON AVE STREET 2: 21ST FLOOR CITY: NEW YORK STATE: NY ZIP: 10065 FORMER COMPANY: FORMER CONFORMED NAME: BAKER BROS ADVISORS LLC DATE OF NAME CHANGE: 20030911 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001263508 XXXXXXXX 09-30-2015 09-30-2015 false BAKER BROS. ADVISORS LP

667 Madison Ave 21st Floor New York NY 10065

13F HOLDINGS REPORT 028-10519 N Alexandra Toohey Chief Financial Officer 212-339-5690 /s/ Alexandra Toohey New York NY 11-16-2015 0 133 10823762 INFORMATION TABLE 2 infotable.xml AbbVie Inc. COM 00287Y109 782064 14373538 SH SOLE 14373538 0 0 ACADIA Pharmaceuticals Inc. COM 004225108 677321 20481442 SH SOLE 20481442 0 0 Acceleron Pharma, Inc. COM 00434H108 716 28765 SH SOLE 28765 0 0 Achaogen, Inc. COM 004449104 576 100000 SH SOLE 100000 0 0 Achillion Pharmaceuticals, Inc. COM 00448Q201 13820 2000000 SH SOLE 2000000 0 0 Acorda Therapeutics, Inc. COM 00484M106 29078 1096876 SH SOLE 1096876 0 0 Adaptimmune Therapeutics plc ADR SPONDS ADR 00653A107 1197 100000 SH SOLE 100000 0 0 Aerie Pharmaceuticals, Inc. COM 00771V108 5311 299356 SH SOLE 299356 0 0 Affimed N.V. COM N01045108 2468 400000 SH SOLE 400000 0 0 Agios Pharmaceuticals, Inc. COM 00847X104 7059 100000 SH SOLE 100000 0 0 Aimmune Therapeutics, Inc. COM 00900T107 6330 250000 SH SOLE 250000 0 0 Akari Therapeutics PLC ADR SPONSORED ADR 00972G108 9499 395882 SH SOLE 395882 0 0 Alcobra Ltd. SHS M2239P109 9905 1639871 SH SOLE 1639871 0 0 Alder Biopharmaceuticals Inc. COM 014339105 16820 513439 SH SOLE 513439 0 0 Aldeyra Therapeutics, Inc. COM 01438T106 828 142000 SH SOLE 142000 0 0 Alexion Pharmaceuticals, Inc. COM 015351109 1023197 6542599 SH SOLE 6542599 0 0 Alnylam Pharmaceuticals, Inc. COM 02043Q107 911 11340 SH SOLE 11340 0 0 Amarin Corporation plc SPONS ADR NEW 023111206 4257 2205710 SH SOLE 2205710 0 0 Anacor Pharmaceuticals, Inc. COM 032420101 486779 4135412 SH SOLE 4135412 0 0 Aptose Biosciences, Inc. COM NEW 03835T200 144 33397 SH SOLE 33397 0 0 Aquinox Pharmaceuticals, Inc. COM 03842B101 94935 6747332 SH SOLE 6747332 0 0 Array BioPharma Inc. COM 04269X105 19657 4310666 SH SOLE 4310666 0 0 Arrowhead Research Corp. COM NEW 042797209 5815 1009509 SH SOLE 1009509 0 0 Ascendis Pharma A/S SPONSORED ADR 04351P101 7709 435540 SH SOLE 435540 0 0 Assembly Biosciences, Inc. COM 045396108 2390 250000 SH SOLE 250000 0 0 aTyr Pharma Inc. COM 002120103 23958 2335125 SH SOLE 2335125 0 0 Aurinia Pharmaceuticals Inc. COM 05156V102 1999 711499 SH SOLE 711499 0 0 Bellerophon Therapeutics, Inc. COM 078771102 1832 352928 SH SOLE 352928 0 0 Bellicum Pharmaceuticals, Inc. COM 079481107 60889 