Chief Financial Officer

0001144204-15-049845.txt : 20150814 0001144204-15-049845.hdr.sgml : 20150814 20150814161940 ACCESSION NUMBER: 0001144204-15-049845 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20150630 FILED AS OF DATE: 20150814 DATE AS OF CHANGE: 20150814 EFFECTIVENESS DATE: 20150814 FILER: COMPANY DATA: COMPANY CONFORMED NAME: BAKER BROS. ADVISORS LP CENTRAL INDEX KEY: 0001263508 IRS NUMBER: 134093645 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10519 FILM NUMBER: 151056117 BUSINESS ADDRESS: STREET 1: 667 MADISON AVE STREET 2: 21ST FLOOR CITY: NEW YORK STATE: NY ZIP: 10065 BUSINESS PHONE: 2123395600 MAIL ADDRESS: STREET 1: 667 MADISON AVE STREET 2: 21ST FLOOR CITY: NEW YORK STATE: NY ZIP: 10065 FORMER COMPANY: FORMER CONFORMED NAME: BAKER BROS ADVISORS LLC DATE OF NAME CHANGE: 20030911 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001263508 XXXXXXXX 06-30-2015 06-30-2015 false BAKER BROS. ADVISORS LP

667 Madison Ave 21st Floor New York NY 10065

13F HOLDINGS REPORT 028-10519 N Alexandra Toohey Chief Financial Officer 212-339-5690 /s/ Alexandra Toohey New York NY 08-14-2015 0 126 11400413 INFORMATION TABLE 2 infotable.xml AbbVie Inc. COM 00287Y109 965758 14373538 SH SOLE 14373538 0 0 ACADIA Pharmaceuticals Inc. COM 004225108 857763 20481442 SH SOLE 20481442 0 0 Acceleron Pharma, Inc. COM 00434H108 910 28765 SH SOLE 28765 0 0 Achaogen, Inc. COM 004449104 603 100000 SH SOLE 100000 0 0 Achillion Pharmaceuticals, Inc. COM 00448Q201 13500 1523739 SH SOLE 1523739 0 0 Acorda Therapeutics, Inc. COM 00484M106 24628 738916 SH SOLE 738916 0 0 Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 1833 100000 SH SOLE 100000 0 0 Aerie Pharmaceuticals, Inc. COM 00771V108 5284 299356 SH SOLE 299356 0 0 Affimed N.V. COM N01045108 5388 400000 SH SOLE 400000 0 0 Agios Pharmaceuticals, Inc. COM 00847X104 11114 100000 SH SOLE 100000 0 0 Alcobra Ltd. SHS M2239P109 11706 1789871 SH SOLE 1789871 0 0 Alder Biopharmaceuticals Inc. COM 014339105 47233 891688 SH SOLE 891688 0 0 Aldeyra Therapeutics, Inc. COM 01438T106 1102 142000 SH SOLE 142000 0 0 Alexion Pharmaceuticals, Inc. COM 015351109 1182706 6542599 SH SOLE 6542599 0 0 Alnylam Pharmaceuticals, Inc. COM 02043Q107 1359 11340 SH SOLE 11340 0 0 Amarin Corporation plc SPONSORED ADR 023111206 5426 2205710 SH SOLE 2205710 0 0 Anacor Pharmaceuticals, Inc. COM 032420101 280722 3625498 SH SOLE 3625498 0 0 Aptose Biosciences, Inc. COM 03835T200 170 33397 SH SOLE 33397 0 0 Aquinox Pharmaceuticals, Inc. COM 03842B101 8310 1197366 SH SOLE 1197366 0 0 Array BioPharma Inc. COM 04269X105 39529 5482505 SH SOLE 