0001012975-18-000425.txt : 20180515 0001012975-18-000425.hdr.sgml : 20180515 20180515161954 ACCESSION NUMBER: 0001012975-18-000425 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20180331 FILED AS OF DATE: 20180515 DATE AS OF CHANGE: 20180515 EFFECTIVENESS DATE: 20180515 FILER: COMPANY DATA: COMPANY CONFORMED NAME: PERCEPTIVE ADVISORS LLC CENTRAL INDEX KEY: 0001224962 IRS NUMBER: 000000000 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10438 FILM NUMBER: 18836800 BUSINESS ADDRESS: STREET 1: 51 ASTOR PLACE, 10TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10003 BUSINESS PHONE: 646-205-5300 MAIL ADDRESS: STREET 1: 51 ASTOR PLACE, 10TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10003 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001224962 XXXXXXXX 03-31-2018 03-31-2018 PERCEPTIVE ADVISORS LLC

51 ASTOR PLACE, 10TH FLOOR NEW YORK NY 10003

13F HOLDINGS REPORT 028-10438 N Joseph Edelman 646.205.5342 /s/ Joseph Edelman New York NY 05-15-2018 0 137 3570243 false INFORMATION TABLE 2 infotable.xml INFORMATION TABLE ABEONA THERAPEUTICS INC W EXP 12/24/201 00289Y115 11966 1259636 SH SOLE 1259636 0 0 ABEONA THERAPEUTICS INC COM 00289Y107 14180 998162 SH SOLE 998162 0 0 ABIOMED INC COM 003654100 96739 332449 SH SOLE 332449 0 0 ABLYNX NV SPONSORED ADR 00372Y105 20187 370000 SH SOLE 370000 0 0 ACADIA PHARMACEUTICALS INC COM 004225108 6179 275000 SH SOLE 275000 0 0 ACASTI PHARMA INC COM 00430K402 190 186559 SH SOLE 186559 0 0 ACCELERON PHARMA INC COM 00434H108 59286 1516259 SH SOLE 1516259 0 0 ACHILLION PHARMACEUTICALS INC COM 00448Q201 3710 1000000 SH SOLE 1000000 0 0 ADAMAS PHARMACEUTICALS INC COM 00548A106 15057 630000 SH SOLE 630000 0 0 ADMA BIOLOGICS INC COM 000899104 17577 3821102 SH SOLE 3821102 0 0 ADVAXIS INC COM NEW 007624208 2535 1500000 SH SOLE 1500000 0 0 ADVERUM BIOTECHNOLOGIES INC COM 00773U108 469 80845 SH SOLE 80845 0 0 AGILE THERAPEUTICS INC COM 00847L100 9072 3530000 SH SOLE 3530000 0 0 AGIO PHARMACEUTICALS INC COM 00847X104 20445 250000 SH SOLE 250000 0 0 AKCEA THERAPEUTICS INC COM 00972L107 2488 97144 SH SOLE 97144 0 0 AKEBIA THERAPEUTICS INC COM 00972D105 23467 2462400 SH SOLE 2462400 0 0 ALBIREO PHARMA INC COM 01345P106 55510 1704330 SH SOLE 1704330 0 0 ALDEYRA THERAPEUTICS INC COM 01438T106 23141 3085458 SH SOLE 3085458 0 0 ALEXION PHARMACEUTICALS INC COM 015351109 97355 873450 SH SOLE 873450 0 0 ALLENA PHARMACEUTICALS INC COM 018119107 2755 250000 SH SOLE 250000 0 0 ALLIQUA BIOMEDICAL INC COM PAR 019621309 821 423394 SH SOLE 423394 0 0 ALNYLAM PHARMACEUTICALS COM 02043Q107 152543 1280802 SH SOLE 1280802 0 0 AMICUS THERAPEUTICS INC COM 03152W109 301167 20024424 SH SOLE 20024424 0 0 ANAPTYSBIO INC COM 032724106 24696 237281 SH SOLE 237281 0 0 ANI PHARMACEUTICALS INC NOTE 3.000%12/0 00182CAA1 8214 7500000 PRN SOLE 7500000 0 0 ARENA PHARMACEUTICALS INC COM NEW 