Managing Member

0001019056-16-001648.txt : 20161114 0001019056-16-001648.hdr.sgml : 20161111 20161114163618 ACCESSION NUMBER: 0001019056-16-001648 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20160930 FILED AS OF DATE: 20161114 DATE AS OF CHANGE: 20161114 EFFECTIVENESS DATE: 20161114 FILER: COMPANY DATA: COMPANY CONFORMED NAME: PERCEPTIVE ADVISORS LLC CENTRAL INDEX KEY: 0001224962 IRS NUMBER: 000000000 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10438 FILM NUMBER: 161995369 BUSINESS ADDRESS: STREET 1: 51 ASTOR PLACE, 10TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10003 BUSINESS PHONE: 646-205-5300 MAIL ADDRESS: STREET 1: 51 ASTOR PLACE, 10TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10003 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001224962 XXXXXXXX 09-30-2016 09-30-2016 false PERCEPTIVE ADVISORS LLC

51 Astor Place, 10th Floor New York NY 10003

13F HOLDINGS REPORT 028-10438 N Joseph Edelman Managing Member 646-205-5342 /s/ Joseph Edelman New York NY 11-14-2016 0 196 1225947 INFORMATION TABLE 2 infotable.xml ABBOTT LABORATORIES Common Stock 002824100 1946 46019 SH SOLE 0 0 0 ABEONA THERAPEUTICS INC Common Stock 00289Y107 8016 1336050 SH SOLE 0 0 0 ABEONA THERAPEUTICS INC-CW19 WARRANTS 00289y115 4093 1259636 SH SOLE 0 0 0 ABIOMED INC Common Stock 003654100 8138 63290 SH SOLE 0 0 0 ACADIA PHARMACEUTICALS INC Common Stock 004225108 2075 65240 SH SOLE 0 0 0 ACASTI PHARMA INC Common Stock 00430K402 414 236559 SH SOLE 0 0 0 ACCELERON PHARMA INC Common Stock 00434H108 21348 589890 SH SOLE 0 0 0 ACCRETIVE HEALTH INC Common Stock 00438V103 305 125000 SH SOLE 0 0 0 ACCURAY INC Common Stock 004397105 174 27300 SH SOLE 0 0 0 ACELRX PHARMACEUTICALS INC Common Stock 00444T100 21040 5408728 SH SOLE 0 0 0 ACETO CORP Common Stock 004446100 115 6054 SH SOLE 0 0 0 ACHILLION PHARMACEUTICALS Common Stock 00448Q201 7527 929290 SH SOLE 0 0 0 ACLARIS THERAPEUTICS INC Common Stock 00461U105 11012 430000 SH SOLE 0 0 0 ADMA BIOLOGICS INC Common Stock 000899104 5327 734793 SH SOLE 0 0 0 AEGLEA BIOTHERAPEUTICS INC Common Stock 00773J103 664 103585 SH SOLE 0 0 0 AERIE PHARMACEUTICALS INC Common Stock 00771V108 15352 406771 SH SOLE 0 0 0 AETNA INC Common Stock 00817Y108 514 4454 SH SOLE 0 0 0 AFFIMED NV Common Stock N01045108 2041 734301 SH SOLE 0 0 0 AGENUS INC Common Stock 00847G705 6462 900000 SH SOLE 0 0 0 AGILE THERAPEUTICS INC Common Stock 00847L100 7120 1020011 SH SOLE 0 0 0 AGILENT TECHNOLOGIES INC Common Stock 00846U101 496 10540 SH SOLE 0 0 0 AKEBIA THERAPEUTICS INC Common Stock 00972D105 7295 809096 SH SOLE 0 0 0 ALBANY MOLECULAR RESEARCH Common Stock 012423109 170 10300 SH SOLE 0 0 0 ALDER BIOPHARMACEUTICALS INC Common Stock 014339105 12822 391280 SH SOLE 0 0 0 ALDEYRA THERAPEUTICS INC Common Stock 01438T106 15174 1940458 SH SOLE 0 0 0 ALLIQUA BIOMEDICAL INC Common Stock 019621200 1537 1921951 SH SOLE 0 0 0 ALLON THERAPEUTICS INC Common Stock 019774108 0 751124 SH SOLE 0 0 0 