0001144204-15-010112.txt : 20150218 0001144204-15-010112.hdr.sgml : 20150216 20150217161559 ACCESSION NUMBER: 0001144204-15-010112 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20141231 FILED AS OF DATE: 20150217 DATE AS OF CHANGE: 20150217 EFFECTIVENESS DATE: 20150217 FILER: COMPANY DATA: COMPANY CONFORMED NAME: BAKER BROS. ADVISORS LP CENTRAL INDEX KEY: 0001263508 IRS NUMBER: 134093645 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10519 FILM NUMBER: 15622652 BUSINESS ADDRESS: STREET 1: 667 MADISON AVE STREET 2: 21ST FLOOR CITY: NEW YORK STATE: NY ZIP: 10065 BUSINESS PHONE: 2123395600 MAIL ADDRESS: STREET 1: 667 MADISON AVE STREET 2: 21ST FLOOR CITY: NEW YORK STATE: NY ZIP: 10065 FORMER COMPANY: FORMER CONFORMED NAME: BAKER BROS ADVISORS LLC DATE OF NAME CHANGE: 20030911 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001263508 XXXXXXXX 12-31-2014 12-31-2014 false BAKER BROS. ADVISORS LP

667 Madison Ave 21st Floor New York NY 10065

13F HOLDINGS REPORT 028-10519 N Alexandra Toohey 212-339-5690 /s/ Alexandra Toohey New York NY 02-17-2015 0 121 9797208 INFORMATION TABLE 2 infotable.xml Acadia Pharmaceuticals Inc. COM 004225108 650286 20481442 SH SOLE 20481442 0 0 Acceleron Pharma Inc. COM 00434H108 1121 28765 SH SOLE 28765 0 0 Achaogen Inc. COM 004449104 1305 100000 SH SOLE 100000 0 0 Achillion COM 00448Q201 5370 438337 SH SOLE 438337 0 0 Acorda Therapeutics, Inc. COM 00484M106 30879 755534 SH SOLE 755534 0 0 Aerie Pharmaceuticals COM 00771V108 8738 299356 SH SOLE 299356 0 0 Affimed Therapeutics B.V. COM N01045108 2480 400000 SH SOLE 400000 0 0 Agios Pharmaceuticals COM 00847X104 18307 163393 SH SOLE 163393 0 0 Alcobra Ltd. SHS M2239P109 1081 289871 SH SOLE 289871 0 0 Alder Biopharmaceutical Inc. COM 014339105 4461 153350 SH SOLE 153350 0 0 Alnylam Pharmaceuticals, Inc. COM 02043Q107 1125 11600 SH SOLE 11600 0 0 Amicus Therapeutics COM 03152W109 4008 481697 SH SOLE 481697 0 0 Anacor Pharmaceuticals COM 032420101 135602 4204702 SH SOLE 4204702 0 0 Aptose Biosciences, Inc. COM 03835T200 2833 479164 SH SOLE 479164 0 0 Aquinox Pharmaceuticals, Inc. COM 03842B101 9078 1210350 SH SOLE 1210350 0 0 Array Biopharma Inc. COM 04269X105 6782 1433797 SH SOLE 1433797 0 0 Arrowhead Research Corp. COM 042797209 9083 1230802 SH SOLE 1230802 0 0 Asterias Biotherapeutics, Inc. COM SER A 04624N107 54 16775 SH SOLE 16775 0 0 Aurinia Pharmaceuticals, Inc. COM 05156V102 2599 727669 SH SOLE 727669 0 0 Avanir Pharmaceuticals COM 05348P401 652807 38513713 SH SOLE 38513713 0 0 Bellicum Pharmaceuticals, Inc. COM 079481107 98697 4283732 SH SOLE 4283732 0 0 Biocryst Pharmaceuticals Inc. COM 09058V103 130278 10713686 SH SOLE 10713686 0 0 BioDelivery Sciences Intl. Inc. COM 09060J106 2524 210021 SH SOLE 210021 0 0 Biomarin Pharmaceuticals COM 09061G101 335741 3713950 SH SOLE 3713950 0 0 Biota Pharmaceuticals COM 090694100 2479 1106910 SH SOLE 1106910 0 0 Biotime Inc. Rights COM 09066L162 22 20525 SH SOLE 20525 0 0 Bluebird Bio Inc. COM 09609G100 13758 150000 SH SOLE 150000 0 0 Catalyst Pharmaceuticals, Inc. COM 14888U101 19945 6715462 SH SOLE 6715462 0 0 Celsus Therapeutics SPONSORED ADR NE 15119A202 3235 673887 SH SOLE 673887 0 0 Cerus COM 157085101 73025 11702727 SH