The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AMN HEALTHCARE SERVICES INC COM 001744101 586 17,428 SH   SOLE   0 0 0
ANI PHARMACEUTICALS INC COM 00182C103 3,839 114,060 SH   SOLE   0 0 0
ANI PHARMACEUTICALS INC NOTE 3.000%12/0 00182CAA1 6,590 7,500,000 PRN   SOLE   0 0 0
ABEONA THERAPEUTICS INC COM 00289Y107 4,512 1,762,881 SH   SOLE   0 0 0
ABEONA THERAPEUTICS INC *W EXP 12/19/201 00289Y115 1,027 1,259,636 SH   SOLE   0 0 0
ABIOMED INC COM 003654100 920 9,700 SH   SOLE   0 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 7,137 255,240 SH   SOLE   0 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 2,796 200,000 SH Put SOLE   0 0 0
ACASTI PHARMA INC CL A NEW 00430K402 360 236,559 SH   SOLE   0 0 0
ACCELERON PHARMA COM 00434H108 21,192 803,036 SH   SOLE   0 0 0
ACELRX PHARMACEUTICALS COM 00444T100 18,466 5,995,760 SH   SOLE   0 0 0
ACHAOGEN INC COM 004449104 166 60,000 SH   SOLE   0 0 0
AFFIMED THERAPEUTICS BV SPONSORED ADR NO1045108 3,071 821,201 SH   SOLE   0 0 0
AGILE THERAPEUTICS INC COM 00847L100 1,087 175,000 SH   SOLE   0 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 7,794 865,000 SH   SOLE   0 0 0
ALDER BIOPHARMACEUTICALS INC COM 14339105 4,898 200,000 SH Put SOLE   0 0 0
ALDER BIOPHARMACEUTICALS INC COM 14339105 9,184 375,000 SH   SOLE   0 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 5,197 1,240,458 SH   SOLE   0 0 0
ALLIQUA BIOMEDICAL INC COM NEW 19621200 1,575 1,921,951 SH   SOLE   0 0 0
ALMOST FAMILY INC COM 20409108 487 13,075 SH   SOLE   0 0 0
AMEDISYS INC COM 23436108 507 10,493 SH   SOLE   0 0 0
AMGEN INC COM 31162100 4,498 30,000 SH   SOLE   0 0 0
AMICUS THERAPEUTICS COM 03152W109 128,773 15,239,444 SH   SOLE   0 0 0
AMPLIPHI BIOSCIENCES CORP COM NEW 03211P202 315 80,000 SH   SOLE   0 0 0
ANTHERA PHARMACEUTICALS INC COM NEW 03674U201 5,402 1,492,156 SH   SOLE   0 0 0
ANTHEM INC COM 36752103 521 3,747 SH   SOLE   0 0 0
APPLIED GENETIC TECHNOL CORP COM 03820J100 9,095 650,591 SH   SOLE   0 0 0
AQUINOX PHARMACEUTICALS INC COM 03842B101 526 59,600 SH   SOLE   0 0 0
ARATANA THERAPEUTICS INC COM 03874P101 1,611 291,800 SH   SOLE   0 0 0
ARDELYX INC COM 39697107 2,455 315,955 SH   SOLE   0 0 0
ARNO THERAPEUTIC INC COM 42564203 1,361 3,463,292 SH   SOLE   0 0 0
ASSEMBLY BIOSCIENCES INC COM 45396108 3,991 795,000 SH   SOLE   0 0 0
AVALANCHE BIOTECHNOLOGIES IN COM 05337G107 103 20,000 SH   SOLE   0 0 0
AVEXIS INC COM 05366U100 4,086 150,000 SH   SOLE   0 0 0
BARCLAYS BK PLC IPATH S&P500 VIX 06742E711 1,057 60,000 SH   SOLE   0 0 0
BAXTER INTERNATIONAL INC COM 71813109 7,168 175,400 SH Call SOLE   0 0 0
BAXTER INTL INC COM 71813109 9,038 220,000 SH   SOLE   0 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 7,299 404,404 SH   SOLE   0 0 0
BOVIE MEDICAL CORP COM 10211F100 272 162,700 SH   SOLE   0 0 0
BRAINSTORM CELL THERAPEUTICS COM 10501E201 1,068 400,000 SH   SOLE   0 0 0