4190594 SH SOLE 4190594 0 0 BioCryst Pharmaceuticals, Inc. COM 09058V103 160856 14110179 SH SOLE 14110179 0 0 BioDelivery Sciences International, Inc. COM 09060J106 1168 210021 SH SOLE 210021 0 0 BioMarin Pharmaceutical Inc. COM 09061G101 429321 4076353 SH SOLE 4076353 0 0 BioTime, Inc. Rights *W EXP 10/01/201 09066L162 17 20084 SH SOLE 20084 0 0 bluebird bio, Inc. COM 09609G100 12072 141105 SH SOLE 141105 0 0 Catalyst Pharmaceuticals, Inc. COM 14888U101 22007 7335692 SH SOLE 7335692 0 0 Cellectis S.A. SPONSORED ADS 15117K103 1318 50000 SH SOLE 50000 0 0 Cerus Corporation COM 157085101 61532 13553275 SH SOLE 13553275 0 0 ChemoCentryx, Inc. COM 16383L106 297 49064 SH SOLE 49064 0 0 Chimerix, Inc. COM 16934W106 4401 115216 SH SOLE 115216 0 0 Clovis Oncology, Inc. COM 189464100 18634 202630 SH SOLE 202630 0 0 Concert Pharmaceuticals, Inc. COM 206022105 9308 495908 SH SOLE 495908 0 0 Curis, Inc. COM 231269101 4039 1999303 SH SOLE 1999303 0 0 Cyclacel Pharmaceuticals, Inc. Pfd. Conv. Ex 6% PFD CONV EX 6% 23254L207 62 13253 SH SOLE 13253 0 0 CytRx Corporation COM PAR $.001 232828509 3128 1319989 SH SOLE 1319989 0 0 DBV Technologies S.A. SPONSORED ADR 23306J101 194393 5462019 SH SOLE 2731009 0 0 Derma Sciences, Inc. COM PAR $.01 249827502 16286 3457841 SH SOLE 3457841 0 0 Dermira, Inc. COM 24983L104 6419 275000 SH SOLE 275000 0 0 Discovery Laboratories, Inc. COM NEW 254668403 1071 3569643 SH SOLE 3569643 0 0 Dyax Corp. COM 26746E103 144349 7561480 SH SOLE 7561480 0 0 Dynavax Technologies Corporation COM NEW 268158201 1841 75000 SH SOLE 75000 0 0 Enanta Pharmaceuticals, Inc. COM 29251M106 2723 75357 SH SOLE 75357 0 0 Endocyte, Inc. COM 29269A102 6213 1356552 SH SOLE 1356552 0 0 Epizyme, Inc. COM 29428V104 2990 232481 SH SOLE 232481 0 0 Five Prime Therapeutics, Inc. COM 33830X104 296 19247 SH SOLE 19247 0 0 Foamix Pharmaceuticals Ltd. SHS M46135105 15004 2046967 SH SOLE 2046967 0 0 Foundation Medicine, Inc. COM 350465100 385 20892 SH SOLE 20892 0 0 Galapagos NV ADR SPON ADR 36315X101 15033 369276 SH SOLE 369276 0 0 Genomic Health Inc. COM 37244C101 289011 13658328 SH SOLE 13658328 0 0 Gilead Sciences, Inc. COM 375558103 24547 249995 SH SOLE 249995 0 0 Global Blood Therapeutics, Inc. COM 37890U108 8432 200000 SH SOLE 200000 0 0 Halozyme Therapeutics, Inc. COM 40637H109 25934 1931057 SH SOLE 1931057 0 0 Heron Therapeutics, Inc. COM 427746102 70950 2907784 SH SOLE 2907784 0 0 Idera Pharmaceuticals, Inc. COM NEW 45168K306 23370 6976162 SH SOLE 6976162 0 0 Ignyta, Inc. COM 451731103 5013 571000 SH SOLE 571000 0 0 Immune Design Corp. COM 45252L103 1817 148937 SH SOLE 