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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 BUtBOedHhzYNPhmTYOuhqfPDeZJjg0c4ysqanfsyK4GQrv56Ojr5zyYTvbmoF8Xc
 At8l4ZvnlrQJZg5OM9yy8g==

<SEC-DOCUMENT>9999999995-10-001237.txt : 20100430
<SEC-HEADER>9999999995-10-001237.hdr.sgml : 20100430
<ACCEPTANCE-DATETIME>20100430001522
ACCESSION NUMBER:		9999999995-10-001237
CONFORMED SUBMISSION TYPE:	EFFECT
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20100429
DATE AS OF CHANGE:		20100430
EFFECTIVENESS DATE:		20100429

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			COMBINATORX, INC
		CENTRAL INDEX KEY:			0001135906
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				043514457
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		EFFECT
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-166117
		FILM NUMBER:		10783748

	BUSINESS ADDRESS:	
		STREET 1:		245 FIRST STREET
		STREET 2:		3RD FLOOR
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02142
		BUSINESS PHONE:		617-301-7000

	MAIL ADDRESS:	
		STREET 1:		245 FIRST STREET
		STREET 2:		3RD FLOOR
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02142

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	COMBINATORX INC
		DATE OF NAME CHANGE:	20010301
</SEC-HEADER>
<DOCUMENT>
<TYPE>EFFECT
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0101</schemaVersion>

    <submissionType>EFFECT</submissionType>

    <act>33</act>

    <testOrLive>LIVE</testOrLive>

    <effectiveData>
        <finalEffectivenessDispDate>2010-04-29</finalEffectivenessDispDate>
        <finalEffectivenessDispTime>16:00:00</finalEffectivenessDispTime>
        <form>S-3</form>
        <filer>
            <cik>0001135906</cik>
            <entityName>COMBINATORX, INC</entityName>
            <fileNumber>333-166117</fileNumber>
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