101 - Document - Document and Entity Information link:calculationLink link:presentationLink link:definitionLink 103 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS link:calculationLink link:presentationLink link:definitionLink 104 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS (Parenthetical) link:calculationLink link:presentationLink link:definitionLink 105 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS link:calculationLink link:presentationLink link:definitionLink 106 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS (Parenthetical) link:calculationLink link:presentationLink link:definitionLink 107 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS link:calculationLink link:presentationLink link:definitionLink 108 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES link:calculationLink link:presentationLink link:definitionLink 109 - Disclosure - SIGNIFICANT AGREEMENTS link:calculationLink link:presentationLink link:definitionLink 110 - Disclosure - REGULUS link:calculationLink link:presentationLink link:definitionLink 111 - Disclosure - COMMITMENTS AND CONTINGENCIES link:calculationLink link:presentationLink link:definitionLink 112 - Disclosure - 2012 RESTRUCTURING link:calculationLink link:presentationLink link:definitionLink 113 - Disclosure - SUBSEQUENT EVENT link:calculationLink link:presentationLink link:definitionLink 114 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Policies) link:calculationLink link:presentationLink link:definitionLink 115 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Tables) link:calculationLink link:presentationLink link:definitionLink 116 - Disclosure - SIGNIFICANT AGREEMENTS (Tables) link:calculationLink link:presentationLink link:definitionLink 117 - Disclosure - REGULUS (Tables) link:calculationLink link:presentationLink link:definitionLink 118 - Disclosure - 2012 RESTRUCTURING (Tables) link:calculationLink link:presentationLink link:definitionLink 119 - Disclosure - Potential Common Shares (Common Shares Excluded From The Calculation Of Net Loss Per Common Share) (Detail) link:calculationLink link:presentationLink link:definitionLink 120 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 121 - Disclosure - Fair Value Measured on Recurring Basis (Detail) link:calculationLink link:presentationLink link:definitionLink 122 - Disclosure - Summary of Company's Marketable Securities (Detail) link:calculationLink link:presentationLink link:definitionLink 123 - Disclosure - Revenue From Research Collaborators (Detail) link:calculationLink link:presentationLink link:definitionLink 124 - Disclosure - Significant Agreements - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 125 - Disclosure - Regulus - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 126 - Disclosure - Summary Results of Regulus' Operation (Detail) link:calculationLink link:presentationLink link:definitionLink 127 - Disclosure - Summary Results of Regulus' Balance Sheet (Detail) link:calculationLink link:presentationLink link:definitionLink 128 - Disclosure - Commitments and Contingencies - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 129 - Disclosure - 2012 Restructuring - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 130 - Disclosure - Restructuring Activities (Detail) link:calculationLink link:presentationLink link:definitionLink 131 - Disclosure - Subsequent Events - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink