0001144204-14-009842.txt : 20140214 0001144204-14-009842.hdr.sgml : 20140214 20140214162128 ACCESSION NUMBER: 0001144204-14-009842 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20131231 FILED AS OF DATE: 20140214 DATE AS OF CHANGE: 20140214 EFFECTIVENESS DATE: 20140214 FILER: COMPANY DATA: COMPANY CONFORMED NAME: BAKER BROS. ADVISORS LP CENTRAL INDEX KEY: 0001263508 IRS NUMBER: 134093645 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10519 FILM NUMBER: 14616937 BUSINESS ADDRESS: STREET 1: 667 MADISON AVE STREET 2: 21ST FLOOR CITY: NEW YORK STATE: NY ZIP: 10065 BUSINESS PHONE: 2123395600 MAIL ADDRESS: STREET 1: 667 MADISON AVE STREET 2: 21ST FLOOR CITY: NEW YORK STATE: NY ZIP: 10065 FORMER COMPANY: FORMER CONFORMED NAME: BAKER BROS ADVISORS LLC DATE OF NAME CHANGE: 20030911 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001263508 XXXXXXXX 12-31-2013 12-31-2013 false BAKER BROS. ADVISORS LP

667 Madison Ave 21st Floor New York NY 10065

13F HOLDINGS REPORT 028-10519 N Alexandra Toohey 212-339-5690 /s/ Alexandra Toohey New York NY 01-31-2014 0 95 7095729 INFORMATION TABLE 2 infotable.xml Acadia Pharmaceuticals Inc. COM 004225108 498679 19955126 SH SOLE 19955126 0 0 Acceleron Pharma Inc. COM 00434H108 1188 30000 SH SOLE 30000 0 0 Achillion COM 00448Q201 1510 455000 SH SOLE 455000 0 0 Aegerion Pharmaceuticals COM 00767E102 35480 500000 SH SOLE 500000 0 0 Aerie Pharmaceuticals COM 00771V108 5388 300000 SH SOLE 300000 0 0 Agios Pharmaceuticals COM 00847X104 4928 205750 SH SOLE 205750 0 0 Ambit Biosciences Corp. COM 02318X100 7210 747954 SH SOLE 747954 0 0 Amicus Therapeutics COM 03152W109 1210 515072 SH SOLE 515072 0 0 Anacor Pharmaceuticals COM 032420101 41950 2500000 SH SOLE 2500000 0 0 Array Biopharma Inc. COM 04269X105 7515 1500000 SH SOLE 1500000 0 0 Arrowhead Research Corp. COM 042797209 33527 3090000 SH SOLE 3090000 0 0 Avanir Pharmaceuticals COM Class A 05348P401 18240 5428591 SH SOLE 5428591 0 0 Biocryst Pharmaceuticals Inc. COM 09058V103 50920 6699979 SH SOLE 6699979 0 0 BioDelivery Sciences Intl. Inc. COM 09060J106 4983 846005 SH SOLE 846005 0 0 Biomarin Pharmaceuticals COM 09061G101 136571 1941304 SH SOLE 1941304 0 0 Biota Pharmaceuticals COM 090694100 4735 1130113 SH SOLE 1130113 0 0 Bluebird Bio Inc. COM 09609G100 2401 114461 SH SOLE 114461 0 0 Cerus COM 157085101 54537 8455306 SH SOLE 8455306 0 0 Chelsea Therapeutics COM 163428105 25700 5794753 SH SOLE 5794753 0 0 Chemocentryx Inc. COM 16383L106 290 50000 SH SOLE 50000 0 0 Clovis Oncology COM 189464100 31988 530738 SH SOLE 530738 0 0 Cyclacel Pharmaceuticals Pfd. Conv. Ex 6% PFD CONV