CAPITAL SR LIVING CORP COM 140475104 10,087 544,636 SH   SOLE   0 0 0
CAPRICOR THERAPEUTICS INC COM 14070B101 10 4,000 SH   SOLE   0 0 0
CARDINAL HEALTH INC COM 14149Y108 487 5,947 SH   SOLE   0 0 0
CATALYST PHARMACEUTICALS INC COM 14888U101 60 51,200 SH   SOLE   0 0 0
CELATOR PHARMACEUTICALS INC COM 15089R102 12,133 1,100,000 SH   SOLE   0 0 0
CELGENE CORP COM 151020104 5,005 50,000 SH   SOLE   0 0 0
CELLECTIS S A SPONSORED ADS 15117K103 82 2,996 SH   SOLE   0 0 0
CEMPRA INC COM 15130J109 2,628 150,000 SH   SOLE   0 0 0
CENTENE CORP DEL COM 15135B101 305 4,948 SH   SOLE   0 0 0
CHAMPIONS ONCOLOGY INC COM NEW 15870P307 1,356 372,597 SH   SOLE   0 0 0
CHARLES RIV LABS INTL INC COM 159864107 474 6,244 SH   SOLE   0 0 0
CHINA BIOLOGIC PRODS INC COM 16938C106 1,603 14,000 SH   SOLE   0 0 0
CIDARA THERAPEUTICS INC COM 171757107 9,434 742,858 SH   SOLE   0 0 0
COGENTIX MED INC COM 19243A104 741 673,257 SH   SOLE   0 0 0
CORBUS PHARMACEUTICALS INC COM 21833P103 2,262 1,250,000 SH   SOLE   0 0 0
CURIS INC COM 231269101 161 100,000 SH   SOLE   0 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 9,572 742,021 SH   SOLE   0 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 13,563 416,696 SH   SOLE   0 0 0
DERMA SCIENCES INC COM PAR $.01 249827502 1,341 432,884 SH   SOLE   0 0 0
DERMIRA INC COM 24983L104 10,588 512,000 SH   SOLE   0 0 0
DEPOMED INC COM 249908104 9,055 650,000 SH   SOLE   0 0 0
DEXCOM INC COM 252131107 1,798 26,474 SH   SOLE   0 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 268 50,000 SH   SOLE   0 0 0
DIGIRAD CORP COM 253827109 124 24,988 SH   SOLE   0 0 0
EAGLE PHARMACEUTICALS INC COM 269796108 7,582 187,215 SH   SOLE   0 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 1,759 104,920 SH   SOLE   0 0 0
ENANTA PHARMACEUTICALS INC COM 29251M106 514 17,507 SH   SOLE   0 0 0
ENDOLOGIX INC COM 29266S106 209 25,000 SH   SOLE   0 0 0
ENDOCHOICE HLDGS INC COM 29272U103 130 25,000 SH   SOLE   0 0 0
EVOLENT HEALTH INC CL A 30050B101 6,536 618,930 SH   SOLE   0 0 0
FIVE PRIME THERAPEUTICS INC COM 33830X104 18,451 454,129 SH   SOLE   0 0 0
FLEX PHARMA INC COM 33938A105 3 237 SH   SOLE   0 0 0
FONAR CORP COM NEW 344437405 130 8,473 SH   SOLE   0 0 0
FORWARD PHARMA A/S SPONSORED ADR 34986J105 3,167 186,300 SH   SOLE   0 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 946 13,109 SH   SOLE   0 0 0
GENOCEA BIOSCIENCES INC COM 372427104 3,999 516,618 SH   SOLE   0 0 0
GENVEC INC COM NEW 37246C307 489 606,644 SH   SOLE   0 0 0
GILEAD SCIENCES INC COM 375558103 553 6,024 SH   SOLE   0 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 20,577 1,297,468 SH   SOLE   0 0 0
HCA HOLDINGS INC COM 40412C101 561 7,186 SH   SOLE   0 0 0
HOLOGIC INC COM 436440101 508 14,732 SH   SOLE   0 0 0
HUMANA INC COM 444859102 20,124 110,000 SH   SOLE   0 0 0
IGNYTA INC COM 451731103 9,119 1,347,060 SH   SOLE   0 0 0
IMMUNOMEDICS INC COM 452907108 3,550 1,420,000 SH   SOLE   0 0 0
