0001144204-14-031196.txt : 20140515 0001144204-14-031196.hdr.sgml : 20140515 20140515161037 ACCESSION NUMBER: 0001144204-14-031196 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20140331 FILED AS OF DATE: 20140515 DATE AS OF CHANGE: 20140515 EFFECTIVENESS DATE: 20140515 FILER: COMPANY DATA: COMPANY CONFORMED NAME: BAKER BROS. ADVISORS LP CENTRAL INDEX KEY: 0001263508 IRS NUMBER: 134093645 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10519 FILM NUMBER: 14847265 BUSINESS ADDRESS: STREET 1: 667 MADISON AVE STREET 2: 21ST FLOOR CITY: NEW YORK STATE: NY ZIP: 10065 BUSINESS PHONE: 2123395600 MAIL ADDRESS: STREET 1: 667 MADISON AVE STREET 2: 21ST FLOOR CITY: NEW YORK STATE: NY ZIP: 10065 FORMER COMPANY: FORMER CONFORMED NAME: BAKER BROS ADVISORS LLC DATE OF NAME CHANGE: 20030911 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001263508 XXXXXXXX 03-31-2014 03-31-2014 false BAKER BROS. ADVISORS LP

667 Madison Ave 21st Floor New York NY 10065

13F HOLDINGS REPORT 028-10519 N Alexandra Toohey 212-339-5690 /s/ Alexandra Toohey New York NY 05-15-2014 0 108 7867925 INFORMATION TABLE 2 infotable.xml Aquinox Pharmaceuticals, Inc. COM 03842B101 15427 1211851 SH SOLE 1211851 0 0 Celsus Therapeutics COM 15119A202 4374 673887 SH SOLE 673887 0 0 Heron Therapeutics, Inc. COM 427746102 30153 2167784 SH SOLE 2167784 0 0 Ignyta COM 451731103 4739 571000 SH SOLE 571000 0 0 La Jolla Pharmaceuticals, Inc. COM 503459604 2394 221631 SH SOLE 221631 0 0 Retrophin Inc. COM 761299106 4194 197178 SH SOLE 197178 0 0 Ultragenyx Pharmaceuticals COM 90400D108 4889 100000 SH SOLE 100000 0 0 Uniquere B.V. COM N90064101 477 30672 SH SOLE 30672 0 0 Acadia Pharmaceuticals Inc. COM 004225108 498313 20481442 SH SOLE 20481442 0 0 Acceleron Pharma Inc. COM 00434H108 992 28765 SH SOLE 28765 0 0 Achaogen Inc. COM 004449104 1546 100000 SH SOLE 100000 0 0 Achillion COM 00448Q201 1442 438337 SH SOLE 438337 0 0 Acorda Therapeutics, Inc. COM 00484M106 37910 1000000 SH SOLE 1000000 0 0 Aegerion Pharmaceuticals COM 00767E102 23702 513922 SH SOLE 513922 0 0 Aerie Pharmaceuticals COM 00771V108 6343 299356 SH SOLE 299356 0 0 Agios Pharmaceuticals COM 00847X104 7826 199893 SH SOLE 199893 0 0 Alnylam Pharmaceuticals, Inc. COM 02043Q107 779 11600 SH SOLE 11600 0 0 Ambit Biosciences Corp. COM 02318X100 6821 747954 SH SOLE 747954 0 0 Amicus Therapeutics COM 03152W109 997 481697 SH SOLE 481697 0 0 Anacor Pharmaceuticals COM 032420101 61937 3095318 SH SOLE 3095318 0 0 Array Biopharma Inc. COM 04269X105 6739 1433797 SH SOLE 1433797 0 0 Arrowhead Research Corp. COM 042797209 12020 732062 SH SOLE 732062 0 0 Auxilium Pharmaceuticals, Inc. COM 05334D107 1591 58544 SH SOLE 58544 0 0 Avanir Pharmaceuticals COM Class A 05348P401 21250 5790139 SH SOLE 5790139 0 0 Biocryst Pharmaceuticals Inc. COM 09058V103 62073 5867031 SH SOLE 5867031 0 0 BioDelivery Sciences Intl. Inc. COM 09060J106 3553 421005 SH SOLE 421005 