0001104659-24-024053.txt : 20240214 0001104659-24-024053.hdr.sgml : 20240214 20240214171205 ACCESSION NUMBER: 0001104659-24-024053 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20231231 FILED AS OF DATE: 20240214 DATE AS OF CHANGE: 20240214 EFFECTIVENESS DATE: 20240214 FILER: COMPANY DATA: COMPANY CONFORMED NAME: BAKER BROS. ADVISORS LP CENTRAL INDEX KEY: 0001263508 ORGANIZATION NAME: IRS NUMBER: 134093645 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10519 FILM NUMBER: 24640470 BUSINESS ADDRESS: STREET 1: 860 WASHINGTON STREET STREET 2: 3RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 BUSINESS PHONE: 2123395600 MAIL ADDRESS: STREET 1: 860 WASHINGTON STREET STREET 2: 3RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 FORMER COMPANY: FORMER CONFORMED NAME: BAKER BROS ADVISORS LLC DATE OF NAME CHANGE: 20030911 13F-HR 1 primary_doc.xml X0202 13F-HR LIVE false false false 0001263508 XXXXXXXX 12-31-2023 12-31-2023 false BAKER BROS. ADVISORS LP

860 WASHINGTON STREET 3RD FLOOR NEW YORK NY 10014

13F HOLDINGS REPORT 028-10519 000158149 801-73446 N Alexandra Toohey 212-339-5690 /s/ Alexandra Toohey New York NY 02-14-2024 0 84 8788600529 INFORMATION TABLE 2 infotable.xml 2seventy bio, Inc. COM 901384107 10664436 2497526 SH SOLE 2497526 0 0 Aadi Bioscience, Inc. COM 00032Q104 508489 251727 SH SOLE 251727 0 0 AbCellera Biologics Inc. COM 00288U106 130814690 22909753 SH SOLE 22909753 0 0 ACADIA Pharmaceuticals Inc. COM 004225108 1342091002 42864612 SH SOLE 42864612 0 0 Achilles Therapeutics plc SPONSORED ADS 00449L102 1869382 2102792 SH SOLE 2102792 0 0 Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 8698641 10969282 SH SOLE 10969282 0 0 Aerovate Therapeutics, Inc. COM 008064107 38030100 1680517 SH SOLE 1680517 0 0 Akero Therapeutics, Inc. COM 00973Y108 55301626 2368378 SH SOLE 2368378 0 0 Aligos Therapeutics, Inc. COM 01626L105 1378730 2076400 SH SOLE 2076400 0 0 argenx SE SPONSORED ADR 04016X101 57526722 151215 SH SOLE 151215 0 0 ARS Pharmaceuticals, Inc. COM 82835W108 10995351 2006451 SH SOLE 2006451 0 0 Athira Pharma, Inc. COM 04746L104 7663751 3153807 SH SOLE 3153807 0 0 Atreca, Inc. CL A COM 04965G109 287430 2177499 SH SOLE 2177499 0 0 BeiGene, Ltd. SPONSORED ADR 07725L102 1906206263 10568897 SH SOLE 10568897 0 0 Bicycle Therapeutics plc SPONSORED ADS 088786108 32370251 1790390 SH SOLE 1790390 0 0 BioCryst Pharmaceuticals, Inc. COM 09058V103 60655794 10126176 SH SOLE 10126176 0 0 Biomea Fusion, Inc. COM 09077A106 30621939 2108949 SH SOLE 2108949 0 0 Cabaletta Bio, Inc. COM 12674W109 302614 13331 SH SOLE 13331 0 0 Celcuity Inc. COM 15102K100 7801914 535478 SH SOLE 535478 0 0 Celldex Therapeutics, Inc. COM 15117B202 9821561 247644 SH SOLE 247644 0 0 Century Therapeutics, Inc. COM 15673T100 2647567 797460 SH SOLE 797460 0 0 Cerevel Therapeutics Holdings, Inc. COM 15678U128 67840000 1600000 SH SOLE 1600000 0 0 Cerus Corporation COM 157085101 42071052 19477339 SH SOLE 19477339 0 0 Compass Therapeutics, Inc. COM 20454B104 2429903 1557630 SH SOLE 1557630 0 0 Day One Biopharmaceuticals, Inc. COM 23954D109 14600000 1000000 SH SOLE 1000000 0 0 DBV Technologies S.A. SPONSORED ADR 23306J101 13924471 14614264 SH SOLE 14614264 0 0 Denali Therapeutics Inc. COM 24823R105 55950426 2607196 SH SOLE 2607196 0 0 Design Therapeutics, Inc. COM 25056L103 3975000 1500000 SH SOLE 1500000 0 0 Edgewise Therapeutics, Inc. COM 28036F105 34053879 3112786 SH SOLE 3112786 0 0 Entrada Therapeutics, Inc. COM 29384C108 73425209 4865819 SH SOLE 4865819 0 0 Foghorn Therapeutics Inc. COM 344174107 290424 45027 SH SOLE 45027 0 0 Gracell Biotechnologies Inc. SPONSORED ADS 38406L103 20883200 2080000 SH SOLE 2080000 0 0 HOOKIPA Pharma Inc. COM 43906K100 6583802 8128151 SH SOLE 8128151 0 0 IDEAYA Biosciences, Inc. COM 45166A102 37790336 