040047607 6793 171978 SH SOLE 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2927449 0 0 BLUEPRINT MEDICINES CORP COM 09627Y109 94491 1030434 SH SOLE 1030434 0 0 BRAINSTORM CELL THERAPEUTICS COM NEW 10501E201 1260 400000 SH SOLE 400000 0 0 CAPITAL SR LIVING CORP COM 140475104 1077 100173 SH SOLE 100173 0 0 CAPRICOR THERAPEUTICS INC COM 14070B101 5 4000 SH SOLE 4000 0 0 CAREDX INC COM 14167L103 8294 1040676 SH SOLE 1040676 0 0 CASI PHARMACEUTICALS INC COM 14757U109 182 43682 SH SOLE 43682 0 0 CATALYST BIOSCIENCES IINC COM NEW 14888D208 1419 55000 SH SOLE 55000 0 0 CELLECTIS S A SPONSORED ADS 15117K103 9453 300000 SH SOLE 300000 0 0 CHAMPIONS ONCOLOGY INC COM NEW 15870P307 1335 366973 SH SOLE 366973 0 0 CLEARSIDE BIOMEDICAL INC COM 185063104 7681 715181 SH SOLE 715181 0 0 CORIUM INTERNATIONAL INC COM 21887L107 72916 6357133 SH SOLE 6357133 0 0 CUTERA INC COM 232109108 602 11981 SH SOLE 11981 0 0 CYMABAY THERAPEUTICS INC COM 23257D103 33745 2802821 SH SOLE 2802821 0 0 CYTOMX THERAPEUTICS INC COM 23284F105 62841 2208812 SH SOLE 2208812 0 0 DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 48296 2093498 SH SOLE 2093498 0 0 DOVA PHARMACEUTICALS INC COM 25985T102 75420 2780977 SH SOLE 2780977 0 0 DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 1106 55713 SH SOLE 55713 0 0 EIGER BIOPHARMACEUTICALS INC COM 28249U105 1553 157679 SH SOLE 157679 0 0 ENANTA PHARMACEUTICALS INC COM 29251M106 739 9132 SH SOLE 9132 0 0 ENDOCYTE INC COM 29269A102 20013 2201700 SH SOLE 2201700 0 0 ESPERION THERAPEUTICS INC NE COM 29664W105 779 10769 SH SOLE 10769 0 0 FERRARI N V COM N3167Y103 747 6200 SH SOLE 6200 0 0 FIAT CHRYSLER AUTOMOBILES N SHS N31738102 1272 62000 SH SOLE 62000 0 0 FLEXION THERAPEUTICS INC COM 33938J106 6902 307989 SH SOLE 307989 0 0 FOAMIX PHARMACEUTICALS LTD COM M46135105 5732 1117324 SH SOLE 1117324 0 0 GALAPAGOS N V SPON ADR 36315X101 20581 206305 SH SOLE 206305 0 0 GERON CORP COM 374163103 600 600000 SH Put SOLE 600000 0 0 GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 240971 4989066 SH SOLE 4989066 0 0 HISTOGENICS CORP COM 43358V109 6059 2203277 SH SOLE 2203277 0 0 HUMANA INC COM 444859102 16323 60718 SH SOLE 60718 0 0 HUTCHISON CHINA MEDITECH LTD SPONSORED ADR 44842L103 296 10000 SH SOLE 10000 0 0 INCYTE CORP COM 45337C102 6946 1510000 SH Call SOLE 1510000 0 0 INCYTE CORP COM 45337C102 2230 100000 SH Put SOLE 100000 0 0 INTRA CELLULAR THERAPIES INC COM 46116X101 1474 70000 SH SOLE 70000 0 0 INTUITIVE SURGICAL INC COM NEW 46120E602 4128 10000 SH SOLE 10000 0 0 INVACARE CORP COM 461203101 3480 200000 SH SOLE 200000 0 0 INVITAE CORP COM 46185L103 8700 1851100 SH SOLE 1851100 0 0 IOVANCE BIOTHERAPEUTICS INC COM 462260100 104141 6162202 SH SOLE 6162202 0 0 IRHYTHM TECHNOLOGIES INC COM 450056106 26420 419706 SH SOLE 419706 0 0 KADMON HLDGS INC COM 48283N106 21954 5165746 SH SOLE 5165746 0 