0 0 Biomarin Pharmaceuticals COM 09061G101 128455 1883230 SH SOLE 1883230 0 0 Biota Pharmaceuticals COM 090694100 6763 1106910 SH SOLE 1106910 0 0 Bluebird Bio Inc. COM 09609G100 4508 198260 SH SOLE 198260 0 0 Catalyst Pharmaceuticals, Inc. COM 14888U101 1288 569853 SH SOLE 569853 0 0 Cerus COM 157085101 40585 8455306 SH SOLE 8455306 0 0 Chelsea Therapeutics COM 163428105 37317 6760394 SH SOLE 6760394 0 0 Chemocentryx Inc. COM 16383L106 332 50000 SH SOLE 50000 0 0 Clovis Oncology COM 189464100 36712 529990 SH SOLE 529990 0 0 Cyclacel Pharmaceuticals Pfd. Conv. Ex 6% PFD CONV EX 23254L207 113 13253 SH SOLE 13253 0 0 Cytrx Corp. COM 232828509 4712 1350000 SH SOLE 1350000 0 0 Derma Sciences COM 249827502 44851 3537137 SH SOLE 3537137 0 0 Discovery Laboratories Inc. COM 254668403 7852 3652117 SH SOLE 3652117 0 0 Dyax Corp. COM 26746E103 22735 2531766 SH SOLE 2531766 0 0 Enanta Pharmaceuticals COM 29251M106 3237 80957 SH SOLE 80957 0 0 Epizyme Inc. COM 29428V104 4873 214012 SH SOLE 214012 0 0 Five Prime Therapeutics Inc. COM 33830X104 390 19823 SH SOLE 19823 0 0 Furiex Pharmaceuticals, Inc. COM 36106P101 3507 40309 SH SOLE 40309 0 0 Galectin Therapeutics Inc. COM 363225202 7655 500000 SH SOLE 500000 0 0 Genomic Health Inc. COM 37244C101 359650 13654150 SH SOLE 13654150 0 0 Geron Corp. COM 374163103 837 402629 SH SOLE 402629 0 0 Gilead Sciences Inc. COM 375558103 39406 556108 SH SOLE 556108 0 0 Halozyme Therapeutics Inc. COM 40637H109 72366 5698139 SH SOLE 5698139 0 0 Idera Pharmaceuticals Inc. COM 45168K306 6581 1613076 SH SOLE 1613076 0 0 Incyte Corp. COM 45337C102 793999 14835559 SH SOLE 14835559 0 0 Infinity Pharmaceuticals Inc. COM 45665G303 7420 624050 SH SOLE 624050 0 0 Insmed Inc. COM 457669307 10549 554050 SH SOLE 554050 0 0 Intercept Pharmaceuticals, Inc. COM 45845P108 84550 256375 SH SOLE 256375 0 0 Intermune Inc. COM 45884X103 144752 4324843 SH SOLE 4324843 0 0 Ironwood Pharmaceuticals COM 46333X108 5497 446160 SH SOLE 446160 0 0 Isis Pharmaceuticals, Inc. COM 464330109 4161 96303 SH SOLE 96303 0 0 Karyopharm Therapeutics COM 48576U106 1825 59095 SH SOLE 59095 0 0 Kythera Biopharmaceuticals COM 501570105 12375 311255 SH SOLE 311255 0 0 Ligand Pharmaceuticals CLASS B 53220K504 4937 73400 SH SOLE 73400 0 0 Macrogenics, Inc. COM 556099109 2676 96165 SH SOLE 96165 0 0 Mast Therapeutics, Inc. COM 576314108 2040 3000000 SH SOLE 3000000 0 0 Mirati Therapeutics Inc. COM 60468T105 45388 2380074 SH SOLE 2380074 0 0 Neurocrine Biosciences, Inc. COM 64125C109 7211 447874 SH SOLE 447874 0 0 Novavax Inc. COM 670002104 5542 1223362 SH SOLE 1223362 0 0 Omeros Corp. COM 682143102 9098 753804 SH SOLE 753804 0 0 Ophthotech Corp. COM 683745103 1314 36776 SH SOLE 36776 0 0 Orasure Technologies Inc. COM 68554V108 1870 234664 SH SOLE 234664 0 0 Osiris Therapeutics Inc. COM 68827R108 4747 361530 SH SOLE 361530 0 0 Pharmacyclics Inc. COM 716933106 875711 8737888 SH SOLE 8737888 