Chief Financial Officer

0001104659-19-064169.txt : 20191114 0001104659-19-064169.hdr.sgml : 20191114 20191114160531 ACCESSION NUMBER: 0001104659-19-064169 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20190930 FILED AS OF DATE: 20191114 DATE AS OF CHANGE: 20191114 EFFECTIVENESS DATE: 20191114 FILER: COMPANY DATA: COMPANY CONFORMED NAME: BAKER BROS. ADVISORS LP CENTRAL INDEX KEY: 0001263508 IRS NUMBER: 134093645 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10519 FILM NUMBER: 191220012 BUSINESS ADDRESS: STREET 1: 860 WASHINGTON STREET STREET 2: 3RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 BUSINESS PHONE: 2123395600 MAIL ADDRESS: STREET 1: 860 WASHINGTON STREET STREET 2: 3RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 FORMER COMPANY: FORMER CONFORMED NAME: BAKER BROS ADVISORS LLC DATE OF NAME CHANGE: 20030911 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001263508 XXXXXXXX 09-30-2019 09-30-2019 false BAKER BROS. ADVISORS LP

860 WASHINGTON STREET 3RD FLOOR NEW YORK NY 10014

13F HOLDINGS REPORT 028-10519 N Alexandra Toohey Chief Financial Officer 212-339-5690 /s/ Alexandra Toohey New York NY 11-14-2019 0 109 14699689 INFORMATION TABLE 2 infotable.xml Abeona Therapeutics Inc. COM 00289Y107 2911 1288235 SH SOLE 1288235 0 0 ACADIA Pharmaceuticals Inc. COM 004225108 1470357 40854586 SH SOLE 40854586 0 0 Acceleron Pharma Inc. COM 00434H108 3315 83900 SH SOLE 83900 0 0 Achillion Pharmaceuticals, Inc. COM 00448Q201 3943 1095359 SH SOLE 1095359 0 0 Acorda Therapeutics, Inc. COM 00484M106 6408 2232589 SH SOLE 2232589 0 0 Adamas Pharmaceuticals, Inc. COM 00548A106 883 172630 SH SOLE 172630 0 0 Adaptive Biotechnologies Corporation COM 00650F109 36011 1165411 SH SOLE 1165411 0 0 Aeglea BioTherapeutics, Inc. COM 00773J103 13178 1713604 SH SOLE 1713604 0 0 Affimed N.V. COM N01045108 588 200000 SH SOLE 200000 0 0 Aimmune Therapeutics, Inc. COM 00900T107 14112 673908 SH SOLE 673908 0 0 Albireo Pharma, Inc. COM 01345P106 5000 250000 SH SOLE 250000 0 0 Alexion Pharmaceuticals, Inc. COM 015351109 808795 8258068 SH SOLE 8258068 0 0 Alkermes plc SHS G01767105 12194 625030 SH SOLE 625030 0 0 Allakos Inc. COM 01671P100 26710 339690 SH SOLE 339690 0 0 Amarin Corporation plc SPONSORED ADR 023111206 629811 41544288 SH SOLE 41544288 0 0 AnaptysBio, Inc. COM 032724106 3957 113086 SH SOLE 113086 0 0 Apellis Pharmaceuticals, Inc. COM 03753U106 7558 313725 SH SOLE 313725 0 0 Aquestive Therapeutics, Inc. COM 03843E104 317 99600 SH SOLE 99600 0 0 Neoleukin Therapeutics, Inc. COM 64049K104 32221 11305679 SH SOLE 11305679 0 0 Aravive, Inc. COM 03890D108 4981 664088 SH SOLE 664088 0 0 Arcus Biosciences, Inc. COM 03969F109 1106 121534 SH SOLE 121534 0 0 argenx SE SPONSORED ADR 04016X101 116189 1019557 SH SOLE 1019557 0 0 Ascendis Pharma A/S SPONSORED ADR 04351P101 326551 3390270 SH SOLE 3390270 0 0 Assembly Biosciences, Inc. COM 045396108 7896 803246 SH SOLE 803246 0 0 Atreca, Inc. CL A Common 04965G109 43241 3532760 SH SOLE 3532760 0 0 Audentes Therapeutics, Inc. COM 