ALMOST FAMILY INC Common Stock 020409108 439 11942 SH SOLE 0 0 0 AMAG PHARMACEUTICALS INC Common Stock 00163U106 479 19524 SH SOLE 0 0 0 AMARIN CORP PLC-ADR Depository Receipt 023111206 5175 1622280 SH SOLE 0 0 0 AMERISOURCEBERGEN CORP Common Stock 03073E105 525 6500 SH SOLE 0 0 0 AMICUS THERAPEUTICS INC Common Stock 03152W109 104463 14116644 SH SOLE 0 0 0 AMN HEALTHCARE INC Common Stock 001744101 428 13445 SH SOLE 0 0 0 AMSURG CORP Common Stock 03232P405 444 6618 SH SOLE 0 0 0 ANI PHARMACEUTICALS INC Common Stock 00182C103 767 11561 SH SOLE 0 0 0 ANI PHARMACEUTICALS INC NOTE 3.000% 00182CAA1 9279 7500000 PRN SOLE 0 0 0 ANTARES PHARMA INC Common Stock 036642106 912 0 SH SOLE 0 0 0 ANTHEM INC Common Stock 036752103 426 3400 SH SOLE 0 0 0 ANTHERA PHARMACEUTICALS INC Common Stock 03674U201 4598 1459627 SH SOLE 0 0 0 APPLIED GENETIC TECHNOLOGIES Common Stock 03820J100 4167 426048 SH SOLE 0 0 0 APTEVO THERAPEUTICS INC Common Stock 03835L108 2530 988133 SH SOLE 0 0 0 ARDELYX INC Common Stock 039697107 13680 1057257 SH SOLE 0 0 0 ARNO THERAPEUTICS INC Common Stock 042564203 1963 4177577 SH SOLE 0 0 0 ARROWHEAD PHARMACEUTICALS INC Common Stock 04280A100 6228 847458 SH SOLE 0 0 0 ASSEMBLY BIOSCIENCES INC Common Stock 045396108 5606 777669 SH SOLE 0 0 0 ATRICURE INC Common Stock 04963C209 126 7949 SH SOLE 0 0 0 AUDENTES THERAPEUTICS INC Common Stock 05070R104 134 7500 SH SOLE 0 0 0 AVEO PHARMACEUTICALS INC Common Stock 053588109 2766 3108808 SH SOLE 0 0 0 AVEXIS INC Common Stock 05366U100 7830 190000 SH SOLE 0 0 0 AVINGER INC Common Stock 053734109 5 1062 SH SOLE 0 0 0 BEIGENE LTD Depository Receipt 07725L102 4069 132057 SH SOLE 0 0 0 BIO RAD LABORATORIES CLASS A Common Stock 090572207 1638 10000 SH SOLE 0 0 0 BIOGEN INC Common Stock 09062X103 601 1921 SH SOLE 0 0 0 BIOMARIN PHARMACEUTICAL INC Common Stock 09061G101 23 250 SH SOLE 0 0 0 BLUEPRINT MEDICINES CORP Common Stock 09627Y109 13662 460024 SH SOLE 0 0 0 BOVIE MEDICAL CORP Common Stock 10211F100 253 48544 SH SOLE 0 0 0 BRAINSTORM CELL THERAPEUTICS Common Stock 10501E102 964 400000 SH SOLE 0 0 0 CAPITAL SENIOR LIVING CORP Common Stock 140475104 6305 375306 SH SOLE 0 0 0 CAPRICOR THERAPEUTICS INC Common Stock 14070B101 13 4000 SH SOLE 0 0 0 CARDINAL HEALTH INC Common Stock 14149Y108 497 6398 SH SOLE 0 0 0 CASCADIAN THERAPEUTICS INC Common Stock 14740B101 5599 3414121 SH SOLE 0 0 0 CELLECTIS ADR Depository Receipt 15117K103 4323 179506 SH SOLE 0 0 0 CEMPRA INC Common Stock 15130J109 4247 175503 SH SOLE 0 0 0 CHAMPIONS ONCOLOGY INC Common Stock 15870P307 625 372597 SH SOLE 0 0 0 CHARLES RIVER LABORATORIES Common Stock 159864107 457 5482 SH SOLE 0 0 0 CHINA BIOLOGIC PRODUCTS INC Common Stock 16938C106 1705 13695 SH SOLE 0 0 0 CIDARA THERAPEUTICS INC Common Stock 171757107 8855 773369 SH SOLE 0 0 0 CLEARSIDE BIOMEDICAL INC COMMON Stock 185063104 11013 634801 SH SOLE 0 0 0 CLOVIS ONCOLOGY INC Common Stock 189464100 6183 171500 SH SOLE 0 0 0 COGENTIX MEDICAL INC Common