Exhibit

We consent to the incorporation by reference in the Registration Statements on Form S-1 (No. 333-220040), Form S-3 (No. 333-217051) and Form S-8 (Nos.333-138631, 333-145232, 333-155115, 333-157869, 333-165405, 333-172724, 333-181268, 333-187589, 333-194858, 333-194859, 333-202983, 333-217052 and 333-226731) of Yield10 Bioscience, Inc. of our report dated March 28, 2019, relating to our audit of the consolidated financial statements for the year ending December 31, 2018 of Yield10 Bioscience, Inc. and its subsidiaries which appears in this Annual Report on Form 10-K of Yield10 Bioscience, Inc., for the year ending December 31, 2018.