Managing Member

0001012975-21-000086.txt : 20210216 0001012975-21-000086.hdr.sgml : 20210216 20210216163219 ACCESSION NUMBER: 0001012975-21-000086 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20201231 FILED AS OF DATE: 20210216 DATE AS OF CHANGE: 20210216 EFFECTIVENESS DATE: 20210216 FILER: COMPANY DATA: COMPANY CONFORMED NAME: PERCEPTIVE ADVISORS LLC CENTRAL INDEX KEY: 0001224962 IRS NUMBER: 000000000 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10438 FILM NUMBER: 21639336 BUSINESS ADDRESS: STREET 1: 51 ASTOR PLACE, 10TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10003 BUSINESS PHONE: 646-205-5300 MAIL ADDRESS: STREET 1: 51 ASTOR PLACE, 10TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10003 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001224962 XXXXXXXX 12-31-2020 12-31-2020 PERCEPTIVE ADVISORS LLC

51 ASTOR PLACE, 10TH FLOOR NEW YORK NY 10003

13F HOLDINGS REPORT 028-10438 N Joseph Edelman Managing Member 646-205-5342 /s/ Joseph Edelman New York NY 02-16-2021 0 139 9318287 false INFORMATION TABLE 2 infotable.xml INFORMATION TABLE 1LIFE HEALTHCARE INC COM 68269G107 22691 519844 SH SOLE 519844 0 0 4D MOLECULAR THERAPEUTICS IN COM 35104E100 24881 600256 SH SOLE 600256 0 0 908 DEVICES INC COM 65443P102 4414 77500 SH SOLE 77500 0 0 ABCELLERA BIOLOGICS INC COM 00288U106 805 20000 SH SOLE 20000 0 0 ACCOLADE INC COM 00437E102 27256 626591 SH SOLE 626591 0 0 ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 2156 400000 SH SOLE 400000 0 0 ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 53504 904854 SH SOLE 904854 0 0 ADMA BIOLOGICS INC COM 000899104 32340 16584802 SH SOLE 16584802 0 0 AGILE THERAPEUTICS INC COM 00847L100 45690 15919925 SH SOLE 15919925 0 0 ALBIREO PHARMA INC COM 01345P106 88529 2360139 SH SOLE 2360139 0 0 ALDEYRA THERAPEUTICS INC COM 01438T106 43118 6285458 SH SOLE 6285458 0 0 ALLOGENE THERAPEUTICS INC COM 019770106 28869 1143790 SH SOLE 1143790 0 0 AMERICAN WELL CORP CL A 03044L105 13298 525000 SH SOLE 525000 0 0 AMICUS THERAPEUTICS INC COM 03152W109 579837 25112048 SH SOLE 25112048 0 0 AMYRIS INC COM NEW 03236M200 20583 3333332 SH SOLE 3333332 0 0 ANAPTYSBIO INC COM 032724106 25700 1195336 SH SOLE 1195336 0 0 ANAVEX LIFE SCIENCES CORP COM NEW 032797300 4212 780007 SH SOLE 780007 0 0 AQUESTIVE THERAPEUTICS INC COM 03843E104 7414 1385720 SH SOLE 1385720 0 0 ARENA PHARMACEUTICALS INC COM NEW 040047607 44178 575007 SH SOLE 575007 0 0 ARROWHEAD PHARMACEUTICALS IN COM 04280A100 82164 1070814 SH SOLE 1070814 0 0 ATEA PHARMACEUTICALS INC COM 04683R106 129903 3109224 SH SOLE 3109224 0 0 ATHENEX INC COM 04685N103 149669 13532467 SH SOLE 13532467 0 0 ATHIRA PHARMA INC COM 04746L104 106682 3114805 SH SOLE 3114805 0 0 AVIDITY BIOSCIENCES INC