INC RESH HLDGS INC CL A 45329R109 488 11,846 SH   SOLE   0 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303 527 100,000 SH   SOLE   0 0 0
INOGEN INC COM 45780L104 6 125 SH   SOLE   0 0 0
INVITAE CORP COM 46185L103 1,211 118,366 SH   SOLE   0 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 14,627 699,515 SH   SOLE   0 0 0
LION BIOTECHNOLOGIES INC COM 53619R102 14,159 2,787,256 SH   SOLE   0 0 0
MGC DIAGNOSTICS CORP COM 552768103 2,045 336,287 SH   SOLE   0 0 0
MAGELLAN HEALTH INC COM NEW 559079207 596 8,772 SH   SOLE   0 0 0
MCKESSON CORP COM 58155Q103 501 3,188 SH   SOLE   0 0 0
MEDIVATION INC COM 58501N101 15,633 340,000 SH   SOLE   0 0 0
MERRIMACK PHARMACEUTICALS IN COM 590328100 419 50,000 SH   SOLE   0 0 0
MINERVA NEUROSCIENCES INC COM 603380106 4,976 810,537 SH   SOLE   0 0 0
MIRATI THERAPEUTICS INC COM 60468T105 5,842 273,000 SH   SOLE   0 0 0
MOLINA HEALTHCARE INC COM 60855R100 519 8,052 SH   SOLE   0 0 0
MYRIAD GENETICS INC COM 62855J104 125 3,333 SH   SOLE   0 0 0
MYOKARDIA INC COM 62857M105 5,385 502,894 SH   SOLE   0 0 0
NANOSPHERE INC COM NEW 63009F204 28 35,379 SH   SOLE   0 0 0
NEOS THERAPEUTICS INC COM 64052L106 1,079 100,000 SH   SOLE   0 0 0
NEPTUNE TECHNOLOGIES BIORESO COM 64077P108 6,750 6,750,444 SH   SOLE   0 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 107,614 2,720,967 SH   SOLE   0 0 0
NEVRO CORP COM 64157F103 19,612 348,600 SH   SOLE   0 0 0
NEVRO CORP COM 64157F103 5,626 100,000 SH Call SOLE   0 0 0
NIVALIS THERAPEUTICS INC COM 65481J109 521 125,000 SH   SOLE   0 0 0
NOVO-NORDISK A S ADR 670100205 6,322 116,660 SH   SOLE   0 0 0
OMEROS CORP COM 682143102 3,068 200,000 SH   SOLE   0 0 0
ONCOTHYREON INC COM 682324108 4,335 3,414,121 SH   SOLE   0 0 0
OTONOMY INC COM 68906L105 3,521 235,986 SH   SOLE   0 0 0
PRA HEALTH SCIENCES INC COM 69354M108 502 11,751 SH   SOLE   0 0 0
PEREGRINE PHARMACEUTICALS IN COM NEW 713661304 10 24,332 SH   SOLE   0 0 0
PFENEX INC COM 717071104 9,446 960,877 SH   SOLE   0 0 0
PHARMERICA CORP COM 71714F104 372 16,841 SH   SOLE   0 0 0
PROTEON THERAPEUTICS INC COM 74371L109 2,129 275,000 SH   SOLE   0 0 0
PROTEOSTASIS THERAPEUTICS IN COM 74373B109 2,410 250,000 SH   SOLE   0 0 0
PSIVIDA CORPORATION COM 74440J101 7,142 2,665,000 SH   SOLE   0 0 0
QUINTILES TRANSNATIO HLDGS I COM 74876Y101 485 7,447 SH   SOLE   0 0 0
REGENXBIO INC COM 75901B107 8,914 825,396 SH   SOLE   0 0 0
REGULUS THERAPEUTICS INC COM 75915K101 2,256 325,407 SH   SOLE   0 0 0
RETROPHIN INC COM 761299106 40,971 2,999,380 SH   SOLE   0 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 329 1,600 SH   SOLE   0 0 0
SAREPTA THERAPEUTICS INC COM 803607100 74,823 3,833,128 SH   SOLE   0 0 0
Sarepta Therapeutics Inc COM 803607100 10,736 550,000 SH Call SOLE   0 0 0
SCYNEXIS INC COM 811292101 705 175,000 SH   SOLE   0 0 0
SPECTRANETICS CORP COM 84760C107 3,877 267,070 SH   SOLE   0 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 366 78,603 SH   SOLE   0 0 0