148937 0 0 ImmunoGen, Inc. COM 45253H101 34061 3548040 SH SOLE 3548040 0 0 Incyte Corporation COM 45337C102 2148673 19474969 SH SOLE 19474969 0 0 Insmed, Inc. COM PAR $.01 457669307 29405 1583490 SH SOLE 1583490 0 0 Intra-Cellular Therapies, Inc. COM 46116X101 24391 609166 SH SOLE 609166 0 0 Invitae Corporation COM 46185L103 47327 6554967 SH SOLE 6554967 0 0 Ironwood Pharmaceuticals, Inc. COM CL A 46333X108 1763 169163 SH SOLE 169163 0 0 Isis Pharmaceuticals, Inc. COM 464330109 2310 57140 SH SOLE 57140 0 0 Juno Therapeutics, Inc. COM 48205A109 3255 80000 SH SOLE 80000 0 0 Karyopharm Therapeutics Inc. COM 48576U106 2285 216990 SH SOLE 216990 0 0 La Jolla Pharmaceutical Company COM PAR $.0001 2 503459604 11450 412008 SH SOLE 412008 0 0 Ligand Pharmaceuticals Incorporated COM NEW 53220K504 6286 73386 SH SOLE 73386 0 0 Lion Biotechnologies, Inc. COM 53619R102 10468 1817429 SH SOLE 1817429 0 0 Loxo Oncology, Inc. COM 548862101 1748 100000 SH SOLE 100000 0 0 MacroGenics, Inc. COM 556099109 7449 347776 SH SOLE 347776 0 0 Marinus Pharmaceuticals, Inc. COM 56854Q101 1668 200000 SH SOLE 200000 0 0 Mast Therapeutics, Inc. COM 576314108 2730 4707464 SH SOLE 4707464 0 0 Medivation, Inc. COM 58501N101 28039 659752 SH SOLE 659752 0 0 MediWound Ltd. ORD SHS M68830104 1717 225000 SH SOLE 225000 0 0 Mirati Therapeutics, Inc. COM 60468T105 101714 2955074 SH SOLE 2955074 0 0 Nabriva Therapeutics AG SPONSORED ADR 62957M104 3325 350000 SH SOLE 350000 0 0 Natera, Inc. COM 632307104 2713 250000 SH SOLE 250000 0 0 Neurocrine Biosciences, Inc. COM 64125C109 29872 750739 SH SOLE 750739 0 0 NeuroDerm Ltd. ORD SHS M74231107 6304 305000 SH SOLE 305000 0 0 Novavax, Inc. COM 670002104 15524 2195687 SH SOLE 2195687 0 0 Ohr Pharmaceuticals, Inc. COM NEW 67778H200 1022 370370 SH SOLE 370370 0 0 Omeros Corporation COM 682143102 3685 336226 SH SOLE 336226 0 0 Ophthotech Corporation COM 683745103 1444 35649 SH SOLE 35649 0 0 Osiris Therapeutics, Inc. COM 68827R108 9220 499193 SH SOLE 499193 0 0 Palatin Technologies, Inc. COM PAR $ .01 696077403 1661 2050000 SH SOLE 2050000 0 0 Progenics Pharmaceuticals, Inc. COM 743187106 24887 4350808 SH SOLE 4350808 0 0 Pronai Therapeutics, Inc. COM 74346L101 4104 200000 SH SOLE 200000 0 0 ProQR Therapeutics N.V. SHS EURO N71542109 14400 988299 SH SOLE 988299 0 0 Proteon Therapeutics, Inc. COM 74371L109 3820 274617 SH SOLE 274617 0 0 Repros Therapeutics Inc. COM NEW 76028H209 14533 1955944 SH SOLE 1955944 0 0 Ritter Pharmaceuticals, Inc. COM 767836109 820 400000 SH SOLE 400000 0 0 Sage Therapeutics, Inc. COM 78667J108 4444 105000 SH SOLE 105000 0 0 