5482505 0 0 Arrowhead Research Corp. COM 042797209 7218 1009509 SH SOLE 1009509 0 0 Ascendis Pharma A/S SPONSORED ADR 04351P101 1768 100000 SH SOLE 100000 0 0 Assembly Biosciences, Inc. COM 045396108 4815 250000 SH SOLE 250000 0 0 aTyr Pharma Inc. COM 002120103 43247 2335125 SH SOLE 2335125 0 0 Aurinia Pharmaceuticals Inc. COM 05156V102 2130 711499 SH SOLE 711499 0 0 Bellerophon Therapeutics, Inc. COM 078771102 2776 350000 SH SOLE 350000 0 0 Bellicum Pharmaceuticals, Inc. COM 079481107 89134 4190594 SH SOLE 4190594 0 0 BioCryst Pharmaceuticals, Inc. COM 09058V103 172849 11577299 SH SOLE 11577299 0 0 BioDelivery Sciences International, Inc. COM 09060J106 1672 210021 SH SOLE 210021 0 0 BioMarin Pharmaceutical Inc. COM 09061G101 560148 4095247 SH SOLE 4095247 0 0 Biota Pharmaceuticals, Inc. COM 090694100 1719 830440 SH SOLE 830440 0 0 BioTime, Inc. Rights WARRANTS 09066L162 23 20084 SH SOLE 20084 0 0 bluebird bio, Inc. COM 09609G100 25442 151105 SH SOLE 151105 0 0 Catalyst Pharmaceuticals, Inc. COM 14888U101 30296 7335692 SH SOLE 7335692 0 0 Cellectis S.A. SPONSORED ADR 15117K103 1804 50000 SH SOLE 50000 0 0 Cerus Corporation COM 157085101 70341 13553275 SH SOLE 13553275 0 0 ChemoCentryx, Inc. COM 16383L106 404 49064 SH SOLE 49064 0 0 Chimerix, Inc. COM 16934W106 5323 115216 SH SOLE 115216 0 0 Clovis Oncology, Inc. COM 189464100 17807 202630 SH SOLE 202630 0 0 Concert Pharmaceuticals, Inc. COM 206022105 7384 495908 SH SOLE 495908 0 0 Curis, Inc. COM 231269101 3567 1077663 SH SOLE 1077663 0 0 Cyclacel Pharmaceuticals, Inc. Pfd. Conv. Ex 6% PFD CONV EX 6% 23254L207 85 13253 SH SOLE 13253 0 0 CytRx Corporation COM 232828509 4910 1319989 SH SOLE 1319989 0 0 DBV Technologies S.A. SPONSORED ADR 23306J101 55451 1862019 SH SOLE 1862019 0 0 Derma Sciences, Inc. COM 249827502 24758 3457841 SH SOLE 3457841 0 0 Dermira, Inc. COM 24983L104 1755 100000 SH SOLE 100000 0 0 Discovery Laboratories, Inc. COM 254668403 2427 3569643 SH SOLE 3569643 0 0 Dyax Corp. COM 26746E103 210056 7926630 SH SOLE 7926630 0 0 Enanta Pharmaceuticals, Inc. COM 29251M106 3390 75357 SH SOLE 75357 0 0 Epizyme, Inc. COM 29428V104 5580 232481 SH SOLE 232481 0 0 Five Prime Therapeutics, Inc. COM 33830X104 478 19247 SH SOLE 19247 0 0 Foamix Pharmaceuticals Ltd. SHS M46135105 20981 2046967 SH SOLE 2046967 0 0 Foundation Medicine, Inc. COM 350465100 707 20892 SH SOLE 20892 0 0 Galapagos NV SPONSORED ADR 36315X101 19018 369276 SH SOLE 369276 0 0 Genomic Health Inc. COM 37244C101 379545 13657598 SH SOLE 13657598 0 0 Gilead Sciences, Inc. COM 375558103 29269 249995 SH SOLE 249995 0 0 Halozyme