SEC FORM 3

SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person^*

PORWOLL JOE

(Last)

(First)

(Middle)

1001 WEST SAINT PAUL AVE

(Street)

MILWAUKEE

53233

(City)

(State)

(Zip)

2. Date of Event Requiring Statement (Month/Day/Year)
08/02/2010

3. Issuer Name and Ticker or Trading Symbol
SIGMA ALDRICH CORP [ SIAL ]

4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

Director		10% Owner
Officer (give title below)	X	Other (specify below)
		VP-Supply Chain-Global

5. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock, $1 Par Value	10,240	D

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
1. Title of Derivative Security (Instr. 4)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
ISO Stock Option, Right to Buy	05/07/2003	05/07/2012	Common Stock, $1 Par Value	4,100	$25.315	D
ISO Stock Option, Right to Buy	05/06/2004	05/06/2013	Common Stock, $1 Par Value	7,600	$25.86	D
NQ Stock Option, Right to Buy	05/06/2004	05/06/2013	Common Stock, $1 Par Value	7,400	$25.86	D
ISO Stock Option, Right to Buy	05/04/2005	05/04/2014	Common Stock, $1 Par Value	3,400	$28.66	D
NQ Stock Option, Right to Buy	05/04/2005	05/04/2014	Common Stock, $1 Par Value	11,600	$28.66	D
ISO Stock Option, Right to Buy	07/08/2006	07/08/2015	Common Stock, $1 Par Value	2,500	$28.825	D
NQ Stock Option, Right to Buy	07/08/2006	07/08/2015	Common Stock, $1 Par Value	5,000	$28.825	D
ISO Stock Option, Right to Buy	05/01/2007	05/01/2016	Common Stock, $1 Par Value	2,500	$34.03	D
NQ Stock Option, Right to Buy	05/01/2007	05/01/2016	Common Stock, $1 Par Value	5,000	$34.03	D
ISO Stock Option, Right to Buy	02/16/2008	02/16/2017	Common Stock, $1 Par Value	3,400	$41.62	D
NQ Stock Option, Right to Buy	02/16/2008	02/16/2017	Common Stock, $1 Par Value	4,100	$41.62	D
NQ Stock Option, Right to Buy	02/15/2009	02/15/2018	Common Stock, $1 Par Value	4,050	$52.76	D
ISO Stock Option, Right to Buy	02/15/2009	02/15/2018	Common Stock, $1 Par Value	1,850	$52.76	D
ISO Stock Option, Right to Buy	02/17/2010	02/17/2019	Common Stock, $1 Par Value	2,032	$37.56	D
NQ Stock Option, Right to Buy	02/17/2010	02/17/2019	Common Stock, $1 Par Value	3,868	$37.56	D
ISO Stock Option, Right to Buy	02/16/2011	02/16/2020	Common Stock, $1 Par Value	2,204	$48.61	D
NQ Stock Option, Right to Buy	02/16/2011	02/16/2020	Common Stock, $1 Par Value	2,796	$48.61	D

Explanation of Responses:

	Carrie Fields, Attorney in Fact	08/04/2010
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.