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UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2seventy bio, Inc. COM 901384107   10,664,436 2,497,526 SH   SOLE   2,497,526 0 0
Aadi Bioscience, Inc. COM 00032Q104   508,489 251,727 SH   SOLE   251,727 0 0
AbCellera Biologics Inc. COM 00288U106   130,814,690 22,909,753 SH   SOLE   22,909,753 0 0
ACADIA Pharmaceuticals Inc. COM 004225108   1,342,091,002 42,864,612 SH   SOLE   42,864,612 0 0
Achilles Therapeutics plc SPONSORED ADS 00449L102   1,869,382 2,102,792 SH   SOLE   2,102,792 0 0
Adaptimmune Therapeutics plc SPONSORED ADR 00653A107   8,698,641 10,969,282 SH   SOLE   10,969,282 0 0
Aerovate Therapeutics, Inc. COM 008064107   38,030,100 1,680,517 SH   SOLE   1,680,517 0 0
Akero Therapeutics, Inc. COM 00973Y108   55,301,626 2,368,378 SH   SOLE   2,368,378 0 0
Aligos Therapeutics, Inc. COM 01626L105   1,378,730 2,076,400 SH   SOLE   2,076,400 0 0
argenx SE SPONSORED ADR 04016X101   57,526,722 151,215 SH   SOLE   151,215 0 0
ARS Pharmaceuticals, Inc. COM 82835W108   10,995,351 2,006,451 SH   SOLE   2,006,451 0 0
Athira Pharma, Inc. COM 04746L104   7,663,751 3,153,807 SH   SOLE   3,153,807 0 0
Atreca, Inc. CL A COM 04965G109   287,430 2,177,499 SH   SOLE   2,177,499 0 0
BeiGene, Ltd. SPONSORED ADR 07725L102   1,906,206,263 10,568,897 SH   SOLE   10,568,897 0 0
Bicycle Therapeutics plc SPONSORED ADS 088786108   32,370,251 1,790,390 SH   SOLE   1,790,390 0 0
BioCryst Pharmaceuticals, Inc. COM 09058V103   60,655,794 10,126,176 SH   SOLE   10,126,176 0 0
Biomea Fusion, Inc. COM 09077A106   30,621,939 2,108,949 SH   SOLE   2,108,949 0 0
Cabaletta Bio, Inc. COM 12674W109   302,614 13,331 SH   SOLE   13,331 0 0
Celcuity Inc. COM 15102K100   7,801,914 535,478 SH   SOLE   535,478 0 0
Celldex Therapeutics, Inc. COM 15117B202   9,821,561 247,644 SH   SOLE   247,644 0 0
Century Therapeutics, Inc. COM 15673T100   2,647,567 797,460 SH   SOLE   797,460 0 0
Cerevel Therapeutics Holdings, Inc. COM 15678U128   67,840,000 1,600,000 SH   SOLE   1,600,000 0 0
Cerus Corporation COM 157085101   42,071,052 19,477,339 SH   SOLE   19,477,339 0 0
Compass Therapeutics, Inc. COM 20454B104   2,429,903 1,557,630 SH   SOLE   1,557,630 0 0
Day One Biopharmaceuticals, Inc. COM 23954D109   14,600,000 1,000,000 SH   SOLE   1,000,000 0 0
DBV Technologies S.A. SPONSORED ADR 23306J101   13,924,471 14,614,264 SH   SOLE   14,614,264 0 0
Denali Therapeutics Inc. COM 24823R105   55,950,426 2,607,196 SH   SOLE   2,607,196 0 0
Design Therapeutics, Inc. COM 25056L103   3,975,000 1,500,000 SH   SOLE   1,500,000 0 0
Edgewise Therapeutics, Inc. COM 28036F105   34,053,879 3,112,786 SH   SOLE   3,112,786 0 0
Entrada Therapeutics, Inc. COM 29384C108   73,425,209 4,865,819 SH   SOLE   4,865,819 0 0
Foghorn Therapeutics Inc. COM 344174107   290,424 45,027 SH   SOLE   45,027 0 0
Gracell Biotechnologies Inc. SPONSORED ADS 38406L103   20,883,200 2,080,000 SH   SOLE   2,080,000 0 0
HOOKIPA Pharma Inc. COM 43906K100   6,583,802 8,128,151 SH   SOLE   8,128,151 0 0
IDEAYA Biosciences, Inc. COM 45166A102   37,790,336 1,062,123 SH   SOLE   1,062,123 0 0
IGM Biosciences, Inc. COM 449585108   30,672,301 3,691,011 SH   SOLE   3,691,011 0 0
Immatics N.V. SHS N44445109   61,483,122 5,838,853 SH   SOLE   5,838,853 0 0
Immunocore Holdings plc ADS 45258D105   172,216,342 2,520,731 SH   SOLE   2,520,731 0 0
Immunovant, Inc. COM 45258J102   17,905,629 425,009 SH   SOLE   425,009 0 0
Incyte Corporation COM 45337C102   2,271,687,070 36,179,122 SH   SOLE   36,179,122 0 0
Insmed Incorporated COM PAR $.01 457669307   10,629,570 343,000 SH   SOLE   343,000 0 0
Invitae Corporation COM 46185L103   1,106,017 1,764,546 SH   SOLE   1,764,546 0 0
KALA BIO, Inc. COM 483119202   1,866,291 266,613 SH   SOLE   266,613 0 0
Kiniksa Pharmaceuticals, Ltd. COM CL A G5269C101   49,279,981 2,809,577 SH   SOLE   2,809,577 0 0
Kodiak Sciences Inc. COM 50015M109   52,623,890 17,310,490 SH   SOLE   17,310,490 0 0
Krystal Biotech, Inc. COM 501147102   21,082,012 169,934 SH   SOLE   169,934 0 0
Kymera Therapeutics, Inc. COM 501575104   152,656,327 5,995,928 SH   SOLE   5,995,928 0 0
Leap Therapeutics, Inc. COM 52187K200   4,858,665 1,172,175 SH   SOLE   1,172,175 0 0
Madrigal Pharmaceuticals, Inc. COM 558868105   455,771,861 1,969,798 SH   SOLE   1,969,798 0 0
Mersana Therapeutics, Inc. COM 59045L106   2,519,787 1,086,115 SH   SOLE   1,086,115 0 0
Mirati Therapeutics, Inc. COM 60468T105   242,134,600 4,121,440 SH   SOLE   4,121,440 0 0
Mirum Pharmaceuticals, Inc. COM 604749101   5,622,852 190,476 SH   SOLE   190,476 0 0
Monte Rosa Therapeutics, Inc. COM 61225M102   27,775,937 4,916,095 SH   SOLE   4,916,095 0 0
Neurogene Inc. COM 64135M105   8,789,140 453,516 SH   SOLE   453,516 0 0
Nurix Therapeutics, Inc. COM 67080M103   40,063,530 3,882,125 SH   SOLE   3,882,125 0 0
Opthea Limited SPONSORED ADS 68386J208   7,636,503 2,588,645 SH   SOLE   2,588,645 0 0
Perspective Therapeutics, Inc. COM 46489V104   3,071,161 7,639,703 SH   SOLE   7,639,703 0 0
Pfizer Inc. COM 717081103   1,007,650 35,000 SH   SOLE   35,000 0 0
PMV Pharmaceuticals, Inc. COM 69353Y103   998,274 322,024 SH   SOLE   322,024 0 0
Praxis Precision Medicines, Inc. COM 74006W108   2,930,555 131,533 SH   SOLE   131,533 0 0
Prelude Therapeutics Inc. COM 74065P101   43,228,728 10,123,824 SH   SOLE   10,123,824 0 0
Prime Medicine, Inc. COM 74168J101   9,112,209 1,028,466 SH   SOLE   1,028,466 0 0
Protara Therapeutics, Inc. COM STK 74365U107   374,403 199,671 SH   SOLE   199,671 0 0
Relay Therapeutics, Inc. COM 75943R102   12,772,888 1,160,117 SH   SOLE   1,160,117 0 0
Replimune Group, Inc. COM 76029N106   80,467,182 9,545,336 SH   SOLE   9,545,336 0 0
Revolution Medicines, Inc. COM 76155X100   147,663,483 5,148,657 SH   SOLE   5,148,657 0 0
Rhythm Pharmaceuticals, Inc. COM 76243J105   294,132,839 6,398,365 SH   SOLE   6,398,365 0 0
Roivant Sciences Ltd. SHS G76279101   85,269,660 7,593,024 SH   SOLE   7,593,024 0 0
Sagimet Biosciences Inc. COM SER A 786700104   7,894,328 1,456,518 SH   SOLE   1,456,518 0 0
Sana Biotechnology, Inc. COM 799566104   8,160,000 2,000,000 SH   SOLE   2,000,000 0 0
Sera Prognostics, Inc. CLASS A COM 81749D107   32,497,706 5,434,399 SH   SOLE   5,434,399 0 0
Stoke Therapeutics, Inc. COM 86150R107   10,678,505 2,030,134 SH   SOLE   2,030,134 0 0
Surrozen, Inc. W EXP 8/11/2026 86889P117   16,167 833,333 SH   SOLE   833,333 0 0
Talis Biomedical Corporation COM 87424L207   3,787,006 508,323 SH   SOLE   508,323 0 0
Tango Therapeutics, Inc. COM 87583X109   7,425,000 750,000 SH   SOLE   750,000 0 0
Taysha Gene Therapies, Inc. COM SHS 877619106   7,088,418 4,004,756 SH   SOLE   4,004,756 0 0
TScan Therapeutics, Inc. COM 89854M101   16,235,337 2,784,792 SH   SOLE   2,784,792 0 0
Tyra Biosciences, Inc. COM 90240B106   146,907 10,607 SH   SOLE   10,607 0 0
Ultragenyx Pharmaceutical Inc. COM 90400D108   70,130,278 1,466,547 SH   SOLE   1,466,547 0 0
Vaxcyte, Inc. COM 92243G108   3,069,978 48,885 SH   SOLE   48,885 0 0
Verve Therapeutics, Inc. COM 92539P101   23,579,928 1,691,530 SH   SOLE   1,691,530 0 0
Xencor, Inc. COM 98401F105   5,210,500 245,431 SH   SOLE   245,431 0 0
Xenon Pharmaceuticals Inc. COM 98420N105   45,768,855 993,679 SH   SOLE   993,679 0 0
Invitae Corporation Notes 1.5% 4/1/2028 46185LAD5   131,152,500 300,000,000 PRN   SOLE   300,000,000 0 0
Invitae Corporation Series A Notes 4.5% 3/15/2028 46185LAH6   6,272,702 9,274,000 PRN   SOLE   9,274,000 0 0