0001144204-15-031569.txt : 20150515 0001144204-15-031569.hdr.sgml : 20150515 20150515160656 ACCESSION NUMBER: 0001144204-15-031569 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20150331 FILED AS OF DATE: 20150515 DATE AS OF CHANGE: 20150515 EFFECTIVENESS DATE: 20150515 FILER: COMPANY DATA: COMPANY CONFORMED NAME: BAKER BROS. ADVISORS LP CENTRAL INDEX KEY: 0001263508 IRS NUMBER: 134093645 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10519 FILM NUMBER: 15869295 BUSINESS ADDRESS: STREET 1: 667 MADISON AVE STREET 2: 21ST FLOOR CITY: NEW YORK STATE: NY ZIP: 10065 BUSINESS PHONE: 2123395600 MAIL ADDRESS: STREET 1: 667 MADISON AVE STREET 2: 21ST FLOOR CITY: NEW YORK STATE: NY ZIP: 10065 FORMER COMPANY: FORMER CONFORMED NAME: BAKER BROS ADVISORS LLC DATE OF NAME CHANGE: 20030911 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001263508 XXXXXXXX 03-31-2015 03-31-2015 false BAKER BROS. ADVISORS LP

667 Madison Ave 21st Floor New York NY 10065

13F HOLDINGS REPORT 028-10519 N Alexandra Toohey 212-339-5690 /s/ Alexandra Toohey New York NY 04-23-2015 0 130 12022854 INFORMATION TABLE 2 infotable.xml Acadia Pharmaceuticals Inc. COM 004225108 667490 20481442 SH SOLE 20481442 0 0 Acceleron Pharma Inc. COM 00434H108 1095 28765 SH SOLE 28765 0 0 Achaogen Inc. COM 004449104 976 100000 SH SOLE 100000 0 0 Achillion Pharmaceuticals, Inc. COM 00448Q201 2112 214237 SH SOLE 214237 0 0 Acorda Therapeutics, Inc. COM 00484M106 24591 738916 SH SOLE 738916 0 0 Aegerion Pharmaceuticals, Inc. COM 00767E102 374 14300 SH SOLE 14300 0 0 Aerie Pharmaceuticals Inc. COM 00771V108 9382 299356 SH SOLE 299356 0 0 Affimed N.V. COM N01045108 2520 400000 SH SOLE 400000 0 0 Agios Pharmaceuticals Inc. COM 00847X104 14141 149954 SH SOLE 149954 0 0 Alcobra Ltd. SHS M2239P109 10077 1789871 SH SOLE 1789871 0 0 Alder Biopharmaceuticals Inc. COM 014339105 25385 879581 SH SOLE 879581 0 0 Aldeyra Therapeutics, Inc. COM 01438T106 1446 142000 SH SOLE 142000 0 0 Alnylam Pharmaceuticals, Inc. COM 02043Q107 1184 11340 SH SOLE 11340 0 0 Amarin Corp. PLC SPONSORED ADR 023111206 5161 2205710 SH SOLE 2205710 0 0 Anacor Pharmaceuticals Inc. COM 032420101 243242 4204702 SH SOLE 4204702 0 0 Aptose Biosciences, Inc. COM 03835T200 181 33397 SH SOLE 33397 0 0 Aquinox Pharmaceuticals, Inc. COM 03842B101 9763 1187666 SH SOLE 1187666 0 0 Array Biopharma Inc. COM 04269X105 41705 5658755 SH SOLE 5658755 0 0 Arrowhead Research Corp. COM 042797209 8728 1290187 SH SOLE 1290187 0 0 Ascendis Pharma SA SPONSORED ADR 04351P101 1735 100000 SH SOLE 100000 0 0 Assembly Biosciences, Inc. COM 045396108 3310 250000 SH SOLE 250000 0 0 Aurinia