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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
 V2Oe9tWjkPcbUeIrVfKw6Co6UP1NJzMyAHkASGYEEI9hV1BCNuyrIN8ae5faDle/
 tlP4+g6pNoPJW9oiU/mDeA==

<SEC-DOCUMENT>0001225208-09-024885.txt : 20091222
<SEC-HEADER>0001225208-09-024885.hdr.sgml : 20091222
<ACCEPTANCE-DATETIME>20091222162858
ACCESSION NUMBER:		0001225208-09-024885
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20091222
FILED AS OF DATE:		20091222
DATE AS OF CHANGE:		20091222

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			HUMAN GENOME SCIENCES INC
		CENTRAL INDEX KEY:			0000901219
		STANDARD INDUSTRIAL CLASSIFICATION:	IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES [2835]
		IRS NUMBER:				223178468
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		14200 SHADY GROVE ROAD
		CITY:			ROCKVILLE
		STATE:			MD
		ZIP:			20850-3338
		BUSINESS PHONE:		3013098504

	MAIL ADDRESS:	
		STREET 1:		14200 SHADY GROVE ROAD
		CITY:			ROCKVILLE
		STATE:			MD
		ZIP:			20850

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Bateson Susan D.
		CENTRAL INDEX KEY:			0001191234

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-14169
		FILM NUMBER:		091255501

	MAIL ADDRESS:	
		STREET 1:		14200 SHADY GROVE ROAD
		CITY:			ROCKVILLE
		STATE:			MD
		ZIP:			20850

	FORMER NAME:	
		FORMER CONFORMED NAME:	MCKAY SUSAN D BATESON
		DATE OF NAME CHANGE:	20020920
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>doc4.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2009-12-22</periodOfReport>

    <issuer>
        <issuerCik>0000901219</issuerCik>
        <issuerName>HUMAN GENOME SCIENCES INC</issuerName>
        <issuerTradingSymbol>HGSI</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001191234</rptOwnerCik>
            <rptOwnerName>Bateson Susan D.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>14200 SHADY GROVE ROAD</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>ROCKVILLE</rptOwnerCity>
            <rptOwnerState>MD</rptOwnerState>
            <rptOwnerZipCode>20850</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isOfficer>1</isOfficer>
            <officerTitle>Senior Vice President</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2009-12-22</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>10000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>30</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>60358</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the reporting person and Merrill Lynch effective October 12, 2009.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>Susan D. Bateson</signatureName>
        <signatureDate>2009-12-22</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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