COM 05370A108 31538 1235818 SH SOLE 1235818 0 0 BCLS ACQUISITION CORP COM CL A G0904B105 11140 1000000 SH SOLE 1000000 0 0 BCTG ACQUISITION CORP COM 05492W103 5720 500000 SH SOLE 500000 0 0 BRIDGEBIO PHARMA INC COM 10806X102 476883 6706268 SH SOLE 6706268 0 0 BURNING ROCK BIOTECH LTD SPONSORED ADS 12233L107 3465 150000 SH SOLE 150000 0 0 C4 THERAPEUTICS INC COM STK 12529R107 104643 3158566 SH SOLE 3158566 0 0 CEREVEL THERAPEUTICS HLDNG I COM 15678U128 75340 4544062 SH SOLE 4544062 0 0 COGENT BIOSCIENCES INC COM 19240Q201 35810 3188750 SH SOLE 3188750 0 0 COHERUS BIOSCIENCES INC COM 19249H103 81197 4671836 SH SOLE 4671836 0 0 COLLEGIUM PHARMACEUTICAL INC COM 19459J104 41223 2058068 SH SOLE 2058068 0 0 COLLEGIUM PHARMACEUTICAL INC NOTE 2.625% 2/1 19459JAA2 173250 17500000 PRN SOLE 17500000 0 0 COMPASS PATHWAYS PLC SPONSORED ADS 20451W101 49898 1047404 SH SOLE 1047404 0 0 CONCERT PHARMACEUTICALS INC COM 206022105 27184 2150641 SH SOLE 2150641 0 0 CONSONANCE HFW ACQUISITION C UNIT 99/99/9999 G2445M129 5235 500000 SH SOLE 500000 0 0 CRINETICS PHARMACEUTICALS IN COM 22663K107 51634 3659381 SH SOLE 3659381 0 0 CURIS INC COM NEW 231269200 10238 1250000 SH SOLE 1250000 0 0 CYTOMX THERAPEUTICS INC COM 23284F105 16880 2577043 SH SOLE 2577043 0 0 DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 17280 6595505 SH SOLE 6595505 0 0 DEERFIELD HEALTHCARE TECH AC COM CL A 244413100 312 20000 SH SOLE 20000 0 0 DEERFIELD HEALTHCARE TECH AC UNIT 07/16/2025 244413209 4500 300000 SH SOLE 300000 0 0 DICERNA PHARMACEUTICALS INC COM 253031108 17624 800000 SH SOLE 800000 0 0 DYNE THERAPEUTICS INC COM 26818M108 8400 400000 SH SOLE 400000 0 0 EIDOS THERAPEUTICS INC COM 28249H104 90385 686922 SH SOLE 686922 0 0 EIGER BIOPHARMACEUTICALS INC COM 28249U105 1719 139890 SH SOLE 139890 0 0 ESTABLISHMENT LABS HLDGS INC COM G31249108 26221 696633 SH SOLE 696633 0 0 FERRARI N V COM N3167Y103 1423 6200 SH SOLE 6200 0 0 FORMA THERAPEUTICS HLDGS INC SHS 34633R104 43625 1250000 SH SOLE 1250000 0 0 FORTE BIOSCIENCES INC COM 34962G109 12744 350000 SH SOLE 350000 0 0 FREQUENCY THERAPEUTICS INC COM 35803L108 114935 3259635 SH SOLE 3259635 0 0 FUSION PHARMACEUTICALS INC COM 36118A100 26273 2235983 SH SOLE 2235983 0 0 GALERA THERAPEUTICS INC COM 36338D108 3325 325000 SH SOLE 325000 0 0 GERON CORP COM 374163103 21404 13461538 SH SOLE 13461538 0 0 GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 245771 5674711 SH SOLE 5674711 0 0 HARMONY BIOSCIENCES HLDGS IN COM 413197104 18170 502622 SH SOLE 502622 0 0 HEALTH CATALYST INC COM 42225T107 12018 276084 SH SOLE 276084 0 0 HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109 5765 450000 SH SOLE 450000 0 0 HORIZON THERAPEUTICS PUB L SHS G46188101 225597 3084042 SH SOLE 3084042 0 0 