Pharmaceuticals, Inc. COM 05156V102 3118 711499 SH SOLE 711499 0 0 Auspex Pharmaceuticals, Inc. COM 05211J102 2507 25000 SH SOLE 25000 0 0 Bellerophon Therapeutics, Inc. COM 078771102 3213 350000 SH SOLE 350000 0 0 Bellicum Pharmaceuticals, Inc. COM 079481107 97096 4190594 SH SOLE 4190594 0 0 Biocryst Pharmaceuticals Inc. COM 09058V103 94618 10478204 SH SOLE 10478204 0 0 BioDelivery Sciences Intl. Inc. COM 09060J106 2686 255866 SH SOLE 255866 0 0 Biodel Inc. COM 09064M204 36 30179 SH SOLE 30179 0 0 Biomarin Pharmaceuticals Inc. COM 09061G101 523461 4200456 SH SOLE 4200456 0 0 Biota Pharmaceuticals Inc. COM 090694100 1985 863184 SH SOLE 863184 0 0 Biotime Inc. WARRANTS 09066L162 40 20084 SH SOLE 20084 0 0 Bluebird Bio Inc. COM 09609G100 17703 146581 SH SOLE 146581 0 0 Catalyst Pharmaceuticals, Inc. COM 14888U101 32758 7565462 SH SOLE 7565462 0 0 Celladon Corp COM 15117E107 6947 366806 SH SOLE 366806 0 0 Cellectis SA SPONSORED ADR 15117K103 1729 50000 SH SOLE 50000 0 0 Cerus Corp. COM 157085101 56517 13553275 SH SOLE 13553275 0 0 Chemocentryx Inc. COM 16383L106 370 49064 SH SOLE 49064 0 0 Chimerix Inc. COM 16934W106 4342 115216 SH SOLE 115216 0 0 Clovis Oncology Inc. COM 189464100 15041 202630 SH SOLE 202630 0 0 Concert Pharmaceuticals, Inc. COM 206022105 7511 495908 SH SOLE 495908 0 0 Cyclacel Pharmaceuticals Inc. PFD CONV EX 6% 23254L207 86 13253 SH SOLE 13253 0 0 Cytrx Corp. COM 232828509 4448 1319989 SH SOLE 1319989 0 0 DBV Technologies Inc. SPONSORED ADR 23306J101 35489 1519229 SH SOLE 1519229 0 0 Derma Sciences Inc. COM 249827502 29288 3457841 SH SOLE 3457841 0 0 Dermira Inc. COM 24983L104 1535 100000 SH SOLE 100000 0 0 Discovery Laboratories Inc. COM 254668403 4248 3569643 SH SOLE 3569643 0 0 Dyax Corp. COM 26746E103 100890 6021485 SH SOLE 6021485 0 0 Enanta Pharmaceuticals Inc. COM 29251M106 2307 75357 SH SOLE 75357 0 0 Epizyme Inc. COM 29428V104 4366 232481 SH SOLE 232481 0 0 Five Prime Therapeutics Inc. COM 33830X104 440 19247 SH SOLE 19247 0 0 Foamix Pharmaceuticals Ltd. SHS M46135105 16853 1821967 SH SOLE 1821967 0 0 Foundation Medicine Inc. COM 350465100 5978 124255 SH SOLE 124255 0 0 Genomic Health Inc. COM 37244C101 417220 13656942 SH SOLE 13656942 0 0 Gilead Sciences Inc. COM 375558103 24532 249995 SH SOLE 249995 0 0 Halozyme Therapeutics Inc. COM 40637H109 32104 2248152 SH SOLE 2248152 0 0 Heron Therapeutics, Inc. COM 427746102 37943 2607784 SH SOLE 2607784 0 0 Idera Pharmaceuticals Inc. COM 45168K306 25842 6965432 SH SOLE 6965432 0 0 Ignyta Inc. COM 451731103 5681 571000 SH SOLE 571000 0 0 Immunogen, Inc. COM 45253H101 8945 999496 SH SOLE 999496 0 0 Incyte Corp. COM 45337C102 