Therapeutics, Inc. COM 40637H109 43603 1931057 SH SOLE 1931057 0 0 Heron Therapeutics, Inc. COM 427746102 87491 2807784 SH SOLE 2807784 0 0 Idera Pharmaceuticals, Inc. COM 45168K306 25862 6970902 SH SOLE 6970902 0 0 Ignyta, Inc. COM 451731103 8616 571000 SH SOLE 571000 0 0 Immune Design Corp. COM 45252L103 3076 148937 SH SOLE 148937 0 0 ImmunoGen, Inc. COM 45253H101 33368 2320424 SH SOLE 2320424 0 0 Incyte Corporation COM 45337C102 1549140 14865559 SH SOLE 14845559 0 0 Insmed, Inc. COM 457669307 38669 1583490 SH SOLE 1583490 0 0 Intra-Cellular Therapies, Inc. COM 46116X101 3328 104166 SH SOLE 104166 0 0 Invitae Corporation COM 46185L103 97538 6554967 SH SOLE 6554967 0 0 Ironwood Pharmaceuticals, Inc. COM 46333X108 2040 169163 SH SOLE 169163 0 0 Isis Pharmaceuticals, Inc. COM 464330109 3288 57140 SH SOLE 57140 0 0 Juno Therapeutics, Inc. COM 48205A109 4266 80000 SH SOLE 80000 0 0 Karyopharm Therapeutics Inc. COM 48576U106 5904 216990 SH SOLE 216990 0 0 Kythera Biopharmaceuticals, Inc. COM 501570105 29201 387741 SH SOLE 387741 0 0 La Jolla Pharmaceutical Company COM 503459604 10098 412008 SH SOLE 412008 0 0 Ligand Pharmaceuticals Incorporated COM 53220K504 7405 73386 SH SOLE 73386 0 0 Lion Biotechnologies, Inc. COM 53619R102 16666 1817429 SH SOLE 1817429 0 0 Loxo Oncology, Inc. COM 548862101 1803 100000 SH SOLE 100000 0 0 MacroGenics, Inc. COM 556099109 11582 305043 SH SOLE 305043 0 0 Marinus Pharmaceuticals, Inc. COM 56854Q101 2320 200000 SH SOLE 200000 0 0 Mast Therapeutics, Inc. COM 576314108 2307 4707464 SH SOLE 4707464 0 0 MediWound Ltd. ORD SHS M68830104 1591 225000 SH SOLE 225000 0 0 Mirati Therapeutics, Inc. COM 60468T105 88276 2805074 SH SOLE 2805074 0 0 Neurocrine Biosciences, Inc. COM 64125C109 25897 542236 SH SOLE 542236 0 0 NeuroDerm Ltd. ORD SHS M74231107 3838 250000 SH SOLE 250000 0 0 Novavax, Inc. COM 670002104 21675 1945687 SH SOLE 1945687 0 0 Ohr Pharmaceuticals, Inc. COM 67778H200 930 370370 SH SOLE 370370 0 0 Omeros Corporation COM 682143102 17354 964621 SH SOLE 964621 0 0 Ophthotech Corporation COM 683745103 1856 35649 SH SOLE 35649 0 0 Osiris Therapeutics, Inc. COM 68827R108 9714 499193 SH SOLE 499193 0 0 Palatin Technologies, Inc. COM 696077403 1825 2050000 SH SOLE 2050000 0 0 Progenics Pharmaceuticals, Inc. COM 743187106 32457 4350808 SH SOLE 4350808 0 0 ProQR Therapeutics N.V. SHS N71542109 16475 988299 SH SOLE 988299 0 0 Proteon Therapeutics, Inc. COM 74371L109 3157 176762 SH SOLE 176762 0 0 Receptos, Inc. COM 756207106 4542 23900 SH SOLE 23900 0 0 Repros Therapeutics Inc. COM 76028H209 13985 1955944 SH SOLE 1955944 0 0 Ritter Pharmaceuticals, Inc. COM 