Exhibit 8.1 – List of Significant Subsidiaries and

Consolidated Affiliated Entity

LIST OF SIGNIFICANT SUBSIDIARIES AND
CONSOLIDATED AFFILIATED ENTITIES

Significant Subsidiaries

Name of Company	Jurisdiction of Incorporation	Percentage of Equity Owned
Medicure International, Inc.	Barbados		100	%
Medicure Pharma Inc.	United States (Delaware)		100	%
Medicure U.S.A. Inc.	United States (Delaware)		100	%
Medicure Pharma Europe Ltd	Ireland		100	%
Medicure Mauritius Limited	Mauritius		100	%
Apigen Investments Limited	Mauritius		100	%

All significant subsidiaries do business under their respective legal names.