1360744 14845559 SH SOLE 14845559 0 0 Infinity Pharmaceuticals Inc. COM 45665G303 4264 305037 SH SOLE 305037 0 0 Insmed Inc. COM 457669307 32937 1583490 SH SOLE 1583490 0 0 Intra Cellular Therapies Inc. COM 46116X101 2487 104166 SH SOLE 104166 0 0 Invitae Corp. COM 46185L103 109861 6554967 SH SOLE 6554967 0 0 Ironwood Pharmaceuticals Inc. COM 46333X108 2707 169163 SH SOLE 169163 0 0 Isis Pharmaceuticals, Inc. COM 464330109 3638 57140 SH SOLE 57140 0 0 Juno Therapeutics Inc. COM 48205A109 6066 100000 SH SOLE 100000 0 0 Karyopharm Therapeutics Inc. COM 48576U106 6642 216990 SH SOLE 216990 0 0 Kythera Biopharmaceuticals Inc. COM 501570105 17766 354265 SH SOLE 354265 0 0 La Jolla Pharmaceuticals, Co. COM 503459604 7540 412008 SH SOLE 412008 0 0 Ligand Pharmaceuticals Inc. COM 53220K504 5659 73386 SH SOLE 73386 0 0 Lion Biotechnologies Inc. COM 53619R102 16046 1325000 SH SOLE 1325000 0 0 Lipocine Inc. COM 53630X104 3375 489175 SH SOLE 489175 0 0 Loxo Oncology Inc. COM 548862101 1245 100000 SH SOLE 100000 0 0 Macrogenics, Inc. COM 556099109 9569 305043 SH SOLE 305043 0 0 Marinus Pharmaceuticals Inc. COM 56854Q101 1798 200000 SH SOLE 200000 0 0 Mast Therapeutics, Inc. COM 576314108 2283 4707464 SH SOLE 4707464 0 0 Mediwound Ltd. ORD SHS M68830104 1629 225000 SH SOLE 225000 0 0 Mirati Therapeutics Inc. COM 60468T105 82245 2805074 SH SOLE 2805074 0 0 Neurocrine Biosciences, Inc. COM 64125C109 21532 542236 SH SOLE 542236 0 0 Neuroderm Ltd. ORD SHS M74231107 3355 250000 SH SOLE 250000 0 0 Novavax Inc. COM 670002104 16091 1945687 SH SOLE 1945687 0 0 Ohr Pharmaceuticals, Inc. COM 67778H200 941 370370 SH SOLE 370370 0 0 Omeros Corp. COM 682143102 14043 637446 SH SOLE 637446 0 0 Ophthotech Corp. COM 683745103 1659 35649 SH SOLE 35649 0 0 Orasure Technologies Inc. COM 68554V108 1500 229397 SH SOLE 229397 0 0 Osiris Therapeutics Inc. COM 68827R108 8776 499193 SH SOLE 499193 0 0 Palatin Technologies Inc. COM 696077403 2091 2050000 SH SOLE 2050000 0 0 Pharmacyclics Inc. COM 716933106 2313699 9039652 SH SOLE 9039652 0 0 Progenics Pharmaceuticals, Inc. COM 743187106 26018 4350808 SH SOLE 4350808 0 0 ProQR Therapeutics NV SHS N71542109 8752 400000 SH SOLE 400000 0 0 Proteon Therapeutics, Inc. COM 74371L109 2011 172917 SH SOLE 172917 0 0 Receptos Inc. COM 756207106 3941 23900 SH SOLE 23900 0 0 Repros Therapeutics Inc. COM 76028H209 17180 2000000 SH SOLE 2000000 0 0 Rigel Pharmaceuticals Inc. COM 766559603 1275 357187 SH SOLE 357187 0 0 Sage Therapeutics Inc. COM 78667J108 3767 75000 SH SOLE 75000 0 0 Sangamo Biosciences, Inc. COM 800677106 22023 1404544 SH SOLE 1404544 0 0 Seattle Genetics, Inc. COM 812578102 