0001104659-20-095518.txt : 20200814 0001104659-20-095518.hdr.sgml : 20200814 20200814160840 ACCESSION NUMBER: 0001104659-20-095518 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20200630 FILED AS OF DATE: 20200814 DATE AS OF CHANGE: 20200814 EFFECTIVENESS DATE: 20200814 FILER: COMPANY DATA: COMPANY CONFORMED NAME: BAKER BROS. ADVISORS LP CENTRAL INDEX KEY: 0001263508 IRS NUMBER: 134093645 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10519 FILM NUMBER: 201105092 BUSINESS ADDRESS: STREET 1: 860 WASHINGTON STREET STREET 2: 3RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 BUSINESS PHONE: 2123395600 MAIL ADDRESS: STREET 1: 860 WASHINGTON STREET STREET 2: 3RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 FORMER COMPANY: FORMER CONFORMED NAME: BAKER BROS ADVISORS LLC DATE OF NAME CHANGE: 20030911 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001263508 XXXXXXXX 06-30-2020 06-30-2020 false BAKER BROS. ADVISORS LP

860 WASHINGTON STREET 3RD FLOOR NEW YORK NY 10014

13F HOLDINGS REPORT 028-10519 N Alexandra Toohey 212-339-5690 /s/ Alexandra Toohey New York NY 08-14-2020 0 114 22670991 INFORMATION TABLE 2 infotable.xml Abeona Therapeutics Inc. COM 00289Y107 4637 1590686 SH SOLE 1590686 0 0 ACADIA Pharmaceuticals Inc. COM 004225108 2031115 41904586 SH SOLE 41904586 0 0 Acceleron Pharma Inc. COM 00434H108 2572 27000 SH SOLE 27000 0 0 Adamas Pharmaceuticals, Inc. COM 00548A106 442 172630 SH SOLE 172630 0 0 Adaptive Biotechnologies Corporation COM 00650F109 22426 463539 SH SOLE 463539 0 0 Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 66819 6675181 SH SOLE 6675181 0 0 ADC Therapeutics SA SHS H0036K147 78992 1687500 SH SOLE 1687500 0 0 Aeglea BioTherapeutics, Inc. COM 00773J103 40511 4379592 SH SOLE 4379592 0 0 Affimed N.V. COM N01045108 923 200000 SH SOLE 200000 0 0 Aimmune Therapeutics, Inc. COM 00900T107 11261 673908 SH SOLE 673908 0 0 Albireo Pharma, Inc. COM 01345P106 9776 369047 SH SOLE 369047 0 0 Alector, Inc. COM 014442107 6843 280000 SH SOLE 280000 0 0 Alexion Pharmaceuticals, Inc. COM 015351109 983312 8760794 SH SOLE 8760794 0 0 Alkermes plc SHS G01767105 24154 1244744 SH SOLE 1244744 0 0 Allakos Inc. COM 01671P100 52851 735469 SH SOLE 735469 0 0 Altimmune, Inc. COM 02155H200 22572 2107600 SH SOLE 2107600 0 0 Amarin Corporation plc SPONSORED ADR 023111206 238717 34496685 SH SOLE 34496685 0 0 AnaptysBio, Inc. COM 032724106 11476 513677 SH SOLE 513677 0 0 Apellis Pharmaceuticals, Inc. COM 03753U106 29281 896551 SH SOLE 896551 0 0 Applied Therapeutics, Inc. COM 03828A101 2384 65934 SH SOLE 65934 0 0 Aravive, Inc. COM 03890D108 2841 244055 SH SOLE 244055 0 0 Arcus Biosciences, Inc. COM 03969F109 3007 121534 SH SOLE 121534 0 0 argenx SE SPONSORED ADR 04016X101 229635 1019557 SH SOLE 1019557 0 0 ARYA Sciences Acquisition Corp. SHS CL A G3165V109 2361 150000 SH SOLE 150000 0 0 Ascendis Pharma A/S SPONSORED ADR 04351P101 501421 3390270 SH SOLE 3390270 0 0 Assembly Biosciences, Inc. COM 045396108 35951 1541618 SH SOLE 1541618 0 0 Atreca, Inc. CL A COM 04965G109 75177 3532760 SH SOLE 3532760 0 0 Aurinia Pharmaceuticals Inc. COM 05156V102 27656 1701929 SH SOLE 1701929 0 0 Autolus Therapeutics plc SPON ADS 05280R100 7785 485624 SH SOLE 485624 0 0 Axsome Therapeutics, Inc. COM 05464T104 83083 1009757 SH SOLE 1009757 0 0 BeiGene, Ltd. SPONSORED ADR 07725L102 2218840 11777285 SH SOLE 11777285 0 0 Bellicum Pharmaceuticals, Inc. COM 079481404 1851 249123 SH SOLE 249123 0 0 BioCryst Pharmaceuticals, Inc. COM 09058V103 65597 13766405 SH SOLE 13766405 0 0 BioMarin Pharmaceutical Inc. COM 09061G101 936064 7589294 SH SOLE 7589294 0 0 bluebird bio, Inc. COM 09609G100 16176 265000 SH SOLE 265000 0 0 Burning Rock Biotech Limited SPONSORED ADS 12233L107 6753 250000 SH SOLE 250000 0 0 Cabaletta Bio, Inc. COM 12674W109 7089 636363 SH SOLE 636363 0 0 Catalyst Pharmaceuticals, Inc. COM 14888U101 2310 500000 SH SOLE 500000 0 0 Cerus Corporation COM 157085101 90507 13713195 SH SOLE 13713195 0 0 ChemoCentryx, Inc. COM 16383L106 54388 945221 SH SOLE 945221 0 0 Chiasma, Inc. COM 16706W102 5093 946701 SH SOLE 946701 0 0 Constellation Pharmaceuticals, Inc. COM 210373106 4007 133333 SH SOLE 133333 0 0 Crinetics Pharmaceuticals, Inc. COM 22663K107 5569 317857 SH SOLE 317857 0 0 CymaBay Therapeutics, Inc. COM 23257D103 5315 1522792 SH SOLE 1522792 0 0 DBV Technologies S.A. SPONSORED ADR 23306J101 64157 14614264 SH SOLE 14614264 0 0 Denali Therapeutics Inc. COM 24823R105 2536 104900 SH SOLE 104900 0 0 Dicerna Pharmaceuticals, Inc. COM 253031108 3031 119335 SH SOLE 119335 0 0 Exact Sciences Corporation COM 30063P105 160503 1846139 SH SOLE 1846139 0 0 Evofem Biosciences, Inc. COM 30048L104 4033 1425000 SH SOLE 1425000 0 0 Frequency Therapeutics, Inc. COM 35803L108 21988 945719 SH SOLE 945719 0 0 Forma Therapeutics Holdings, Inc. SHS 34633R104 92980 2000000 SH SOLE 2000000 0 0 Fulgent Genetics, Inc. COM 359664109 9111 569444 SH SOLE 569444 0 0 Galapagos NV SPON ADR 36315X101 2579 13072 SH SOLE 13072 0 0 Galmed Pharmaceuticals Ltd. SHS M47238106 1031 215594 SH SOLE 215594 0 0 Gamida Cell Ltd. SHS M47364100 3047 666666 SH SOLE 666666 0 0 Genfit SA ADS 372279109 156 28396 SH SOLE 28396 0 0 Global Blood Therapeutics, Inc. COM 37890U108 2967 47000 SH SOLE 47000 0 0 GW Pharmaceuticals plc ADS 36197T103 22709 185045 SH SOLE 185045 0 0 Heron Therapeutics, Inc. COM 427746102 88526 6018104 SH SOLE 6018104 0 0 HOOKIPA Pharma Inc. COM 43906K100 8140 700481 SH SOLE 700481 0 0 Horizon Therapeutics Public Ltd Co SHS G46188101 11116 200000 SH SOLE 200000 0 0 Idera Pharmaceuticals, Inc. COM PAR 45168K405 8250 4608786 SH SOLE 4608786 0 0 IGM Biosciences, Inc. COM 449585108 229528 3144223 SH SOLE 3144223 0 0 Immunomedics, Inc. COM 452907108 11695 330000 SH SOLE 330000 0 0 Incyte Corporation COM 45337C102 3326944 31999081 SH SOLE 31999081 0 0 Infinity Pharmaceuticals, Inc. COM 45665G303 525 580400 SH SOLE 580400 0 0 Inflarx N.V. COM N44821101 4859 1058555 SH SOLE 1058555 0 0 Insmed Incorporated COM PAR $.01 457669307 83319 3025384 SH SOLE 3025384 0 0 Intellia Therapeutics, Inc. COM 45826J105 2702 128538 SH SOLE 128538 0 0 Invitae Corporation COM 46185L103 358966 11850962 SH SOLE 11850962 0 0 IVERIC bio, Inc. COM 46583P102 8341 1635501 