Stock 19243A104 180 99008 SH SOLE 0 0 0 COLUCID PHARMACEUTICALS INC Common Stock 19716T101 21060 552030 SH SOLE 0 0 0 CORBUS PHARMACEUTICALS HOLDINGS Common Stock 21833P103 18339 2701023 SH SOLE 0 0 0 CRYOLIFE INC Common Stock 228903100 2 123 SH SOLE 0 0 0 CYNOSURE INC CLASS A Common Stock 232577205 92 1800 SH SOLE 0 0 0 CYTOMX THERAPEUTICS, INC Preferred Stock 232996751 11634 742021 SH SOLE 0 0 0 DBV TECHNOLOGIES SA-SPON ADR Depository Receipt 23306J101 20464 563268 SH SOLE 0 0 0 DEPOMED INC Common Stock 249908104 13370 535000 SH SOLE 0 0 0 DERMA SCIENCES INC Common Stock 249827502 14 2970 SH SOLE 0 0 0 DERMIRA INC Common Stock 24983L104 11215 331610 SH SOLE 0 0 0 DEXCOM INC Common Stock 252131107 15678 178849 SH SOLE 0 0 0 DIGIRAD CORP Common Stock 253827109 127 24988 SH SOLE 0 0 0 DYNAVAX TECHNOLOGIES CORP SHS PUT 12 12/16/2016 US Equity Option 268158201 3120 6000 SH Put SOLE 0 0 0 DYNAVAX TECHNOLOGIES CORP SHS PUT 11 12/16/2016 US Equity Option 268158201 1780 4000 SH Put SOLE 0 0 0 DYNAVAX TECHNOLOGIES CORP SHS PUT 10 12/16/2016 US Equity Option 268158201 2280 6000 SH Put SOLE 0 0 0 EAGLE PHARMACEUTICALS INC Common Stock 269796108 3 544770 SH SOLE 0 0 0 EIGER BIOPHARMACEUTICALS INC Common Stock 28249U105 1739 129920 SH SOLE 0 0 0 ELI LILLY & CO CALL 90 01/20/2017 US Equity Option 532457108 250 1000 SH Call SOLE 0 0 0 ENZO BIOCHEM INC Common Stock 294100102 342 67113 SH SOLE 0 0 0 EVOLENT HEALTH INC CLASS A Common Stock 30050B101 10544 428284 SH SOLE 0 0 0 FERRARI NV Common Stock N3167Y103 322 6200 SH SOLE 0 0 0 FIAT CHRYSLER AUTOMOBILES NV Common Stock N31738102 397 62000 SH SOLE 0 0 0 FIVE PRIME THERAPEUTICS INC Common Stock 33830X104 8740 166509 SH SOLE 0 0 0 FLAMEL TECHNOLOGIES -SP ADR Depository Receipt 338488109 16910 1363711 SH SOLE 0 0 0 FLEX PHARMA INC Common Stock 33938A105 3 237 SH SOLE 0 0 0 FOAMIX PHARMACEUTICALS LTD Common Stock M46135105 12717 1373284 SH SOLE 0 0 0 FORWARD PHARMA A/S-ADR Depository Receipt 34986J105 8494 404472 SH SOLE 0 0 0 GENVEC INC Common Stock 37246C307 259 561320 SH SOLE 0 0 0 GLAUKOS CORP Common Stock 377322102 200 5300 SH SOLE 0 0 0 GLOBAL BLOOD THERAPEUTICS INC Common Stock 37890U108 53802 2334168 SH SOLE 0 0 0 HANGER INC Common Stock 41043F208 128 15038 SH SOLE 0 0 0 HCA HOLDINGS INC Common Stock 40412C101 469 6202 SH SOLE 0 0 0 HEALTHWAYS INC Common Stock 422245100 572 21608 SH SOLE 0 0 0 HILL ROM HOLDINGS INC Common Stock 431475102 593 9563 SH SOLE 0 0 0 HISTOGENCIS CORP Common Stock 43358V109 5706 1777777 SH SOLE 0 0 0 HUMANA INC CALL 190 04/21/2017 US Equity Option 444859102 526 400 SH Call SOLE 0 0 0 ICON INC Common Stock G4705A100 532 6873 SH SOLE 0 0 0 IGNYTA INC Common Stock 451731103 2137 339727 SH SOLE 0 0 0 IMMUNE DESIGN CORP Common Stock 45252L103 589 77725 SH SOLE 0 0 0 IMMUNOMEDICS INC Common Stock 452907108 17 5343 SH SOLE 0 0 0 INC RESEARCH HOLDINGS INC CLASS A Common Stock 45329R109 563 12636 SH SOLE 0 0 0 INCYTE CORP Common Stock 45337C102 