X0304 4 2011-09-16 0001375151 ZOGENIX, INC. ZGNX 0001207786 DOVEY BRIAN H C/O DOMAIN ASSOCIATES, LLC ONE PALMER SQUARE PRINCETON NJ 08542 0 0 1 0 Common Stock 2011-09-16 4 P 0 3441304 2.00 A 9923335 I By Domain Partners VII, L.P. Common Stock 2011-09-16 4 P 0 58696 2.00 A 169251 I By DP VII Associates, L.P. The Reporting Person also indirectly beneficially owns 11,000 shares of Common Stock held by Domain Associates, LLC, 9,894 shares held by Domain Partners VI, L.P., and 106 shares held by DP VI Associates, L.P. The Reporting Person is a Managing Member of (i) One Palmer Square Associates VII, LLC, which is the sole general partner of Domain Partners VII, L.P. and DP VII Associates, L.P., (ii) One Palmer Square Associates VI, LLC, which is the sole general partner of Domain Partners VI, L.P. and DP VI Associates, L.P., and (iii) Domain Associates, LLC. Pursuant to Instruction (4)(b)(iv) of Form 4, the Reporting Person has elected to report as indirectly beneficially owned the entire number of securities beneficially owned by each such entity. The Reporting Person disclaims beneficial ownership of any securities, and any proceeds thereof, that exceed his or her pecuniary interest therein and/or that are not actually distributed to him or her. /s/Kathleen K. Schoemaker, Attorney-in-Fact 2011-09-20