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Cash, Cash Equivalents and Available-for-Sale Investments (Tables) link:presentationLink link:calculationLink link:definitionLink 3030 - Disclosure - Basic and Diluted Net Loss Attributable to Common Stockholders per Common Share (Tables) link:presentationLink link:calculationLink link:definitionLink 3040 - Disclosure - Stockholders' Equity (Tables) link:presentationLink link:calculationLink link:definitionLink 3060 - Disclosure - Assets and Liabilities Measured at Fair Value (Tables) link:presentationLink link:calculationLink link:definitionLink 3080 - Disclosure - Restructuring Charges (Tables) link:presentationLink link:calculationLink link:definitionLink 4010 - Disclosure - Description of Business and Significant Accounting Policies (Details) link:presentationLink link:calculationLink link:definitionLink 4020 - Disclosure - Cash, Cash Equivalents and Available-for-Sale Investments (Details) link:presentationLink link:calculationLink link:definitionLink 4030 - Disclosure - Basic and Diluted Net Loss Attributable to Common Stockholders per Common Share (Details) link:presentationLink link:calculationLink link:definitionLink 4040 - Disclosure - Stockholders' Equity (Details) link:presentationLink link:calculationLink link:definitionLink 4041 - Disclosure - Stockholders' Equity (Details 2) link:presentationLink link:calculationLink link:definitionLink 4050 - Disclosure - Short-Term Borrowings and Long-Term Debt (Details) link:presentationLink link:calculationLink link:definitionLink 4060 - Disclosure - Assets and Liabilities Measured at Fair Value (Details) link:presentationLink link:calculationLink link:definitionLink 4070 - Disclosure - Collaborative Agreements (Details) link:presentationLink link:calculationLink link:definitionLink 4080 - Disclosure - Restructuring Charges (Details) link:presentationLink link:calculationLink link:definitionLink 8000 - Statement - Consolidated Statements of Stockholders' (Deficiency)/Equity link:presentationLink link:calculationLink link:definitionLink 8010 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 8020 - Disclosure - Property and Equipment link:presentationLink link:calculationLink link:definitionLink 8030 - Disclosure - Accounts Payable and Accrued Expenses link:presentationLink link:calculationLink link:definitionLink 8040 - Disclosure - 401(k) Plan link:presentationLink link:calculationLink link:definitionLink 8050 - Disclosure - Leases link:presentationLink link:calculationLink link:definitionLink 8060 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 8070 - Disclosure - Licenses link:presentationLink link:calculationLink link:definitionLink 8080 - Disclosure - Comprehensive Loss link:presentationLink link:calculationLink link:definitionLink 8090 - Disclosure - Selected Quarterly Financial Data (Unaudited - in thousands except per share data) link:presentationLink link:calculationLink link:definitionLink 8100 - Disclosure - Assets and Liabilities Measured at Fair Value (Details 2) link:presentationLink link:calculationLink link:definitionLink 8110 - Disclosure - Subsequent Events (Details) link:presentationLink link:calculationLink link:definitionLink