05070R104 42316 1506438 SH SOLE 1506438 0 0 Autolus Therapeutics plc SPON ADS 05280R100 1947 156773 SH SOLE 156773 0 0 Axsome Therapeutics, Inc. COM 05464T104 15631 772286 SH SOLE 772286 0 0 BeiGene, Ltd. SPONSORED ADR 07725L102 1442246 11777285 SH SOLE 11777285 0 0 Bellicum Pharmaceuticals, Inc. COM 079481107 2812 2677818 SH SOLE 2677818 0 0 BioCryst Pharmaceuticals, Inc. COM 09058V103 36458 12725472 SH SOLE 12725472 0 0 BioMarin Pharmaceutical Inc. COM 09061G101 511518 7589294 SH SOLE 7589294 0 0 BioMarin Pharmaceutical Inc. NOTE 0.599% 8/1/2024 09061GAH4 14722 15000000 PRN SOLE 15000000 0 0 bluebird bio, Inc. COM 09609G100 3673 40000 SH SOLE 40000 0 0 Catalyst Pharmaceuticals, Inc. COM 14888U101 7125 1341902 SH SOLE 1341902 0 0 Cerus Corporation COM 157085101 55416 10749937 SH SOLE 10749937 0 0 ChemoCentryx, Inc. COM 16383L106 1404 207029 SH SOLE 207029 0 0 Constellation Pharmaceuticals, Inc. COM 210373106 861 133333 SH SOLE 133333 0 0 Crinetics Pharmaceuticals, Inc. COM 22663K107 2632 175000 SH SOLE 175000 0 0 Cyclerion Therapeutics, Inc. COM 23255M105 2455 202581 SH SOLE 202581 0 0 CymaBay Therapeutics, Inc. COM 23257D103 29222 5707411 SH SOLE 5707411 0 0 CytomX Therapeutics, Inc. COM 23284F105 1435 194377 SH SOLE 194377 0 0 DBV Technologies S.A. SPONSORED ADR 23306J101 47382 5509560 SH SOLE 5509560 0 0 Dermira, Inc. COM 24983L104 5795 906943 SH SOLE 906943 0 0 Dova Pharmaceuticals, Inc. COM 25985T102 2857 102205 SH SOLE 102205 0 0 Dynavax Technologies Corporation COM 268158201 268 75000 SH SOLE 75000 0 0 Evofem Biosciences, Inc. COM 30048L104 514 102048 SH SOLE 102048 0 0 Foamix Pharmaceuticals Ltd. SHS M46135105 1514 498189 SH SOLE 498189 0 0 Forty Seven, Inc. COM 34983P104 1605 250000 SH SOLE 250000 0 0 Fulgent Genetics, Inc. COM 359664109 1299 125000 SH SOLE 125000 0 0 G1 Therapeutics, Inc. COM 3621LQ109 2898 127236 SH SOLE 127236 0 0 Galapagos NV SPONSORED ADR 36315X101 3827 25072 SH SOLE 25072 0 0 Galmed Pharmaceuticals Ltd. SHS M47238106 1031 215594 SH SOLE 215594 0 0 Genomic Health, Inc. COM 37244C101 626973 9244665 SH SOLE 9244665 0 0 GW Pharmaceuticals plc ADS 36197T103 42658 370845 SH SOLE 370845 0 0 Halozyme Therapeutics, Inc. COM 40637H109 4653 299969 SH SOLE 299969 0 0 Harpoon Therapeutics, Inc. COM 41358P106 2927 214285 SH SOLE 214285 0 0 Heron Therapeutics, Inc. COM 427746102 111335 6018104 SH SOLE 6018104 0 0 HOOKIPA Pharma Inc. COM 43906K100 6696 892857 SH SOLE 892857 0 0 IDEAYA Biosciences, Inc. COM 45166A102 1800 200000 SH SOLE 200000 0 0 Idera Pharmaceuticals, Inc. COM PAR 45168K405 13319 4608786 SH SOLE 4608786 0 0 IGM Biosciences, Inc. COM 449585108 55806 3144000 SH SOLE 3144000 0 0 Incyte Corporation COM 45337C102 2373620 31976557 SH SOLE 31976557 0 0 Infinity Pharmaceuticals, Inc. COM 45665G303 598 580400 SH SOLE 580400 0 0 Inflarx N.V. COM N44821101 4393 1778415 SH SOLE 1778415 0 0 Insmed Incorporated COM PAR $.01 457669307 39333 2229760 SH SOLE 2229760 0 0 Intellia Therapeutics, Inc. COM 45826J105 1716 128538 SH SOLE 128538 0 0 