-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, GVW3BO1W1xoJ1uWi2yokiFRSeI/k+qgOZcVMxyyb+ftvvref0VOPjd82/d/rbKlQ 74GXpwEFwanIz38BPYfuBg== 0000950149-07-000027.txt : 20070212 0000950149-07-000027.hdr.sgml : 20070212 20070212134708 ACCESSION NUMBER: 0000950149-07-000027 CONFORMED SUBMISSION TYPE: SC 13G PUBLIC DOCUMENT COUNT: 1 FILED AS OF DATE: 20070212 DATE AS OF CHANGE: 20070212 GROUP MEMBERS: ANSBERT GADICKE GROUP MEMBERS: LUKE EVNIN GROUP MEMBERS: MPM ASSET MANAGEMENT INVESTORS 2001 LLC GROUP MEMBERS: MPM BIOVENTURES GMBH & CO PARALLEL BETEILIGUNGS KG GROUP MEMBERS: MPM BIOVENTURES II-QP LP GROUP MEMBERS: MPM BIOVENTURES STRATEGIC FUND LP SUBJECT COMPANY: COMPANY DATA: COMPANY CONFORMED NAME: AFFYMAX INC CENTRAL INDEX KEY: 0001158223 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 000000000 FILING VALUES: FORM TYPE: SC 13G SEC ACT: 1934 Act SEC FILE NUMBER: 005-82530 FILM NUMBER: 07601746 BUSINESS ADDRESS: STREET 1: 4001 MIRANDA AVE CITY: PALO ALTO STATE: CA ZIP: 94304 FILED BY: COMPANY DATA: COMPANY CONFORMED NAME: MPM BIOVENTURES II LP CENTRAL INDEX KEY: 0001264829 IRS NUMBER: 043523685 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: SC 13G BUSINESS ADDRESS: STREET 1: THE JOHN HANCOCK TOWER STREET 2: 200 CLARENDON STREET, 54TH FLOOR CITY: BOSTON STATE: MA ZIP: 02116 BUSINESS PHONE: 6174259200 MAIL ADDRESS: STREET 1: THE JOHN HANCOCK TOWER STREET 2: 200 CLARENDON STREET, 54TH FLOOR CITY: BOSTON STATE: MA ZIP: 02116 SC 13G 1 f27252sc13g.htm SCHEDULE 13G sc13g
 

     
 
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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 13G

Under the Securities Exchange Act of 1934
(Amendment No. _____)*

AFFYMAX, INC.
(Name of Issuer)
Common Stock
(Title of Class of Securities)
00826A 1G 9
(CUSIP Number)
December 31, 2006
(Date of Event Which Requires Filing of This Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

     o Rule 13d-1(b)

     o Rule 13d-1(c)

     þ Rule 13d-1(d)

* The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

 
 

Page 1 of 13

 

                     
CUSIP No.
  
00826A 1G 9 
  

 

           
1   NAMES OF REPORTING PERSONS:
   
  I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):
MPM BioVentures II, L.P.
   
     
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS):
  (a)   o
  (b)   þ
     
3   SEC USE ONLY:
   
   
     
4   CITIZENSHIP OR PLACE OF ORGANIZATION:
   
  Delaware
       
  5   SOLE VOTING POWER:
     
NUMBER OF   109,213
       
SHARES 6   SHARED VOTING POWER:
BENEFICIALLY    
OWNED BY   0
       
EACH 7   SOLE DISPOSITIVE POWER:
REPORTING    
PERSON   109,213
       
WITH: 8   SHARED DISPOSITIVE POWER:
     
    0
     
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON:
   
  109,213
     
10   CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS):
   
   
     
11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9):
   
  0.76%
     
12   TYPE OF REPORTING PERSON (SEE INSTRUCTIONS):
   
  PN

Page 2 of 13

 

                     
CUSIP No.
  
00826A 1G 9 
  

 

           
1   NAMES OF REPORTING PERSONS:
   
  I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):
MPM BioVentures II-QP, L.P.
   
     
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS):
  (a)   o
  (b)   þ
     
3   SEC USE ONLY:
   
   
     
4   CITIZENSHIP OR PLACE OF ORGANIZATION:
   
  Delaware
       
  5   SOLE VOTING POWER:
     
NUMBER OF   989,697
       
SHARES 6   SHARED VOTING POWER:
BENEFICIALLY    
OWNED BY   0
       
EACH 7   SOLE DISPOSITIVE POWER:
REPORTING    
PERSON   989,697
       
WITH: 8   SHARED DISPOSITIVE POWER:
     
    0
     
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON:
   
  989,697
     
10   CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS):
   
   
     
11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9):
   
  6.92%
     
12   TYPE OF REPORTING PERSON (SEE INSTRUCTIONS):
   
  PN

Page 3 of 13

 

                     
CUSIP No.
  