530 5619 SH SOLE 0 0 0 INNOCOLL HOLDINGS PLC Common Stock G4783X105 3221 547792 SH SOLE 0 0 0 INOGEN INC Common Stock 45780L104 7 125 SH SOLE 0 0 0 INTELLIA THERAPEUTICS INC Common Stock 45826J105 250 14673 SH SOLE 0 0 0 INTUITIVE SURGICAL INC Common Stock 46120E602 145 200 SH SOLE 0 0 0 INVACARE CORP Common Stock 461203101 147 13200 SH SOLE 0 0 0 KADMON INC Common Stock 48283N106 16218 2209657 SH SOLE 0 0 0 KINDRED HEATHCARE INC Common Stock 494580103 432 42301 SH SOLE 0 0 0 LA JOLLA PHARMACEUTICAL COMPANY Common Stock 503459604 31482 1323324 SH SOLE 0 0 0 LABORATORY CORPORATION OF AMERICA HOLDINGS Common Stock 50540R409 549 3990 SH SOLE 0 0 0 LANNETT COMPANY INC Common Stock 516012101 709 26670 SH SOLE 0 0 0 LANTHEUS HOLDINGS INC Common Stock 516544103 445 53763 SH SOLE 0 0 0 LHC GROUP INC Common Stock 50187A107 175 4745 SH SOLE 0 0 0 LION BIOTECHNOLOGIES INC Common Stock 53619R102 29360 3567553 SH SOLE 0 0 0 MAGELLAN HEALTH INC Common Stock 559079207 471 8772 SH SOLE 0 0 0 MALLINCKRODT PLC Common Stock G5785G107 314 4500 SH SOLE 0 0 0 MCKESSON CORP Common Stock 58155Q103 497 2979 SH SOLE 0 0 0 MEDGENICS INC Common Stock 58436Q203 1635 293460 SH SOLE 0 0 0 MEDIDATA SOLUTIONS INC Common Stock 58471A105 160 2865 SH SOLE 0 0 0 MEDNAX INC Common Stock 58502B106 2 29 SH SOLE 0 0 0 MERRIMACK PHARMACEUTICALS INC Common Stock 590328100 311 48910 SH SOLE 0 0 0 METTLER TOLEDO INTERNATIONAL Common Stock 592688105 174 415 SH SOLE 0 0 0 MGC DIAGNOSTICS CORP Common Stock 552768103 2275 329733 SH SOLE 0 0 0 MINERVA NEUROSCIENCES INC Common Stock 603380106 11440 810537 SH SOLE 0 0 0 MOLINA HEALTHCARE INC Common Stock 60855R100 518 8879 SH SOLE 0 0 0 MYLAN NV Common Stock N59465109 3610 94711 SH SOLE 0 0 0 MYOKARDIA INC Common Stock 62857M105 10374 634894 SH SOLE 0 0 0 NANOSTRING TECHNOLOGIES INC Common Stock 63009R109 210 10518 SH SOLE 0 0 0 NEOS THERAPEUTICS INC Common Stock 64052L106 2175 330593 SH SOLE 0 0 0 NEPTUNE TECHNOLOGIES AND BIORESOURCES Common Stock 64077P108 7155 6750444 SH SOLE 0 0 0 NEUROCRINE BIOSCIENCES INC Common Stock 64125C109 125398 2476272 SH SOLE 0 0 0 NEURODERM LTD Common Stock M74231107 4883 264114 SH SOLE 0 0 0 NEVRO CORP Common Stock 64157F103 1226 11746 SH SOLE 0 0 0 NIVALIS THERAPEUTICS INC Common Stock 65481J109 994 122275 SH SOLE 0 0 0 NUVASIVE INC Common Stock 670704105 173 2589 SH SOLE 0 0 0 NXSTAGE MEDICAL INC Common Stock 67072V103 41726 1669703 SH SOLE 0 0 0 ONCOBIOLOGICS INC Common Stock 68235M105 5308 1248990 SH SOLE 0 0 0 ONCOBIOLOGICS INC *W EXP 2/18/2017 68235M121 787 656382 SH SOLE 0 0 0 ONCOBIOLOGICS INC *W EXP 2/18/2017 68235M113 313 656382 SH SOLE 0 0 0 OPHTHOTECH CORP CALL 80 12/16/2016 US Equity Option 683745103 2350 500000 SH Call SOLE 0 0 0 OPHTHOTECH CORP CALL 75 12/16/2016 US Equity Option 683745103 390 100000 SH Call SOLE 0 0 0 PEREGRINE PHARMACEUTICALS Common Stock 713661304 10 24332 SH SOLE 0 0 0 PERNIX THERAPEUTICS HLDINGS INC DBCV 4.25% 4/01/2021 71426VAK4 292 1000000 