767836109 1780 400000 SH SOLE 400000 0 0 Sage Therapeutics, Inc. COM 78667J108 7665 105000 SH SOLE 105000 0 0 Sangamo BioSciences, Inc. COM 800677106 35831 3230932 SH SOLE 3230932 0 0 Seattle Genetics, Inc. COM 812578102 1494121 30870262 SH SOLE 30860262 0 0 Seres Therapeutics, Inc. COM 81750R102 5188 125000 SH SOLE 125000 0 0 Spark Therapeutics, Inc. COM 84652J103 76084 1262382 SH SOLE 1262382 0 0 Stemline Therapeutics, Inc. COM 85858C107 3925 333497 SH SOLE 333497 0 0 Sunesis Pharmaceuticals, Inc. COM 867328601 9632 3200000 SH SOLE 3200000 0 0 Tekmira Pharmaceuticals Corp. COM 87911B209 2142 180582 SH SOLE 180582 0 0 Tenax Therapeutics Inc. COM 88032L100 1311 355348 SH SOLE 355348 0 0 TG Therapeutics, Inc. COM 88322Q108 33246 2003991 SH SOLE 2003991 0 0 Threshold Pharmaceuticals, Inc. COM 885807206 11819 2925519 SH SOLE 2925519 0 0 Ultragenyx Pharmaceuticals COM 90400D108 12686 123894 SH SOLE 123894 0 0 UniQure B.V. SHS N90064101 810 30000 SH SOLE 30000 0 0 Vanda Pharmaceuticals Inc. COM 921659108 5201 409881 SH SOLE 409881 0 0 Versartis, Inc. COM 92529L102 52305 3436585 SH SOLE 3436585 0 0 Vitae Pharmaceuticals, Inc. COM 92847N103 2701 187597 SH SOLE 187597 0 0 Xencor, Inc. COM 98401F105 19159 872072 SH SOLE 872072 0 0 XenoPort, Inc. COM 98411C100 39898 6508622 SH SOLE 6508622 0 0 XOMA Corporation COM 98419J107 56972 14683513 SH SOLE 14683513 0 0 Zafgen, Inc. COM 98885E103 9962 287677 SH SOLE 287677 0 0 ZIOPHARM Oncology, Inc. COM 98973P101 2271 189259 SH SOLE 189259 0 0 Zogenix, Inc. COM 98978L105 16848 10028564 SH SOLE 10028564 0 0 Acorda Therapeutics, Inc. Notes 1.75% 6/15/2021 CONV BONDS 00484MAA4 60049 59583000 PRN SOLE 59583000 0 0 Array BioPharma Inc. Notes 3.0% 6/1/2020 CONV BONDS 04269XAA3 3780 3000000 PRN SOLE 3000000 0 0 BioMarin Pharmaceutical Inc. Notes 1.875% 4/23/2017 CONV BONDS 09061GAD3 149970 22379000 PRN SOLE 22379000 0 0 BioMarin Pharmaceutical Inc. Notes 0.75% 10/15/2018 CONV BONDS 09061GAE1 18940 12228000 PRN SOLE 12228000 0 0 Gilead, Inc. 1.625% 5/1/16 CONV BONDS 375558AP8 107926 20944000 PRN SOLE 20944000 0 0 Incyte Corporation Notes 4.75% 10/1/2015 144A CONV BONDS 45337CAJ1 478833 40446000 PRN SOLE 40446000 0 0 Incyte Corporation Notes 0.375% 11/15/2018 144A CONV BONDS 45337CAK8 529519 259000000 PRN SOLE 259000000 0 0 Incyte Corporation Notes 1.25% 11/15/2020 144A CONV BONDS 45337CAL6 567758 274500000 PRN SOLE 274500000 0 0 Medivation, Inc. 2.625% 4/1/17 CONV BONDS 58501NAA9 75011 33889000 PRN SOLE 33889000 0 0 Protalix BioTherapeutics, Inc. Notes 4.5% 9/15/18 CONV BONDS 74365AAB7 2606 3423000 PRN SOLE 3423000 0 0