00826A 1G 9 
  

 

           
1   NAMES OF REPORTING PERSONS:
   
  I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):
MPM BioVentures GmbH & Co. Parallel-Beteiligungs KG
   
     
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS):
  (a)   o
  (b)   þ
     
3   SEC USE ONLY:
   
   
     
4   CITIZENSHIP OR PLACE OF ORGANIZATION:
   
  Germany
       
  5   SOLE VOTING POWER:
     
NUMBER OF   348,491
       
SHARES 6   SHARED VOTING POWER:
BENEFICIALLY    
OWNED BY   0
       
EACH 7   SOLE DISPOSITIVE POWER:
REPORTING    
PERSON   348,491
       
WITH: 8   SHARED DISPOSITIVE POWER:
     
    0
     
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON:
   
  348,491
     
10   CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS):
   
   
     
11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9):
   
  2.43%
     
12   TYPE OF REPORTING PERSON (SEE INSTRUCTIONS):
   
  PN

Page 4 of 13

 

                     
CUSIP No.
  
00826A 1G 9 
  

 

           
1   NAMES OF REPORTING PERSONS:
   
  I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):
MPM Asset Management Investors 2001 LLC
   
     
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS):
  (a)   o
  (b)   þ
     
3   SEC USE ONLY:
   
   
     
4   CITIZENSHIP OR PLACE OF ORGANIZATION:
   
  Delaware
       
  5   SOLE VOTING POWER:
     
NUMBER OF   20,548
       
SHARES 6   SHARED VOTING POWER:
BENEFICIALLY    
OWNED BY   0
       
EACH 7   SOLE DISPOSITIVE POWER:
REPORTING    
PERSON   20,548
       
WITH: 8   SHARED DISPOSITIVE POWER:
     
    0
     
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON:
   
  20,548
     
10   CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS):
   
   
     
11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9):
   
  0.14%
     
12   TYPE OF REPORTING PERSON (SEE INSTRUCTIONS):
   
  OO

Page 5 of 13

 

                     
CUSIP No.
  
00826A 1G 9 
  

 

           
1   NAMES OF REPORTING PERSONS:
   
  I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):
MPM BioVentures Strategic Fund, L.P.
   
     
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS):
  (a)   o
  (b)   þ
     
3   SEC USE ONLY:
   
   
     
4   CITIZENSHIP OR PLACE OF ORGANIZATION:
   
  Delaware
       
  5   SOLE VOTING POWER:
     
NUMBER OF   132,520
       
SHARES 6   SHARED VOTING POWER:
BENEFICIALLY    
OWNED BY   0
       
EACH 7   SOLE DISPOSITIVE POWER:
REPORTING    
PERSON   132,520
       
WITH: 8   SHARED DISPOSITIVE POWER:
     
    0
     
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON:
   
  132,520
     
10   CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS):
   
   
     
11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9):
   
  0.93%
     
12   TYPE OF REPORTING PERSON (SEE INSTRUCTIONS):
   
  PN

Page 6 of 13

 

                     
CUSIP No.
  
00826A 1G 9 
  

 

           
1   NAMES OF REPORTING PERSONS:
   
  I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):
Ansbert Gadicke
   
     
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS):
  (a)   o
  (b)   þ
     
3   SEC USE ONLY:
   
   
     
4   CITIZENSHIP OR PLACE OF ORGANIZATION:
   
  United States
       
  5   SOLE VOTING POWER:
     
NUMBER OF   0
       
SHARES 6   SHARED VOTING POWER:
BENEFICIALLY    
OWNED BY   1,600,469*
       
EACH 7   SOLE DISPOSITIVE POWER:
REPORTING    
PERSON  
       
WITH: 8   SHARED DISPOSITIVE POWER:
     
    1,600,469*
     
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON:
   
  1,600,469*
     
10   CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS):
   
   
     
11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9):
   