0 LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 128459 4313611 SH SOLE 4313611 0 0 MADRIGAL PHARMACEUTICALS INC COM 558868105 16645 142522 SH SOLE 142522 0 0 MARINUS PHARMACEUTICALS INC COM 56854Q101 3467 907732 SH SOLE 907732 0 0 MCKESSON CORP 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1000000 0 0 PORTOLA PHARMACEUTICALS INC COM 737010108 14370 440000 SH SOLE 440000 0 0 PORTOLA PHARMACEUTICALS INC COM 737010108 158 100000 SH Put SOLE 100000 0 0 PROGENICS PHARMACEUTICALS IN COM 743187106 1212 162500 SH SOLE 162500 0 0 PROTEON THERAPEUTICS INC COM 74371L109 835 334116 SH SOLE 334116 0 0 PTC THERAPEUTICS INC COM 69366J200 8118 300000 SH SOLE 300000 0 0 PUMA BIOTECHNOLOGY INC COM 74587V107 1610 200000 SH Call SOLE 200000 0 0 PUMA BIOTECHNOLOGY INC COM 74587V107 30090 442179 SH SOLE 442179 0 0 QUOTIENT LTD COM G73268107 28415 6033020 SH SOLE 6033020 0 0 REGENERON PHARMACEUTICALS COM 75886F107 335 50000 SH Call SOLE 50000 0 0 REGENXBIO INC COM 75901B107 26301 881106 SH SOLE 881106 0 0 RETROPHIN INC COM 761299106 71839 3212871 SH SOLE 3212871 0 0 REVANCE THERAPEUTICS INC COM 761330109 19064 618957 SH SOLE 618957 0 0 RHYTHM PHARMACEUTICALS INC COM 76243J105 11786 592286 SH SOLE 592286 0 0 SANGAMO THERAPEUTICS INC COM 800677106 475 25000 SH SOLE 25000 0 0 SELECTA BIOSCIENCES INC COM 816212104 6050 593750 SH SOLE 593750 0 0 SENSEONICS HLDGS INC COM 81727U105 345 115000 SH SOLE 115000 0 0 SIERRA ONCOLOGY INC COM 82640U107 10350 5000000 SH SOLE 5000000 0 0 SOLID BIOSCIENCES INC COM 3422E1055 29454 3927222 SH SOLE 3927222 0 0 SPDR SERIES TRUST S&P BIOTECH 78464A870 1548 900000 SH Put SOLE 900000 0 0 STRONGBRIDGE BIOPHARMA PLC SHS USD G85347105 2434 275000 SH SOLE 275000 0 0 SYNERGY PHARMACEUTICALS DEL COM NEW 871639308 183 100000 SH SOLE 100000 0 0 SYNLOGIC INC COM 87166L100 8844 942852 SH SOLE 942852 0 0 TABULA RASA HEALTHCARE INC COM 873379101 569 14663 SH SOLE 14663 0 0 TELADOC INC COM 87918A105 20956 520000 SH SOLE 520000 0 0 TELEFLEX INC COM 879369106 10429 40900 SH SOLE 40900 0 0 UNIQURE NV COM N90064101 32774 1394628 SH SOLE 1394628 0 0 VBI VACCINES INC COM NEW 91822J103 33830 9665843 SH SOLE 9665843 0 0 VERICEL CORP COM 92346J108 271 27211 SH SOLE 27211 0 0 VERONA PHARMA PLC SPONSORED ADS 925050106 1123 56168 SH SOLE 56168 0 0 VERTEX PHARMACEUTICALS INC COM 92532F100 24756 151898 SH SOLE 151898 0 0 VICAL INC COM 925602203 1657 1142858 SH SOLE 1142858 0 0 VIEWRAY INC COM 92672L107 643 100000 SH SOLE 100000 0 0 VITAL THERAPIES INC COM 92847R104 454 150000 SH Put SOLE 150000 0 0 VIVEVE MED INC COM NEW 92852W204 1226 334894 SH SOLE 334894 0 0 WAVE LIFE SCIENCES LTD SHS Y95308105 18558 462798 SH SOLE 462798 0 0 XENCOR INC COM 98401F105 39516 1318095 SH SOLE 1318095 0 0 ZOGENIX INC COM NEW 98978L204 159012 3970357 SH SOLE 3970357 0 0 ZYMEWORKS INC COM 98985W102 7779 693890 SH SOLE 693890 0 0