101 - Document - Document and Entity Information link:calculationLink link:presentationLink link:definitionLink 103 - Statement - Condensed Consolidated Balance Sheets link:calculationLink link:presentationLink link:definitionLink 104 - Statement - Condensed Consolidated Balance Sheets (Parenthetical) link:calculationLink link:presentationLink link:definitionLink 105 - Statement - Condensed Consolidated Statements Of Operations And Comprehensive Income (Loss) link:calculationLink link:presentationLink link:definitionLink 106 - Statement - Condensed Consolidated Statements Of Cash Flows link:calculationLink link:presentationLink link:definitionLink 107 - Disclosure - Organization link:calculationLink link:presentationLink link:definitionLink 108 - Disclosure - Basis of Presentation link:calculationLink link:presentationLink link:definitionLink 109 - Disclosure - Significant Accounting Policies link:calculationLink link:presentationLink link:definitionLink 110 - Disclosure - Stock-Based Compensation link:calculationLink link:presentationLink link:definitionLink 111 - Disclosure - Cash, Cash Equivalents and Available-For-Sale Securities link:calculationLink link:presentationLink link:definitionLink 112 - Disclosure - Fair Value link:calculationLink link:presentationLink link:definitionLink 113 - Disclosure - Collaborations link:calculationLink link:presentationLink link:definitionLink 114 - Disclosure - Accrued Expenses link:calculationLink link:presentationLink link:definitionLink 115 - Disclosure - Common Stock Offering link:calculationLink link:presentationLink link:definitionLink 116 - Disclosure - Income from Massachusetts Tax Incentive Award link:calculationLink link:presentationLink link:definitionLink 117 - Disclosure - Restructuring Activities link:calculationLink link:presentationLink link:definitionLink 118 - Disclosure - Significant Accounting Policies (Policies) link:calculationLink link:presentationLink link:definitionLink 119 - Disclosure - Significant Accounting Policies (Tables) link:calculationLink link:presentationLink link:definitionLink 120 - Disclosure - Stock-Based Compensation (Tables) link:calculationLink link:presentationLink link:definitionLink 121 - Disclosure - Cash, Cash Equivalents and Available-For-Sale Securities (Tables) link:calculationLink link:presentationLink link:definitionLink 122 - Disclosure - Fair Value (Tables) link:calculationLink link:presentationLink link:definitionLink 123 - Disclosure - Accrued Expenses (Tables) link:calculationLink link:presentationLink link:definitionLink 124 - Disclosure - Restructuring Activities (Tables) link:calculationLink link:presentationLink link:definitionLink 125 - Disclosure - Significant Accounting Policies - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 126 - Disclosure - Total Potential Gross Common Equivalent Shares (Detail) link:calculationLink link:presentationLink link:definitionLink 127 - Disclosure - Basic and Diluted Earnings (Loss) per Common Share (Detail) link:calculationLink link:presentationLink link:definitionLink 128 - Disclosure - Property and Equipment, Depreciated Periods (Detail) link:calculationLink link:presentationLink link:definitionLink 129 - Disclosure - Stock-Based Compensation Expense, Related to All Equity Awards (Detail) link:calculationLink link:presentationLink link:definitionLink 130 - Disclosure - Stock-Based Compensation - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 131 - Disclosure - Black-Scholes Valuation Model, Weighted-Average Assumptions (Detail) link:calculationLink link:presentationLink link:definitionLink 132 - Disclosure - Summary of Cash, Cash Equivalents and Available-for-sale Securities (Detail) link:calculationLink link:presentationLink link:definitionLink 133 - Disclosure - Cash, Cash Equivalents and Available-for-Sale Securities - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 134 - Disclosure - Assets Carried at Fair Value Measured on Recurring Basis (Detail) link:calculationLink link:presentationLink link:definitionLink 135 - Disclosure - Fair Value - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 136 - Disclosure - Collaborations - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 137 - Disclosure - Accrued Expenses (Detail) link:calculationLink link:presentationLink link:definitionLink 138 - Disclosure - Common Stock Offering - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 139 - Disclosure - Income from Massachusetts Tax Incentive Award -Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 140 - Disclosure - Restructuring Activities - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 141 - Disclosure - Restructuring Activities (Detail) link:calculationLink link:presentationLink link:definitionLink