EX 23254L207 193 20979 SH SOLE 20979 0 0 Derma Sciences COM 249827502 27687 2558857 SH SOLE 2558857 0 0 Discovery Laboratories Inc. COM 254668403 8367 3718617 SH SOLE 3718617 0 0 Dyax Corp. COM 26746E103 15270 2026537 SH SOLE 2026537 0 0 Enanta Pharmaceuticals COM 29251M106 2976 109097 SH SOLE 109097 0 0 Epizyme Inc. COM 29428V104 4576 220000 SH SOLE 220000 0 0 Five Prime Therapeutics Inc. COM 33830X104 333 19823 SH SOLE 19823 0 0 Foundation Medicine Inc. COM 350465100 476 20000 SH SOLE 20000 0 0 Galectin Therapeutics Inc. COM 363225202 813 100600 SH SOLE 100600 0 0 Genomic Health Inc. COM 37244C101 399560 13650835 SH SOLE 13650835 0 0 Geron Corp. COM 374163103 1908 402629 SH SOLE 402629 0 0 Gilead Sciences Inc. COM 375558103 41764 556108 SH SOLE 556108 0 0 GW Pharmaceuticals PLC ADS 36197T103 3912 94172 SH SOLE 94172 0 0 Halozyme Therapeutics Inc. COM 40637H109 94392 6297026 SH SOLE 6297026 0 0 Idera Pharmaceuticals Inc. COM 45168K306 14685 3171765 SH SOLE 3171765 0 0 Incyte Corp. COM 45337C102 749859 14810559 SH SOLE 14810559 0 0 Infinity Pharmaceuticals Inc. COM 45665303 8883 643256 SH SOLE 643256 0 0 Insmed Inc. COM 457669307 13538 796378 SH SOLE 796378 0 0 Intercept Pharmaceuticals, Inc. COM 45845P108 24775 362847 SH SOLE 362847 0 0 Intermune Inc. COM 45884X103 2210 150000 SH SOLE 150000 0 0 Ironwood Pharmaceuticals COM 46333X108 6341 546160 SH SOLE 546160 0 0 Isis Pharmaceuticals COM 464330109 9842 247036 SH SOLE 247036 0 0 Karyopharm Therapeutics COM 48576U106 1406 61330 SH SOLE 61330 0 0 Kythera Biopharmaceuticals COM 501570105 11698 313191 SH SOLE 313191 0 0 Ligand Pharmaceuticals Inc. CLASS B 53220K207 3861 73400 SH SOLE 73400 0 0 Macrogenics COM 556099109 2743 100000 SH SOLE 100000 0 0 Medivation Inc. COM 58501N101 25421 398331 SH SOLE 398331 0 0 Mirati Therapeutics Inc. COM 60468T105 39581 2380074 SH SOLE 2380074 0 0 Novavax COM 670002104 6589 1286913 SH SOLE 1286913 0 0 Omeros Corp COM 682143102 6869 608404 SH SOLE 608404 0 0 Ophthotech Corp. COM 683745103 3333 103040 SH SOLE 103040 0 0 Orasure Technologies Inc. COM 68554V108 1531 243467 SH SOLE 243467 0 0 Osiris Therapeutics Inc. COM 68827R108 6035 375282 SH SOLE 375282 0 0 Pharmacyclics Inc. COM 716933106 922319 8719218 SH SOLE 8719218 0 0 Portola Pharmaceuticals, Inc. COM 737010108 5779 224434 SH SOLE 224434 0 0 Progenics Pharmaceuticals, Inc. COM 743187106 22386 4200000 SH SOLE 4200000 0 0 Prothena Corp. PLC SHS G72800108 8935 336918 SH SOLE 336918 0 0 Puma Biotechnology COM 74587V107 2588 25000 SH SOLE 25000 0 0 QLT, Inc. COM 746927102 8555 1535863 SH SOLE 1535863 0 0 Questcor Pharmaceuticals, Inc. COM 