1020792 28876712 SH SOLE 28876712 0 0 Spark Therapeutics, Inc. COM 84652J103 102878 1327451 SH SOLE 1327451 0 0 Stemline Therapeutics Inc. COM 85858C107 4826 333497 SH SOLE 333497 0 0 Sunesis Pharmaceuticals, Inc. COM 867328601 7840 3200000 SH SOLE 3200000 0 0 Synageva Biopharma Corp. COM 87159A103 1137242 11660432 SH SOLE 11660432 0 0 Synta Pharmaceuticals Corp. COM 87162T206 949 489053 SH SOLE 489053 0 0 Tekmira Pharmaceuticals Corp. COM 87911B209 3153 180582 SH SOLE 180582 0 0 TG Therapeutics Inc. COM 88322Q108 31739 2050313 SH SOLE 2050313 0 0 Threshold Pharmaceuticals Inc. COM 885807206 11878 2925519 SH SOLE 2925519 0 0 Transition Therapeutics, Inc. COM 893716209 5254 769230 SH SOLE 769230 0 0 Ultragenyx Pharmaceuticals Inc. COM 90400D108 9245 148894 SH SOLE 148894 0 0 UniQure N.V. SHS N90064101 730 30000 SH SOLE 30000 0 0 Vanda Pharmaceuticals, Inc. COM 921659108 16277 1750230 SH SOLE 1750230 0 0 Versartis Inc. COM 92529L102 54694 2977396 SH SOLE 2977396 0 0 Vitae Pharmaceuticals Inc. COM 92847N103 2197 187597 SH SOLE 187597 0 0 Xencor Inc. COM 98401F105 13360 872072 SH SOLE 872072 0 0 Xenoport Inc. COM 98411C100 46341 6508622 SH SOLE 6508622 0 0 Xoma Corp. COM 98419J107 53539 14708613 SH SOLE 14708613 0 0 Zafgen, Inc. COM 98885E103 3753 94745 SH SOLE 94745 0 0 Ziopharm Oncology Inc. COM 98973P101 2038 189259 SH SOLE 189259 0 0 Zogenix, Inc. COM 98978L105 3149 2298466 SH SOLE 2298466 0 0 Acorda Therapeutics Inc. Notes 1.75% 6/15/2021 CONV BONDS 00484MAA4 60762 59583000 PRN SOLE 59583000 0 0 Array Biopharma, Inc. Notes 3.0% 6/1/2020 CONV BONDS 04269XAA3 3759 3000000 PRN SOLE 3000000 0 0 Biomarin Pharmaceuticals Inc. Notes 1.875% 4/23/2017 CONV BONDS 09061GAD3 136987 22379000 PRN SOLE 22379000 0 0 Biomarin Pharmaceuticals Inc. Notes 0.75% 10/15/2018 CONV BONDS 09061GAE1 17970 12228000 PRN SOLE 12228000 0 0 Gilead Sciences Inc. 1.625% 5/1/16 CONV BONDS 375558AP8 90193 20944000 PRN SOLE 20944000 0 0 Incyte Corp. Notes 4.75% 10/1/2015 144A CONV BONDS 45337CAJ1 421673 40446000 PRN SOLE 40446000 0 0 Incyte Corp. Notes 0.375% 11/15/2018 144A CONV BONDS 45337CAK8 471944 259000000 PRN SOLE 259000000 0 0 Incyte Corp. Notes 1.25% 11/15/2020 144A CONV BONDS 45337CAL6 508427 274500000 PRN SOLE 274500000 0 0 Medivation Inc. 2.625% 4/1/17 CONV BONDS 58501NAA9 84927 33889000 PRN SOLE 33889000 0 0 Protalix Biotherapeutics, Inc. Notes 4.5% 9/15/18 CONV BONDS 74365AAB7 2612 3500000 PRN SOLE 3500000 0 0 Salix Pharmaceuticals Inc. 2.75% 5/15/15 CONV BONDS 795435AC0 801152 216077000 PRN SOLE 216077000 0 0 Salix Pharmaceuticals Inc. 1.5% 3/15/19 CONV BONDS 795435AE6 38948 14668000 PRN SOLE 14668000 0 0