X0305 4 2012-05-21 0 0001532063 Express Scripts Holding Co. ESRX 0001214130 POTTER MYRTLE S C/O EXPRESS SCRIPTS HOLDING COMPANY ONE EXPRESS WAY ST. LOUIS MO 63121 1 0 0 0 Common Stock 2012-05-21 4 M 0 538 36.50 A 7409.674 D Common Stock 2012-05-21 4 S 0 538 51.873 D 6871.674 D Common Stock 2012-05-21 4 M 0 10644 34.79 A 17515.674 D Common Stock 2012-05-21 4 S 0 10644 51.863 D 6871.674 D Common Stock 2012-05-21 4 M 0 5000 32.94 A 11871.674 D Common Stock 2012-05-21 4 S 0 5000 51.902 D 6871.674 D Non-Qualified Stock Option (Right-to-Buy) 36.50 2012-05-21 4 M 0 538 0 D 2008-12-11 2017-12-10 Express Scripts Holding Company Common Stock 538 0 D Non-Qualified Stock Option (Right-to-Buy) 34.79 2012-05-21 4 M 0 10644 0 D 2009-05-22 2018-05-21 Express Scripts Holding Company Common Stock 10644 0 D Non-Qualified Stock Option (Right-to-Buy) 32.94 2012-05-21 4 M 0 5000 0 D 2010-05-21 2019-05-20 Express Scripts Holding Company Common Stock 5000.00 6587 D Myrtle Potter 2012-05-21