SOLE 11702727 0 0 Chemocentryx Inc. COM 16383L106 342 50000 SH SOLE 50000 0 0 Chimerix COM 16934W106 6941 172414 SH SOLE 172414 0 0 Clovis Oncology COM 189464100 11347 202630 SH SOLE 202630 0 0 Concert Pharmaceuticals, Inc. COM 206022105 6732 505418 SH SOLE 505418 0 0 Cyclacel Pharmaceuticals Pfd. Conv. Ex 6% PFD CONV EX 6% 23254L207 82 13253 SH SOLE 13253 0 0 Cytrx Corp. COM 232828509 3699 1350000 SH SOLE 1350000 0 0 DBV Technologies Inc. SPONSORED ADR 23306J101 41201 1519229 SH SOLE 1519229 0 0 Derma Sciences COM 249827502 32931 3537137 SH SOLE 3537137 0 0 Dermira COM 24983L104 1811 100000 SH SOLE 100000 0 0 Discovery Laboratories Inc. COM 254668403 4236 3652117 SH SOLE 3652117 0 0 Dyax Corp. COM 26746E103 86579 6157789 SH SOLE 6157789 0 0 Enanta Pharmaceuticals COM 29251M106 3832 75357 SH SOLE 75357 0 0 Epizyme Inc. COM 29428V104 3811 201963 SH SOLE 201963 0 0 Five Prime Therapeutics Inc. COM 33830X104 535 19823 SH SOLE 19823 0 0 Foamix Pharmaceuticals Ltd. SHS M46135105 7161 1021600 SH SOLE 1021600 0 0 Foundation Medicine Inc. COM 350465100 2803 126147 SH SOLE 126147 0 0 Genomic Health Inc. COM 37244C101 436592 13656318 SH SOLE 13656318 0 0 Geron Corp. COM 374163103 1309 402629 SH SOLE 402629 0 0 Gilead Sciences Inc. COM 375558103 24141 256108 SH SOLE 256108 0 0 Halozyme Therapeutics Inc. COM 40637H109 26790 2776143 SH SOLE 2776143 0 0 Heron Therapeutics, Inc. COM 427746102 26234 2607784 SH SOLE 2607784 0 0 Idera Pharmaceuticals Inc. COM 45168K306 7181 1628172 SH SOLE 1628172 0 0 Ignyta COM 451731103 3911 571000 SH SOLE 571000 0 0 Incyte Corp. COM 45337C102 1085359 14845559 SH SOLE 14845559 0 0 Infinity Pharmaceuticals Inc. COM 45665G303 5270 312025 SH SOLE 312025 0 0 Insmed Inc. COM 457669307 17138 1107850 SH SOLE 1107850 0 0 Ironwood Pharmaceuticals COM 46333X108 5303 346160 SH SOLE 346160 0 0 Isis Pharmaceuticals, Inc. COM 464330109 5946 96303 SH SOLE 96303 0 0 Juno Therapeutics Inc. COM 48205A109 5222 100000 SH SOLE 100000 0 0 Karyopharm Therapeutics COM 48576U106 3522 94095 SH SOLE 94095 0 0 Kythera Biopharmaceuticals COM 501570105 9927 286255 SH SOLE 286255 0 0 La Jolla Pharmaceuticals, Inc. COM 503459604 7779 421631 SH SOLE 421631 0 0 Ligand Pharmaceuticals COM 53220K504 3906 73400 SH SOLE 73400 0 0 Lipocine Inc. COM 53630X104 2630 500000 SH SOLE 500000 0 0 Loxo Oncology Inc. COM 548862101 1175 100000 SH SOLE 100000 0 0 Macrogenics, Inc. COM 556099109 10938 311891 SH SOLE 311891 0 0 Marinus Pharmaceuticals Inc. COM 56854Q101 2161 204476 SH SOLE 204476 0 0 Mast Therapeutics, Inc. COM 576314108 2674 4774434 SH SOLE 4774434 0 0 Mediwound Ltd. ORD SHS M68830104 1499 225000 SH SOLE 225000 0 0 Mirati Therapeutics Inc. COM 60468T105 44079 2380074 SH SOLE 2380074 0 0 Neurocrine Biosciences, Inc. COM 64125C109 12390 554590 SH SOLE 554590 0 0 Neuroderm Ltd. ORD SHS M74231107 3510 250000 SH SOLE 250000 0 0 Novavax Inc. COM 670002104 7255 1223362 SH SOLE 1223362 0 0 Omeros Corp. COM 682143102 16060 648101 SH SOLE 648101 0 0 Ophthotech Corp. COM 683745103 1650 36776 SH SOLE 36776 0 0 Orasure Technologies Inc. COM 68554V108 2379 234664 SH SOLE 234664 0 0 Osiris Therapeutics Inc. COM 68827R108 8165 510606 SH SOLE 510606 0 0 Palatin Technologies Inc. COM 696077403 