Invitae Corporation COM 46185L103 169435 8792678 SH SOLE 8792678 0 0 Kiniksa Pharmaceuticals, Ltd. COM CL A G5269C101 23824 2799577 SH SOLE 2799577 0 0 Kodiak Sciences Inc. COM 50015M109 131507 9145116 SH SOLE 9145116 0 0 Krystal Biotech, Inc. COM 501147102 35929 1034674 SH SOLE 1034674 0 0 La Jolla Pharmaceutical Company COM PAR $.0001 2 503459604 13721 1559231 SH SOLE 1559231 0 0 Leap Therapeutics, Inc. COM 52187K101 1145 978454 SH SOLE 978454 0 0 Madrigal Pharmaceuticals, Inc. COM 558868105 100815 1169278 SH SOLE 1169278 0 0 Marker Therapeutics, Inc. COM 57055L107 7665 1500000 SH SOLE 1500000 0 0 Matinas BioPharma Holdings, Inc. COM 576810105 1252 1984965 SH SOLE 1984965 0 0 Menlo Therapeutics Inc. COM 586858102 3136 700000 SH SOLE 700000 0 0 Merus N.V. COM N5749R100 20671 1160014 SH SOLE 1160014 0 0 Milestone Pharmaceuticals Inc. COM 59935V107 4973 266667 SH SOLE 266667 0 0 Mirati Therapeutics, Inc. COM 60468T105 101846 1307220 SH SOLE 1307220 0 0 Mirum Pharmaceuticals, Inc. COM 604749101 3353 333333 SH SOLE 333333 0 0 Molecular Templates, Inc. COM 608550109 1675 254230 SH SOLE 254230 0 0 MyoKardia, Inc. COM 62857M105 79124 1517237 SH SOLE 1517237 0 0 Neurocrine Biosciences, Inc. COM 64125C109 127531 1415283 SH SOLE 1415283 0 0 Neurocrine Biosciences, Inc. NOTE 2.25% 5/15/2024 64125CAD1 42113 30770000 PRN SOLE 30770000 0 0 NextCure, Inc. COM 65343E108 4628 150000 SH SOLE 150000 0 0 NGM Biopharmaceuticals, Inc. COM 62921N105 3463 250000 SH SOLE 250000 0 0 Orchard Therapeutics plc ADS 68570P101 4820 405702 SH SOLE 405702 0 0 Principia Biopharma Inc. COM 74257L108 46710 1654029 SH SOLE 1654029 0 0 Protagonist Therapeutics, Inc. COM 74366E102 14103 1174282 SH SOLE 1174282 0 0 Ra Pharmaceuticals, Inc. COM 74933V108 55471 2345496 SH SOLE 2345496 0 0 Rhythm Pharmaceuticals, Inc. COM 76243J105 58470 2708200 SH SOLE 2708200 0 0 Ritter Pharmaceuticals, Inc. COM 767836307 87 279999 SH SOLE 279999 0 0 Sangamo Therapeutics, Inc. COM 800677106 9048 999823 SH SOLE 999823 0 0 Seattle Genetics, Inc. COM 812578102 4274891 50057277 SH SOLE 50057277 0 0 Sierra Oncology, Inc. COM 82640U107 781 2000000 SH SOLE 2000000 0 0 Spark Therapeutics, Inc. COM 84652J103 72922 751927 SH SOLE 751927 0 0 Spring Bank Pharmaceuticals, Inc. COM 849431101 2109 613144 SH SOLE 613144 0 0 Sunesis Pharmaceuticals, Inc. COM 867328700 401 556665 SH SOLE 556665 0 0 Syros Pharmaceuticals, Inc. COM 87184Q107 10119 974835 SH SOLE 974835 0 0 Tricida, Inc. COM 89610F101 60811 1969905 SH SOLE 1969905 0 0 Trillium Therapeutics Inc. COM 89620X506 155 505262 SH SOLE 505262 0 0 uniQure N.V. SHS N90064101 20377 517700 SH SOLE 517700 0 0 UroGen Pharma Ltd. COM M96088105 17819 747751 SH SOLE 747751 0 0 Viking Therapeutics, Inc. COM 92686J106 2924 425000 SH SOLE 425000 0 0 Xbiotech Inc. COM 98400H102 5453 521327 SH SOLE 521327 0 0 Xencor, Inc. COM 98401F105 14440 428120 SH SOLE 428120 0 0 Y-mAbs Therapeutics, Inc. COM 984241109 2679 102800 SH SOLE 102800 0 0 Zymeworks Inc. COM 98985W102 42370 1708472 SH SOLE 1708472 0 0