  11.18%
     
12   TYPE OF REPORTING PERSON (SEE INSTRUCTIONS):
   
  IN
* The shares are held as follows: 989,697 by MPM BioVentures II-QP, L.P. ("BV II QP"), 109,213 by MPM BioVentures II, L.P. ("BV II"), 20,548 by MPM Asset Management Investors 2001 LLC ("AM 2001"), 348,491 by MPM BioVentures GmbH & Co. Parallel-Beteiligungs KG ("BV KG") and 132,520 by MPM BioVentures Strategic Fund, L.P. (“MPM SF”) . BV II, BV II QP, BV KG and AM 2001 are under common control. MPM Asset Management II, L.P. ("AM II GP") and MPM Asset Management II LLC ("AM II LLC") are the direct and indirect general partners of BV II QP, BV II and BV KG. MPM BioVentures III GP, L.P. ("BV III GP") and MPM BioVentures III LLC ("BV III LLC") are the direct and indirect general partners of MPM SF. The Reporting Person is a member of AM II LP, AM II LLC, AM 2001, BV III GP and BV III LLC.

Page 7 of 13

 

                     
CUSIP No.
  
00826A 1G 9 
  

 

           
1   NAMES OF REPORTING PERSONS:
   
  I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):
Luke Evnin
   
     
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS):
  (a)   o
  (b)   þ
     
3   SEC USE ONLY:
   
   
     
4   CITIZENSHIP OR PLACE OF ORGANIZATION:
   
  United States
       
  5   SOLE VOTING POWER:
     
NUMBER OF   0
       
SHARES 6   SHARED VOTING POWER:
BENEFICIALLY    
OWNED BY   1,600,469*
       
EACH 7   SOLE DISPOSITIVE POWER:
REPORTING    
PERSON   0
       
WITH: 8   SHARED DISPOSITIVE POWER:
     
    1,600,469*
     
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON:
   
  1,600,469*
     
10   CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS):
   
   
     
11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9):
   
  11.18%
     
12   TYPE OF REPORTING PERSON (SEE INSTRUCTIONS):
   
  IN
* The shares are held as follows: 989,697 by MPM BioVentures II-QP, L.P. ("BV II QP"), 109,213 by MPM BioVentures II, L.P. ("BV II"), 20,548 by MPM Asset Management Investors 2001 LLC ("AM 2001"), 348,491 by MPM BioVentures GmbH & Co. Parallel-Beteiligungs KG ("BV KG") and 132,520 by MPM BioVentures Strategic Fund, L.P. (“MPM SF”) . BV II, BV II QP, BV KG and AM 2001 are under common control. MPM Asset Management II, L.P. ("AM II GP") and MPM Asset Management II LLC ("AM II LLC") are the direct and indirect general partners of BV II QP, BV II and BV KG. MPM BioVentures III GP, L.P. ("BV III GP") and MPM BioVentures III LLC ("BV III LLC") are the direct and indirect general partners of MPM SF. The Reporting Person is a member of AM II LP, AM II LLC, AM 2001, BV III GP and BV III LLC.

Page 8 of 13

 

Item 1.
  (a)   Name of Issuer
 
      Affymax, Inc.
 
  (b)   Address of Issuer’s Principal Executive Offices
 
      4001 Miranda Avenue
Palo Alto, CA 94304
Item 2.
  (a)   Name of Person Filing
      MPM BioVentures II, LP
MPM BioVentures II-QP, L.P.
MPM BioVentures GmbH & Co. Parallel-Beteiligungs KG
MPM Asset Management Investors 2001 LLC
MPM BioVentures Strategic Fund, L.P.
Ansbert Gadicke
Luke Evnin
  (b)   Address of Principal Business Office or, if none, Residence
      c/o MPM Capital L.P.
The John Hancock Tower
200 Clarendon Street, 54th Floor
Boston, MA 02116
  (c)   Citizenship
      All entities were organized in Delaware, except MPM BioVentures GmbH & Co. Parallel-Beteiligungs KG which was organized in Germany. The individuals are United States citizens.
  (d)   Title of Class of Securities
      Common Stock
  (e)   CUSIP Number
      00826A 1G 9
Item 3.   If this statement is filed pursuant to §§240.13d-1(b), or 240.13d-2(b) or (c), check whether the person filing is a:
      Not applicable

Page 9 of 13

 

Item 4. Ownership
          (a) Amount Beneficially Owned:
         
MPM BioVentures II, LP
     109,213  
MPM BioVentures II-QP, L.P.
     989,697  
MPM BioVentures GmbH & Co. Parallel-Beteiligungs KG
     348,491  
MPM Asset Management Investors 2001 LLC
     20,548  
MPM BioVentures Strategic Fund, L.P.
     132,520  
Ansbert Gadicke
     1,600,469 *
Luke Evnin
     1,600,469 *
 
