0000 - Document - Document and Entity Information link:presentationLink link:calculationLink link:definitionLink 0010 - Statement - Condensed Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 0015 - Statement - Condensed Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 0020 - Statement - Condensed Consolidated Statements of Operations link:presentationLink link:calculationLink link:definitionLink 0030 - Statement - Condensed Consolidated Statements of Comprehensive Loss link:presentationLink link:calculationLink link:definitionLink 0040 - Statement - Condensed Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 1010 - Disclosure - Nature of Business link:presentationLink link:calculationLink link:definitionLink 1020 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 1030 - Disclosure - Cash, Cash Equivalents and Marketable Securities link:presentationLink link:calculationLink link:definitionLink 1040 - Disclosure - Property and Equipment link:presentationLink link:calculationLink link:definitionLink 1050 - Disclosure - Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 1060 - Disclosure - Stock-Based Compensation link:presentationLink link:calculationLink link:definitionLink 1070 - Disclosure - Other Accrued Liabilities link:presentationLink link:calculationLink link:definitionLink 1080 - Disclosure - License and Development Agreements link:presentationLink link:calculationLink link:definitionLink 1090 - Disclosure - Term Loans link:presentationLink link:calculationLink link:definitionLink 2020 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 3020 - Disclosure - Summary of Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 3030 - Disclosure - Cash, Cash Equivalents and Marketable Securities (Tables) link:presentationLink link:calculationLink link:definitionLink 3040 - Disclosure - Property and Equipment (Tables) link:presentationLink link:calculationLink link:definitionLink 3060 - Disclosure - Stock-Based Compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 3070 - Disclosure - Other Accrued Liabilities (Tables) link:presentationLink link:calculationLink link:definitionLink 3090 - Disclosure - Term Loans (Tables) link:presentationLink link:calculationLink link:definitionLink 4021 - Disclosure - Summary of Significant Accounting Policies (Details 2) link:presentationLink link:calculationLink link:definitionLink 4020 - Disclosure - Summary of Significant Accounting Policies (Details) link:presentationLink link:calculationLink link:definitionLink 4030 - Disclosure - Cash, Cash Equivalents and Marketable Securities (Details) link:presentationLink link:calculationLink link:definitionLink 4040 - Disclosure - Property and Equipment (Details) link:presentationLink link:calculationLink link:definitionLink 4050 - Disclosure - Stockholders' Equity (Details) link:presentationLink link:calculationLink link:definitionLink 4060 - Disclosure - Stock-Based Compensation (Details) link:presentationLink link:calculationLink link:definitionLink 4061 - Disclosure - Stock-Based Compensation (Details 2) link:presentationLink link:calculationLink link:definitionLink 4062 - Disclosure - Stock-Based Compensation (Details 3) link:presentationLink link:calculationLink link:definitionLink 4070 - Disclosure - Other Accrued Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 4080 - Disclosure - License and Development Agreements (Details) link:presentationLink link:calculationLink link:definitionLink 4090 - Disclosure - Term Loans (Details) link:presentationLink link:calculationLink link:definitionLink 8000 - Statement - Consolidated Statements of Stockholders' Equity and Comprehensive Income (Loss) link:presentationLink link:calculationLink link:definitionLink 8010 - Disclosure - Quarterly Financial Data (unaudited) link:presentationLink link:calculationLink link:definitionLink 8020 - Disclosure - Restructuring link:presentationLink link:calculationLink link:definitionLink 8030 - Disclosure - Fair Value Measurements link:presentationLink link:calculationLink link:definitionLink 8040 - Disclosure - Collaborative Development, Commercialization and License Agreement with GSK link:presentationLink link:calculationLink link:definitionLink 8050 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 8060 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 8070 - Disclosure - Related Party Transactions link:presentationLink link:calculationLink link:definitionLink 8080 - Disclosure - Retirement Plan link:presentationLink link:calculationLink link:definitionLink 8090 - Disclosure - Subsequent Event-Registered Direct Offering (Details) link:presentationLink link:calculationLink link:definitionLink 8100 - Disclosure - Subsequent Event-Registered Direct Offering link:presentationLink link:calculationLink link:definitionLink