SH SOLE 1635501 0 0 Karuna Therapeutics, Inc. COM 48576A100 9137 81976 SH SOLE 81976 0 0 Kezar Life Sciences, Inc. COM 49372L100 3108 600000 SH SOLE 600000 0 0 Kiniksa Pharmaceuticals, Ltd. COM CL A G5269C101 71333 2799577 SH SOLE 2799577 0 0 Kodiak Sciences Inc. COM 50015M109 626414 11574538 SH SOLE 11574538 0 0 Krystal Biotech, Inc. COM 501147102 33866 817631 SH SOLE 817631 0 0 Leap Therapeutics, Inc. COM 52187K101 2045 978454 SH SOLE 978454 0 0 Legend Biotech Corporation SPONSORED ADS 52490G102 5746 135000 SH SOLE 135000 0 0 Madrigal Pharmaceuticals, Inc. COM 558868105 169786 1499212 SH SOLE 1499212 0 0 Marker Therapeutics, Inc. COM 57055L107 498 240505 SH SOLE 240505 0 0 Matinas BioPharma Holdings, Inc. COM 576810105 1620 2096375 SH SOLE 2096375 0 0 Merus N.V. COM N5749R100 32783 2037469 SH SOLE 2037469 0 0 Mirati Therapeutics, Inc. COM 60468T105 160955 1409784 SH SOLE 1409784 0 0 Mirum Pharmaceuticals, Inc. COM 604749101 11352 583333 SH SOLE 583333 0 0 Molecular Templates, Inc. COM 608550109 2182 158217 SH SOLE 158217 0 0 MyoKardia, Inc. COM 62857M105 305728 3164234 SH SOLE 3164234 0 0 Neoleukin Therapeutics, Inc. COM 64049K104 56402 3397740 SH SOLE 3397740 0 0 Neurocrine Biosciences, Inc. COM 64125C109 110652 906986 SH SOLE 906986 0 0 NGM Biopharmaceuticals, Inc. COM 62921N105 2456 124400 SH SOLE 124400 0 0 Novavax, Inc. COM 670002401 20119 241376 SH SOLE 241376 0 0 Orchard Therapeutics plc ADS 68570P101 2434 405702 SH SOLE 405702 0 0 Ovid Therapeutics Inc. COM 690469101 3377 458253 SH SOLE 458253 0 0 Oyster Point Pharma, Inc. COM 69242L106 2063 71428 SH SOLE 71428 0 0 Passage Bio, Inc. COM 702712100 7516 275000 SH SOLE 275000 0 0 Principia Biopharma Inc. COM 74257L108 94520 1580873 SH SOLE 1580873 0 0 Protagonist Therapeutics, Inc. COM 74366E102 33756 1911446 SH SOLE 1911446 0 0 Protara Therapeutics, Inc. COM STK 74365U107 5854 199671 SH SOLE 199671 0 0 Reata Pharmaceuticals, Inc. CL A 75615P103 8734 55983 SH SOLE 55983 0 0 Replimune Group, Inc. COM 76029N106 128 5141 SH SOLE 5141 0 0 Rhythm Pharmaceuticals, Inc. COM 76243J105 60211 2700055 SH SOLE 2700055 0 0 Sangamo Therapeutics, Inc. COM 800677106 8958 999823 SH SOLE 999823 0 0 Seattle Genetics, Inc. COM 812578102 8032021 47269424 SH SOLE 47269424 0 0 Sunesis Pharmaceuticals, Inc. COM 867328700 147 556665 SH SOLE 556665 0 0 Syros Pharmaceuticals, Inc. COM 87184Q107 7357 690167 SH SOLE 690167 0 0 Tricida, Inc. COM 89610F101 21643 787582 SH SOLE 787582 0 0 uniQure N.V. SHS N90064101 10404 230883 SH SOLE 230883 0 0 Urovant Sciences Ltd. SHS G9381B108 9840 1000000 SH SOLE 1000000 0 0 Vaxart, Inc. COM 92243A200 14506 1639121 SH SOLE 1639121 0 0 Viking Therapeutics, Inc. COM 92686J106 3064 425000 SH SOLE 425000 0 0 Xencor, Inc. COM 98401F105 13867 428120 SH SOLE 428120 0 0 Xenon Pharmaceuticals Inc. COM 98420N105 10021 799102 SH SOLE 799102 0 0 Zymeworks Inc. COM 98985W102 61625 1708472 SH SOLE 1708472 0 0 BioMarin Pharmaceutical Inc. NOTE 0.599% 8/1/2024 09061GAH4 18340 15000000 PRN SOLE 15000000 0 0 Neurocrine Biosciences, Inc. NOTE 2.25% 5/15/2024 64125CAD1 51144 30770000 PRN SOLE 30770000 0 0