0 0 Portola Pharmaceuticals, Inc. COM 737010108 4729 182591 SH SOLE 182591 0 0 Progenics Pharmaceuticals, Inc. COM 743187106 18200 4449797 SH SOLE 4449797 0 0 Prothena Corp. PLC SHS G72800108 8817 230142 SH SOLE 230142 0 0 QLT Inc. COM 746927102 8539 1535863 SH SOLE 1535863 0 0 Questcor Pharmaceuticals, Inc. COM 74835Y101 46603 717745 SH SOLE 717745 0 0 Receptos Inc. COM 756207106 1002 23900 SH SOLE 23900 0 0 Regado COM 75874Q107 5008 400000 SH SOLE 400000 0 0 Repros Therapeutics COM 76028H209 49293 2778654 SH SOLE 2778654 0 0 Rigel Pharmaceuticals COM 766559603 1870 481972 SH SOLE 481972 0 0 Salix Pharmaceuticals COM 795435106 375 3621 SH SOLE 3621 0 0 Sangamo Biosceiences, Inc. COM 800677106 9452 522764 SH SOLE 522764 0 0 Seattle Genetics, Inc. COM 812578102 944887 20739426 SH SOLE 20739426 0 0 Stemline Therapeutics Inc. COM 85858C107 6895 338671 SH SOLE 338671 0 0 Synageva Biopharma Corp. COM 87159A103 883480 10648182 SH SOLE 10648182 0 0 Synergy Pharmaceuticals COM 871639308 9336 1758271 SH SOLE 1758271 0 0 Synta Pharmaceuticals COM 87162T206 2155 500000 SH SOLE 500000 0 0 Tekmire Pharmaceuticals Corp. COM 87911B209 10405 484156 SH SOLE 484156 0 0 Tesaro Inc. COM 881569107 920 31218 SH SOLE 31218 0 0 TG Therapeutics COM 88322Q108 14911 2160965 SH SOLE 2160965 0 0 Threshold Pharma COM 885807206 8693 1826358 SH SOLE 1826358 0 0 Vanda Pharmaceuticals, Inc. COM 921659108 72243 4445696 SH SOLE 4445696 0 0 Ventrus Biosciences, Inc. COM 922822101 535 417690 SH SOLE 417690 0 0 Xencor COM 98401F105 6362 542363 SH SOLE 542363 0 0 Xenoport COM 98411C100 20856 4034112 SH SOLE 4034112 0 0 Xoma Corp. COM 98419J107 120130 23057572 SH SOLE 23057572 0 0 Ziopharm Oncology Inc. COM 98973P101 1120 244619 SH SOLE 244619 0 0 Zogenix, Inc. COM 98978L105 6687 2350400 SH SOLE 2350400 0 0 Auxilium 1.5% 7/15/2018 CONV BONDS 05334DAA5 128796 97990000 PRN SOLE 97990000 0 0 Biomarin Pharmaceuticals Notes 1.875% 4/23/2017 CONV BONDS 09061GAD3 77127 22898000 PRN SOLE 22898000 0 0 Biomarin Pharmaceuticals Notes 0.75% 10/15/2018 CONV BONDS 09061GAE1 13699 12500000 PRN SOLE 12500000 0 0 Gilead 1.625% 5/1/16 CONV BONDS 375558AP8 66903 21500000 PRN SOLE 21500000 0 0 Incyte Genomics Notes 4.75% 10/1/2015 144A CONV BONDS 45337CAJ1 245887 40446000 PRN SOLE 40446000 0 0 Incyte Genomics Notes 0.375% 11/15/2018 144A CONV BONDS 45337CAK8 326745 259000000 PRN SOLE 259000000 0 0 Incyte Genomics Notes 1.25% 11/15/2020 144A CONV BONDS 45337CAL6 350417 274500000 PRN SOLE 274500000 0 0 Intermune Inc Notes 5% 3/1/15 CONV BONDS 45884XAD5 30590 16860000 PRN SOLE 16860000 0 0 Intermune Inc Notes 2.5% 12/15/17 CONV BONDS 45884XAF0 107856 41000000 PRN SOLE 41000000 0 0 Medivation 2.625% 4/1/17 CONV BONDS 58501NAA9 56288 39500000 PRN SOLE 39500000 0 0 Salix 2.75% 5/15/15 CONV BONDS 795435AC0 491957 219440000 PRN SOLE 219440000 0 0 Salix 1.5% 3/15/19 CONV BONDS 795435AE6 25289 15000000 PRN SOLE 15000000 0 0