74835Y101 42246 775864 SH SOLE 775864 0 0 Receptos Inc. COM 756207106 2899 100000 SH SOLE 100000 0 0 Repros Therapeutics COM 76028H209 50849 2778654 SH SOLE 2778654 0 0 Rigel Pharmaceuticals COM 766559603 1425 500000 SH SOLE 500000 0 0 Salix Pharmaceuticals, Inc. COM 795435106 326 3621 SH SOLE 3621 0 0 Sangamo COM 800677106 5894 424308 SH SOLE 424308 0 0 Seattle Genetics Inc. COM 812578102 827156 20735926 SH SOLE 20735926 0 0 Stemline Therapeutics Inc. COM 85858C107 13231 675042 SH SOLE 675042 0 0 Synageva Biopharma Corp. COM 87159A103 664880 10273182 SH SOLE 10273182 0 0 Synergy Pharmaceuticals COM 871639308 14685 2608271 SH SOLE 2608271 0 0 Synta Pharmaceuticals COM 87162T206 2620 500000 SH SOLE 500000 0 0 Tekmire Pharmaceuticals Corp. COM 87911B209 3985 500000 SH SOLE 500000 0 0 Tesaro Inc. COM 881569107 882 31218 SH SOLE 31218 0 0 TG Therapeutics COM 88322Q108 8579 2199656 SH SOLE 2199656 0 0 Threshold Pharma COM 885807206 8651 1852399 SH SOLE 1852399 0 0 United Therapeutics Corp. COM 91307C102 2262 20000 SH SOLE 20000 0 0 Vanda Pharmaceuticals, Inc. COM 921659108 59459 4791179 SH SOLE 4791179 0 0 Ventrus Biosciences, Inc. COM 922822101 4645 1215840 SH SOLE 1215840 0 0 Xencor COM 98401F105 5027 550000 SH SOLE 550000 0 0 Xenoport COM 98411C100 5946 1034112 SH SOLE 1034112 0 0 Xoma Corp. COM 98419J107 155008 23032372 SH SOLE 23032372 0 0 Ziopharm Oncology Inc. COM 98973P101 1103 254199 SH SOLE 254199 0 0 Zogenix, Inc. COM 98978L105 9463 2751000 SH SOLE 2751000 0 0 Auxilium 1.5% 7/15/2018 CONV BONDS 05334DAA5 96343 87090000 PRN SOLE 87090000 0 0 Biomarin Pharmaceuticals Notes 1.875% 4/23/2017 CONV BONDS 09061GAD3 79367 22898000 PRN SOLE 22898000 0 0 Biomarin Pharmaceuticals Notes 0.75% 10/15/2018 CONV BONDS 09061GAE1 13262 12500000 PRN SOLE 12500000 0 0 Gilead 1.625% 5/1/16 CONV BONDS 375558AP8 70910 21500000 PRN SOLE 21500000 0 0 Incyte Genomics Notes 4.75% 10/1/2015 144A CONV BONDS 45337CAH5 233032 40446000 PRN SOLE 40446000 0 0 Incyte Genomics Notes 0.375% 11/15/2018 144A CONV BONDS 45337CAK8 310045 259000000 PRN SOLE 259000000 0 0 Incyte Genomics Notes 1.25% 11/15/2020 144A CONV BONDS 45337CAL6 333004 274500000 PRN SOLE 274500000 0 0 Intermune Inc Notes 5% 3/1/15 CONV BONDS 45884XAD5 19526 16860000 PRN SOLE 16860000 0 0 Intermune Inc Notes 2.5% 12/15/17 CONV BONDS 45884XAF0 56157 41000000 PRN SOLE 41000000 0 0 Medivation 2.625% 4/1/17 CONV BONDS 58501NAA9 57806 39500000 PRN SOLE 39500000 0 0 Salix 2.75% 5/15/15 CONV BONDS 795435AC0 431748 219440000 PRN SOLE 219440000 0 0 Salix 1.5% 3/15/19 CONV BONDS 795435AE6 22369 15000000 PRN SOLE 15000000 0 0