               Percent of Class:
 
MPM BioVentures II, LP
     0.76 %
MPM BioVentures II-QP, L.P.
     6.92 %
MPM BioVentures GmbH & Co. Parallel-Beteiligungs KG
     2.43 %
MPM Asset Management Investors 2001 LLC
     0.14 %
MPM BioVentures Strategic Fund, L.P.
     0.93 %
Ansbert Gadicke
     11.18 %
Luke Evnin
     11.18 %
 
          (b) Number of shares as to which the person has:
 
               (i) Sole power to vote or to direct the vote
 
         
MPM BioVentures II, LP
     109,213  
MPM BioVentures II-QP, L.P.
     989,697  
MPM BioVentures GmbH & Co. Parallel-Beteiligungs KG
     348,491  
MPM Asset Management Investors 2001 LLC
     20,548  
MPM BioVentures Strategic Fund, L.P.
     132,520  
Ansbert Gadicke
     0  
Luke Evnin
     0  
 
               (ii) Shared power to vote or to direct the vote
 
         
MPM BioVentures II, LP
     0  
MPM BioVentures II-QP, L.P.
     0  
MPM BioVentures GmbH & Co. Parallel-Beteiligungs KG
     0  
MPM Asset Management Investors 2001 LLC
     0  
MPM BioVentures Strategic Fund L.P.
     0  
Ansbert Gadicke
     1,600,469 *
Luke Evnin
     1,600,469 *

Page 10 of 13

 

               (iii) Sole power to dispose or to direct the disposition of
         
MPM BioVentures II, LP
     109,213  
MPM BioVentures II-QP, L.P.
     989,697  
MPM BioVentures GmbH & Co. Parallel-Beteiligungs KG
     348,491  
MPM Asset Management Investors 2001 LLC
     20,548  
MPM BioVentures Strategic Fund, L.P.
     132,520  
Ansbert Gadicke
     0  
Luke Evnin
     0  
                (iv) Shared power to dispose or to direct the disposition of
         
MPM BioVentures II, LP
     0  
MPM BioVentures II-QP, L.P.
     0  
MPM BioVentures GmbH & Co. Parallel-Beteiligungs KG
     0  
MPM Asset Management Investors 2001 LLC
     0  
MPM BioVentures Strategic Fund, L.P.
     0  
Ansbert Gadicke
     1,600,469 *
Luke Evnin
     1,600,469 *
 
*   The shares are held as follows: 989,697 by MPM BioVentures II-QP, L.P. (“BV II QP”), 109,213 by MPM BioVentures II, L.P. (“BV II”), 20,548 by MPM Asset Management Investors 2001 LLC (“AM 2001”), 348,491 by MPM BioVentures GmbH & Co. Parallel-Beteiligungs KG (“BV KG”) and 132,520 by MPM BioVentures Strategic Fund, L.P. (“MPM SF”). BV II, BV II QP, BV KG and AM 2001 are under common control. MPM Asset Management II, L.P. (“AM II GP”) and MPM Asset Management II LLC (“AM II LLC”) are the direct and indirect general partners of BV II QP, BV II and BV KG. MPM BioVentures III GP, L.P. (“BV III GP”) and MPM BioVentures III LLC (“BV III LLC”) are the direct and indirect general partners of MPM SF. The Reporting Person is a member of AM II LP, AM II LLC, AM 2001, BV III GP and BV III LLC.
Item 5. Ownership of Five Percent or Less of a Class
If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following o.
Item 6. Ownership of More than Five Percent on Behalf of Another Person
     Not Applicable
Item 7.   Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person.
     Not Applicable
Item 8. Identification and Classification of Members of the Group
     Not Applicable
Item 9. Notice of Dissolution of a Group
     Not Applicable
Item 10. Certification
     Not Applicable

Page 11 of 13

 

SIGNATURE
     After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.
Dated: February 9, 2007
                     
MPM BIOVENTURES II, L.P.       MPM BIOVENTURES II-QP, L.P.    
 
