SEC FORM 3

SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0104
Estimated average burden
hours per response:			0.5

1. Name and Address of Reporting Person^*

LESCHLY MARK

(Last)

(First)

(Middle)

C/O RHO MANAGEMENT TRUST I

152 WEST 57TH STREET, 23RD FLOOR

(Street)

NEW YORK

10019

(City)

(State)

(Zip)

2. Date of Event Requiring Statement (Month/Day/Year)
06/21/2004

3. Issuer Name and Ticker or Trading Symbol
SENOMYX INC [ SNMX ]

4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director	10% Owner
	Officer (give title below)	Other (specify below)

5. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock, $0.001 par value per share	67,317	I	By Rho Management Trust I⁽¹⁾

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
1. Title of Derivative Security (Instr. 4)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
Series A Preferred	⁽²⁾	⁽³⁾	Common Stock	703,482⁽⁴⁾	⁽⁴⁾⁽⁵⁾	I	By Rho Management Trust I⁽¹⁾
Series B Preferred	⁽²⁾	⁽³⁾	Common Stock	186,021⁽⁴⁾	⁽⁴⁾⁽⁶⁾	I	By Rho Management Trust I⁽¹⁾
Series E Preferred	⁽²⁾	⁽³⁾	Common Stock	2,413,877⁽⁴⁾	⁽⁴⁾⁽⁵⁾	I	By Rho Management Trust I⁽¹⁾

Explanation of Responses:

1. The Reporting Person is a managing partner of Rho Capital Partners, Inc., which is the investment advisor to Rho Management Trust I and disclaims beneficial ownership of the shares held by Rho Management Trust I.

2. Immed.

3. N/A

4. The number of shares listed in column 3 is the number of preferred shares held by the Reporting Person as of the date hereof. These shares are convertible at any time at the option of the holder, and will automatically convert upon the closing of the Issuer's initial public offering, in each case into the number of shares of common stock obtained by multiplying by the conversion rate listed in column 4 (.40798874 or .45503209, as applicable).

5. 1-for-.40798874.

6. 1-for-.45503209.

Remarks:

	Mark Leschly	06/21/2004
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.