Sangamo BioSciences, Inc. COM 800677106 21183 3755876 SH SOLE 3755876 0 0 Seattle Genetics, Inc. COM 812578102 1389307 36029746 SH SOLE 36029746 0 0 Seres Therapeutics, Inc. COM 81750R102 3705 125000 SH SOLE 125000 0 0 Spark Therapeutics, Inc. COM 84652J103 52679 1262382 SH SOLE 1262382 0 0 Stemline Therapeutics, Inc. COM 85858C107 2945 333497 SH SOLE 333497 0 0 Sunesis Pharmaceuticals, Inc. COM NEW 867328601 2592 3200000 SH SOLE 3200000 0 0 Synergy Pharmaceuticals, Inc. COM NEW 871639308 356 67100 SH SOLE 67100 0 0 Arbutus Biopharma Corporation COM 03879J100 1100 180582 SH SOLE 180582 0 0 Tenax Therapeutics Inc. COM 88032L100 1260 420000 SH SOLE 420000 0 0 TG Therapeutics, Inc. COM 88322Q108 20200 2003991 SH SOLE 2003991 0 0 Threshold Pharmaceuticals, Inc. COM NEW 885807206 11907 2925519 SH SOLE 2925519 0 0 Trevena, Inc. COM 89532E109 4658 450000 SH SOLE 450000 0 0 Trillium Therapeutics, Inc. COM NEW 89620X506 821 63014 SH SOLE 63014 0 0 Ultragenyx Pharmaceuticals COM 90400D108 11932 123894 SH SOLE 123894 0 0 UniQure B.V. SHS N90064101 614 30000 SH SOLE 30000 0 0 Versartis, Inc. COM 92529L102 37378 3241783 SH SOLE 3241783 0 0 Vitae Pharmaceuticals, Inc. COM 92847N103 2065 187597 SH SOLE 187597 0 0 Xencor, Inc. COM 98401F105 10665 872072 SH SOLE 872072 0 0 XenoPort, Inc. COM 98411C100 22585 6508622 SH SOLE 6508622 0 0 Zafgen, Inc. COM 98885E103 12472 390346 SH SOLE 390346 0 0 Zogenix, Inc. COM NEW 98978L204 24278 1798365 SH SOLE 1798365 0 0 Acorda Therapeutics, Inc. Notes 1.75% 6/15/2021 CONV BONDS 00484MAA4 54123 59583000 PRN SOLE 59583000 0 0 Aegerion Pharmaceuticals, Inc. Notes 2.0% 8/15/2019 CONV BONDS 00767EAB8 19873 26517000 PRN SOLE 26517000 0 0 Array BioPharma Inc. Notes 3.0% 6/1/2020 CONV BONDS 04269XAA3 2921 3000000 PRN SOLE 3000000 0 0 BioMarin Pharmaceutical Inc. Notes 1.875% 4/23/2017 CONV BONDS 09061GAD3 115619 22379000 PRN SOLE 22379000 0 0 BioMarin Pharmaceutical Inc. Notes 0.75% 10/15/2018 CONV BONDS 09061GAE1 15899 12228000 PRN SOLE 12228000 0 0 Clovis Oncology Inc. 2.5% 9/15/2021 CONV BONDS 189464AB6 215311 129300000 PRN SOLE 129300000 0 0 Exelisis, Inc. Notes 4.25% 8/15/2019 CONV BONDS 30161QAC8 23988 20000000 PRN SOLE 20000000 0 0 Gilead, Inc. 1.625% 5/1/16 CONV BONDS 375558AP8 90326 20944000 PRN SOLE 20944000 0 0 Incyte Corporation Notes 0.375% 11/15/2018 144A CONV BONDS 45337CAK8 559636 259000000 PRN SOLE 259000000 0 0 Incyte Corporation Notes 1.25% 11/15/2020 144A CONV BONDS 45337CAL6 598696 274500000 PRN SOLE 274500000 0 0 Protalix BioTherapeutics, Inc. Notes 4.5% 9/15/18 CONV BONDS 74365AAB7 2450 3423000 PRN SOLE 3423000 0 0