PRN SOLE 0 0 0 PFENEX INC Common Stock 717071104 8412 939930 SH SOLE 0 0 0 PHASERX INC Common Stock 71723F103 514 200000 SH SOLE 0 0 0 PHIBRO ANIMAL HEALTH CLASS A Common Stock 71742Q106 660 24300 SH SOLE 0 0 0 PROTEON THERAPEUTICS INC Common Stock 74371L109 2510 269005 SH SOLE 0 0 0 PROTEOSTASIS THERAPEUTICS INC Common Stock 74373B109 5372 344550 SH SOLE 0 0 0 PSIVIDA CORP Common Stock 74440J101 7683 2552431 SH SOLE 0 0 0 PSYCHEMEDICS CORP Common Stock 744375205 250 12626 SH SOLE 0 0 0 PUMA BIOTECHNOLOGY INC Common Stock 74587V107 492 7344 SH SOLE 0 0 0 QUINTILES IMS HOLDINGS INC Common Stock 74876Y101 414 5103 SH SOLE 0 0 0 QUOTIENT LTD Common Stock G73268107 20893 2671794 SH SOLE 0 0 0 RADIUS HEALTH INC Common Stock 750469207 16957 313502 SH SOLE 0 0 0 REGENXBIO INC Common Stock 75901B107 17964 1282286 SH SOLE 0 0 0 RETROPHIN INC Common Stock 761299106 54752 2446482 SH SOLE 0 0 0 SANGAMO BIOSCIENCES INC Common Stock 800677106 1 272 SH SOLE 0 0 0 SAREPTA THERAPEUTICS INC Common Stock 803607100 208506 3395236 SH SOLE 0 0 0 SCYNEXIS INC Common Stock 811292101 662 171185 SH SOLE 0 0 0 SELECTA BIOSCIENCES INC Common Stock 816212104 4961 348150 SH SOLE 0 0 0 SEVION THERAPEUTICS INC Common Stock 81834Q104 10 59220 SH SOLE 0 0 0 STEMLINE THERAPEUTICS INC Common Stock 85858C107 116 10702 SH SOLE 0 0 0 SUCAMPO PHARMACEUTICALS CLASS A Common Stock 864909106 506 41096 SH SOLE 0 0 0 SUPERNUS PHARMACEUTICALS INC Common Stock 868459108 6048 244550 SH SOLE 0 0 0 SYNERGY PHARMACEUTICALS INC Common Stock 871639308 491 89127 SH SOLE 0 0 0 TELADOC INC Common Stock 87918A105 275 15000 SH SOLE 0 0 0 TENET HEALTHCARE CORP Common Stock 88033G407 367 16200 SH SOLE 0 0 0 TENGION INC Common Stock 88034G208 1 1826399 SH SOLE 0 0 0 TESARO INC Common Stock 881569107 68405 682415 SH SOLE 0 0 0 UNIQURE NV Common Stock N90064101 10043 1312836 SH SOLE 0 0 0 UNITED THERAPEUTICS INC Common Stock 91307C102 561 4753 SH SOLE 0 0 0 UNITEDHEALTH GROUP INC Common Stock 91324P102 452 3231 SH SOLE 0 0 0 UNIVERSAL HEALTH SERVICES CLASS B Common Stock 913903100 492 3989 SH SOLE 0 0 0 VBI VACCINES INC Common Stock 91822J103 10490 3058433 SH SOLE 0 0 0 VCA INC Common Stock 918194101 556 7940 SH SOLE 0 0 0 VERICEL CORP Common Stock 92346J108 1526 544996 SH SOLE 0 0 0 VERSARTIS INC Common Stock 92529L102 49351 4028685 SH SOLE 0 0 0 VERTEX PHARMACEUTICALS INC Common Stock 92532F100 9331 107000 SH SOLE 0 0 0 VOCERA COMMUNICATIONS INC Common Stock 92857F107 1593 94236 SH SOLE 0 0 0 VWR CORP Common Stock 91843L103 529 18657 SH SOLE 0 0 0 WAVE LIFE SCIENCES LTD Common Stock Y95308105 22191 683448 SH SOLE 0 0 0 WELLCARE HEALTHCARE PLANS INC Common Stock 94946T106 592 5056 SH SOLE 0 0 0 XENCOR INC Common Stock 98401F105 36643 1496229 SH SOLE 0 0 0 XENON PHARMACEUTICALS INC Common Stock 98420N105 6179 762800 SH SOLE 0 0 0 ZOGENIX INC Common Stock 98978L204 212 18541 SH SOLE 0 0 0 ZYNERBA PHARMACEUTICALS INC Common Stock 98986X109 11339 868897 SH SOLE 0 0 0