                    
By:
  MPM Asset Management II, L.P.,       By:   MPM Asset Management II, L.P.,    
 
  its General Partner           its General Partner    
 
                    
By:
  MPM Asset Management II LLC,
its General Partner 		      By:   MPM Asset Management II LLC,
its General Partner		    
 
                    
By:
        /s/ Luke Evnin       By:         /s/ Luke Evnin    
 
                   
 
  Name: Luke B. Evnin           Name: Luke B. Evnin    
 
  Title: Manager           Title: Manager    
 
                    
MPM BIOVENTURES GMBH & CO. PARALLEL-BETEILIGUNGS KG       MPM ASSET MANAGEMENT INVESTORS 2001 LLC    
 
                    
 
          By:         /s/ Luke Evnin    
 
                   
By:
  MPM Asset Management II LP, in its capacity as the Special Limited Partner           Name: Luke B. Evnin
Title: Manager		    
 
                    
By:
  MPM Asset Management II LLC, its General Partner                
 
                    
By:
        /s/ Luke Evnin                
 
                   
 
  Name: Luke B. Evnin                
 
  Title: Manager                
 
                    
MPM BIOVENTURES STRATEGIC FUND, L.P.       MPM BIOVENTURES III GP, L.P.    
 
                    
By:
  MPM BioVentures III GP, L.P.,       By:   MPM BioVentures III LLC,    
 
  its General Partner           its General Partner    
 
                    
By:
  MPM BioVentures III LLC,       By:         /s/ Luke Evnin    
 
                   
    its General Partner       Name: Luke Evnin    
            Title: Series A Member    
By:
        /s/ Luke Evnin                
 
                   
 
  Name: Luke B. Evnin                
 
  Title: Series A Member                
 
                    
MPM BIOVENTURES III LLC                
 
                    
By:
        /s/ Luke Evnin                
 
                   
Name: Luke Evnin                
Title: Series A Member                
 
                    
By:
        /s/ Ansbert Gadicke       By:         /s/ Luke Evnin    
 
                   
 
  Name: Ansbert Gadicke           Name: Luke B. Evnin    

Page 12 of 13

 

EXHIBIT A
JOINT FILING AGREEMENT
     In accordance with Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, the undersigned agree to the joint filing on behalf of each of them of a statement on Schedule 13G (including amendments thereto) with respect to the Common Stock of Affymax, Inc. and further agree that this agreement be included as an exhibit to such filing. Each party to the agreement expressly authorizes each other party to file on its behalf any and all amendments to such statement. Each party to this agreement agrees that this joint filing agreement may be signed in counterparts.
     In evidence whereof, the undersigned have caused this Agreement to be executed on their behalf this 9th day of February, 2007.
                     
MPM BIOVENTURES II, L.P.       MPM BIOVENTURES II-QP, L.P.    
 
                    
By:
  MPM Asset Management II, L.P.,       By:   MPM Asset Management II, L.P.,    
 
  its General Partner           its General Partner    
 
                    
By:
  MPM Asset Management II LLC,
its General Partner 		      By:   MPM Asset Management II LLC,
its General Partner		    
 
                    
By:
        /s/ Luke Evnin       By:         /s/ Luke Evnin    
 
                   
 
  Name: Luke B. Evnin           Name: Luke B. Evnin    
 
  Title: Manager           Title: Manager    
 
                    
MPM BIOVENTURES GMBH & CO. PARALLEL-BETEILIGUNGS KG       MPM ASSET MANAGEMENT INVESTORS 2001 LLC    
 
                    
 
          By:         /s/ Luke Evnin    
 
                   
By:
  MPM Asset Management II LP, in its capacity as the Special Limited Partner           Name: Luke B. Evnin
Title: Manager		    
 
                    
By:
  MPM Asset Management II LLC, its General Partner                
 
                    
By:
        /s/ Luke Evnin                
 
                   
 
  Name: Luke B. Evnin                
 
  Title: Manager                
 
                    
MPM BIOVENTURES STRATEGIC FUND, L.P.       MPM BIOVENTURES III GP, L.P.    
 
                    
By:
  MPM BioVentures III GP, L.P.,       By:   MPM BioVentures III LLC,    
 
  its General Partner           its General Partner    
 
                    
By:
  MPM BioVentures III LLC,       By:         /s/ Luke Evnin    
 
                   
    its General Partner       Name: Luke Evnin    
            Title: Series A Member    
By:
        /s/ Luke Evnin                
 
                   
 
  Name: Luke B. Evnin                
 
  Title: Series A Member                
 
                    
MPM BIOVENTURES III LLC                
 
                    
By:
        /s/ Luke Evnin                
 
                   
Name: Luke Evnin                
Title: Series A Member                
 
                    
By:
        /s/ Ansbert Gadicke       By:         /s/ Luke Evnin    
 
                   
 
  Name: Ansbert Gadicke           Name: Luke B. Evnin    

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