SCHEDULE 13G

Amendment No. 1
ORAGENICS INC
Common Stock
Cusip #684023203


Cusip #684023203
Item 1:	Reporting Person - FMR LLC
Item 4:	Delaware
Item 5:	0
Item 6:	0
Item 7:	2,866,666
Item 8:	0
Item 9:	2,866,666
Item 11:	8.212%
Item 12:	    HC


Cusip #684023203
Item 1:	Reporting Person - Edward C. Johnson 3d
Item 4:	United States of America
Item 5:	0
Item 6:	0
Item 7:	2,866,666
Item 8:	0
Item 9:	2,866,666
Item 11:	8.212%
Item 12:	IN




	SCHEDULE 13G - TO BE INCLUDED IN
STATEMENTS
	FILED PURSUANT TO RULE 13d-1(b) or 13d-2(b)



Item 1(a).	Name of Issuer:

		ORAGENICS INC

Item 1(b).	Name of Issuer's Principal Executive Offices:

		12085 Research Dr
		Alachua, FL  32615
		USA

Item 2(a).	Name of Person Filing:

		FMR LLC

Item 2(b).	Address or Principal Business Office or, if None,
Residence:

		245 Summer Street, Boston,
Massachusetts  02210

Item 2(c).	Citizenship:

		Not applicable

Item 2(d).	Title of Class of Securities:

		Common Stock

Item 2(e).	CUSIP Number:

		684023203

Item 3.	This statement is filed pursuant to Rule 13d-1(b) or 13d-2(b)
and the person filing, FMR LLC, is a parent holding company
in accordance with Section 240.13d-1(b)(ii)(G).  (Note:  See
Item 7).

Item 4.	Ownership

	(a)	Amount Beneficially Owned:	2,866,666

	(b)	Percent of Class:	8.212%

	(c)	Number of shares as to which such
person has:

	(i)	sole power to vote or to direct
the vote:	0

	(ii)	shared power to vote or to
direct the vote:	0

	(iii)	sole power to dispose or to
direct the disposition of:	2,866,666

	(iv)	shared power to dispose or to
direct the disposition of:	0



Item 5.	Ownership of Five Percent or Less of a Class.

	Not applicable.

Item 6.	Ownership of More than Five Percent on Behalf of Another
Person.

	Various persons have the right to receive or the power to
direct the receipt of dividends from, or the proceeds from the
sale of, the Common Stock of ORAGENICS INC.  The
interest of one person, Fidelity Select Biotechnology Portfolio,
an investment company registered under the Investment
Company Act of 1940, in the Common Stock of
ORAGENICS INC, amounted to 2,616,358 shares or 7.495%
of the total outstanding Common Stock at December 31, 2013.

Item 7.	Identification and Classification of the Subsidiary Which
Acquired the Security Being Reported on By the Parent
Holding Company.

	See attached Exhibit A.

Item 8.	Identification and Classification of Members of
the Group.

	Not applicable.  See attached Exhibit A.

Item 9.	Notice of Dissolution of Group.

	Not applicable.

Item 10.	Certification.

	By signing below I certify that, to the best of my knowledge
and belief, the securities referred to above were acquired in the
ordinary course of business and were not acquired for the
purpose of and do not have the effect of changing or
influencing the control of the issuer of such securities and
were not acquired in connection with or as a participant in any
transaction having such purpose or effect.

Signature

	After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement
is true, complete and correct.

February 13, 2014
Date

 /s/ Scott C. Goebel
Signature

Scott C. Goebel
Duly authorized under Power of Attorney
effective as of June 1, 2008 by and on behalf of FMR LLC
and its direct and indirect  subsidiaries


	SCHEDULE 13G - TO BE INCLUDED IN
STATEMENTS
	FILED PURSUANT TO RULE 13d-1(b) or 13d-2(b)



	Pursuant to the instructions in Item 7 of Schedule 13G,
Fidelity SelectCo, LLC ("SelectCo"), 1225 17th Street, Suite
1100, Denver, Colorado 80202, a wholly-owned subsidiary of
FMR LLC and an investment adviser registered under Section
203 of the Investment Advisers Act of 1940, is the beneficial
owner of 2,866,666 shares or 8.212% of the Common Stock
outstanding of ORAGENICS INC ("the Company") as a result
of acting as investment adviser to various investment
companies registered under Section 8 of the Investment
Company Act of 1940 (the "SelectCo Funds"). The number of
shares of Common Stock of ORAGENICS INC owned by the
institutional account(s) at December 31, 2013 included
1,666,666 shares of Common Stock resulting from the
assumed conversion of 1,666,666 shares of ORAGENICS INC
PIPE (1 shares of Common Stock for each share of
Convertible Preferred Stock).

	Edward C. Johnson 3d and FMR LLC, through its
control of SelectCo, and the SelectCo Funds each has sole
power to dispose of the 2,866,666 owned by the SelectCo
Funds. The number of shares of Common Stock of
ORAGENICS INC owned by the institutional account(s) at
December 31, 2013 included 1,666,666 shares of Common
Stock resulting from the assumed conversion of 1,666,666
shares of ORAGENICS INC PIPE (1 shares of Common
Stock for each share of Convertible Preferred Stock).

	The ownership of one investment company, Fidelity
Select Biotechnology Portfolio, amounted to 2,616,358 shares
or 7.495% of the Common Stock outstanding. Fidelity Select
Biotechnology Portfolio has its principal business office at
245 Summer Street, Boston, Massachusetts 02210.

	Members of the family of Edward C. Johnson 3d,
Chairman of FMR LLC, are the predominant owners, directly
or through trusts, of Series B voting common shares of FMR
LLC, representing 49% of the voting power of FMR LLC.
The Johnson family group and all other Series B shareholders
have entered into a shareholders' voting agreement under
which all Series B voting common shares will be voted in
accordance with the majority vote of Series B voting common
shares.  Accordingly, through their ownership of voting
common shares and the execution of the shareholders' voting
agreement, members of the Johnson family may be deemed,
under the Investment Company Act of 1940, to form a
controlling group with respect to FMR LLC.



	SCHEDULE 13G - TO BE INCLUDED IN
STATEMENTS
	FILED PURSUANT TO RULE 13d-1(b) or 13d-2(b)
	RULE 13d-1(f)(1)  AGREEMENT

	The undersigned persons, on February 13, 2014, agree
and consent to the joint filing on their behalf of this Schedule
13G in connection with their beneficial ownership of the
Common Stock of ORAGENICS INC at December 31, 2013.

	FMR LLC

	By /s/ Scott C. Goebel
	Scott C. Goebel
	Duly authorized under Power of Attorney effective as
of June 1, 2008, by and on behalf of FMR LLC and its direct
and indirect subsidiaries

	Edward C. Johnson 3d

	By /s/ Scott C. Goebel
	Scott C. Goebel
	Duly authorized under Power of Attorney effective as
of June 1, 2008, by and on behalf of Edward C. Johnson 3d

	Fidelity Select Biotechnology Portfolio

	By /s/ Scott C. Goebel
	Scott C. Goebel
	Secretary