IMMATICS N.V SHS N44445109 26975 2500000 SH SOLE 2500000 0 0 IMMUNOVANT INC COM 45258J102 64666 1400000 SH SOLE 1400000 0 0 INARI MED INC COM 45332Y109 58353 668500 SH SOLE 668500 0 0 INVITAE CORP COM 46185L103 304563 7284466 SH SOLE 7284466 0 0 IOVANCE BIOTHERAPEUTICS INC COM 462260100 425316 9166304 SH SOLE 9166304 0 0 IVERIC BIO INC COM 46583P102 30976 4482713 SH SOLE 4482713 0 0 KADMON HLDGS INC COM 48283N106 65202 15711334 SH SOLE 15711334 0 0 KODIAK SCIENCES INC COM 50015M109 110408 751533 SH SOLE 751533 0 0 KRONOS BIO INC COM 50107A104 83041 2780097 SH SOLE 2780097 0 0 LEAP THERAPEUTICS INC COM 52187K101 19072 8476496 SH SOLE 8476496 0 0 LEGEND BIOTECH CORP SPONSORED ADS 52490G102 704 25000 SH SOLE 25000 0 0 LIFESCI ACQUISITION II CORP COM 53229E103 3201 300000 SH SOLE 300000 0 0 LONGVIEW ACQUISITION CORP UNIT 99/99/9999 543195200 15155 700000 SH SOLE 700000 0 0 LYRA THERAPEUTICS INC COM 55234L105 36737 3222561 SH SOLE 3222561 0 0 MACROGENICS INC COM 556099109 28828 1261060 SH SOLE 1261060 0 0 MARAVAI LIFESCIENCES HLDGS I COM LA A 56600D107 9818 350000 SH SOLE 350000 0 0 MEIRAGTX HLDGS PLC COM G59665102 104970 6933277 SH SOLE 6933277 0 0 MIRATI THERAPEUTICS INC COM 60468T105 811244 3693516 SH SOLE 3693516 0 0 MOLECULAR TEMPLATES INC COM 608550109 3867 411818 SH SOLE 411818 0 0 MORPHIC HLDG INC COM 61775R105 16339 487000 SH SOLE 487000 0 0 MOTUS GI HLDGS INC COM 62014P108 3906 4210542 SH SOLE 4210542 0 0 NANOBIOTIX SA SPONSORED ADS 63009J107 18150 1100000 SH SOLE 1100000 0 0 NANOSTRING TECHNOLOGIES INC COM 63009R109 22592 337800 SH SOLE 337800 0 0 NEPTUNE WELLNESS SOLUTIONS I COM 64079L105 34655 22214683 SH SOLE 22214683 0 0 NEUROCRINE BIOSCIENCES INC COM 64125C109 182040 1899215 SH SOLE 1899215 0 0 NEVRO CORP COM 64157F103 169217 977565 SH SOLE 977565 0 0 NEVRO CORP NOTE 2.750% 4/0 64157FAC7 165420 9000000 PRN SOLE 9000000 0 0 NOVAVAX INC COM NEW 670002401 116305 1043000 SH SOLE 1043000 0 0 ONCORUS INC COM 68236R103 64336 1989987 SH SOLE 1989987 0 0 OUTLOOK THERAPEUTICS INC *W EXP 02/18/202 69012T115 93 420875 SH SOLE 420875 0 0 OUTSET MED INC COM 690145107 161870 2847822 SH SOLE 2847822 0 0 PHREESIA INC COM 71944F106 5426 100000 SH SOLE 100000 0 0 PMV PHARMACEUTICALS INC COM 69353Y103 54471 885556 SH SOLE 885556 0 0 POSEIDA THERAPEUTICS INC COM 73730P108 8642 787745 SH SOLE 787745 0 0 PROTAGONIST THERAPEUTICS INC COM 74366E102 4104 203591 SH SOLE 203591 0 0 PROTARA THERAPEUTICS INC COM STK 74365U107 14733 608544 SH SOLE 608544 0 0 PROVENTION BIO INC COM 74374N102 71561 4224389 SH SOLE 4224389 0 0 PULMONX CORP COM 745848101 26573 385000 SH SOLE 385000 0 0 QUOTIENT LTD SHS G73268107 84406 16200818 SH SOLE 16200818 0 0 RAPT THERAPEUTICS INC COM 75382E109 31155 1577481 SH SOLE 1577481 0 0 REGENERON PHARMACEUTICALS COM 75886F107 26656 55175 SH SOLE 55175 0 0 RELAY THERAPEUTICS INC COM 75943R102 96810 2329407 SH SOLE 2329407 0 0 REPLIGEN CORP COM 759916109 18684 97500 SH SOLE 97500 0 0 RETROPHIN INC NOTE 2.500% 9/1 761299AB2 442521 45000000 PRN SOLE 45000000 0 0 REVOLUTION MEDICINES INC COM 76155X100 8877 224224 SH SOLE 224224 0 0 ROCKET PHARMACEUTICALS INC COM 77313F106 186284 3396867 SH SOLE 3396867 0 0 SAGE THERAPEUTICS INC COM 78667J108 38064 440000 SH SOLE 440000 0 0 SC HEALTH CORP UNIT 99/99/9999 G78516302 10990 1000000 SH SOLE 1000000 0 0 SCYNEXIS INC COM NEW 811292200 18360 2400000 SH SOLE 2400000 0 0 SIERRA ONCOLOGY INC COM NEW 82640U404 1068 66655 SH SOLE 66655 0 0 SIGILON THERAPEUTICS INC COM 82657L107 6004 125000 SH SOLE 125000 0 0 SILK RD MED INC COM 82710M100 29292 465100 SH SOLE 465100 0 0 SOCIAL CAPITAL HEDOSOPHIA HLD SHS CL A G8251L105 671 40000 SH SOLE 40000 0 0 SOLID BIOSCIENCES INC COM 83422E105 81893 10803857 SH SOLE 10803857 0 0 SOTERA HEALTH CO COM 83601L102 8232 300000 SH SOLE 300000 0 0 SPDR SER TR S&P BIOTECH 78464A870 28156 200000 SH Put SOLE 200000 0 0 SPRINGWORKS THERAPEUTICS INC COM 85205L107 302968 4177721 SH SOLE 4177721 0 0 STOKE THERAPEUTICS INC COM 86150R107 41616 671978 SH SOLE 671978 0 0 SYNDAX PHARMACEUTICALS INC COM 87164F105 6672 300000 SH SOLE 300000 0 0 TARSUS PHARMACEUTICALS INC COM 87650L103 53580 1296416 SH SOLE 1296416 0 0 TAYSHA GENE THERAPIES INC COM SHS 877619106 12485 470440 SH SOLE 470440 0 0 TCR2 THERAPEUTICS INC COM 87808K106 12372 400000 SH SOLE 400000 0 0 THERAPEUTICS ACQUISITION COR COM CL A 88339T103 20880 1500000 SH SOLE 1500000 0 0 TRAVERE THERAPEUTICS INC COM 89422G107 95218 3493607 SH SOLE 3493607 0 0 UROVANT SCIENCES LTD SHS G9381B108 50274 3116831 SH SOLE 3116831 0 0 VANECK VECTORS ETF TR PHARMACEUTICAL 92189F692 13294 200000 SH Put SOLE 200000 0 0 VAXCYTE INC COM 92243G108 22585 850000 SH SOLE 850000 0 0 VBI VACCINES INC COM NEW 91822J103 151366 55042465 SH SOLE 55042465 0 0 VERONA PHARMA PLC SPONSORED ADS 925050106 20222 2888889 SH SOLE 2888889 0 0 VERRICA PHARMACEUTICALS INC COM 92511W108 39254 3410412 SH SOLE 3410412 0 0 VERU INC COM 92536C103 28113 3250000 SH SOLE 3250000 0 0 VIATRIS INC COM 92556V106 18823 1004419 SH SOLE 1004419 0 0 VIEWRAY INC COM 92672L107 9366 2451748 SH SOLE 2451748 0 0 VINCERA PHARMA INC COM 92731L106 6273 300000 SH SOLE 300000 0 0 VINCERA PHARMA INC *W EXP 12/24/202 92731L114 990 300000 SH SOLE 300000 0 0 VYNE THERAPEUTICS INC COM NEW 92941V100 36145 22876410 SH SOLE 22876410 0 0 WAVE LIFE SCIENCES LTD SHS Y95308105 19675 2500000 SH SOLE 2500000 0 0 ZENTALIS PHARMACEUTICALS INC COM 98943L107 54537 1050003 SH SOLE 1050003 0 0 ZYMEWORKS INC COM 98985W102 203265 4300999 SH SOLE 4300999 0 0