1497 2050000 SH SOLE 2050000 0 0 Pharmacyclics Inc. COM 716933106 1116140 9129231 SH SOLE 9129231 0 0 Progenics Pharmaceuticals, Inc. COM 743187106 33640 4449797 SH SOLE 4449797 0 0 ProQR Therapeutics NV SHS N71542109 8668 400000 SH SOLE 400000 0 0 Proteon Therapeutics, Inc. COM 74371L109 1798 172917 SH SOLE 172917 0 0 QLT Inc. COM 746927102 6159 1535863 SH SOLE 1535863 0 0 Receptos Inc. COM 756207106 2928 23900 SH SOLE 23900 0 0 Repros Therapeutics COM 76028H209 19940 2000000 SH SOLE 2000000 0 0 Rigel Pharmaceuticals COM 766559603 1094 481972 SH SOLE 481972 0 0 Sage Therapeutics Inc. COM 78667J108 2745 75000 SH SOLE 75000 0 0 Salix Pharmaceuticals COM 795435106 73024 635321 SH SOLE 635321 0 0 Sangamo Biosciences, Inc. COM 800677106 14531 955332 SH SOLE 955332 0 0 Seattle Genetics, Inc. COM 812578102 895197 27861720 SH SOLE 27861720 0 0 Stemline Therapeutics Inc. COM 85858C107 5778 338671 SH SOLE 338671 0 0 Sunesis Pharmaceuticals Inc. COM 867328601 8160 3200000 SH SOLE 3200000 0 0 Synageva Biopharma Corp. COM 87159A103 989182 10660432 SH SOLE 10660432 0 0 Synergy Pharmaceuticals COM 871639308 2968 973245 SH SOLE 973245 0 0 Synta Pharmaceuticals COM 87162T206 1325 500000 SH SOLE 500000 0 0 Tekmira Pharmaceuticals Corp. COM 87911B209 7335 484156 SH SOLE 484156 0 0 Tesaro Inc. COM 881569107 1161 31218 SH SOLE 31218 0 0 TG Therapeutics COM 88322Q108 32477 2050313 SH SOLE 2050313 0 0 Threshold Pharma COM 885807206 6855 2155516 SH SOLE 2155516 0 0 Ultragenyx Pharmaceuticals COM 90400D108 6582 150000 SH SOLE 150000 0 0 UniQure B.V. SHS N90064101 454 30672 SH SOLE 30672 0 0 Vanda Pharmaceuticals, Inc. COM 921659108 64041 4472153 SH SOLE 4472153 0 0 Versartis Inc. COM 92529L102 51225 2281744 SH SOLE 2281744 0 0 Xencor COM 98401F105 9486 591371 SH SOLE 591371 0 0 Xenoport COM 98411C100 60545 6903628 SH SOLE 6903628 0 0 Xoma Corp. COM 98419J107 60757 16924013 SH SOLE 16924013 0 0 Ziopharm Oncology Inc. COM 98973P101 982 193640 SH SOLE 193640 0 0 Zogenix, Inc. COM 98978L105 3220 2350400 SH SOLE 2350400 0 0 Celladon Corp COM 15117E107 7324 375000 SH SOLE 375000 0 0 Mallinckrodt PUB LTD CO SHS G5785G107 4621 46666 SH SOLE 46666 0 0 Acorda Therapeutics Notes 1.75% 6/15/2021 CONV BONDS 00484MAA4 69839 60900000 PRN SOLE 60900000 0 0 Biomarin Pharmaceuticals Notes 1.875% 4/23/2017 CONV BONDS 09061GAD3 102104 22898000 PRN SOLE 22898000 0 0 Biomarin Pharmaceuticals Notes 0.75% 10/15/2018 CONV BONDS 09061GAE1 14715 12500000 PRN SOLE 12500000 0 0 Gilead 1.625% 5/1/16 CONV BONDS 375558AP8 88977 21500000 PRN SOLE 21500000 0 0 Incyte Corporation Notes 4.75% 10/1/2015 144A CONV BONDS 45337CAJ1 336182 40446000 PRN SOLE 40446000 0 0 Incyte Corporation Notes 0.375% 11/15/2018 144A CONV BONDS 45337CAK8 388039 259000000 PRN SOLE 259000000 0 0 Incyte Corporation Notes 1.25% 11/15/2020 144A CONV BONDS 45337CAL6 421613 274500000 PRN SOLE 274500000 0 0 Medivation 2.625% 4/1/17 CONV BONDS 58501NAA9 67334 34720000 PRN SOLE 34720000 0 0 Protalix Biotherapeutics, Inc. Notes 4.5% 9/15/18 CONV BONDS 74365AAB7 2645 3500000 PRN SOLE 3500000 0 0 Salix 2.75% 5/15/15 CONV BONDS 795435AC0 542741 219440000 PRN SOLE 219440000 0 0 Salix 1.5% 3/15/19 CONV BONDS 795435AE6 27339 15000000 PRN SOLE 15000000 0 0