1062123 SH SOLE 1062123 0 0 IGM Biosciences, Inc. COM 449585108 30672301 3691011 SH SOLE 3691011 0 0 Immatics N.V. SHS N44445109 61483122 5838853 SH SOLE 5838853 0 0 Immunocore Holdings plc ADS 45258D105 172216342 2520731 SH SOLE 2520731 0 0 Immunovant, Inc. COM 45258J102 17905629 425009 SH SOLE 425009 0 0 Incyte Corporation COM 45337C102 2271687070 36179122 SH SOLE 36179122 0 0 Insmed Incorporated COM PAR $.01 457669307 10629570 343000 SH SOLE 343000 0 0 Invitae Corporation COM 46185L103 1106017 1764546 SH SOLE 1764546 0 0 KALA BIO, Inc. COM 483119202 1866291 266613 SH SOLE 266613 0 0 Kiniksa Pharmaceuticals, Ltd. COM CL A G5269C101 49279981 2809577 SH SOLE 2809577 0 0 Kodiak Sciences Inc. COM 50015M109 52623890 17310490 SH SOLE 17310490 0 0 Krystal Biotech, Inc. COM 501147102 21082012 169934 SH SOLE 169934 0 0 Kymera Therapeutics, Inc. COM 501575104 152656327 5995928 SH SOLE 5995928 0 0 Leap Therapeutics, Inc. COM 52187K200 4858665 1172175 SH SOLE 1172175 0 0 Madrigal Pharmaceuticals, Inc. COM 558868105 455771861 1969798 SH SOLE 1969798 0 0 Mersana Therapeutics, Inc. COM 59045L106 2519787 1086115 SH SOLE 1086115 0 0 Mirati Therapeutics, Inc. COM 60468T105 242134600 4121440 SH SOLE 4121440 0 0 Mirum Pharmaceuticals, Inc. COM 604749101 5622852 190476 SH SOLE 190476 0 0 Monte Rosa Therapeutics, Inc. COM 61225M102 27775937 4916095 SH SOLE 4916095 0 0 Neurogene Inc. COM 64135M105 8789140 453516 SH SOLE 453516 0 0 Nurix Therapeutics, Inc. COM 67080M103 40063530 3882125 SH SOLE 3882125 0 0 Opthea Limited SPONSORED ADS 68386J208 7636503 2588645 SH SOLE 2588645 0 0 Perspective Therapeutics, Inc. COM 46489V104 3071161 7639703 SH SOLE 7639703 0 0 Pfizer Inc. COM 717081103 1007650 35000 SH SOLE 35000 0 0 PMV Pharmaceuticals, Inc. COM 69353Y103 998274 322024 SH SOLE 322024 0 0 Praxis Precision Medicines, Inc. COM 74006W108 2930555 131533 SH SOLE 131533 0 0 Prelude Therapeutics Inc. COM 74065P101 43228728 10123824 SH SOLE 10123824 0 0 Prime Medicine, Inc. COM 74168J101 9112209 1028466 SH SOLE 1028466 0 0 Protara Therapeutics, Inc. COM STK 74365U107 374403 199671 SH SOLE 199671 0 0 Relay Therapeutics, Inc. COM 75943R102 12772888 1160117 SH SOLE 1160117 0 0 Replimune Group, Inc. COM 76029N106 80467182 9545336 SH SOLE 9545336 0 0 Revolution Medicines, Inc. COM 76155X100 147663483 5148657 SH SOLE 5148657 0 0 Rhythm Pharmaceuticals, Inc. COM 76243J105 294132839 6398365 SH SOLE 6398365 0 0 Roivant Sciences Ltd. SHS G76279101 85269660 7593024 SH SOLE 7593024 0 0 Sagimet Biosciences Inc. COM SER A 786700104 7894328 1456518 SH SOLE 1456518 0 0 Sana Biotechnology, Inc. COM 799566104 8160000 2000000 SH SOLE 2000000 0 0 Sera Prognostics, Inc. CLASS A COM 81749D107 32497706 5434399 SH SOLE 5434399 0 0 Stoke Therapeutics, Inc. COM 86150R107 10678505 2030134 SH SOLE 2030134 0 0 Surrozen, Inc. W EXP 8/11/2026 86889P117 16167 833333 SH SOLE 833333 0 0 Talis Biomedical Corporation COM 87424L207 3787006 508323 SH SOLE 508323 0 0 Tango Therapeutics, Inc. COM 87583X109 7425000 750000 SH SOLE 750000 0 0 Taysha Gene Therapies, Inc. COM SHS 877619106 7088418 4004756 SH SOLE 4004756 0 0 TScan Therapeutics, Inc. COM 89854M101 16235337 2784792 SH SOLE 2784792 0 0 Tyra Biosciences, Inc. COM 90240B106 146907 10607 SH SOLE 10607 0 0 Ultragenyx Pharmaceutical Inc. COM 90400D108 70130278 1466547 SH SOLE 1466547 0 0 Vaxcyte, Inc. COM 92243G108 3069978 48885 SH SOLE 48885 0 0 Verve Therapeutics, Inc. COM 92539P101 23579928 1691530 SH SOLE 1691530 0 0 Xencor, Inc. COM 98401F105 5210500 245431 SH SOLE 245431 0 0 Xenon Pharmaceuticals Inc. COM 98420N105 45768855 993679 SH SOLE 993679 0 0 Invitae Corporation Notes 1.5% 4/1/2028 46185LAD5 131152500 300000000 PRN SOLE 300000000 0 0 Invitae Corporation Series A Notes 4.5% 3/15/2028 46185LAH6 6272702 9274000 PRN SOLE 9274000 0 0