SUCAMPO PHARMACEUTICALS INC CL A 864909106 8 759 SH   SOLE   0 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108 3,050 200,000 SH   SOLE   0 0 0
TANDEM DIABETES CARE INC COM 875372104 217 25,000 SH   SOLE   0 0 0
TESARO INC COM 881569107 48,374 1,098,659 SH   SOLE   0 0 0
TEVA PHARMACEUTICAL INDS LTD ADR 881624209 13,966 261,000 SH   SOLE   0 0 0
TITAN PHARMACEUTICALS INC DE COM NEW 888314309 0 1 SH   SOLE   0 0 0
TOKAI PHARMACEUTICALS INC COM 88907J107 2,723 485,338 SH   SOLE   0 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 278 30,000 SH   SOLE   0 0 0
TRIPLE-S MGMT CORP CL B 896749108 264 10,605 SH   SOLE   0 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 2,229 20,000 SH   SOLE   0 0 0
UNITEDHEALTH GROUP INC COM 91324P102 560 4,346 SH   SOLE   0 0 0
UNIVERSAL HLTH SVCS INC CL B 913903100 498 3,989 SH   SOLE   0 0 0
VWR CORP COM 91843L103 505 18,657 SH   SOLE   0 0 0
VANDA PHARMACEUTICALS INC COM 921659108 601 71,849 SH   SOLE   0 0 0
VBI VACCINES INC COM 91790E102 7,661 3,260,356 SH   SOLE   0 0 0
VERICEL CORP COM 92346J108 7,310 1,247,312 SH   SOLE   0 0 0
VERSARTIS INC COM 92529L102 22,742 2,835,754 SH   SOLE   0 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 12,718 160,000 SH   SOLE   0 0 0
VITAL THERAPIES INC COM 92847R104 271 29,968 SH   SOLE   0 0 0
WALGREENS BOOTS ALLIANCE INC COM 931427108 2,973 35,292 SH   SOLE   0 0 0
WELLCARE HEALTH PLANS INC COM 94946T106 505 5,448 SH   SOLE   0 0 0
XENCOR INC COM 98401F105 24,220 1,804,784 SH   SOLE   0 0 0
XENON PHARMACEUTICALS INC COM 98420N105 1,438 205,800 SH   SOLE   0 0 0
ZELTIQ AESTHETICS INC COM 98933Q108 3,314 122,000 SH   SOLE   0 0 0
ZIMMER BIOMET HLDGS INC COM 98956P102 17 156 SH   SOLE   0 0 0
ZYNERBA PHARMACEUTICALS INC COM 98986X109 8,026 849,350 SH   SOLE   0 0 0
ALLERGAN PLC SHS G0177J108 41,545 155,000 SH   SOLE   0 0 0
AXOVANT SCIENCES LTD COM G0750W104 5,568 485,000 SH   SOLE   0 0 0
HERBALIFE LTD COM USD SHS G4412G101 77 1,250 SH   SOLE   0 0 0
HORIZON PHARMA PLC SHS G4617B105 5,800 350,000 SH   SOLE   0 0 0
ICON PLC SHS G4705A100 570 7,585 SH   SOLE   0 0 0
MALLINCKRODT PUB LTD CO SHS G5785G107 164 2,673 SH   SOLE   0 0 0
QUOTIENT LTD SHS G73268107 19,132 2,189,067 SH   SOLE   0 0 0
ALCOBRA LTD SHS M2239P109 3,897 1,028,272 SH   SOLE   0 0 0
GALMED PHARMACEUTICALS LTD SHS M47238106 369 75,000 SH   SOLE   0 0 0
INTEC PHARMA LTD JERUSALEM SHS M53644106 795 192,580 SH   SOLE   0 0 0
NEURODERM LTD ORD SHS M74231107 3,812 270,000 SH   SOLE   0 0 0
TARO PHARMACEUTICAL INDS LTD SHS M8737E108 491 3,429 SH   SOLE   0 0 0
FERRARI N V COM N3167Y103 259 6,200 SH   SOLE   0 0 0
FIAT CHRYSLER AUTOMOBILES N SHS N31738102 500 62,000 SH   SOLE   0 0 0
UNIQURE NV SHS N90064101 17,132 1,442,093 SH   SOLE   0 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 2,443 176,000 SH   SOLE   0 0 0